جست‌وجوی استاد و پژوهشگر

Dimitris Lagosمشاهده پروفایل

استاد

• RNA Biology
• Immunology
• Cancer Research
• +۹ مورد دیگر

Professor Dimitris Lagos is a faculty member at the Hull York Medical School under the University of York . He holds the role of Professor of Immunology and serves as the Director of Research , leading the Departmental Research Committee. His academic career includes prior appointments as Lecturer , Senior Lecturer , and Reader at Hull York Medical School. Professor Lagos' research focuses on RNA Biology and RNA Medicine , specifically investigating RNA-driven immune gene regulation in infection and cancer. His group explores transcriptome instability in cancer, sexual dimorphism in lymphocytes, and circulating non-coding RNAs as disease biomarkers. He utilizes advanced transcriptomics platforms like long-read RNA sequencing and spatial omics for discovery, with pharmacological RNA targeting as a therapeutic strategy. His recent publications highlight trends in immune checkpoint regulation (e.g., PD-L1, IDO1), Cancer Immunology , and RNA-based biomarkers for disease prognosis. He leads the MANIFEST immuno-oncology consortium and collaborates with Oxford Nanopore Technologies . His group has historically spearheaded molecular pathology themes in global infectious disease consortia, including the UK Coronavirus Immunology Consortium . Professor Lagos is funded by Cancer Research UK and UKRI (MRC and BBSRC). He supervises postgraduate students Mags Gwynne , Ali Deghany , Charlotte Booth , and Molly Cartwright . His work bridges gene regulation , RNA Medicine , and Immunology , emphasizing translational applications.

• Immunology
• Molecular Immunology
• Inflammation
• +۳ مورد دیگر

Irina Udalova serves as Professor of Molecular Immunology at the Kennedy Institute of Rheumatology, part of the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) at the University of Oxford. She leads the "Genomics of Inflammation" research group, focusing on transcriptional regulation in inflammatory diseases through integrated genomic and immunological approaches. Her academic foundation includes a joint BSc/MSc in physics and mathematics and a PhD in molecular biology, both from the Moscow Institute of Physics and Technology. This unique interdisciplinary background underpins her innovative research methodology. Professor Udalova's work centers on transcriptional regulators controlling myeloid cell phenotypes in inflammation. Her laboratory combines functional genomics with classical immunology to dissect regulatory networks involving factors like IRF5 and type III interferons. Key discoveries include identifying IRF5 as a molecular switch for inflammatory macrophages and revealing anti-inflammatory properties of type III IFNs that specifically target neutrophil function. This research bridges fundamental mechanisms with translational applications in rheumatoid arthritis, obesity-related inflammation, and infectious diseases. Recent publications demonstrate evolving expertise in single-cell and spatial analysis techniques, particularly in COVID-19 lung pathology and sepsis immunology. Her work consistently emphasizes neutrophil-macrophage crosstalk and microenvironment-specific immune responses across inflammatory conditions. Through the University of Oxford, Professor Udalova actively supervises doctoral candidates in Cancer Sciences, Genomic Medicine and Statistics, and Interdisciplinary Biosciences programs. Her laboratory maintains strong collaborative networks and regularly recruits postdoctoral researchers for projects investigating transcriptional circuitry in inflammatory diseases. The "Genomics of Inflammation" group operates at the cutting edge of immunogenomics, utilizing advanced techniques to map regulatory landscapes in myeloid cells. Current work focuses on validating novel therapeutic targets for chronic inflammatory conditions and deciphering context-dependent immune responses in tissue microenvironments.

