Joseph A. Murray

Joseph A. Murray is a Professor of Medicine at Mayo Clinic in Rochester, Minnesota, where he serves as a Consultant in the Division of Gastroenterology and Hepatology, Department of Internal Medicine, and holds a joint appointment in the Department of Immunology. He is affiliated with key research centers including the Robert and Arlene Kogod Center on Aging, the Immunology Research Center, and the Center for Cell Signaling in Gastroenterology (C-SiG).

Education:

• MD, National University of Ireland, Galway
• Fellow, Gastroenterology-Hepatology, University of Iowa Hospitals and Clinics
• Tutor/Registrar, Medicine and GI, St. Laurences and Beaumont Hospitals, Dublin
• Senior House Officer, Internal Medicine, University of Dublin, Trinity College
• DCH, Child Health, National University of Ireland, University College of Dublin
• Internship in Medicine and Surgery, Regional Hospital, Galway
• MB BCh/BAO, National University of Ireland, Galway

Dr. Murray's research focuses on celiac disease, gluten sensitivity, mucosal immunology, and autoimmune gastrointestinal disorders. His work integrates clinical investigation with molecular and immunological approaches, particularly in understanding the mechanisms of gluten-induced immune activation and developing novel diagnostic and therapeutic strategies. He has pioneered research on HLA mouse models of gluten sensitivity and clinical trials of enzyme-based therapies like latiglutenase.

The trends in his recent publications reflect a strong emphasis on celiac disease pathogenesis, biomarker discovery, and therapeutic interventions. His studies explore T-cell activation, mucosal healing, biopsy quantification, and cross-disease autoimmunity, often involving multidisciplinary collaboration and translational applications.

Scientific Awards:

Dr. Murray has been principal or co-principal investigator on multiple NIH-funded grants, including projects from NIDDK, NIAID, and NCCIH, supporting research on tissue destruction and healing in celiac disease, clinical trials of latiglutenase, and the development of animal models for gluten sensitivity. While no formal students are listed, his leadership in large collaborative projects suggests mentorship of junior researchers and fellows. He is actively involved in the Clinical Immunology and Immunotherapeutics Program and has contributed to advancing the scientific understanding of celiac disease through sustained, high-impact research.

Labs and Research Teams:

• Center for Cell Signaling in Gastroenterology (C-SiG)
• Clinical Immunology and Immunotherapeutics Program
• Collaborative research network involving Mayo Clinic, University of Chicago, Stanford, and University of Southern Denmark