Spindle Assembly Checkpoint Professors and Supervisors

Prasad Jallepalliمشاهده پروفایل

استاد

Cornell UniversityUnited States

Prasad Jallepalli, MD, PhD, is a Professor at Weill Cornell Medicine and a Member of the Molecular Biology Program. He leads a research laboratory focused on understanding how human cells accurately duplicate and transmit chromosomes during cell division. His work integrates genome engineering, chemical genetics, and high-resolution microscopy to explore cell cycle regulation, chromosome segregation, and genome stability. Education: MD, PhD – Johns Hopkins University School of Medicine Phi Beta Kappa – Harvard University (1992) Research Interests: Dr. Jallepalli's lab investigates the molecular mechanisms ensuring accurate chromosome transmission. Key areas include: Cell cycle checkpoints and mitotic regulation DNA replication and repair Sister chromatid cohesion and cohesin biology Genome editing and chemical genetics in human cells Nuclear pore function in mitotic control His lab has pioneered the use of adeno-associated virus (AAV)-mediated gene targeting and analog-sensitive kinase systems to dissect the roles of key mitotic regulators such as Plk1 and Mps1. These tools have enabled precise temporal control of kinase activity and discovery of novel substrates and pathways. Scientific Awards: Pew Scholar in the Biomedical Sciences (2003–2007) Louise & Allston Boyer Young Investigator Award (2008) American Cancer Society Research Scholar (2008–2011) Frederick R. Adler Chair for Junior Faculty (2003–2007) Lab and Team: The Jallepalli lab is affiliated with the Molecular Biology Program, Center for Molecular Imaging & Bioengineering, and the Gerstner Sloan Kettering Graduate School. The team includes postdocs, graduate students, and research technicians working on chromosome biology and cell cycle control.

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Lia Paimمشاهده پروفایل

استاد مدعو

University of MontrealCanada

Lia Paim serves as an Adjunct Professor in the Department of Veterinary Biomedicine at the University of Montreal's Faculty of Veterinary Medicine. Her research focuses on microtubule dynamics in cellular processes critical to reproduction and development. She maintains active laboratory operations at the Pavillon 3200, rue Sicotte (Aile B, local 2980) and holds dual affiliations with the Centre de recherche en reproduction et fertilité (CRRF) and Centre d’expertise et de recherche clinique en santé et bien être animal (CERCL). Her educational background includes: B.Sc. in Biomedicine from Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil M.Sc. in Health Sciences from Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil (thesis: Development of a protocol for rat oocyte cryopreservation) Ph.D. in Biomedical Sciences from Université de Montréal, Canada (thesis: Cytokinesis in the mouse preimplantation embryo: mechanism and consequence of failure) Postdoctoral training in Cell Biology at McGill University, Canada (research: Regulation of microtubule dynamics by microtubule-associated proteins) Dr. Paim's research investigates how microtubule-associated proteins (MAPs) and tubulin post-translational modifications regulate cytoskeletal dynamics in somatic cells, oocytes, and embryos. Her laboratory employs genetics, live-cell microscopy, immunofluorescence, and proteomics to explore connections between microtubule dysfunction and pathologies including cancer, developmental disorders, and infertility. A significant focus examines how assisted reproductive techniques like cryopreservation affect microtubule integrity and how protocol modifications can mitigate these impacts. Current projects include studying microtubule acetylation in mouse embryos, regulation of spindle microtubule subpopulations, and cellular impacts of egg cryopreservation. Her publication record demonstrates consistent output in high-impact journals including PNAS, Nature Communications, and Cell Cycle, with research themes centering on chromosomal instability, cytokinesis mechanisms, and cytoskeletal regulation in developmental contexts. Recent work increasingly integrates proteomics with live-cell imaging to uncover molecular mechanisms. Scientific recognition includes: NSERC Postdoctoral Fellowship (2022-2024) FRQS Doctoral Scholarship (2018-2021) Multiple travel awards from Canadian research societies (CRRF, SRF) Five best presentation awards at national conferences (2020-2023) CRCHUM Excellence Award for high-impact publication (2020) Dr. Paim actively recruits Master's students for projects involving embryo culture, micromanipulation, and advanced microscopy. Her laboratory provides scholarship support and emphasizes training in developmental biology, cell biology, and high-resolution imaging techniques. She maintains professional memberships in the Canadian Fertility and Andrology Society and Society for the Study of Reproduction, contributing to national reproductive science networks.

