Prasad Jallepalli

Prasad Jallepalli, MD, PhD, is a Professor at Weill Cornell Medicine and a Member of the Molecular Biology Program. He leads a research laboratory focused on understanding how human cells accurately duplicate and transmit chromosomes during cell division. His work integrates genome engineering, chemical genetics, and high-resolution microscopy to explore cell cycle regulation, chromosome segregation, and genome stability.

Education:

• MD, PhD – Johns Hopkins University School of Medicine
• Phi Beta Kappa – Harvard University (1992)

Research Interests:
Dr. Jallepalli's lab investigates the molecular mechanisms ensuring accurate chromosome transmission. Key areas include:

• Cell cycle checkpoints and mitotic regulation
• DNA replication and repair
• Sister chromatid cohesion and cohesin biology
• Genome editing and chemical genetics in human cells
• Nuclear pore function in mitotic control

His lab has pioneered the use of adeno-associated virus (AAV)-mediated gene targeting and analog-sensitive kinase systems to dissect the roles of key mitotic regulators such as Plk1 and Mps1. These tools have enabled precise temporal control of kinase activity and discovery of novel substrates and pathways.

Scientific Awards:

• Pew Scholar in the Biomedical Sciences (2003–2007)
• Louise & Allston Boyer Young Investigator Award (2008)
• American Cancer Society Research Scholar (2008–2011)
• Frederick R. Adler Chair for Junior Faculty (2003–2007)

Lab and Team:
The Jallepalli lab is affiliated with the Molecular Biology Program, Center for Molecular Imaging & Bioengineering, and the Gerstner Sloan Kettering Graduate School. The team includes postdocs, graduate students, and research technicians working on chromosome biology and cell cycle control.