جستجوی استاد راهنمای دانشگاهی

Henry H.Q. Hengمشاهده پروفایل

استاد

• Genomics
• Evolutionary Biology
• Cancer Research
• +۳ مورد دیگر

Dr. Henry H.Q. Heng is a tenured Professor of Molecular Medicine and Genetics and Pathology at Wayne State University , affiliated with the Karmanos Cancer Institute . His research spans genomics, evolutionary biology, and cancer systems theory. Education: PhD from University of Toronto (1994) Key research areas: Genomics, Evolutionary Biology, Cancer Research, Precision Medicine Dr. Heng's groundbreaking Genome Architecture Theory challenges traditional neo-Darwinism by emphasizing genomic topology and system inheritance over gene-level mechanisms. His team introduced the two-phased cancer evolution model (punctuated macroevolution followed by microevolution), explaining rapid cancer adaptation through genome chaos and non-clonal chromosome aberrations. Recent publications focus on karyotype coding , therapy-induced genome chaos, and the limitations of precision medicine approaches that ignore genomic heterogeneity. His work reveals how stress-induced genomic instability drives cancer evolution and drug resistance. 2020 PROSE Award Finalist for 'Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine' Dr. Heng's lab develops innovative genomic techniques like high-resolution Fiber-FISH and investigates Gulf War Illness through genomic instability lens. He actively debates foundational issues in cancer research through books like 'Debating Cancer: The Paradox in Cancer Research' (2015) and 'Genome Chaos' (2019).

• Non-coding RNA
• Gene Expression
• Developmental Biology
• +۶ مورد دیگر

Matthew Ronshaugen is a Senior Lecturer in the Division of Developmental Biology & Medicine (L5) at the Faculty of Life Sciences, University of Manchester. He has held academic positions since 2007 as a Manchester Fellow, followed by Lecturer (2012-2017), and Senior Lecturer since 2017. 1991-1995: Bachelor of Arts in Philosophy and Linguistics, University of Nevada, Las Vegas 1995-1997: Master of Science in Systematics, University of Nevada, Las Vegas 1997-2002: Doctor of Philosophy in Cell and Molecular Biology, University of California, San Diego 2003-2007: Ruth L. Kirschstein NIH Postdoctoral Fellow at University of California, Berkeley His research focuses on non-coding RNAs (ncRNAs), particularly their roles in gene expression and developmental differentiation. His lab investigates how ncRNA evolution contributes to metazoan body plan diversification, centering on the Hox complex—a conserved genomic region rich in ncRNAs. He uses tiling microarrays and fluorescent in situ hybridization to analyze ncRNA dynamics in Drosophila, Tribolium, and Parhyale. Recent publications highlight his work on miRNA functions in embryonic development, aging-related changes in myeloid cells, and comparative transcriptomics across arthropods. His team employs genetics tools to dissect ncRNA roles in transcriptional regulation, epigenetic control, and silencing mechanisms. Scientific Awards: Ruth L. Kirschstein NIH Postdoctoral Fellow Manchester Fellow He supervises research on developmental transcriptomes and contributes to datasets on piRNA expression and Hox complex analysis. Collaborations span immunology, genomics, and evolutionary development, with outputs cited in fields like RNA interference, transgenics, and wound healing.

Emilia Limمشاهده پروفایل

استادیار

• Bioinformatics
• Cancer
• Aging
• +۵ مورد دیگر

Dr. Emilia Lim is an Assistant Professor in the Department of Biochemistry and Molecular Biology at the University of British Columbia's Faculty of Medicine , with an investigator role at the Edwin S.H. Leong Centre for Healthy Aging . She specializes in computational analysis of environmental exposures, particularly pollution, in age-related diseases like cancer. Education: BSc from University of Alberta (2009) PhD from University of British Columbia (2016) Postdoctoral training at Francis Crick Research Institute, University College London (2023) Her research integrates multi-omic approaches (genomics, transcriptomics, epigenomics) to investigate how environmental pollutants drive disease states in samples like cancer patients. Recent work focuses on lung cancer evolution , immune evasion , and epigenetic aging under pollution exposure, with applications in precision oncology and healthy aging initiatives across Canada. Publications highlight her expertise in cancer genomics , environmental toxicology , and computational biology , with key contributions to understanding air pollution-induced carcinogenesis (2023) and subclonal tumor dynamics (2020, 2023). Her lab develops tools like SPRINTER for single-cell cancer evolution analysis and explores haplotype-specific copy number in tumor heterogeneity ( Refphase , 2023).

