جست‌وجوی استاد و پژوهشگر

• Oncology
• Neuro-Oncology
• Hematology
• +۵ مورد دیگر

Radu O. Minea is an Assistant Professor of Research in Neurological Surgery at the University of Southern California (USC). His research focuses on developing conjugated drug therapies for cancers such as glioblastoma, leukemia, and lymphoma. He specializes in preclinical models to evaluate the efficacy of novel compounds like NEO212, NEO214, and NEO100, which target cancer cells through mechanisms including autophagy inhibition, macrophage differentiation, and enhanced drug delivery to tumor sites. His work bridges molecular oncology, drug design, and translational medicine, with a particular emphasis on overcoming drug resistance in malignant tumors. Key research areas include: Design and testing of conjugated chemotherapeutic agents Mechanisms of drug resistance in gliomas and hematologic malignancies Targeted drug delivery strategies for brain-localized cancers Role of disintegrins and venom-derived peptides in cancer therapy Dr. Minea’s publications highlight innovations in radiosensitization, antiviral cancer therapies, and the application of multi-integrin targeting proteins. His research has implications for improving treatment outcomes in aggressive cancers like glioblastoma and acute myeloid leukemia.

• Pulmonary Research
• Lung Development
• Bronchopulmonary Dysplasia
• +۵ مورد دیگر

Parviz Minoo, PhD is a Professor of Pediatrics at the Keck School of Medicine, University of Southern California, where he also serves as Director of the USC Hastings Center for Pulmonary Research. His research focuses on pulmonary development and disease, with particular emphasis on understanding the molecular mechanisms underlying lung morphogenesis and alveolar development. Dr. Minoo's research interests center on pulmonary biology with a focus on lung development, alveologenesis, and bronchopulmonary dysplasia. His work investigates the complex signaling pathways involved in lung formation, including Wnt, FGF, TGF-β, and Hedgehog signaling networks. He has made significant contributions to understanding how transcription factors like NKX21 regulate lung epithelial cell differentiation and how growth factors such as FGF10 drive alveolar formation. His research bridges basic developmental biology with clinical applications for neonatal respiratory disorders. Analysis of Dr. Minoo's recent publications reveals a consistent focus on the molecular mechanisms of alveologenesis and lung regeneration. His work demonstrates how specific signaling pathways (Wnt5a, FGF10, Hedgehog) interact with transcription factors (NKX21, FOXO1) to regulate alveolar cell differentiation. The research spans from fundamental developmental biology to potential therapeutic applications for bronchopulmonary dysplasia and pulmonary fibrosis, with increasing attention to cellular plasticity, progenitor cell niches, and the role of the extracellular matrix in lung development. As Director of the USC Hastings Center for Pulmonary Research, Dr. Minoo oversees a multidisciplinary team investigating lung development, injury, and repair mechanisms. His laboratory employs sophisticated mouse models, organoid cultures, and molecular techniques to unravel the complexities of pulmonary biology. The center serves as a hub for collaborative research connecting basic science with clinical applications in neonatal and pediatric pulmonary medicine.

• Pediatrics
• Regenerative Medicine
• Developmental Biology
• +۵ مورد دیگر

David Warburton, MD is a Professor of Pediatrics at the University of Southern California (USC), affiliated with the Saban Research Institute at Children's Hospital Los Angeles (CHLA). His work bridges neonatal-perinatal medicine, developmental biology, and regenerative medicine, with a focus on lung morphogenesis, repair, and fibrosis. He has pioneered studies on molecular embryology of the lung, including growth factor and extracellular matrix roles in lung development and disease. Warburton's research spans clinical and basic science, including management practices for extreme prematurity, fetal lung maturation, and pediatric interstitial lung diseases. He collaborates internationally, particularly in the UK, and mentors doctoral and postdoctoral fellows. His awards include the Order of the British Empire (2009) for UK/US scientific collaboration and fellowships from Royal Colleges of Surgeons, Physicians, and Paediatrics. Key research areas include environmental health impacts (e.g., air pollution in Mongolia), post-COVID-19 pediatric sequelae, and clinical trials for nintedanib in fibrosing interstitial lung diseases. His studies leverage stem cells, extracellular vesicles, and molecular signaling pathways to advance regenerative therapies. Awards: OBE (2009), Royal College Fellowships Grants: NIH, CIRM, UK MRC/BBSRC Key Projects: LungMAP molecular atlas, Mongolian air pollution cohort studies

