جست‌وجوی استاد و پژوهشگر

Richard G. Vileمشاهده پروفایل

استاد

• Cancer Immunotherapy
• Oncolytic Virotherapy
• Chimeric Antigen Receptor (CAR) T-cell Therapy
• +۷ مورد دیگر

Richard G. Vile, Ph.D., is a Professor of Immunology at Mayo Clinic in Rochester, Minnesota, with primary appointments as Consultant in the Department of Molecular Medicine and joint appointment in the Department of Immunology. He is also the Richard M. Schulze Family Foundation Professor, an honor awarded in 2008. His research is centered on developing innovative cancer immunotherapies, particularly through oncolytic virotherapy, CAR T-cell therapy, and combination strategies with radiotherapy. Dr. Vile’s research focuses on stimulating antitumor immune responses using murine immune-competent models and syngeneic tumors. His work spans multiple cancer types, including melanoma, prostate cancer, glioma, brain metastases, and hepatocellular carcinoma. A major innovation from his lab is engineering vesicular stomatitis virus (VSV) to express tumor antigen libraries, enhancing immune recognition and destruction of tumors. His recent publications reveal a strong emphasis on enhancing CAR T-cell efficacy, overcoming immune evasion, and combining oncolytic viruses with checkpoint inhibitors. These studies highlight his leadership in advancing immunovirotherapeutic strategies for solid tumors, particularly through genetic engineering of viral vectors and immune cell therapies. The Richard M. Schulze Family Foundation Professor (2008) Dr. Vile has secured substantial research funding from the National Cancer Institute and the National Institute of Allergy and Infectious Diseases, supporting active projects into 2026. He is directly involved in clinical translation, including an ongoing trial for hepatocellular carcinoma using a VSV-based therapy. He mentors a research team and collaborates internationally, particularly with researchers in the UK. His lab is part of the Mayo Clinic Comprehensive Cancer Center and the David F. and Margaret T. Grohne Cancer Immunology and Immunotherapeutics Program.

Joseph A. Murrayمشاهده پروفایل

استاد

• Celiac Disease
• Gluten Sensitivity
• Gastroenterology
• +۷ مورد دیگر

Joseph A. Murray is a Professor of Medicine at Mayo Clinic in Rochester, Minnesota, where he serves as a Consultant in the Division of Gastroenterology and Hepatology, Department of Internal Medicine, and holds a joint appointment in the Department of Immunology. He is affiliated with key research centers including the Robert and Arlene Kogod Center on Aging, the Immunology Research Center, and the Center for Cell Signaling in Gastroenterology (C-SiG). Education: MD, National University of Ireland, Galway Fellow, Gastroenterology-Hepatology, University of Iowa Hospitals and Clinics Tutor/Registrar, Medicine and GI, St. Laurences and Beaumont Hospitals, Dublin Senior House Officer, Internal Medicine, University of Dublin, Trinity College DCH, Child Health, National University of Ireland, University College of Dublin Internship in Medicine and Surgery, Regional Hospital, Galway MB BCh/BAO, National University of Ireland, Galway Dr. Murray's research focuses on celiac disease, gluten sensitivity, mucosal immunology, and autoimmune gastrointestinal disorders. His work integrates clinical investigation with molecular and immunological approaches, particularly in understanding the mechanisms of gluten-induced immune activation and developing novel diagnostic and therapeutic strategies. He has pioneered research on HLA mouse models of gluten sensitivity and clinical trials of enzyme-based therapies like latiglutenase. The trends in his recent publications reflect a strong emphasis on celiac disease pathogenesis, biomarker discovery, and therapeutic interventions. His studies explore T-cell activation, mucosal healing, biopsy quantification, and cross-disease autoimmunity, often involving multidisciplinary collaboration and translational applications. Scientific Awards: Dr. Murray has been principal or co-principal investigator on multiple NIH-funded grants, including projects from NIDDK, NIAID, and NCCIH, supporting research on tissue destruction and healing in celiac disease, clinical trials of latiglutenase, and the development of animal models for gluten sensitivity. While no formal students are listed, his leadership in large collaborative projects suggests mentorship of junior researchers and fellows. He is actively involved in the Clinical Immunology and Immunotherapeutics Program and has contributed to advancing the scientific understanding of celiac disease through sustained, high-impact research. Labs and Research Teams: Center for Cell Signaling in Gastroenterology (C-SiG) Clinical Immunology and Immunotherapeutics Program Collaborative research network involving Mayo Clinic, University of Chicago, Stanford, and University of Southern Denmark

