جست‌وجوی استاد و پژوهشگر

Brian McCabeمشاهده پروفایل

دانشیار

• Motor Neuroscience
• Neurodegenerative Diseases
• Drosophila Genetics
• +۳ مورد دیگر

Brian McCabe is an Associate Professor and Director of the Laboratory of Neural Genetics and Disease at the École Polytechnique Fédérale de Lausanne (EPFL). He holds roles as Director of the Brain Mind Institute (BMI) and serves on the PhD program committee for the Neuroscience Doctoral Program (EDNE). His research focuses on motor system neurobiology, leveraging Drosophila genetics to study synapse function, circuit dynamics, and neurodegenerative disorders such as ALS and SMA. McCabe’s lab employs advanced neurogenetic tools and in vivo imaging to dissect molecular mechanisms underlying motor circuit dysfunction across aging and disease. Education details are not explicitly provided in the text. His current academic positions include: Associate Professor, School of Life Sciences (SV) Director, Brain Mind Institute (BMI) PhD Program Committee Member, Doctoral Program Neuroscience Research Interests: Motor synapse maintenance and plasticity Neurodegenerative disease modeling in Drosophila Age-related synaptic decline Genetic conservation in motor neuron disorders His lab integrates molecular genetics, electrophysiology, and behavioral analysis to study how synapses and circuits adapt during health and disease. Publications reflect a focus on synaptic biology, aging mechanisms, and neurodegenerative pathways. Grants and collaborations support his work on motor system dysfunction. He advises multiple PhD students and oversees lab members including postdoctoral scientists and technicians. Laboratory activities include developing genetic tools (e.g., pBID vectors) and sharing reagents with the scientific community. The lab is part of EPFL’s Brain Mind Institute, emphasizing interdisciplinary research in neuroscience.

• Neuroscience
• Genetics
• Metabolic Disorders
• +۳ مورد دیگر

Roman Chrast is a Lecturer at the School of Life Sciences, EPFL, and serves as Head of Research Core Facilities under the Deanship SV. His roles include overseeing research infrastructure and teaching life sciences engineering courses. He holds a PhD in Life Sciences from the University of Geneva and a CAS in Management of Medtech, Biotech, and Pharma Ventures from EPFL. Research interests focus on metabolic interactions in myelinating Schwann cells, genetic neuropathies (e.g., Charcot-Marie-Tooth), and mitochondrial dysfunction in neurological diseases. His work bridges basic science and translational medicine, exploring molecular mechanisms underlying axonal degeneration and glial cell biology. Publications highlight contributions to understanding Schwann cell metabolism, mitochondrial dynamics, and gene therapy approaches for neuropathies. His administrative roles involve coordinating core facilities to support interdisciplinary research in life sciences.

• Neurology
• Neuroscience
• Neurodegenerative Disorders
• +۳ مورد دیگر

Paul Rosenberg is an Associate Professor of Neurology at Harvard Medical School and a Senior Associate in the Department of Neurology at the Waltham Sleep Center. His research focuses on neurodegenerative diseases, brain injury in premature infants, sleep mechanisms, and glutamate signaling. He holds an MD from Albert Einstein College of Medicine (1978) and a PhD, with residency training at Longwood Area Neurological Training Program (1982) and a fellowship at Boston Children's Hospital (1985). Rosenberg's research spans neurodegeneration (Alzheimer's, Huntington's), excitotoxic mechanisms, and the role of glutamate transporters like GLT-1. His work also addresses oxidative stress, zinc homeostasis, and developmental neurobiology. Clinically, he combines sleep medicine practice with neurology, emphasizing translational research. Key areas of study include the pathophysiology of periventricular leukomalacia, cerebral white matter injury, and the interplay between glutamate transport and neurodegeneration. His findings on GLT-1's role in synaptic and mitochondrial function have advanced understanding of excitotoxic injury and therapeutic targets. Publications highlight his contributions to glutamate transporter biology, neurovascular reactivity in Alzheimer's, and the redox mechanisms of excitotoxicity. Rosenberg's work bridges basic science and clinical applications, particularly in neuroprotection strategies for neurodegenerative and developmental disorders.