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Mathias Girbigمشاهده پروفایل

پژوهشگر

Max Planck Institute for Terrestrial MicrobiologyGermany

Dr. Mathias Girbig is a Postdoctoral Researcher at the Department of Chemistry, Philipps University of Marburg. His research focuses on structural biology and molecular mechanisms of transcription and RNA processing.

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LeAnn Howeمشاهده پروفایل

استاد

University of British ColumbiaCanada

Dr. LeAnn Howe is a Professor in the Department of Biochemistry and Molecular Biology within the Faculty of Medicine at the University of British Columbia. Her research focuses on chromatin structure, histone modifications, and gene expression regulation, employing molecular biology and bioinformatics approaches to investigate how epigenetic mechanisms maintain cellular identity and contribute to human diseases. Education: CIHR Post-Doctoral Fellow, Pennsylvania State University, 2003 PhD, University of Victoria, 1998 BSc, University of Victoria, 1992 Dr. Howe's research primarily investigates how chromatin structure influences gene expression patterns in eukaryotic cells. Her work examines the roles of histones, histone chaperones, histone variants, and histone post-translational modifications in preserving active gene expression states. She has made significant contributions to understanding how transcription shapes histone acetylation patterns, how histone modifications recruit chromatin-modifying complexes, and how these processes maintain cellular identity. Her research has important implications for understanding aberrant gene expression in human diseases, including cancer. Her recent publications (2021-2025) demonstrate a continued focus on chromatin biology and epigenetic regulation, with expanding interests in the intersection of genetics, environmental factors, and human health. Her work spans from fundamental molecular mechanisms in yeast models to human health applications, showing a trajectory from basic science to translational research. The breadth of her work covers chromatin structure, transcription regulation, epigenetic inheritance, and the application of genetic methodologies to understand complex traits and disease mechanisms. Scientific Contributions: Elucidated mechanisms of histone modification and chromatin structure maintenance Investigated transcription's role in shaping genome-wide histone acetylation patterns Explored connections between epigenetic mechanisms and human disease Expanded research into genetic epidemiology and complex trait analysis Dr. Howe maintains an active research program with consistent publication output across multiple high-impact journals including Nature Communications, Genetics, and Proceedings of the National Academy of Sciences. She leads a research group focused on chromatin and epigenetics at UBC's Life Sciences Centre (office 5509), combining molecular biology techniques with bioinformatics approaches to study fundamental mechanisms of gene regulation.

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Einar Hallbergمشاهده پروفایل

استاد

Stockholm UniversitySweden

Einar Hallberg is a Professor of Biochemistry at the Department of Biochemistry and Biophysics, Stockholm University . His research focuses on nuclear envelope proteins and their roles in Cell signaling Chromatin organization Mitotic machinery Neurodegenerative disease mechanisms The Hallberg group investigates how nuclear pore complexes (NPCs) and LINC complexes mediate mechanical signal transduction between cell surface and nucleus. Their work connects nuclear envelope proteomics to Laminopathies Cancer Alzheimer's disease Neuroblastoma models Recent publications highlight advanced imaging techniques like FRAP, FLIP and FRET to study Chromatin accessibility changes Caspase activation dynamics Mechanical signal transmission Membrane protein interactions through nuclear envelope structures. Scientific recognition includes Swedish Brain Foundation grants (2023) Extensive publication record in Cell Reports, Journal of Cell Science and Molecular Biology of the Cell

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Masamitsu Satoمشاهده پروفایل