Elisa Gomez Perdigueroمشاهده پروفایل

عضو هیئت علمی

• Immunology
• Developmental Biology
• Cell Biology
• +۹ مورد دیگر

Elisa Gomez Perdiguero is a Permanent Researcher at the Institut Pasteur in Paris, affiliated with the Membrane, Cytoskeleton and Cell Division unit. She leads the research group focused on the development, maintenance, and functions of tissue-resident macrophages, with a particular emphasis on their embryonic origins and roles in homeostasis and tissue repair. Her work bridges immunology, developmental biology, and cell biology, and she is the Principal Investigator of the ERC-funded project 'ResidentMacroPhage'. Her research primarily investigates the role of yolk sac-derived erythro-myeloid progenitors (EMPs) in generating tissue-resident macrophages such as microglia, Kupffer cells, and Langerhans cells, which self-maintain independently of hematopoietic stem cells (HSCs). She uses mouse and zebrafish models, along with advanced techniques like flow cytometry, lineage tracing, and transgenesis, to explore the ontogeny and functional specialization of macrophages during development and in response to injury. The trends in her recent publications highlight a consistent focus on developmental hematopoiesis, macrophage heterogeneity, and the interplay between macrophages and endothelial cells. Her work has demonstrated the critical role of early macrophage waves in shaping immune and vascular development, with implications for regenerative medicine and inflammatory diseases. Scientific awards and recognitions include: ERC-2016-StG _ResidentMacroPhage – Development, Maintenance and Functions of Resident Macrophages She has actively mentored numerous PhD students and postdoctoral researchers, including Lorea Iturri, Rebeca Ponce Landete, Alina Sommer, and others. Her lab has received funding from major programs such as LabEx Revive and the IP Stem Cell Initiative, supporting research in regenerative biology and medicine. She is currently recruiting for fully funded postdoctoral and PhD fellowships. Elisa Gomez Perdiguero's team collaborates within transversal programs such as 'Mother and Child Health' and participates in the broader Institut Pasteur ecosystem focused on precision medicine and open science.

Pierre Lafayeمشاهده پروفایل

پژوهشگر

• Antibody Engineering
• Nanobodies (VHH)
• Immunotherapy
• +۱۳ مورد دیگر

Pierre Lafaye is the Head of the Antibody Engineering Platform at the Institut Pasteur, a leading institution in biological and medical research. His work is situated within the Technology Department, where he leads a core facility focused on the development and application of VHH (nanobody) technologies. The platform supports a wide range of academic and translational research projects, leveraging the unique properties of nanobodies such as small size, high stability, tissue penetration, and blood-brain barrier crossing ability. Research Interests: Dr. Lafaye’s research spans multiple domains, including cancer immunotherapy (e.g., targeting ILT4 as an immune checkpoint), neurodegenerative diseases (e.g., imaging Alzheimer’s plaques and tangles), infectious diseases (e.g., SARS-CoV-2 diagnostics and therapeutics), and antimicrobial resistance (e.g., targeting β-lactamases). His expertise lies in phage display, protein engineering, and in vivo molecular imaging. He has pioneered the use of dimeric VHHs for sensitive immunoassays and targeted diagnostics. Recent Publication Trends: His recent publications (2021–2024) reflect a strong emphasis on structural biology (using cryo-EM), viral entry mechanisms (especially coronaviruses), and the therapeutic and diagnostic application of nanobodies. Collaborative, high-impact studies in journals like Nature , Cell , and Nature Communications highlight his role in cutting-edge interdisciplinary research. Scientific Awards: While no specific awards are listed in the provided text, his leadership in IBiSA-certified core facilities and participation in major networks like EuroMabNet, Core For Life (CFL), and CTLS reflect recognition of his technical and scientific contributions. Advising and Grants: Dr. Lafaye has supervised multiple PhD students and postdoctoral researchers, indicating an active mentoring role. He leads several funded projects, including the ongoing CORONABODIES and Advances in Cancer Immunotherapy projects, as well as completed initiatives like ChagasDiag and VenoMATIcs. These projects involve collaborations across international Pasteur Institutes and academic partners. Labs and Teams: As head of the Antibody Engineering Platform, he oversees a multidisciplinary team comprising research engineers, technicians, postdocs, and PhD students. The facility is part of broader transversal initiatives at the Institut Pasteur, including those in brain connectivity, cancer, and emerging infectious diseases.