Ann Rittenhouseمشاهده پروفایل

دانشیار

• Voltage-Gated Calcium Channels
• Neuronal Plasticity
• Schizophrenia
• +۳ مورد دیگر

Ann Rittenhouse is an Associate Professor at UMass Chan Medical School's Department of Microbiology. Her research focuses on voltage-gated calcium channels (VGCCs) and their roles in neuronal plasticity, schizophrenia, and pancreatic β-cell function. She holds affiliations with T.H. Chan School of Medicine's Microbiology and NeuroNexus Institute departments, as well as the Morningside Graduate School's Interdisciplinary Graduate Program and Neuroscience Department. Rittenhouse earned an AB in Biology from Mount Holyoke College and a PhD in Biology from Boston University. Her laboratory investigates how VGCC subunits influence calcium influx in neurons and pancreatic cells, linking these processes to learning, behavior, and disease. Key research themes include modulation of VGCCs by neurotransmitters, lipids, and cytoplasmic proteins, with implications for schizophrenia and metabolic disorders. Recent work includes studies on DISC1 mutations affecting calcium channel function and transgenic mouse models of lysosomal storage disorders. Publications span topics like muscarinic receptor signaling, β-cell dysfunction, and potassium channel regulation. Her work integrates electrophysiology, imaging, and genetic approaches to understand molecular mechanisms underlying neurological and metabolic diseases. The lab collaborates widely, including with co-authors like Greiner, Melikian, and Bortell, and maintains an active presence in neurobiology and physiology fields.

Jean Giacomottoمشاهده پروفایل

مدرس ارشد

• Genetics
• Human Diseases
• Drug Discovery
• +۷ مورد دیگر

Dr. Jean Giacomotto is a Senior Lecturer at Griffith University , affiliated with the Griffith Institute for Drug Discovery and Institute for Biomedicine and Glycomics . His work bridges translational research, genetics, and zebrafish model development for neuromuscular and neurological disorders. Education : PhD in Genetics (CNRS/Université Lyon 1, France), Engineer (CNRS, France) Current Roles : NHMRC Emerging Leader Fellow, Research Leader at Institute for Biomedicine and Glycomics Research Interests focus on leveraging zebrafish models for drug discovery , synaptic dysfunction in schizophrenia/autism, and neurodegenerative disease mechanisms . Key methodologies include CRISPR/Cas9 , chemical genetics , and high-throughput phenotypic screening . Scientific Contributions include 5.3 million in grants, 3 drug patents, and pioneering inducible zebrafish models for ALS and SMA. His work has identified novel SMN1 variants and C9orf72 dysfunction mechanisms. Collaborations : University of Queensland, Metro South Health, FightMND Labs : Giacomotto Lab at GRIDD and Discovery Biology, Griffith University

Stephanie Olivier-Van Stichelenمشاهده پروفایل

دانشیار

• O-GlcNAcylation
• Non-Nutritive Sweeteners
• Metabolic Homeostasis
• +۳ مورد دیگر

Stephanie Olivier-Van Stichelen, PhD, is an Associate Professor in the Department of Biochemistry at the Medical College of Wisconsin, with secondary faculty appointments in Neurosurgery and Obstetrics & Gynecology. Her research focuses on O-GlcNAcylation's role in development, metabolism, and the impact of sweeteners on health. She leads a lab established in 2019, creating mouse models and the O-GlcNAc database, a key resource for glycoprotein research. Dr. Olivier-Van Stichelen earned her PhD in Biochemistry from the University of Lille, France (2012), studying O-GlcNAcylation in colorectal cancer. Her postdoctoral training at the NIH (Bethesda, MD) explored O-GlcNAcylation in developmental processes, including X-inactivation and brain function. Current projects investigate O-GlcNAcylation in pituitary pathophysiology, gestational diabetes sex differences, and artificial sweeteners' effects on detoxification pathways. Her work bridges developmental biology, endocrinology, and nutrition. Key themes include: (1) O-GlcNAc cycling's role in metabolic homeostasis, (2) non-nutritive sweeteners' impact on gut microbiota and detoxification, (3) placental O-GlcNAc regulation in pregnancy. She collaborates on database development and interdisciplinary projects linking glycobiology to clinical applications. Publications highlight food-drug interactions involving sweeteners, O-GlcNAc's endocrine roles, and placental biology. Her lab emphasizes translational research with potential implications for metabolic disease prevention and treatment.