استاد

Waseda UniversityJapan

Masamitsu Sato is a Professor at the Department of Life Science and Medical Bioscience , Faculty of Science and Engineering , Waseda University . His research focuses on the molecular mechanisms of microtubule formation , gene expression during the cell cycle , and chromosome segregation in fission yeast (Schizosaccharomyces pombe) . He also investigates microtubule regulation in mammalian systems , such as tracheal cilia and renal tubules. Education: Ph.D. in Biophysics and Biochemistry, Graduate School of Science, University of Tokyo (2001) Master’s and Bachelor’s in Biophysics and Biochemistry, University of Tokyo His research interests span cell polarity , meiosis/mitosis differentiation , non-coding RNA , and cytoskeleton dynamics . Recent work includes microtubule catastrophe mechanisms , artificial chromosome segregation devices , and single-cell RNA-seq for dormancy breaking . His scientific awards include the Waseda Research Award (2018) , Yeast Consortium Fellow (2020, 2022) , and the Young Scientists' Prize (2012) . He has contributed to CRISPR/Cas9 optimization and fission yeast plasmid systems .

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Satoshi Yoshidaمشاهده پروفایل

استاد

Waseda UniversityJapan

Genetics
Yeast Genetics
Cell Biology
+۵ مورد دیگر

Satoshi Yoshida is a Professor at Waseda University's School of International Liberal Studies and Graduate School of Advanced Science and Engineering, where he leads research in yeast genetics and cell biology. His academic journey includes positions at Brandeis University as Assistant Professor and research at Harvard University, with his doctoral training completed at The University of Tokyo. Current Position: Professor, School of International Liberal Studies, Waseda University (2020-Present) Previous Positions: Assistant Professor at Brandeis University (2009-2014), Researcher at Gunma University (2014-2018) Education: Doctor of Science from The University of Tokyo (1998-2003) Professor Yoshida's research focuses on the molecular mechanisms of cell cycle regulation, particularly studying Rho GTPase signaling pathways in yeast models. His work spans from fundamental cell biological processes like cytokinesis and spindle pole body dynamics to translational applications related to aging, protein aggregation, and potential therapeutic targets for diseases including neurodegeneration and cancer. His laboratory has made significant contributions to understanding how Rho1 GTPase selects specific signaling outputs and maintains cellular homeostasis under stress conditions. Analysis of his recent publications shows a strong emphasis on ATP homeostasis, protein aggregation, and the development of high-throughput methods for morphological profiling in yeast. His work connects fundamental cell biology with potential applications in understanding human diseases, particularly neurodegenerative conditions where protein aggregation plays a key role. Fellow, OFSF (2019) Bast papers award, Genetics Society of Japan (2019) Presidential award, Yeast Genetics Society of Japan (2018) New Investigator Award, Massachusetts Life Science Center (2010) Professor Yoshida has received continuous research funding from prestigious organizations including JSPS, JST PRESTO, and the Takeda Science Foundation. His current projects focus on elucidating Rho GTPase signaling mechanisms with potential applications in drug development. He also maintains international collaborations, including recent work with Oxford University investigating how cellular metabolic environments affect protein structural changes. In addition to his research, he teaches advanced courses in health science and life sciences at both undergraduate and graduate levels at Waseda University.

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Tanya Solimanمشاهده پروفایل

مدرس ارشد

Queen Mary University of LondonUnited Kingdom

Tanya Soliman is a Senior Lecturer and Group Leader whose research bridges fundamental kinase biology and novel personalised oncology strategies. Her affiliations include the Centre for Cancer Evolution, focusing on understanding kinase substrate specificity and pathological signaling in cancer. Research Interests: Kinase biology and substrate specificity Cancer cell signaling and mitotic regulation Proteomics for therapeutic target discovery Personalised oncology approaches Cancer evolution mechanisms Publications Trends: Her work centers on kinases like Aurora B and PKCε in mitotic processes, DNA damage response, and cancer vulnerabilities. Studies explore their roles in cell cycle regulation, spindle assembly, and checkpoint resolution across high-impact journals. Funding: MRC-New Investigator Research Grant (2024-2027): £876,294 for TP53 mutant cancers MRC-DTP studentship (2023-2027): £96,000 for DNA damage pathway rewiring Barts Charity Seed Funding (2023-2024): £59,077 for ovarian cancer mitotic pathways AMS Springboard (2023-2025): £99,998 for kinase substrate mapping Cancer Research UK studentship (2022-2026): £146,443 for Aurora B in Topo2-dependent G2 checkpoint