Pierre Guermonprezمشاهده پروفایل

پژوهشگر

• Immunology
• Cellular Immunology
• Cancer Immunotherapy
• +۶ مورد دیگر

Pierre Guermonprez is a Researcher at the Pasteur Institute in Paris. His work focuses on dendritic cell biology, tumor immunology, and adaptive immunity, with an emphasis on Cancer immunotherapy Tumor microenvironment manipulation T cell memory development Myeloid cell reprogramming in disease Recent publications highlight his contributions to understanding FLT3L-based dendritic cell therapies Mechanisms of cross-priming in tumors DC subset cooperation for immune activation Neoantigen response modulation His research spans both murine and human models of dendritic cell development. Current advisees include PhD students Louise Gorline , Jérémie Borneres , Aurélie Semervil , Matthieu Rastello , and Nathan Vaudiau , along with Master’s student Bilge Demerci . Team members also include technical staff, postdocs, and administrative personnel.

Lucie Pedutoمشاهده پروفایل

پژوهشگر

• Cancer biology
• Immunology
• Stromal microenvironment
• +۱۱ مورد دیگر

Lucie Peduto is a Principal Investigator and Structure Manager at the Institut Pasteur in Paris, where she leads a research team investigating the role of stromal and perivascular cells in immunity, inflammation, regeneration, and cancer. Her work focuses on understanding how the stromal microenvironment regulates intestinal homeostasis, tumor progression, and immune responses. Her research interests include: Cancer biology and tumor microenvironment Intestinal immunity and barrier function Mesenchymal and perivascular stromal cells Inflammation and fibrosis Regenerative mechanisms and tissue repair Immune cell-stromal cell crosstalk The recent publications highlight a strong focus on stromal regulation in immunity and cancer, with particular emphasis on PDGFRα+ mesenchymal cells, intestinal barrier integrity, and macrophage interactions. Her work integrates genetic models, organoid systems, and immunological assays to dissect molecular and cellular mechanisms in vivo. Scientific awards and recognitions: ERC Proof of Concept Grant 2023 Dr. Peduto supervises several postdoctoral fellows and PhD students, indicating an active mentoring and training role. She leads multiple funded projects, including ERC-CoG-PERIF on perivascular cells in inflammation and regeneration. Her research is supported by major initiatives at the Institut Pasteur, including the Cancer Initiative and stem cell programs. She collaborates with other leading immunologists and cell biologists at the institute and internationally.

• Respiratory Medicine
• Pneumology
• Oncology
• +۱۷ مورد دیگر

Jan Siwiec, MD, PhD, is an Assistant Professor and Chair of the Department of Pneumology, Oncology and Allergology at the Faculty of Medicine, Medical University of Lublin. His academic and clinical work centers on respiratory diseases, with a strong focus on asthma, occupational lung disorders, lung cancer, and immunological mechanisms involving interleukin-18 and TH1 cell responses. Institution: Medical University of Lublin School: Faculty of Medicine Department: Department of Pneumology, Oncology and Allergology Position: Assistant Professor and Department Chair Dr. Siwiec’s research spans immunology, genetics, occupational health, and clinical pulmonology. His work investigates how genetic polymorphisms (especially in IL-18), environmental exposures (such as wood and organic dust), and occupational settings influence respiratory disease development and progression. He has contributed significantly to understanding asthma in both general and occupational contexts, lung cancer risk among exposed workers, and immune responses in chronic respiratory conditions. The 15 most recent publications reflect a consistent focus on respiratory health, with strong emphasis on occupational exposures, genetic susceptibility, and inflammatory pathways. Research trends show integration of molecular biology with epidemiological and clinical data, particularly in Polish populations. Key themes include biomarker discovery (e.g., IL-18), public health implications of workplace hazards, and the interplay between infection, immunity, and chronic airway disease. While no formal scientific awards are listed in the provided text, Dr. Siwiec has one recorded achievement and maintains an active research profile with 48 documented publications. His work likely involves collaboration across clinical, research, and public health domains. Dr. Siwiec advises or mentors graduate students in medical and scientific research, though specific names are not listed. His department likely functions as a research and teaching hub within the Faculty of Medicine, engaging in multicenter studies and contributing to national data on respiratory diseases. Research may be supported by institutional or national grants, particularly in occupational health and respiratory epidemiology. The Department of Pneumology, Oncology and Allergology serves as the primary research and clinical team under his leadership, focusing on patient care, education, and investigation into lung diseases. The team appears to collaborate on multi-center projects, especially those involving occupational exposure, genetic studies, and pandemic-related respiratory impacts.

