معرفی
Lars Sävendahl is a Professor/Senior Physician and Head of Division at the Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. He also serves as a Senior Consultant in Paediatric Endocrinology and Metabolic Diseases at Karolinska University Hospital and Director of Research and Development at Astrid Lindgren Children's Hospital. His academic journey includes an M.D. (1986), Ph.D. (1989), and certification as a pediatrician (1997), with a professorship in Pediatric Endocrinology awarded in 2005.
Research focuses on longitudinal bone growth regulation, particularly in the growth plate cartilage. His team developed novel models to study cellular mechanisms of growth, leading to advancements in treating growth disorders. Key areas include glucocorticoid-induced growth failure, epiphyseal stem cell biology, and the impact of mechanical loading on bone development. Current projects address treatment strategies for tall stature using selective estrogen receptor modulators (SERMs) and mitigating growth defects from cancer therapies.
Grants include funding from VINNOVA (2021–2023) for AI-driven bone age assessment and the Swedish Research Council (2021–2024) for growth plate therapeutics. Collaborations span international registries like GloBE-Reg and clinical trials evaluating long-acting growth hormone therapies.
Publications emphasize growth plate biology, GH therapy safety, and pediatric endocrine disorders. Over 200 peer-reviewed articles highlight his contributions to understanding bone growth mechanisms and translational therapies.
His research group, Experimental Growth Research, includes 10+ PhD students and postdocs working on projects like humanin's role in bone protection and imaging techniques for growth plate analysis. Clinical interests include managing growth disorders, cancer survivor bone health, and optimizing GH treatment safety.
