Ann Marie Leen, Ph.D., is a Professor in the Department of Pediatrics-Hem-Onc and a Member of the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine. Her research focuses on T cell immunotherapy for viruses and cancer, particularly in the context of hematopoietic stem cell transplantation. She holds a PhD from the University of Birmingham (2002) and Baylor College of Medicine (2005). Education: PhD, University of Birmingham, United Kingdom (2002) PhD, Baylor College of Medicine, Houston, TX (2005) Research Interests: Dr. Leen’s work centers on cytotoxic T cell (CTL) therapies for viral infections and malignant diseases. Key areas include: Adoptive transfer of donor-derived virus-specific CTLs for adenoviral infections post-transplant Development of tumor-specific CTLs targeting cancer testis antigens (SSX2/SSX4) Immunotherapy protocols for relapsed EBV-negative Hodgkin’s disease and non-Hodgkin lymphoma Engineering T-cells with enhanced specificity and potency Her research combines clinical trials, translational studies, and preclinical models to advance T-cell-based therapies. Articles Overview: Recent work highlights advancements in CAR-T cell engineering, viral immunity, and tumor microenvironment modulation. Notable themes include: Optimizing CAR-T cell persistence and specificity Targeting viral antigens (EBV, Adenovirus) in immunocompromised patients Novel approaches to overcome tumor immune suppression Advising & Grants: Dr. Leen collaborates extensively on clinical trials and T-cell manufacturing protocols. While specific grant details are not listed, her work aligns with major initiatives in adoptive immunotherapy and cell therapy. Labs/Teams: Affiliated with the Center for Cell & Gene Therapy , a hub for pioneering cell-based therapies at Baylor College of Medicine.