Rick Greenoughمشاهده پروفایل

استاد

• Industrial sustainability
• Low carbon manufacturing
• Energy efficient manufacturing
• +۵ مورد دیگر

Professor Rick Greenough at De Montfort University is a leading academic in energy systems and sustainable manufacturing. Affiliated with the School of Engineering and Sustainable Development and the Institute of Energy and Sustainable Development (IESD), he focuses on industrial sustainability, low carbon manufacturing, and energy efficiency. Based in Leicester, UK, he teaches courses like Renewable Energy Technology and Low Impact Manufacturing while leading research on thermal energy systems. His research spans renewable energy integration, biomass power systems, and exergy analysis. Key projects analyze geothermal storage, solar-thermal hybrid systems, and energy flows in manufacturing. His work bridges academia and industry through EPSRC-funded initiatives and EU FP7 partnerships. Publications highlight shallow boreholes for ground source heat pumps, steam storage in biomass CHP plants, and rural energy solutions for Central Asia. He contributes to professional societies like IET and the Energy Institute, emphasizing sustainable development across engineering disciplines.

• Machine Learning
• Bioinformatics
• Medical Engineering
• +۴ مورد دیگر

Susanne Schaller is an Assistant Professor at FH Hagenberg's Research Center Hagenberg, specializing in Medical Engineering and Bioinformatics. She leads interdisciplinary projects focusing on AI-driven solutions in healthcare, including applications in oncology, immunology, and geriatric care. Her work integrates machine learning with genomic data analysis to address challenges in disease diagnosis and treatment. Her research interests include machine learning techniques for gene expression prediction, bioinformatics tool development, and AI applications in chronic disease management. Notable projects include the SmartBeetle initiative (AI-based pest control) and TrainYourBrain Optimizer (Alzheimer’s training software). Projects: 8 active/completed projects (e.g., BF-SigSim, ImmuneProfiler) Collaborations: Interreg Austria-Czech Republic, MAS Demenzservicestellen Key Focus Areas: T-cell signaling, mutation identification in leukemia, and AI-driven healthcare systems Her work bridges computational methods with clinical needs, exemplified by her role in developing IMPI—a tool for low-frequency mutation analysis in chronic myeloid leukemia. She has authored 66+ research outputs, including peer-reviewed articles and commissioned reports on healthcare innovation.

Neville Sanjanaمشاهده پروفایل

دانشیار

• Genome Engineering
• Neuroscience
• Cancer Research
• +۴ مورد دیگر

Neville Sanjana is an Associate Professor at the Department of Neuroscience , NYU Grossman School of Medicine , with a joint affiliation at the New York Genome Center . His academic journey began with a PhD at Massachusetts Institute of Technology . Research Interests in genome engineering, CRISPR technology, and functional genomics focus on: Dissecting noncoding genomic elements across cancers Developing high-throughput CRISPR screening methods Engineering therapies for neurological and genetic diseases Understanding transcriptional regulation in neuronal differentiation Recent Articles span cancer genomics, synthetic biology, and CRISPR-based diagnostics, with a thematic emphasis on: Drug resistance mechanisms in melanoma Noncoding element function in disease Advancements in base and prime editing Applications in immunotherapy and hemoglobin disorders Scientific Honors : NIH Director's New Innovator Award Sidney Kimmel Scholars Program DARPA Young Faculty Award Simons Foundation Autism Research Initiative Melanoma Research Alliance Young Investigator Award Teaching : In Spring 2022, he taught Special Topics: Genome Engineering (BIOL-UA 920) at NYU Biology, covering CRISPR evolution, gene therapies, and ethical implications of genome editing. Lab Operations : The Sanjana Lab operates from two locations - NY Genome Center (101 Avenue of the Americas, 4th floor, New York, NY 10013) and NYU Biology (755 Brown, 100 Washington Sq East, New York, NY 10003).