Karol Nowicki-Osuchمشاهده پروفایل

پژوهشگر ارشد

• Cancer Biology
• Molecular Oncology
• Gastrointestinal Cancers
• +۳ مورد دیگر

Dr. Karol Nowicki-Osuch is a Group Leader at the German Cancer Research Center (DKFZ) , leading a research group focused on tumorigenesis and molecular cancer prevention. His work emphasizes understanding early stages of gastrointestinal tumor development using multimodal techniques like single-cell RNA sequencing, organoid models, and spatial transcriptomics. Key research areas include the molecular mechanisms underlying Barrett's esophagus, gastric intestinal metaplasia, and the transition to adenocarcinoma. Collaborations span institutions in Germany, Poland, the UK, and the US. His team investigates how normal epithelial cells lose molecular identity and progress to precancerous states. Notable achievements include demonstrating that esophageal adenocarcinoma originates from gastric tissue and identifying novel mutational signatures using the mutREAD method. Current projects aim to develop early cancer detection strategies and in vivo models of tumor progression. Dr. Nowicki-Osuch supervises PhD students and employs cutting-edge technologies such as spatial transcriptomics and organoid platforms. His lab integrates computational biology with experimental approaches to address gaps in understanding clonal evolution and somatic mutations in gastroesophageal cancers.

• Cancer Genomics
• Genome Analysis
• Metagenomics
• +۳ مورد دیگر

Avraam Tapinos is a Researcher at the University of Manchester's Division of Cancer Sciences (L5), part of the Manchester Cancer Research Centre. His work contributes to UN Sustainable Development Goals related to health and innovation. Research focuses include cancer genomics, metagenomics, and bioinformatics methodologies. Affiliations: Manchester Cancer Research Centre, Digital Futures Research Beacon Key expertise: Cancer genomics, germline analysis, metagenomic binning Recent research explores genomic landscapes of testicular germ cell tumors, breast cancer evolution in diverse populations, and respiratory virome dynamics in asthma. His computational methods advance alignment-free genomic analysis. Publications span high-impact journals like Nature Communications and American Journal of Human Genetics, with interdisciplinary collaborations in oncology, microbiology, and bioinformatics.

Louis Lambrechtsمشاهده پروفایل

پژوهشگر

• Arbovirus transmission
• Insect-virus interactions
• Mosquito genetics
• +۱۲ مورد دیگر

Louis Lambrechts is a Researcher and Head of the Insect Infection & Immunity Group at the Institut Pasteur in Paris, France, within the Department of Virology. His research focuses on the ecology, evolution, and genetics of mosquito-virus interactions, particularly involving Aedes aegypti and arboviruses such as dengue and Zika. He leads a dynamic research team and multiple national and international projects funded by agencies including ANR and EU consortia. His research interests include arbovirus transmission dynamics, vectorial capacity, mosquito genetics, evolutionary ecology, host-pathogen interactions, and the role of microbiota in vector competence. He employs genomics, quantitative genetics, and experimental evolution to understand the mechanisms underlying variation in mosquito susceptibility to viral infection. His work has important implications for predicting and controlling arboviral disease outbreaks. Lambrecht’s recent publications reveal key insights into the genetic and environmental factors influencing arbovirus transmission, including the role of mosquito population variation in Zika transmission in Africa, the impact of endogenous viral elements, and the discovery of antiviral roles for cytochrome P450 enzymes. His research integrates molecular biology, field studies, and computational modelling, contributing to a comprehensive understanding of vector-borne disease systems. He has mentored numerous PhD students, postdoctoral researchers, and visiting scientists, fostering a collaborative and interdisciplinary research environment. His lab collaborates widely with institutions across Europe, Africa, and the Americas. Lambrecht’s work is supported by multiple ongoing projects such as CAZIKANO, INTRANZIGEANT, ANR PILGRIM, and LIPOARBO-IVI, focusing on Zika virus transmission, genetic drivers of vectorial capacity, and mosquito-virus specificity. His lab is also involved in broader initiatives like the LabEx IBEID and the Emerging Infectious Diseases program at Institut Pasteur.