Behrouz Zandieh Doulabiمشاهده پروفایل

پژوهشگر

• Tissue Engineering
• Biomaterials
• Nanomedicine
• +۴ مورد دیگر

Behrouz Zandieh Doulabi is a Researcher at the Academic Centre for Dentistry Amsterdam (ACTA) and a Visiting Professor at the University of Tehran since 2013. He is affiliated with the Department of Oral Cell Biology, focusing on interdisciplinary research at the intersection of cell biology, biomaterials, and tissue engineering. His primary research interests include osteosarcoma, stem cell applications, and nanomedicine, with a strong emphasis on bone biology and cell differentiation mechanisms. Dr. Doulabi has been actively involved in collaborative research projects, including studies on bone growth under microgravity conditions and the effects of biomaterials on osteoblast/osteoclast behavior. He holds ancillary academic roles at the University of Tehran, where he contributes to the Research Center for New Technologies in Life Sciences Engineering as a member since 2013. His recent work explores the impact of fluid shear stress on bone cell signaling and the role of paracrine factors in osteoclastogenesis. He has supervised five PhD theses and maintains an active publication record in high-impact journals such as npj Microgravity and Current Issues in Molecular Biology . Contact: bzandiehdoulabi@acta.nl | ORCID

Stefan Hopplerمشاهده پروفایل

استاد

• Developmental Biology
• Molecular Biology
• Cell Signaling
• +۴ مورد دیگر

Professor Stefan Hoppler holds a Personal Chair at the University of Aberdeen's School of Medicine, Medical Sciences and Nutrition, within the Institute of Medical Sciences. He completed a University Diploma (MSc equivalent) in Zoology and Molecular Biology, and a Dr. phil. II (PhD) in Zoology at the University of Zürich, Switzerland. His career includes postdoctoral research at the University of Washington and University of Cambridge, followed by roles as Principal Investigator at the University of Dundee before joining Aberdeen in 2003. He was promoted to Reader (Associate Professor) in 2006 and Full Professor in 2012. His research focuses on Wnt signaling pathways in embryonic development, particularly their roles in heart and brain development using Xenopus models and human embryonic stem cells. Key areas include understanding tissue-specific signaling mechanisms and their implications in congenital heart defects and cancer. Current grants include British Heart Foundation and BBSRC funding for studies on Wnt signaling in cardiomyocyte differentiation and TCF/LEF diversification. Professor Hoppler has held prestigious awards such as the Royal Society/Leverhulme Senior Research Fellowship (2020) and Wellcome Trust Research Career Development Fellowship (1997). He serves on editorial boards (e.g., Genes, Developmental Dynamics) and professional societies (Genetics Society, British Society for Developmental Biology). His work integrates experimental models with theoretical approaches, as seen in recent publications on mathematical modeling of Wnt signaling and evolutionary diversification of TCF/LEF proteins. He leads collaborative projects on cardiovascular regeneration and contributes to training through roles like Scientific Meetings Secretary for the Genetics Society. His lab is part of the Aberdeen Developmental Biology Group and Cardiovascular and Diabetes Centre, emphasizing interdisciplinary research and translational applications.

• Endocrinology and Diabetes
• Pediatrics
• Physiology and Anatomy
• +۳ مورد دیگر

