Prasad Jallepalli

Prasad Jallepalli, MD, PhD, is a distinguished Professor at the Molecular Biology Program of Memorial Sloan Kettering Cancer Center (MSKCC). He holds dual degrees in medicine and molecular biology from Johns Hopkins University School of Medicine and leads the Prasad Jallepalli Lab, dedicated to understanding chromosome transmission accuracy during cell division.

• Affiliation: Molecular Biology Program, Center for Molecular Imaging & Bioengineering, Gerstner Sloan Kettering Graduate School of Biomedical Sciences
• Research Focus: Chromosome segregation, genome stability, mitotic kinases, sister chromatid cohesion, nuclear pore function, and chemical genetics in human cells.

His lab employs advanced genome engineering (AAV/CRISPR), chemical-genetic systems, and quantitative microscopy to dissect mechanisms linking chromosome dynamics to cancer therapy vulnerabilities. Recent studies highlight Mps1 kinase's role in error-free segregation and nuclear pores' contribution to mitotic checkpoint regulation.

• Key Discoveries: Novel roles of Polo-like kinase 1 (Plk1) in cytokinesis, cohesion establishment's feedback on replication fork dynamics, and nuclear pore-associated anaphase inhibitors.

Dr. Jallepalli has received prestigious honors including the Pew Scholar, Damon Runyon Fellowship, and American Cancer Society Research Scholar awards. His lab actively trains graduate students and postdoctoral researchers in cutting-edge methodologies.