Min-Yao Jhuمشاهده پروفایل

پژوهشگر

• Parasitic Plants
• Host-Parasite Interactions
• Nitrogen Fixation
• +۴ مورد دیگر

Min-Yao Jhu is a Postdoctoral Research Associate at the Crop Science Centre , affiliated with the University of Cambridge and the Department of Plant Sciences . Her research focuses on plant-microbe interactions, parasitic plant biology, and nitrogen fixation mechanisms. University: University of Cambridge Department: Department of Plant Sciences Academic Rank: Researcher Key Research Areas: Parasitic Plants, Host-Parasite Interactions, Nitrogen Fixation, Plant Genetics Jhu's work explores the genetic and molecular regulation of symbiotic and parasitic plant interactions. Her recent publications highlight advancements in nitrogen fixation biology, parasitic plant resistance mechanisms, and spatial transcriptomics techniques for studying plant development. Her research has significant implications for sustainable agriculture, particularly in reducing reliance on chemical fertilizers and enhancing crop resilience against parasitic plants like Cuscuta campestris .

• Respiratory Immunology
• Lung Fibrosis
• Tissue-Resident Immune Cells
• +۲ مورد دیگر

Ling-Pei Ho , MD, FRCP, is a Professor of Respiratory Immunology at the University of Oxford within the Nuffield Department of Medicine . She serves as a Consultant in Respiratory Medicine and leads the NIHR BRC Respiratory Theme. Her research focuses on immune mechanisms in lung fibrosis, epithelial regeneration, and translational immunology. Affiliated Institutions: University of Oxford Oxford Sarcoidosis Service NIHR Oxford BRC Respiratory Theme MRC Translational Immunology Discovery Unit Research Themes: The Ho Group investigates the role of tissue-resident immune cells (innate lymphoid cells, Tregs, alveolar macrophages) in lung homeostasis and repair. Key methodologies include spatial transcriptomics and single-cell imaging mass cytometry for mapping immune cell dynamics in lung injury and regeneration. Publication Trends: Recent work spans idiopathic pulmonary fibrosis, COVID-19 immunopathology, and sarcoidosis. Studies emphasize spatial omics, longitudinal murine models, and clinical translation, with a focus on interferon signaling, myeloid cell activation, and fibrotic progression. Contact: For DPhil opportunities or collaborations, email ling-pei.ho@imm.ox.ac.uk .

• Mechanobiology
• Computational Biology
• Spatial Genomics
• +۷ مورد دیگر

Adrien Hallou is a Group Leader in Tissue Biology (Innovation Investigator Track) and Principal Investigator at the Kennedy Institute, University of Oxford. He leads the Laboratory of Cell and Tissue Dynamics, funded by the Kennedy Trust for Rheumatology Research, Royal Society, Clarendon Fund, EPA Cephalosporin Fund, and Innovate UK. He holds an MSc from École Normale Supérieure Paris and an MPhil/PhD from the University of Cambridge. His research integrates mechanobiology , spatial genomics , advanced imaging , machine learning , and mathematical modelling to investigate mechanical/biochemical signaling in cell fate decisions and tissue dynamics during development, homeostasis, and disease. Key themes include tissue fluidity regulation, computational pipelines for mechano-transcriptomics, and biomechanical switches in epithelial tissues. Recent publications emphasize interdisciplinary approaches, with trends in computational biology (55%), tissue mechanics (30%), and machine learning applications (15%). Awards include: Oliver Gatty Studentship in Biophysical Sciences Junior Research Fellowship, Darwin College Cambridge Herchel Smith Research Fellowship He actively recruits PhDs/postdocs and supports fellowship applications (EMBO, Wellcome, HFSP). His lab focuses on collaborative, interdisciplinary work in cell/tissue dynamics.

Roger Barkerمشاهده پروفایل

استاد

• Neurodegenerative Disorders
• Parkinson's Disease
• Huntington's Disease
• +۴ مورد دیگر