Lars Sävendahl is a Professor/Senior Physician and Head of Division at the Department of Women's and Children's Health , Karolinska Institutet, Stockholm, Sweden. He also serves as a Senior Consultant in Paediatric Endocrinology and Metabolic Diseases at Karolinska University Hospital and Director of Research and Development at Astrid Lindgren Children's Hospital. His academic journey includes an M.D. (1986), Ph.D. (1989), and certification as a pediatrician (1997), with a professorship in Pediatric Endocrinology awarded in 2005. Research focuses on longitudinal bone growth regulation , particularly in the growth plate cartilage. His team developed novel models to study cellular mechanisms of growth, leading to advancements in treating growth disorders. Key areas include glucocorticoid-induced growth failure, epiphyseal stem cell biology, and the impact of mechanical loading on bone development. Current projects address treatment strategies for tall stature using selective estrogen receptor modulators (SERMs) and mitigating growth defects from cancer therapies. Grants include funding from VINNOVA (2021–2023) for AI-driven bone age assessment and the Swedish Research Council (2021–2024) for growth plate therapeutics. Collaborations span international registries like GloBE-Reg and clinical trials evaluating long-acting growth hormone therapies. Publications emphasize growth plate biology, GH therapy safety, and pediatric endocrine disorders. Over 200 peer-reviewed articles highlight his contributions to understanding bone growth mechanisms and translational therapies. His research group, Experimental Growth Research , includes 10+ PhD students and postdocs working on projects like humanin's role in bone protection and imaging techniques for growth plate analysis. Clinical interests include managing growth disorders, cancer survivor bone health, and optimizing GH treatment safety.

Zhengdong Zhangمشاهده پروفایل

استاد

• Genetics of complex human diseases
• Systems biology
• Aging
• +۵ مورد دیگر

Zhengdong Zhang is a Professor in the Department of Genetics at Albert Einstein College of Medicine. His research focuses on the genetics of aging, Alzheimer's disease, and complex human diseases, combining computational methods with clinical data to uncover genetic mechanisms. His lab develops novel algorithms for genetic analysis, including post-GWAS gene prioritization, Bayesian statistical methods for genomic data, and systems biology approaches. Education details are not explicitly listed, but his professional background includes significant contributions to computational genetics and aging research. Key research areas include method development for genetic analysis, aging-related genetic networks, and disease genetics of Alzheimer's and schizophrenia. His lab has pioneered studies on long-lived species' genomic features, such as naked mole rats and beavers, to understand longevity and disease resistance. Research highlights include identifying rare coding variants linked to schizophrenia risk in 22q11.2 deletion syndrome patients, developing frameworks for Alzheimer's immune pathway analysis, and exploring DNA repair mechanisms in long-lived species. His work emphasizes interdisciplinary approaches integrating data science with clinical insights. Zhengdong Zhang's lab is located in the Michael F. Price Center at Einstein College of Medicine, focusing on translational research to bridge genetic discoveries with clinical applications.

Alessandro Faroniمشاهده پروفایل

استاد پژوهشی

• Peripheral Nerve Regeneration
• Stem Cell Therapies
• Biomaterials Engineering
• +۲ مورد دیگر

Dr. Alessandro Faroni is Research Associate in the Blond McIndoe Laboratories at University of Manchester, investigating novel strategies for peripheral nervous system repair. Holds PhD in Developmental Biomedicine (Manchester, 2012) and MSc in Pharmaceutical Biotechnology (Milan, 2008). Research develops stem cell therapies and biomaterials for nerve regeneration. Methodological expertise includes neuronal cell culture, molecular biology techniques, and confocal microscopy. Teaches tissue engineering tutorials for MRes students.

Valerie Kouskoffمشاهده پروفایل

دانشیار

• Hematopoietic Stem Cell Biology
• Embryonic Development
• Blood Cell Differentiation
• +۳ مورد دیگر

Valerie Kouskoff is a Reader in the Division of Developmental Biology and Medicine at the University of Manchester, UK (2016–present). Previously, she held roles including Group Leader at the CRUK Manchester Institute (2003–2016) and Assistant Professor at Mount Sinai School of Medicine, New York (2002–2003). She earned her PhD from Louis Pasteur University, Strasbourg, France (1988–1994). Her research focuses on understanding hematopoietic stem cell (HSC) development during embryogenesis, particularly the endothelial-to-hematopoietic transition and genetic/epigenetic mechanisms regulating blood cell specification. Key areas include the role of transcription factors (RUNX1, SOX7, GFI1), hemogenic endothelium differentiation, and therapeutic applications of stem cell engineering. Her work contributes to UN Sustainable Development Goals related to health and regenerative medicine. Recent articles highlight advancements in AML treatment via KAT6A inhibitors, CD82’s role in blood specification, and SOX7-dependent lymphatic patterning. Collaborations span institutions like the Manchester Regenerative Medicine Network and Christabel Pankhurst Institute. She has supervised 8 research projects and published over 100 peer-reviewed articles. Her studies explore genomic instability in cancer, reprogramming fibroblasts to hematopoietic cells, and the interplay between vascular and blood development.