Mackenzie Howardمشاهده پروفایل

عضو هیئت علمی

• Neuroscience
• Molecular Biology
• Genetics and Genomics
• +۷ مورد دیگر

Mackenzie Howard is a Research Assistant Professor of Neurology at the Dell Medical School and University of Texas at Austin. She holds affiliations with the Center for Learning and Memory and directs the Howard Neuro Lab. Her research focuses on cellular and circuit mechanisms linking neurological disease mutations to cognitive deficits, particularly in genetic epilepsies and neurodevelopmental disorders. She uses genetic mouse models to study how mutations affect neuronal subtypes and neural circuits, employing electrophysiological, imaging, and behavioral techniques. Howard earned a BA in Biology from Lewis and Clark College in 1998, followed by a PhD in Physiology and Biophysics from the University of Washington (2008). She completed postdoctoral training at UCSF, shifting her focus to synaptic plasticity in epilepsy. Her lab prioritizes diversity, equity, and inclusion, advocating for underrepresented groups in science. Research themes include synaptic integration in epilepsy models, interneuron transplantation, and the effects of genetic mutations on neuronal physiology. The lab actively publishes on topics like Scn1b knockout mice and Dravet syndrome mechanisms. Mentoring and scientific education are core values, with a commitment to advancing DEI initiatives.

Amy Leeمشاهده پروفایل

استاد

• Neuroscience
• Molecular Biology
• Genetics & Genomics
• +۶ مورد دیگر

Amy Lee is a Professor of Neuroscience and affiliated with the Interdisciplinary Life Sciences Graduate Programs at the University of Iowa. She holds a PhD in Neuroscience from the University of Virginia (mentored by Kevin Lynch) and conducted postdoctoral research with William Catterall at the University of Washington. Her academic journey includes roles as Assistant Professor at Emory University (2002–2009) and subsequent promotions to Professor and Assistant Dean for Research in the Carver College of Medicine (2014–2019). Her research focuses on voltage-gated Ca 2+ channels, particularly their roles in nervous system development and function. Key projects include studying Cav channel structure/function relationships, axonal regeneration mechanisms involving CaBPs, and retinal circuit development. Techniques employed span electrophysiology, imaging, and machine learning. Her articles highlight breakthroughs in channel pharmacology, synaptic organization, and gene therapy applications. Notable awards include the Women of Innovation Award (2015), AAMC Video Competition Award (2016), and teaching excellence recognitions. She leads the Lee Lab, advancing interdisciplinary approaches to neurobiology and disease.

• psychiatry
• stress
• treatment-resistant depression
• +۶ مورد دیگر

Mark D. Kvarta serves as an Adjunct Assistant Professor in the Department of Psychiatry at the University of Maryland School of Medicine, University of Maryland, Baltimore, with primary clinical and research affiliations in psychiatry and neuroscience. His educational trajectory features: BA in Biological Sciences (Neurobiology & Behavior) from Cornell University (2008) PhD in Neuroscience from University of Maryland Baltimore (2015) MD from University of Maryland School of Medicine (2017) Physician Scientist Training Program & Psychiatry Residency at University of Maryland Medical Center/Sheppard-Pratt Hospital (2021) Dr. Kvarta's research centers on stress-induced neurobiological mechanisms underlying depression and serious mental illness, integrating neuroimaging, neuroendocrine, and genetic data with clinical symptom profiles. His work specifically targets treatment-resistant depression, anhedonia, and novel antidepressant development through translational approaches bridging rodent models and human studies. Key methodologies include brain MRI, neurogenetic analysis, and synaptic plasticity assessments in stress-response circuits. His publication record (2013-2021) reveals consistent focus on stress-depression neurocircuitry, evolving from synaptic mechanisms in rodent models (2013-2015) to multimodal human investigations (2018-2021). Core thematic threads include hippocampal-accumbens pathway dysfunction, genetic modulation of stress vulnerability, and translational biomarkers for treatment resistance, with recent work quantifying multidimensional stress-genetic interactions in depression pathophysiology. No scientific awards are documented in current professional materials. As part of the Physician Scientist Training Program, Dr. Kvarta contributes to integrated clinical-research training while collaborating across neuroscience and psychiatry departments. His translational framework connects basic synaptic findings to clinical depression phenotypes through ongoing human neuroimaging and genetic studies.