Roger Barker is Professor of Clinical Neuroscience and Honorary Consultant in Neurology at the University of Cambridge and Addenbrooke's Hospital. He has held this position since 2000 following an MRC Clinician Scientist Fellowship. His primary affiliations are with the Cambridge Stem Cell Institute and the Department of Clinical Neurosciences at the Cambridge Biomedical Campus. Education includes: BA, Oxford University (1983) MBBS, University of London (1986) MRCP, London (1989) PhD, University of Cambridge (1994) Research focuses on neurodegenerative disorders, particularly Parkinson's (PD) and Huntington's diseases (HD). His work bridges basic science exploring novel therapies and clinical studies defining disease heterogeneity. Key initiatives include: Leading the STEM-PD stem cell trial for PD Coordinating the FELL-HD drug repurposing trial for HD Developing disease subtyping models for targeted therapies Collaborating on human brain development mapping for the Human Cell Atlas Research employs snRNA sequencing, post-mortem tissue analysis, and human fetal tissue studies to understand neurodegeneration and neurodevelopment. Recent publications (2023-2025) demonstrate strong focus on: Translational applications of stem cell therapies for Parkinson's Genetic and biomarker studies of neurodegenerative progression Novel therapeutic mechanisms like noradrenergic modulation Advanced cellular modeling techniques including 3D reprogramming Current funding sources include Medical Research Council, Rosetrees Trust, EU, NIHR, Cure Parkinson's Trust, Novo Nordisk, and Wellcome. Lab members include Shaline Fazal (Research Manager), Xiaoling He (Senior Research Assistant), Saeed Kayhanian (Clinical Research Fellow), and Jana Šebestíková (Postgraduate Student). The lab is based at the John van Geest Centre for Brain Repair.

• Cancer Biology
• Developmental Biology
• Melanoma Research
• +۳ مورد دیگر

Richard White is a Professor of Genetics at the University of Oxford , affiliated with Exeter College . His research focuses on leveraging zebrafish models to dissect fundamental mechanisms of cancer biology , particularly melanoma, by integrating genetic tools and advanced imaging techniques . Clinical background in oncology Developed the transparent casper zebrafish strain for tumor imaging Investigates developmental programs co-opted by cancer cells Explores interactions between cancer cells and microenvironment White's work examines how neural crest developmental programs influence melanoma progression, including oncogene response, anatomical positioning effects, and metastasis mechanisms driven by adipocytes and lipid signaling. His recent publications highlight phenotypic plasticity in melanoma and computational tools like BayesTME for spatial transcriptomics analysis. Key research themes: Role of tumor microenvironment in cancer progression Developmental biology parallels in melanoma Imaging and genetic manipulation of cancer ecosystems Therapeutic targeting of microenvironment interactions

Sergio Rutellaمشاهده پروفایل

استاد

• Haematological Cancers
• Immunotherapy
• Acute Myeloid Leukemia (AML)
• +۱۲ مورد دیگر

Professor Sergio Rutella is a licensed haematologist and Director of the John van Geest Cancer Research Centre at Nottingham Trent University . With over 230 peer-reviewed publications and an H-index of 67, his work bridges translational immunology and cancer biology to advance antibody-based therapies and haematopoietic stem cell transplantation . PhD in Experimental Haematology (Catholic University Medical School, Rome) Specialisation in Haematology ( summa cum laude , Rome) Full Registration with Italian Medical Council GMC Specialist Registration in Haematology (UK) Rutella's research focuses on AML immunotherapy , dissecting how IFN-gamma signaling and TP53 mutations drive immune evasion. His team uses single-cell RNA sequencing , spatial transcriptomics , and bioinformatics to identify predictive biomarkers and tailor precision immunotherapy clinical trials . His 2020–2025 publications reveal trends in immune landscape analysis , checkpoint modulators , and AML microenvironment . Notable findings include the role of IFN-stimulated genes in chemotherapy resistance and the 3-gene signature predicting AML outcomes. Fellow, Royal Society of Biology (2022) Vice Chancellor's Outstanding Researcher Award (2019) Scientific Advisory Board, DFG Collaborative Research Centre Editorial Roles: Journal of Clinical Medicine , Frontiers in Immunology As Principal Investigator for >£12M in grants (Wugen, MacroGenics, Sheffield Charity, Kura Oncology), Rutella collaborates with institutions in Germany, Italy, USA, and Qatar. His lab's work on flotetuzumab and memory-like NK cells has been featured in Blood , Science Translational Medicine , and Blood Cancer Discovery .