Julie Ahringerمشاهده پروفایل

استاد

• Chromatin Regulation
• Epigenetics
• Genome Organization
• +۳ مورد دیگر

Julie Ahringer is Professor of Genetics and Genomics at the University of Cambridge and Director of the Wellcome Trust/Cancer Research UK Gurdon Institute. She leads a research group investigating chromatin structure and gene regulation using C. elegans as a model system. Her work integrates genomics, super-resolution microscopy, and computational approaches to understand epigenetic controls in development and disease. She holds fellowships from the Royal Society (FRS) and Academy of Medical Sciences (FMedSci). Research Focus: Her laboratory studies chromatin regulation mechanisms including heterochromatin formation, Polycomb domain function, genome architecture, and enhancer/promoter interactions. Key approaches include single-cell multiomics, high-throughput genomics, and super-resolution microscopy to analyze developmental trajectories. Research areas span: H3K27me3 domain formation and Polycomb repression Constitutive heterochromatin organization Regulatory element characterization 3D genome architecture via ARC-C technology Single-cell resolution developmental mapping Awards & Honors: Fellow of the Royal Society (FRS) Fellow of the Academy of Medical Sciences (FMedSci) Wellcome Senior Research Fellowship Academic Leadership: She mentors PhD students and postdoctoral researchers, with funding from Wellcome, MRC, and CRUK. Her lab develops open-source bioinformatics tools (VplotR, periodicDNA) and maintains the genome-wide C. elegans RNAi feeding library. Lab & Collaborations: The Ahringer Lab is based at the Gurdon Institute and collaborates widely on chromatin dynamics, nuclear organization, and developmental genomics projects across model organisms.

Alexander Gitlinمشاهده پروفایل

استادیار

• Immunology
• Inflammation biology
• Innate immunity
• +۴ مورد دیگر

Alexander Gitlin, MD, PhD , is an Assistant Member in the Immunology Program of the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center , and an Adjunct Assistant Professor (by joint appointment) at the Weill Cornell Graduate School of Medical Sciences . He directs the Gitlin Lab, which investigates how inflammatory cell signaling controls the magnitude and quality of innate immune responses in health and disease. Education & Training AB, Chemistry & Physics – Harvard University, 2009 PhD, Immunology – The Rockefeller University, 2016 (mentor: Michel Nussenzweig) MD – Weill Cornell Medicine, 2017 Residency, Clinical Pathology – Stanford University, 2017-2019 Post-doctoral training – Genentech, Inc. (Vishva Dixit laboratory), 2019-2022 Research Focus The Gitlin Lab combines genome-editing , proteomics , advanced imaging , and in-vivo models to dissect molecular circuits that balance cell survival and death during innate immune activation. By studying genes mutated in inherited autoinflammatory diseases, the group aims to uncover new therapeutic targets for immunodeficiency, auto-inflammation and cancer. Representative Publications Trend Across 25 peer-reviewed articles (2011-2025), Gitlin’s work moves from foundational studies on germinal-center B cell selection to recent high-impact papers that mechanistically link ubiquitin signaling, caspase activity and Toll-like receptor pathways. These studies collectively illuminate how post-translational modifications tune inflammatory intensity. Scientific Awards & Honors Pershing Square Sohn Cancer Prize – 2025 NIH Director’s DP5 Early Independence Award – 2022-2027 Josie Robertson Investigator – 2022-2027 Burroughs Wellcome Fund Career Award for Medical Scientists – 2022 NIAID K08 Mentored Clinical Scientist Award – 2021 Harold M. Weintraub Graduate Student Award – 2016 Training & Mentorship Gitlin currently mentors four PhD students (Kanno, Londoner, Morrison, Pacini) drawn from the Tri-Institutional and Gerstner Sloan Kettering programs. The lab hosts research fellows, technicians, and rotating students, and maintains active recruitment for fully-funded post-doctoral positions. Lab & Institutional Affiliations The Gitlin Lab is physically housed within the Immunology Program at the Sloan Kettering Institute, with access to core facilities for CRISPR editing, single-cell genomics, high-resolution imaging and mouse models. The group is additionally affiliated with the Gerstner Sloan Kettering Graduate School of Biomedical Sciences and the Weill Cornell Immunology & Microbial Pathogenesis PhD program .