Howard E. Gendelmanمشاهده پروفایل

استاد

• Neurodegenerative Disorders
• HIV/AIDS Research
• Antiretroviral Therapies
• +۵ مورد دیگر

Howard E. Gendelman, MD, is the Margaret R. Larson Professor of Internal Medicine and Infectious Diseases and Chair of the Department of Pharmacology and Experimental Neuroscience at the University of Nebraska Medical Center (UNMC). He leads the Center for Neurodegenerative Disorders and has pioneered transformative therapies for HIV/AIDS and neurodegenerative diseases. His research focuses on antiretroviral drug development, immune-based therapies, and neuroimmune mechanisms in diseases like Alzheimer’s and Parkinson’s. Gendelman holds over 132 patents and has authored 600+ peer-reviewed publications. Education: BS in Natural Sciences and Russian Studies, Muhlenberg College MD, Pennsylvania State University-Hershey Medical Center (1979) Residency in Internal Medicine, Montefiore Hospital (Albert Einstein College of Medicine) Fellowships in Neurology and Infectious Diseases, Johns Hopkins Medical Center Research Interests: Howard’s work spans HIV pathogenesis , neurodegenerative diseases , and long-acting drug delivery systems . He co-developed ultra-long-acting antiretroviral medicines and demonstrated brain immunity’s role in neural damage. His lab explores CRISPR-based HIV eradication and immune transformation therapies for Parkinson’s. Collaborations include Exavir Therapeutics, Inc. Grants & Awards: Henry L. Moses Award in Basic Science Jacob Javits Neuroscience Research Award Nebraska Pioneer and UNMC Innovator of the Year Lifetime Service Award (Society on NeuroImmune Pharmacology) Labs/Teams: Directs the Laboratory of Howard E. Gendelman, focused on neuroimmunopharmacology and translational medicine. Active in the Society on NeuroImmune Pharmacology (President, 2022).

• Systems Neuroscience
• Cognitive Neuroscience
• Neurophysiology
• +۶ مورد دیگر

Brian Mathur, PhD is a Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. His research focuses on Systems Neuroscience , particularly investigating neural circuit form and function in health and alcohol use disorder. He also holds a secondary appointment in Psychiatry and leads the Mathur Lab ( mathurlab.org ). Dr. Mathur's research explores the role of the claustrum in cognitive control, striatal circuits in addictive behaviors, and neurovascular coupling mechanisms. His work integrates molecular genetics, electrophysiology, and optogenetics to study ethanol's effects on synaptic inhibition, dopamine signaling, and cortical-subcortical networks. Recent publications highlight his expertise in claustrum-cortical interactions (2025), chronic alcohol effects on striatal interneurons (2023), and neurovascular plasticity (2024). His NIH grants R01AA028070 and R01AA024845 fund research into alcohol-related neural circuit disruptions. Key research themes: Claustrum's role in perception, memory, and attention Striatal microcircuits in addiction and reward processing Endocannabinoid and dopamine interactions Chronic alcohol effects on synaptic plasticity Neurovascular coupling in cognitive function

• Neuroscience
• Molecular Neuroscience
• Alzheimer’s Disease
• +۵ مورد دیگر

Prof. Sarah King is a Professor of Neuroscience (Psychology) at the University of Sussex’s School of Psychology, affiliated with Sussex Neuroscience. She holds a BSc in Biology from the University of Bristol, followed by an MSc in Molecular Genetics and PhD in Neuroscience from Sussex. After a 7-year postdoc at Yale University’s Molecular Psychiatry Department, she returned to Sussex as a lecturer and was promoted to Reader in 2014. Her research focuses on molecular mechanisms of Alzheimer’s Disease (APOE4’s role), GABAA receptor modulation in addiction, and neurovascular dynamics. She has secured grants from the MRC, Alzheimer’s Society, and EU, and serves on committees like the ARUK South Coast Network. Awards include the 2023 University of Sussex Public Engagement Award for the Sussex Brain Bus outreach initiative. Education: BSc Biology, University of Bristol MSc Molecular Genetics, University of Sussex PhD Neuroscience, University of Sussex Research Interests: Neurobiology of APOE4 in Alzheimer’s pathogenesis GABAA receptor regulation in drug addiction circuits Neurovascular coupling in awake mice models Early-life adversity’s impact on addiction vulnerability Grant Highlights (2010–2023): MRC-funded studies on GABAA receptor modulators and hippocampal activity Alzheimer’s Society funding for APOE TR mouse models EU grants exploring cultural/biological binge-drinking factors Awards & Engagement: Recipient of Research Impact through Public Engagement Award (2023) Founder of the Sussex Brain Bus community outreach program Organized public events like the British Neuroscience Association Festival