Uta Paszkowskiمشاهده پروفایل

استاد

• Plant Biology
• Food Security
• Sustainable Agriculture
• +۴ مورد دیگر

Professor Uta Paszkowski leads the Cereal Symbiosis Group at the University of Cambridge's Department of Plant Sciences. Her work focuses on arbuscular mycorrhizal (AM) symbiosis in rice and maize, aiming to optimize nutrient uptake and develop sustainable agricultural practices. She actively collaborates with the Crop Science Centre and participates in public engagement initiatives. EMBO Member (2024) National Academy of Sciences, USA, Member (2025) Her research explores rhizosphere communication and symbiotic phosphate acquisition , with recent studies highlighting 4D imaging techniques and spatial transcriptomics . Her lab's publications emphasize cross-kingdom RNA interference, membrane dynamics, and fungal structure-function relationships. Key projects include understanding signal exchange mechanisms and developing tools like the AMSlide for live imaging. Scientific accolades include: EMBO Membership US National Academy of Sciences Election

Marta Shahbaziمشاهده پروفایل

پژوهشگر ارشد

• Developmental Biology
• Stem Cell Biology
• Embryogenesis
• +۴ مورد دیگر

Dr. Marta Shahbazi is an Affiliated Principal Investigator at the Cambridge Stem Cell Institute, University of Cambridge, and maintains a primary affiliation with the MRC Laboratory of Molecular Biology. She leads the Shahbazi Lab, which focuses on understanding the mechanisms that control pluripotent stem cell identity and fate in physiological 3D contexts. Her research bridges developmental biology and stem cell research, with particular emphasis on how tissue architecture influences stem cell behavior during embryonic development and potential regenerative applications. Dr. Shahbazi's research interests center around pluripotent stem cells and their role in early mammalian development. Her work investigates how pluripotent cells undergo concomitant changes in shape and identity to establish the foundation of the body plan. She is particularly interested in epithelial tissue determinants and their contribution to stem cell fate decisions. Her lab employs novel methods to culture mouse and human embryos, 3D embryonic stem cell models, and adult tissue organoids to understand the molecular pathways coordinating tissue shape and stem cell fate during pluripotency exit and acquisition. Analysis of Dr. Shahbazi's recent publications reveals a strong focus on human and mouse embryogenesis, with particular attention to tissue morphogenesis, cell delamination, and the molecular mechanisms underlying pluripotency transitions. Her work spans from basic developmental mechanisms to potential applications in regenerative medicine, with increasing emphasis on human embryo models in recent years. The research demonstrates interdisciplinary approaches combining cell biology, developmental biology, and tissue engineering principles. Dr. Shahbazi has received recognition through multiple publications in high-impact journals including Nature, Developmental Cell, and Cell Stem Cell. Her work on human embryo development and stem cell-based embryo models has contributed significantly to the field. Dr. Shahbazi mentors several researchers in her lab, including Viviane de Souza Rosa, Miguel Ángel Ortiz Salazar, Rina Sakata, Nanami Satoh, Luca Schwarz, and Anfu Wang. Her research is supported by the Cambridge Stem Cell Institute and the MRC Laboratory of Molecular Biology, providing resources for advanced imaging, genomics, and tissue culture facilities. The Shahbazi Lab is part of the broader Cambridge research ecosystem focused on stem cells and developmental biology, collaborating with other principal investigators at the Cambridge Stem Cell Institute.

