John Maciejowski

Dr. John Maciejowski is a leading molecular biologist at Memorial Sloan Kettering Cancer Center (MSKCC) and the Gerstner Sloan Kettering Graduate School of Biomedical Sciences. His research focuses on understanding how nuclear envelope rupture contributes to genome instability in cancer, particularly through mechanisms like chromothripsis and kataegis during telomere crisis.

• PhD in Biomedical Sciences from MSKCC
• Current lab at MSKCC investigates TREX1 and APOBEC3B roles in DNA repair
• Uses cell biology, biochemistry, and genomics approaches

His work has significant implications for cancer genome architecture and mutation patterns. Key publications include mechanistic studies on TREX1's role in micronuclei repair and APOBEC3B's contribution to mutagenesis.

Scientific honors include:

• NIH Pathway to Independence Award (2016)
• Tri-Institutional Breakout Prize (2016)
• Regeneron Prize for Creative Innovation (2016)
• Pew Biomedical Scholar

Current research explores connections between telomere dysfunction, DNA repair pathways, and immune system interactions with genomic DNA, supported by multiple NIH grants including R00 CA212290 and R35 CA210036.