Florian Sicklingerمشاهده پروفایل

پزشک-پژوهشگر

• Immunocardiology
• Cardiac inflammation
• Cardiac fibrosis
• +۴ مورد دیگر

Dr. Florian Sicklinger is a Physician-Scientist and Assistant Doctor in the Department of Cardiology, Angiology and Pulmonology at Heidelberg University Hospital. He has been working at the Medical Clinic of Heidelberg University Hospital since 2021 and has been a Physician-Scientist in the Immunocardiology Research Group under Prof. Dr. med. Florian Leuschner since 2022. Education Medical studies at Heidelberg University (2013-2020) Doctorate at Heidelberg University Hospital (2016-2022), supervised by Prof. Dr. med. Florian Leuschner Research Interests Dr. Sicklinger's research focuses on the role of the immune system in ischemic heart disease and heart valve diseases, as well as the therapeutic modulation of cardiac inflammation and fibrosis. His work bridges clinical cardiology with immunological mechanisms to develop novel therapeutic approaches for cardiac conditions. He has published extensively on immune cell interactions following myocardial infarction, including studies on basophils, endothelial cells, and macrophages. Publication Trends Dr. Sicklinger's publications demonstrate a strong focus on the intersection of immunology and cardiology, with a clear progression toward increasingly sophisticated methodologies. His early work established standardized approaches for cardiac research models, while his more recent publications employ cutting-edge techniques like single-cell transcriptomics and high-throughput screening. His research consistently addresses the immune mechanisms underlying cardiac injury and repair processes across multiple model systems from mice to pigs. Awards and Recognition Postdoc Start-up Grant from the German Center for Cardiovascular Research (2022-2023) DZHK Paper of the Month (2021 and 2020) Otto-Hess Doctoral Scholarship from the German Cardiac Society (2017-2018) Scholarship from the German National Academic Foundation (2013-2020) Research Leadership As a key member of the Immunocardiology Research Group at Heidelberg University Hospital, Dr. Sicklinger has contributed significantly to developing novel methodologies for cardiac research, including minimal-invasive techniques for inducing myocardial infarction and high-throughput echocardiography-guided approaches. His work on immune cell dynamics after cardiac injury has provided important insights into potential therapeutic targets for improving cardiac recovery following myocardial infarction.

• Nanophotonics
• Quantum Technologies
• Computational Optics
• +۵ مورد دیگر

Dr. Sven Burger is a leading Researcher at the Zuse Institute Berlin (ZIB) within the Modeling and Simulation of Complex Processes department. His work focuses on Nanophotonics , Quantum Technologies , and Optical Resonance Computation , particularly in photonic crystals, plasmonic systems, and quantum light sources. Key projects: NanoLab GRIPS 2024 , MATH+ TES QT , MATH+ PaA-1 (perovskite solar cells), Colour Impression of Solar Cells Collaborations: MATH+ , BIFOLD , Research Campus MODAL His research spans Bayesian optimization for quantum systems, quasinormal mode expansions , chiral plasmonics , and terawatt-scale photovoltaics . Recent work emphasizes RPExpand software for resonance analysis and AAA algorithm applications in photonic design. He contributes to quantum key distribution via plug&play single-photon sources, hot carrier dynamics in plasmonic nanocrystals, and high-efficiency light extraction for deep-UV LEDs. His computational methods address non-Hermitian systems , exceptional points , and self-interference nanoparticle tracking .

Wenrui Liمشاهده پروفایل

استادیار

• Statistics for network data
• Causal inference
• High-dimensional data analysis
• +۳ مورد دیگر