• Plant Breeding
• Fungal Biology
• Lignocellulose Degradation
• +۳ مورد دیگر

Arend van Peer is a Researcher in Plant Breeding at Wageningen University & Research, specializing in fungal biology and biotechnology. His work focuses on leveraging white rot fungi for applications in sustainable agriculture, including lignocellulosic biomass conversion, mycelium-based materials, and improving feed quality for ruminants. Key projects include developing circular leather alternatives and optimizing fungal strains for industrial uses. He leads initiatives like the 'Right Fungus for the Right Job' program and collaborates on interdisciplinary projects bridging horticulture and mushroom cultivation. Peer has contributed to genomic studies of Agaricus bisporus and Pleurotus species, advancing understanding of fungal genetics and reproductive mechanisms. His research integrates molecular biology, genomics, and applied biotechnology to address agricultural challenges. Notable achievements include pioneering agar-based screening methods for fungal incompatibility and co-developing the DigiFungi educational software. Peer actively participates in academic and professional seminars, emphasizing circular economy principles and cross-sectoral innovation.

Qiang Weiمشاهده پروفایل

استاد مدعو

• Cancer Genomics
• Epigenetics
• Computational Biology
• +۳ مورد دیگر

Qiang Wei, Ph.D., is an Adjunct Research Instructor in the Department of Molecular Physiology and Biophysics at Vanderbilt University School of Medicine. His research focuses on computational and systems biology approaches to study genomic and epigenomic mechanisms in cancer, drug response prediction, and disease risk gene prioritization. He has pioneered integrative frameworks combining multi-omics data (genomics, epigenomics, transcriptomics) with clinical information for precision medicine applications. Key research areas include: Developing computational tools for analyzing non-coding variants and DNA methylation patterns Characterizing tumor heterogeneity through circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) Identifying genomic drivers of therapy resistance in metastatic cancers Integrating GWAS data with functional genomics for disease mechanism discovery His work spans multiple cancer types including breast, prostate, and hepatocellular carcinoma, with a particular emphasis on translating genomic insights into clinical diagnostics and therapeutic strategies. Ongoing projects include optimizing liquid biopsy approaches for early cancer detection and leveraging single-cell technologies to understand tumor evolution. In recent years, his lab has developed novel algorithms like TVAR for functional variant analysis and Bayesian frameworks for multi-omics integration. These methods have been applied to study schizophrenia genetics, autism risk genes, and platelet reactivity regulation.

Peter Parkمشاهده پروفایل

استاد

• Genomics
• Bioinformatics
• Computational Biology
• +۴ مورد دیگر

Peter Park is a Professor of Biomedical Informatics at Harvard Medical School and Director of its Bioinformatics and Integrative Genomics (BIG) PhD program. His research focuses on computational analysis of genomic data, particularly in cancer genomics, somatic mosaicism, and epigenetic mechanisms. He leads major projects like the Somatic Mosaicism across Human Tissues (SMaHT) network and contributes to consortia such as The Cancer Genome Atlas (TCGA) and ENCODE. His work integrates advanced computational methods with clinical applications, aiming to advance precision medicine and understand genetic drivers of disease. Education: B.A. in Applied Mathematics, Harvard University Ph.D. in Applied Mathematics, California Institute of Technology Postdoctoral studies in biostatistics, focusing on molecular biology and genetics Research Interests: His lab develops algorithms for genomic data analysis, including methods for detecting copy number variations, mutational signatures, and structural variations. Key areas include cancer genomics, somatic mosaicism in neurodegenerative diseases, and 4D nucleome structure-function relationships. He emphasizes translational research, applying computational tools to clinical problems like tumor evolution and drug response prediction. Funding & Grants: NIH grants (e.g., R01HG012573, R01CA269805) Funding from Mark Foundation, Simons Foundation, and Chan Zuckerberg Initiative Principal Investigator for multiple collaborative projects Labs & Teams: The Park Lab collaborates with interdisciplinary teams in computational biology, oncology, and neuroscience. Current projects include developing tools for single-cell DNA sequencing analysis and exploring mutational signatures in cancer and neurodegenerative disorders.