Nilay Patelمشاهده پروفایل

دانشیار

• Drug Discovery
• Cell Cycle Regulation
• Signal Transduction
• +۳ مورد دیگر

Dr. Nilay Patel is an Associate Professor in the Department of Biological Science at California State University, Fullerton (CSUF). His research focuses on drug discovery, particularly the anti-proliferative effects of niclosamide and related compounds on cancer cells, with collaborations in chemistry and biochemistry. He investigates signal transduction pathways and gene expression regulation in cell cycle processes. Dr. Patel teaches courses in cellular/molecular biology, stem cell biology, and related advanced topics. Education: PhD, The State University of New York, Stony Brook BS, University of Cincinnati Research Interests: Design and testing of anti-cancer compounds targeting β-catenin reduction Impact of signal transduction pathways on cancer proliferation Collaborative drug development with CSUF Chemistry & Biochemistry Department Publications Trends: His work bridges pharmacology and cell biology, emphasizing stem cell pluripotency, neurodegenerative disease mechanisms, and aging-related biomarkers. Key themes include caloric restriction effects on amyloid accumulation and glial cell functions. Awards/Grants: Bridges to Stem Cell Research (BSCR) Program Advising & Mentorship: Supervised multiple student co-authors in stem cell and cancer biology research projects. Active in training through internships (BIOL 495C) and advanced seminars.

Yichen Chenمشاهده پروفایل

پژوهشگر

• Applied Mathematics
• Theoretical Physics
• Medical Imaging
• +۳ مورد دیگر

Yichen (Kelly) Chen is affiliated with the University of Cambridge's Department of Applied Mathematics and Theoretical Physics (DAMTP), contributing to the Centre for Mathematical Imaging in Healthcare. Her research focuses on interdisciplinary applications of mathematics and physics in healthcare, including thermal imaging for security, federated learning methodologies, and immunology risk prediction. She has collaborated on projects involving neural networks, medical data analysis, and stem cell modeling. Her work bridges applied mathematics and clinical challenges, addressing topics such as non-contact thermal imaging systems, automated object detection via infrared thermography, and pitfalls in immunotherapy-related pneumonitis studies. She has also contributed to foundational studies on human pluripotent stem cells' role in modeling neurological diseases like Alzheimer’s. Key collaborations include partnerships with institutions like the BloodCounts! consortium and involve advancements in privacy-preserving healthcare technologies.

Nitish V. Thakorمشاهده پروفایل

استاد

• Biomedical Engineering
• Neuroengineering
• Neural Prosthetics
• +۵ مورد دیگر

Nitish V. Thakor is a Professor of Biomedical Engineering and Neurology at Johns Hopkins University School of Medicine, with secondary appointments in Electrical and Computer Engineering. He directs the Laboratory for Neuroengineering and oversees the NIH Neuroengineering Training Grant. His research focuses on neural prosthetics, brain-machine interfaces, and clinical neurorehabilitation technologies. Education: B.Tech from IIT Bombay (India), M.S. and Ph.D. in Biomedical Engineering from University of Wisconsin-Madison Joined Johns Hopkins faculty in 1983 Research emphasizes translational neuroengineering: developing prosthetic limbs with sensory feedback, advanced neural interfaces, and diagnostic technologies for brain injury monitoring. The lab integrates microfabrication, stem cell biology, and integrated circuit design with clinical applications. Notable projects include DARPA-funded advanced prosthetic systems and temperature-sensitive prosthetic fingertips. Recent lab milestones include robotic hand research published in Science Advances, and student achievements like NIH fellowships and Siebel Scholar awards. Honors: IEEE Fellow (1997), AIMBE Fellow (1996), NSF Presidential Young Investigator (1985) Advising over 20 students/postdocs, he also serves as editor-in-chief of Medical and Biological Engineering and Computing . Active in global biomedical engineering outreach through conferences and educational programs.