• Amyotrophic Lateral Sclerosis (ALS)
• Frontotemporal Dementia (FTD)
• Stem Cell Research
• +۵ مورد دیگر

Ruxandra Dafinca is a Brain Science Research Fellow and Group Leader at the Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, where she leads research within the Oxford Motor Neuron Disease Centre. Her work focuses on unraveling molecular mechanisms in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) using cutting-edge patient-derived stem cell models. Her educational background includes: MSc DPhil Dr. Dafinca's research program investigates intracellular signaling pathways leading to synaptic deficiencies in ALS/FTD through spatial proteomics , transcriptomics , and live imaging of patient-induced pluripotent stem cell (iPSC)-derived neurons. She pioneered iPSC differentiation to motor and cortical neurons in 2013, establishing critical models for studying C9ORF72 hexanucleotide expansions and TDP-43 proteinopathies . Her work targets therapeutic discovery by identifying regulatory pathway disruptions in neurodegenerative processes. Analysis of her 15 most recent publications (2020-2025) reveals dominant themes in C9ORF72-related ALS/FTD mechanisms , mitochondrial dysfunction , axonal transport defects , and neuroinflammation . Key methodologies include high-throughput drug screening, CRISPR genome editing, and multi-omics integration, with strong translational emphasis on biomarker discovery and personalized drug evaluation for ALS therapeutics. Her research is funded by major grants from the My Name'5 Doddie Foundation , Motor Neuron Disease Association , and Oxford University's John Fell Fund and Medical Sciences Division Pump-Priming Award . She actively recruits postdoctoral researchers for multi-omics and microfluidics projects, indicating active mentorship in advanced neurodegenerative disease modeling. Dr. Dafinca collaborates extensively within the Oxford Motor Neuron Disease Centre alongside Professor Kevin Talbot (Head of Department), Associate Professor Martin Turner, and Professor Elizabeth Gray. Her laboratory leverages iPSC co-culture systems and advanced imaging to dissect neuron-microglia interactions and develop novel therapeutic strategies for ALS/FTD.

Syed Murtuza Bakerمشاهده پروفایل

پژوهشگر ارشد

• Bioinformatics
• Single Cell RNA-seq
• Spatial Transcriptomics
• +۲ مورد دیگر

Syed Murtuza Baker is a Research Fellow in the Division of Informatics, Imaging & Data Sciences at the University of Manchester. He earned his doctorate from Martin-Luther University Halle Wittenberg with a focus on kinetic models of biological systems. His expertise includes single-cell genomics, spatial transcriptomics, and bioinformatics. His research investigates gene regulatory networks, immune cell coordination in inflammatory diseases, and computational methods for analyzing spatial transcriptomic data. He contributes to UN Sustainable Development Goals through his work in health and biomedical research. Baker's publications demonstrate consistent focus on computational biology approaches to disease mechanisms, particularly in liver disease, leukemia, and immune disorders. His recent work develops novel algorithms for spatial transcriptomics data analysis. None reported No information is available regarding student advising or research grants. He collaborates extensively with international teams through the Sustainable Futures and Digital Futures research platforms.

• Liver Fibrosis
• Nonalcoholic Fatty Liver Disease
• Gene Regulatory Networks
• +۳ مورد دیگر

Elliot Jokl is a Researcher in the Division of Diabetes, Endocrinology & Gastroenterology. His work focuses on understanding fibrogenic mechanisms in liver diseases, particularly nonalcoholic fatty liver disease (NAFLD) and liver fibrosis. He employs spatial transcriptomics, single-cell RNA sequencing, and multi-omic approaches to study gene regulatory networks and cellular interactions in disease progression. Research interests include the role of SOX9 in myofibroblast activation, circadian rhythm disruption's impact on fibrosis, and the mechanotransduction pathways governing fibroblast behavior. His recent studies explore biomarkers for cystic fibrosis-related liver disease and therapeutic targets for fibrosis using novel spatial and genomic techniques. Notable projects include leading an initiative to identify early biomarkers of hepatocellular carcinoma using high-definition spatial transcriptomics (2025–2026). Collaborations span immunology, genetics, and computational biology to address fibrotic diseases across organs including liver, kidney, and lung. Key findings include SOX9's essential role in hepatic granuloma integrity during schistosomiasis, circadian disruption accelerating fibrosis progression in NAFLD, and PAK1-dependent mechanotransduction pathways in fibroblast nuclear adaptation. His work bridges basic science and clinical applications to improve diagnostics and therapeutic strategies for fibrotic disorders.