Wenrui Li serves as an Assistant Professor in the Department of Statistics at the University of Connecticut, where she develops advanced statistical methodologies for complex biomedical data structures. Her work bridges theoretical statistics and practical healthcare applications, with particular emphasis on network-based modeling and high-dimensional data analysis in oncology and epidemiology. Dr. Li's research program centers on statistics for network data, causal inference under interference, and Bayesian modeling of structured high-dimensional datasets. She pioneers techniques for handling network noise in graph-guided models, with direct applications to cancer genomics, multi-omics integration, and infectious disease surveillance. Her methodological innovations address critical challenges in noisy data environments where traditional statistical approaches fail. Analysis of her 2021-2025 publications reveals three dominant research threads: (1) Digital health interventions to reduce time burden in cancer care, exemplified by her TIME text-messaging system; (2) Graph-guided Bayesian methods for multi-omics data integration with noisy network priors; and (3) Epidemiological modeling of time-varying parameters in noisy surveillance systems. These threads demonstrate consistent focus on methodological rigor applied to pressing biomedical problems. No scientific awards, student advisement records, grant funding details, or laboratory affiliations were documented in the source materials. Her collaborative work spans biostatistics, oncology, and network science, with frequent co-authorship on interdisciplinary projects addressing cancer care optimization and disease modeling.

• Malaria
• Vaccinology
• Human Genetics
• +۳ مورد دیگر

Adrian Hill is the Lakshmi Mittal Professor of Vaccinology and Director of the Jenner Institute at the University of Oxford. He leads research on vaccines for malaria and other major diseases, with a focus on genetic susceptibility to infection and vaccine delivery technologies. Key Achievements: Founded the Jenner Institute in 2005, which now operates clinical-stage vaccine programs against fifteen diseases. Notable Work: Developed the R21 malaria vaccine with matrix-M adjuvant, showing high efficacy in clinical trials (Lancet, 2021). Global Impact: Spearheaded Oxford's rapid response to the COVID-19 pandemic, resulting in the AstraZeneca vaccine. Research Focus: Malaria vaccine development, human genetics in infectious disease susceptibility, and innovative immunization strategies. His work bridges clinical trials, tropical medicine, and translational research. Scientific Leadership: Recognized through fellowships at the Royal Society, Royal College of Physicians, and Academy of Medical Sciences. He has published over 600 papers with 60,000 citations and co-founded multiple spin-off companies.

Joseph R. Testaمشاهده پروفایل

استاد

• Molecular Biology of Mesothelioma
• Cancer Genetics
• Oncogenesis
• +۱۰ مورد دیگر

Joseph R. Testa is a Professor and Senior Member at Fox Chase Cancer Center, where he holds the Carol and Kenneth E. Weg Chair in Human Genetics. He serves as Chief of Genomic Medicine and Director of the Clinical Cytogenomics Laboratory within the Cancer Prevention and Control program. His research is centered on the molecular genetics of malignant mesothelioma and the oncogenic role of the AKT pathway. University: Fox Chase Cancer Center School: Cancer Prevention and Control Department: Genomic Medicine Academic Rank: Professor Dr. Testa’s research focuses on hereditary and somatic mutations in cancer, particularly in mesothelioma. He discovered germline mutations in the BAP1 gene, leading to the identification of the BAP1 tumor predisposition syndrome. His lab uses genetically engineered mouse models to study gene-environment interactions, tumor development, and preclinical drug testing. Key interests include AKT signaling, NF2 inactivation, and inflammation-driven oncogenesis. His work has revealed mechanisms of chemoresistance and potential therapeutic targets such as FAK and RIPK3. His recent publications (2020–2025) reflect a strong focus on molecular mechanisms in mesothelioma, T-cell lymphoma, and cancer immunology. Trends include the use of transgenic models, epigenetic regulation, and pathway crosstalk (e.g., Wnt, cholesterol synthesis). He actively explores immunogenicity, targeted therapy, and synthetic lethality in genetically defined cancers. Scientific awards include: AACR Most-Cited Article (2018) Pioneer Research Award, MARF (2013) Wagner Medal, IMIG (2012) Elected Fellow, AAAS (2012) Landon-AACR Innovator Award (2008) Irving Selikoff Award (1999) Dr. Testa has mentored numerous researchers and leads a multidisciplinary lab team. He has received continuous grant support for studies on mesothelioma genetics and signaling. His lab collaborates internationally, particularly in BAP1 syndrome research. He is an editorial board member for multiple journals and has served on the NCI Board of Scientific Counselors. His work bridges basic discovery and clinical translation, influencing genetic testing and therapeutic strategies. The Testa Lab includes key personnel such as Yuwaraj Kadariya, Eleonora Sementino, Ujjawal Shrestha, and Yinfei Tan, focusing on mouse models, cytogenetics, and molecular mechanisms of tumorigenesis.