Lucas Martin Cheadleمشاهده پروفایل

دانشیار

• Neuroimmunology
• Brain Development
• Synapse Plasticity
• +۶ مورد دیگر

Lucas Martin Cheadle is an Associate Professor at Cold Spring Harbor Laboratory (CSHL) and a Howard Hughes Medical Institute Freeman Hrabowski Scholar. His research bridges neuroimmunology and brain development , focusing on how microglia and oligodendrocyte precursor cells (OPCs) interact with neurons to shape neural circuits. Cheadle's work has significant implications for neurodevelopmental disorders (e.g., autism) and neurodegenerative diseases (e.g., Alzheimer's). Education: B.A. and Ph.D. in Neuroscience from Smith College and Yale University, respectively; postdoctoral training at Harvard Medical School Awards: MIND Prize (2025), HHMI Freeman Hrabowski Scholar (2023), Rita Allen Scholar Award (2021), NIH Director’s New Innovator Award (2022) Cheadle employs two-photon microscopy , single-cell genomics , and transgenic mouse models to dissect how environmental cues influence microglial and OPC functions. His recent work explores synapse protection mechanisms in Alzheimer’s disease, proposing novel therapeutic strategies targeting non-neuronal cells . This aligns with his broader vision of integrating immune system dynamics into fundamental neuroscience. Cheadle actively promotes diversity and inclusion in science, both through lab initiatives and collaborations with the Chickasaw Nation.

Joanna L. Jankowskyمشاهده پروفایل

استاد

• Alzheimer's Disease
• Neurodegenerative Disorders
• Molecular Neuroscience
• +۳ مورد دیگر

Joanna L. Jankowsky is a Professor in the Department of Neuroscience at Baylor College of Medicine, holding the Vivan L. Smith Endowed Chair in Neuroscience. She also serves as Associate Director of the Graduate Program in Neuroscience and a Faculty Member in the Development, Disease Models, and Therapeutics (DDMT) program. Her research focuses on Alzheimer’s disease pathogenesis, exploring genetic and aging factors influencing disease risk and neuronal vulnerability. Education: B.A. in Biology, Amherst College (1991) Ph.D. in Molecular and Cellular Neuroscience, California Institute of Technology (1999) Advanced Training in Neuroscience, Johns Hopkins University School of Medicine (2003) Research Interests: Dr. Jankowsky investigates how aging, genetics, and neural circuitry contribute to Alzheimer’s progression. Her lab uses transgenic mice to study amyloid pathology, cognitive reserve, and selective neuronal vulnerability in brain regions like the entorhinal cortex. Key questions address genetic resilience, age-related risk mechanisms, and circuit dysfunction in disease. Publications: Her recent work highlights discoveries in TMEM106B’s role in neuroprotection, microglial regulation, and novel therapeutic strategies for amyloid reduction. Her studies emphasize translational approaches, leveraging mouse models to uncover mechanisms applicable to human disease. Advising & Grants: No specific grants or student advisees are listed, though her lab engages in collaborative research. Her work aligns with advancements in neurodegenerative disease modeling and therapeutic development. Labs/Teams: Dr. Jankowsky leads the Jankowsky Laboratory, focused on Alzheimer’s pathogenesis and translational neuroscience. The lab integrates molecular, genetic, and behavioral approaches to dissect disease mechanisms.

Daoyun Jiمشاهده پروفایل

استاد

• Neuroscience
• Memory Formation
• Neural Circuits
• +۳ مورد دیگر

Daoyun Ji is a Professor in the Department of Neuroscience at Baylor College of Medicine. His research focuses on neural circuit mechanisms underlying memory formation, consolidation, and utilization, with a particular emphasis on how memories guide behavior. He holds a Ph.D. in Neuroscience from Baylor College of Medicine and advanced training at MIT. Education: Ph.D., Baylor College of Medicine (2000); Ph.D., Nankai University (1996); Advanced training at MIT (2008) Research interests include the interplay between visual cortex and hippocampus during memory encoding, sleep-dependent memory processing (focusing on slow-wave and REM sleep roles), and memory dysfunction in neurodegenerative disorders like Alzheimer’s. His lab uses electrophysiological recordings, genetic models, and computational approaches to study neural circuits in rodents. Key findings include identifying rigid hippocampal firing patterns in tauopathy models and demonstrating sleep’s role in memory consolidation via hippocampal-cortical replay. Collaborations include work with Mauro Costa-Mattioli and Huda Zoghbi. Lab members include postdoctoral associates and a PhD student. Publications highlight breakthroughs in memory replay dynamics, LSD’s impact on spatial perception, and tau-mediated neurodegeneration effects. Ongoing projects explore social learning mechanisms and disease models of memory disorders.