Brian McCabe

Brian McCabe is an Associate Professor and Director of the Laboratory of Neural Genetics and Disease at the École Polytechnique Fédérale de Lausanne (EPFL). He holds roles as Director of the Brain Mind Institute (BMI) and serves on the PhD program committee for the Neuroscience Doctoral Program (EDNE). His research focuses on motor system neurobiology, leveraging Drosophila genetics to study synapse function, circuit dynamics, and neurodegenerative disorders such as ALS and SMA. McCabe’s lab employs advanced neurogenetic tools and in vivo imaging to dissect molecular mechanisms underlying motor circuit dysfunction across aging and disease.

Education details are not explicitly provided in the text. His current academic positions include:

• Associate Professor, School of Life Sciences (SV)
• Director, Brain Mind Institute (BMI)
• PhD Program Committee Member, Doctoral Program Neuroscience

Research Interests:

• Motor synapse maintenance and plasticity
• Neurodegenerative disease modeling in Drosophila
• Age-related synaptic decline
• Genetic conservation in motor neuron disorders

His lab integrates molecular genetics, electrophysiology, and behavioral analysis to study how synapses and circuits adapt during health and disease.

Publications reflect a focus on synaptic biology, aging mechanisms, and neurodegenerative pathways. Grants and collaborations support his work on motor system dysfunction. He advises multiple PhD students and oversees lab members including postdoctoral scientists and technicians.

Laboratory activities include developing genetic tools (e.g., pBID vectors) and sharing reagents with the scientific community. The lab is part of EPFL’s Brain Mind Institute, emphasizing interdisciplinary research in neuroscience.