Robert Nobleمشاهده پروفایل

مدرس ارشد

• Cancer
• Evolutionary Biology
• Mathematical Biology
• +۷ مورد دیگر

Dr. Robert Noble is a Senior Lecturer in Mathematics at City St George's, University of London, specializing in the evolution and ecology of cancer . His research integrates mathematical modeling with computational biology to address four key themes: systematic understanding of somatic evolution, patient-specific tumor forecasting, treatment strategies leveraging evolutionary dynamics, and disentangling ecological contributions to cancer risk. Education: DPhil in Zoology (University of Oxford, 2014) Previous Appointments: Postdoctoral roles at ETH Zurich (2017-2020) and University of Zurich (2018-2020) His methodological toolkit spans agent-based models , stochastic processes , and Bayesian data analysis , with software contributions like the ggmuller and demon packages. Recent work focuses on universal tree balance indices for biological data comparison and adaptive therapy frameworks for clinical translation. Collaborations with experimental biologists and clinicians inform his research, which has produced key insights into spatial tumor evolution , drug resistance dynamics , and clonal diversity-survival relationships . He maintains active peer-review roles for journals like PLOS Computational Biology and Nature Ecology & Evolution.

Lena Strömمشاهده پروفایل

مدرس ارشد

• Cell and Molecular Biology
• Molecular Biology
• Genetics
• +۷ مورد دیگر

Lena Ström, Senior Lecturer at the Department of Cell and Molecular Biology, Karolinska Institutet, specializes in sister chromatid cohesion, DNA damage responses, and genome integrity. Her research explores the role of Structural Maintenance of Chromosome (SMC) complexes in DNA repair, chromosome segregation, and developmental syndromes like Cohesinopathies. 2017: Senior Lecturer at Karolinska Institutet 2015: Docent at Karolinska Institutet 2002: PhD in Cell and Molecular Biology from Karolinska Institutet Her work focuses on the Cohesin complex's dual role in sister chromatid cohesion and DNA repair, particularly in cancer and Cohesinopathies. By studying yeast and human cells, her group investigates how DNA damage activates cohesion, impacts telomere maintenance, and contributes to tumor development and developmental disorders. Recent publications highlight Cohesin's role in damage-induced cohesion, DNA repair regulation, and SMC complex dynamics. Key collaborations span genetics, immunology, and medical research, with applications in cancer treatment and patient support for Cornelia de Lange syndrome. Current projects aim to elucidate Cohesin network mechanisms in chromatin structure, transcriptional regulation, and cancer therapy targets. Her group integrates advanced biochemistry, genomics, and functional studies to address molecular pathways in healthy and malignant cell cycles.

