معرفی
Nikolaus Watson is a Research Fellow at Newcastle University specializing in molecular mechanisms of cell division, with primary focus on histone phosphorylation dynamics during mitosis. His work bridges biochemistry and cell biology through kinase-focused research.
His research interests center on cell cycle regulation, specifically kinase-mediated histone modifications (H3, H2B), chromosome segregation mechanics, and mitotic signaling pathways. This work has direct implications for understanding genomic instability in cancer development, leveraging techniques in kinase inhibition profiling and phosphorylation site mapping.
Analysis of his 2016-2022 publications reveals consistent investigation into how kinases (CDK1, Haspin, VRK1) regulate chromosomal behavior through targeted histone phosphorylation. His methodology emphasizes kinase inhibition profiles to decode site-specific phosphorylation events, advancing fundamental understanding of mitotic fidelity.
Watson operates within Professor Jonathan Higgins' research group at Newcastle University, collaborating with specialists including Dr. Tyrell Cartwright (kinase signaling) and Dr. Onur Sen (chromosome dynamics) in a dedicated cell division research team.