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Stephanie C. Ems-McClungمشاهده پروفایل

استاد پژوهشی

Indiana UniversityUnited States

Dr. Stephanie C. Ems-McClung is an Associate Research Professor in the Department of Biochemistry & Molecular Biology at Indiana University. She earned her PhD from Indiana University School of Medicine in 1998 and joined Dr. Claire Walczak's lab in 2001, where she now serves as Research Supervisor. Her work bridges biochemistry, biophysics, and cell biology to investigate cytoskeletal regulation during mitosis. Her research examines: Mechanisms of microtubule dynamics and motor protein function RanGTP-dependent spatial regulation of kinesins Phospho-regulatory switches in mitotic control Biomechanics of cytoskeletal networks She applies advanced imaging (FLIM-FRET) and structural approaches to study how these processes ensure accurate cell division. Recent publications (2018-2024) focus on: Therapeutic targeting of mitotic kinesins in cancer RanGTP effector gradients in spindle assembly Mechanical properties of motor-driven microtubule bundles Aurora kinase regulation mechanisms As lab supervisor, she mentors students and oversees research on cytoskeletal dysregulation in disease contexts.

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Ivana Gasicمشاهده پروفایل

استادیار

University of GenevaSwitzerland

Ivana Gasic is an Assistant Professor at the University of Geneva in the Department of Molecular and Cellular Biology. She leads the ProMiCe Lab, focusing on proteostasis and microtubule cytoskeleton dynamics. Her research challenges the central dogma of unidirectional gene expression regulation, particularly in tubulin protein-mRNA feedback mechanisms. Role: Assistant Professor Institution: University of Geneva Department: Molecular and Cellular Biology Lab: ProMiCe Lab Her research explores how tubulin protein quantity impacts mRNA stability through specificity factors, employing biochemical, structural, and fluorescent imaging approaches. Key areas include posttranscriptional control, microtubule homeostasis, and cellular adaptation to stress cues. Recent publications span topics like tubulin autoregulation, TTC5 interactions, and microtubule dynamics. Her work bridges molecular mechanisms with broader implications in cell viability and multicellular organization. Scientific Recognition: SNSF Assistant Professor grant Gasic mentors doctoral candidates (e.g., Ana Almeida, Alina Batiuk) and collaborates with researchers including Maxim Assaf and Zahra Jouini. Her lab integrates advanced techniques like mass spectrometry and live-cell imaging to dissect tubulin biology.

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Andreas Villungerمشاهده پروفایل

استاد

University of ViennaAustria

BCL2 family proteins in tissue homeostasis
DNA damage response & checkpoint signaling
Cell cycle – cell death cross-talk
+۵ مورد دیگر

Andreas Villunger is a Professor at the Medical University of Innsbruck, leading the Division of Developmental Immunology at the Biocenter. He joined CeMM as an Adjunct Principal Investigator in 2018 to develop PIDDosome inhibitors. His work bridges cell death signaling, DNA damage response, and cell cycle regulation in health and disease. Research Focus: Role of BH3-only proteins in lymphocyte transformation and cancer therapy Cell cycle-cell death crosstalk, particularly mitotic cell death and post-mitotic fate PIDDosome's role in p53 activation for centrosome abnormalities Polyploidization mechanisms in liver development and regeneration Article Trends: Recent publications emphasize centrosome surveillance, mitotic stress responses, and therapeutic targets in cancer. Key themes include apoptosis, genomic instability, and p53 regulation. Scientific Awards: FWF START Prize (2003) Advising & Grants: Funded by FWF International Programme and European Research Council (ERC). Mentors trainees including Predoctoral Fellows and Postdoctoral Fellows at CeMM and MedUni Innsbruck. Labs & Collaborations: Leads labs at both CeMM and MedUni Innsbruck Biocenter. Collaborates with teams at Walter and Eliza Hall Institute, Georg Winter Lab, and institutions in Austria and Australia.

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