Andrea Münsterbergمشاهده پروفایل

استاد

• Developmental Biology
• Embryonic Development
• Cell Fate Specification
• +۱۴ مورد دیگر

Andrea Münsterberg is Professor of Developmental Biology in the School of Biological Sciences at the University of East Anglia (UEA). She leads a research group focused on the molecular and cellular mechanisms of embryonic development, particularly using chick embryos as a model system. Her work intersects with stem cell science and regenerative medicine, and she is a member of the Cells and Tissues research theme. She has held key administrative roles including Director of Research (2014–2017) and Theme Leader for Cells and Tissues (2010–2013). PhD, National Institute for Medical Research, MRC, Mill Hill, London (1992) German Diploma in Biology, University of Heidelberg (1988) Her research focuses on how cell fate decisions are regulated during vertebrate embryogenesis, especially in somite-derived tissues (muscle, bone, cartilage) and heart development. She investigates signaling pathways, cytoskeletal dynamics, microRNA function, and gene regulatory networks using molecular, genetic, and imaging techniques. Her group employs single-cell genomics and chromatin accessibility profiling to map developmental trajectories. The recent publications and active projects reveal a strong emphasis on transcriptional regulation, chromatin landscape analysis, cardiac progenitor biology, and somite patterning. Her work increasingly leverages cutting-edge technologies like single-cell RNA sequencing and spatial transcriptomics to understand developmental processes at high resolution. Collaborations with researchers such as G. Wheeler and S. Moxon highlight an interdisciplinary approach. Her scientific awards include prestigious fellowships from the Human Frontier Science Program Organization (HFSPO), Muscular Dystrophy Association (MDA), and the Wellcome Trust, all awarded competitively early in her career. She has supervised PhD students and postdoctoral researchers, welcoming applications from candidates seeking funding via fellowships (e.g., EU Marie Curie) or named postdoc positions on grants. She has secured significant research funding from the British Heart Foundation and the Biotechnology and Biological Sciences Research Council (BBSRC) for multiple projects investigating cardiac development, somite maturation, and gene regulation. She leads a dynamic, international research group that benefits from shared facilities such as the Henry Wellcome Bioimaging Lab and Taqman qPCR systems. The group collaborates closely with the Wheeler lab through joint lab meetings and co-led projects, and actively participates in the Cell and Developmental Biology seminar series and international conferences.

Anita Grigoriadisمشاهده پروفایل

استاد

• Triple-Negative Breast Cancer
• Genomic Instability
• Tumor Immunology
• +۶ مورد دیگر

Anita Grigoriadis is a Professor of Molecular and Digital Pathology affiliated with a Comprehensive Cancer Centre, where she leads the Cancer Bioinformatics group. Her research focuses on computational approaches to triple-negative breast cancer (TNBC), genomic instability, and tumor-immune interactions. She collaborates extensively with clinical partners like Professor Andrew Tutt and utilizes high-throughput data to develop biomarkers and therapeutic strategies. Education: Master of Science in Bioinformatics with Systems Biology, UCL University College London (2008) Doctor of Philosophy, University of Salzburg (1997) Master of Natural Science, University of Vienna (1993) Research Focus: Her group investigates TNBC biology through genomic/transcriptomic analysis, machine learning-based histopathology, and immune microenvironment dynamics. Key areas include lymph node alterations in metastasis prediction, drug sensitivity algorithms, and microbial community influences on cancer progression. Research integrates bulk/single-cell transcriptomics, genomics, and multiplexed imaging. Publication Trends: Recent works emphasize tumor microenvironment plasticity, stromal composition in breast cancer prognosis, immune dysregulation in melanoma, and computational pathology innovations. Studies frequently employ multi-omics integration and AI-driven digital pathology. Projects & Leadership: She leads/co-leads 41 projects, including: Wellcome Trust-funded multimodal tissue imaging (2024–2026) CRUK spatial proteogenomics platform for breast cancer detection (2024–2025) EPSRC AI Hub for healthcare causality (2024–2029) She directs PhD training and peer-reviews for journals like Cell Reports Medicine .