Stephanie Panierمشاهده پروفایل

استاد پژوهش

• Genome Stability
• DNA Damage Response
• Aging Research
• +۴ مورد دیگر

Dr. Stephanie Panier serves as a Max Planck Research Group Leader at the Max Planck Institute for Biology of Ageing in Cologne, Germany, and as a Principal Investigator at the Institute for Genome Stability in Aging and Disease within the Medical Faculty of the University of Cologne. Her research program investigates the fundamental mechanisms by which cells maintain genome stability through sophisticated DNA damage response pathways. Her academic journey includes: PhD in Molecular Genetics from the University of Toronto (2008-2013) under Prof. Daniel Durocher Postdoctoral training at the Francis Crick Institute in London (2013-2019) with Prof. Simon Boulton Undergraduate studies in Biology at Ruprecht-Karls-Universität Heidelberg, Germany (2001-2006) Dr. Panier's laboratory focuses on two central questions in genome stability research: how DNA damage response pathways interact with telomere maintenance mechanisms, and how RNAs and RNA-binding proteins organize chromatin-based responses to DNA lesions. Her team employs cutting-edge cell biological and omics approaches to identify and characterize RNA-binding proteins at DNA damage sites, mapping their chromatin dynamics and interactions following genotoxic stress. This research has significant implications for understanding aging-associated diseases driven by genomic instability, including cancer and neurodegeneration. Analysis of her publication record reveals consistent contributions to understanding DNA repair mechanisms, with recent work expanding into cancer biology, telomere maintenance in alternative lengthening pathways, and the emerging role of RNA metabolism in genome stability. Her scientific achievements have been recognized through: Vivash Award for best PhD thesis (2013) FEBS Excellence Award (2023) EMBO Long-Term Fellowship (2013-2014) Vanier Canada Graduate Scholarship (2010-2013) Boehringer Ingelheim Fonds PhD Fellowship (2008-2010) EIRR21st Fellowship (2023) Dr. Panier actively contributes to the scientific community through leadership roles including Vice Coordinator of the DFG Research Unit FOR5504 (2023-2026), membership on the advisory board of the German Society for Research on DNA Repair since 2022, and representation on the Biology and Medicine Section of the Max Planck Society's scientific council since 2022. She also serves as a Principal Investigator in the Cologne Excellence Cluster 'Cellular Stress Responses in Aging-Associated Diseases' (CECAD). Her laboratory comprises postdoctoral researchers and PhD students working collaboratively to advance our understanding of genome stability mechanisms in aging, with current projects focusing on RNA-binding proteins in DNA damage response and telomere maintenance pathways.

Zeynep Erson Omayمشاهده پروفایل

استادیار

• Computational Biology
• Genomics
• Epigenomics
• +۶ مورد دیگر

Dr. Zeynep Erson Omay serves as an Assistant Professor in the Department of Neurosurgery and Biomedical Informatics & Data Science at Yale School of Medicine. Her work bridges computational biology with neurosurgical oncology, focusing on precision medicine applications for brain tumors, with particular emphasis on understanding tumor heterogeneity and molecular mechanisms of CNS tumors. Dr. Erson Omay's educational background includes: PhD in Computer Science from Case Western Reserve University (2011) MS in Computer Science from Bilkent University (2005) BS in Computer Science from Bilkent University (2003) Her research focuses on computational analysis of multi-omic datasets to understand tumor heterogeneity, particularly in central nervous system tumors. Dr. Erson Omay specializes in genomic, transcriptomic, and epigenetic profiling of brain tumors, with emphasis on meningiomas, glioblastomas, and rare CNS tumor subtypes. She leads the Erson Lab, which develops bioinformatics approaches to study large datasets and reveal molecular mechanisms in tumor formation, progression, and clinical outlier subgroups. Her work in precision medicine aims to decipher the molecular architecture of individual tumors to guide personalized treatment approaches, with significant contributions to understanding tumor ecosystems and evolutionary patterns in brain cancers. Dr. Erson Omay's scientific contributions span neuro-oncology, computational biology, and precision medicine, with a strong emphasis on translating genomic findings into clinical applications. Her publications demonstrate consistent innovation in applying computational methods to complex neurosurgical problems, with particular focus on tumor heterogeneity, molecular classification, and racial disparities in tumor genomics. Her notable scientific awards include: 10x Genomics 2021 Pilot Award (2022) Mission Bio Tapestri Grant (2022) Case Western Reserve University, Research ShowCASE-Best Poster Award (2007) Dr. Erson Omay actively mentors students and researchers at various levels, including undergraduate students, graduate students, postdocs, and postgraduate associates. She collaborates extensively within Yale's neurosurgery department and across disciplines to advance computational approaches to brain tumor research. Her work is supported by various grants that enable the development of novel bioinformatics platforms for tumor genomic characterization. She leads the Erson Lab, which focuses on three major research areas: Tumor Ecosystem (studying interactions among tumor and immune cells), Tumor Evolution and Heterogeneity (understanding temporal and spatial tumor evolution), and Precision Medicine (applying genomic techniques to personalize brain tumor treatment). The lab employs diverse omics technologies to explore brain tumor biology and develop computational methods for precision medicine applications.