Wiep Scheperمشاهده پروفایل

استاد مهمان

• Neurodegeneration
• Alzheimer's Disease
• Tau Pathology
• +۳ مورد دیگر

Prof. dr. Wiep Scheper is a Visiting Professor at the Faculty of Science , Vrije Universiteit Amsterdam , affiliated with the Department of Functional Genomics and Amsterdam Neuroscience - Neurodegeneration . He holds a PhD in Molecular and Cellular Biology from Utrecht University. Research Interests: His work focuses on neurodegenerative diseases, particularly Alzheimer’s and tauopathies. Key areas include tau protein pathology, protein homeostasis, and translational neuroscience. His studies explore mechanisms like proteostatic stress signaling and epigenetic biomarkers in neurodegeneration. Recent Articles: Scheper’s recent work includes studies on DNA methylation in frontotemporal dementia, neuron-to-astrocyte stress signaling in tau pathology, and biomarker research using protein disulfide isomerases. His co-culture models for tau aggregation advance disease modeling efforts. Awards: 2021 KNAW Award Wetenschap Gewaardeerd for societal contributions to science. Grants & Activities: Supervised 7 PhD theses. Editorial roles at Alzheimer's Research & Therapy and Acta Neuropathologica Communications . Organized the Advanced Models Of NeurodeGeneration (AMONG) conference. Labs/Teams: Collaborates in interdisciplinary teams at Amsterdam Neuroscience, focusing on neurodegeneration mechanisms and translational research.

• Genomics
• Epigenetics
• Bioinformatics
• +۳ مورد دیگر

Dr. Gary Hon is an Assistant Professor at UT Southwestern Medical Center affiliated with the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Lyda Hill Department of Bioinformatics. He leads a research program focused on decoding the complexity of the human genome through two primary directions: understanding the molecular basis of cell state for regenerative medicine applications, and elucidating how non-coding variants contribute to development and disease. His lab employs integrative techniques at the interface of gene regulation, epigenetics, genome engineering, single-cell genomics, and bioinformatics. His research interests span genomics, epigenetics, bioinformatics, gene regulation, stem cell biology, and disease mechanisms. Dr. Hon earned his graduate degree from UC San Diego's Bioinformatics and Systems Biology Program and completed post-doctoral training in Dr. Bing Ren's lab before joining UT Southwestern in 2015. Dr. Hon has received significant recognition including the CPRIT Scholar award and NIH Director’s New Innovator Award. His recent publications demonstrate a focus on advanced genomic techniques including Perturb-Seq optimization, single-cell transcriptomics in cancer and reproductive biology, enhancer network mapping, and stem cell modeling of human development.

• Alzheimer's Disease
• Neurodegeneration
• Molecular Genetics
• +۳ مورد دیگر

Mikko Hiltunen is a Professor of Tissue and Cell Biology at the Institute of Biomedicine, School of Medicine, University of Eastern Finland. His research focuses on molecular mechanisms of neurodegenerative disorders, particularly Alzheimer's disease and idiopathic normal pressure hydrocephalus (iNPH). He leads several research groups including the Molecular Genetics of Alzheimer's Disease (Hiltunen Lab) and participates in the Brain Research Unit and Genome Center of Eastern Finland. Research interests span Alzheimer's pathogenesis, neuroinflammation, genetic risk factors, biomarker discovery, and therapeutic development. His work integrates molecular biology, genetics, and clinical neuroscience to investigate microglial function, amyloid pathology, and cerebrospinal fluid biomarkers. Key areas include APOE genetics, PLCγ2-mediated neuroprotection, and machine learning applications in neurodegeneration. His recent publications demonstrate a strong focus on cerebrospinal fluid biomarkers, genetic association studies, neuroinflammation mechanisms, and therapeutic interventions. Article themes consistently emphasize microglial biology, genetic risk modifiers, and translational approaches for Alzheimer's and iNPH. Collaborative projects include Neuro-Innovation (2021-2026) and NOVEL MSCA Postdoctoral Programme (2024-2029). Hiltunen leads the Clinical Alzheimer Research group and co-directs the UEF Brain Research Unit. His team utilizes advanced models including iPSC-derived microglia and pericyte systems to study neurovascular interactions. Current work explores phospho-tau immunotherapy, lysosomal dysfunction, and polygenic risk score applications across diverse populations.