جست‌وجوی استاد و پژوهشگر

Thomas Walterمشاهده پروفایل

استاد

• Biomedical Image Analysis
• Machine Learning
• Computational Pathology
• +۴ مورد دیگر

Thomas Walter is a Professor at Mines ParisTech and Director of the Centre for Computational Biology (CBIO) , a research group affiliated with the Institut Curie and INSERM . His work focuses on applying Machine Learning and Computer Vision to biomedical image analysis, particularly in high-content screening and computational pathology . He also serves as Deputy Director of the Computational Oncology (U1331) unit and leads the Statistical Learning and Modeling of Biological Systems team. PhD in Medical Image Analysis (2003, Mines ParisTech) Postdoctoral work at EMBL (European Molecular Biology Laboratory) Director of CBIO since 2018 Holder of a PRAIRIE Chair (Paris Artificial Intelligence Research Institute) since 2019 Dr. Walter's research bridges biomedical imaging , machine learning , and cancer genomics . Key areas include: Statistical reconstruction of biological networks Prediction of tumor progression at genomic/transcriptomic levels Development of deep learning methods for cell cycle analysis Integration of multi-omics data for precision oncology Tools for spatial transcriptomics (e.g., autoFISH, RNA2seg) Recent publications highlight his work in spatial transcriptomics , immunotherapy outcome prediction , and deep learning for digital pathology . His team has developed open-source tools like FISH-quant and pyHiM for single-molecule RNA imaging analysis. Scientific Honors: PRAIRIE Chair (2019) for AI research in life sciences Dr. Walter actively contributes to teaching deep learning for image analysis in multiple graduate programs across France, including courses at Mines ParisTech , Université Paris-Saclay , and Institut Curie . His software tools (FISH-quant, pyHiM) and methodological frameworks (e.g., Cut-Detector, PointFISH) have become standard resources in bioimage informatics.

Alain Trouvéمشاهده پروفایل

استاد

• Shape Spaces and Applications
• Imaging Processing and Computational Vision
• Computational Biology
• +۳ مورد دیگر

Alain Trouvé is a Professor at the Center for Mathematics and Their Applications (CMLA) within the Ecole Normale Supérieure de Cachan , France. His research focuses on Shape Spaces , Computational Anatomy , Imaging Processing , and Biological Imaging , with applications in medical and computational fields. He directs the Mathematics Department at ENS Cachan and contributes to neuroanatomical studies through diffeomorphometry techniques. Key roles include membership in the Conseil National des Universités (Section 26) and teaching responsibilities such as courses on Geometry and Shape Spaces and Probability Theory . His work spans from theoretical frameworks (e.g., Hamiltonian modeling of shape evolution) to practical applications like 3D cell imaging and white matter fiber analysis. Publications emphasize interdisciplinary methods, including diffeomorphic registration, varifold-based image analysis, and stochastic shape evolutions. Current projects explore multi-scale modeling of biological systems and AI-driven medical diagnostics. Key Research Themes: Diffeomorphic mappings, computational vision, and functional shape analysis. Teaching: Courses on geometric modeling and probability at undergraduate and graduate levels. Tools Developed: xIV-LDDMM Toolkit for multi-modal biomedical data analysis.

Eliane Piaggioمشاهده پروفایل

پژوهشگر

• Immunotherapy
• Cancer Immunology
• Regulatory T Cells
• +۳ مورد دیگر

Eliane Piaggio is an Inserm Research Director and Team Leader of the Translational Immunotherapy team at the Institut Curie Research Center (Unit U932 - Immunity and Cancer). Her work focuses on immunotherapy strategies targeting regulatory T lymphocytes in cancer, infectious diseases, and autoimmunity. Studied lymph nodes draining human tumors to identify functional T cell responses Developed IL-2 variants for tumor-specific Treg inhibition Explored neoantigen responses in breast, head/neck, and melanoma cancers Key research areas include tumor microenvironment analysis, biomarker discovery, and personalized immunotherapy development. Her team has established a tumor-draining lymph node biobank and employs advanced technologies like single-cell transcriptomics, CRISPR editing, and mass spectrometry immunopeptidomics. Notable achievement: 2022 Ruban Rose Avenir prize recipient for predictive biomarker research in triple-negative breast cancer. Her projects aim to optimize anti-tumor immune responses through translational approaches in rhabdoid cancers and neoantigen vaccination studies.

Jean-Marc Ghigoمشاهده پروفایل

استاد

• Biofilm Biology
• Bacterial Genetics
• Antibiotic Resistance
• +۷ مورد دیگر

Prof. Jean-Marc Ghigo is a leading researcher at the Institut Pasteur , Paris, affiliated with the Department of Microbiology and head of the Genetics of Biofilms Laboratory . He leads multiple research projects focused on biofilm formation, physiology, and resistance mechanisms in pathogenic and commensal bacteria. Institution: Institut Pasteur School: Department of Microbiology Department: Genetics of Biofilms Laboratory Academic Rank: Professor Email: jmghigo@pasteur.fr His research focuses on biofilm biology , bacterial genetics , antibiotic resistance , and microbial physiology . He investigates how bacteria form biofilms on surfaces, adapt metabolically, and resist antimicrobials, with a particular emphasis on Escherichia coli and Bacteroides thetaiotaomicron . His work includes studying anaerobic biofilms, volatile compounds, colonization resistance, and the development of genetic tools for biofilm research. The recent publications reveal a strong trend in understanding molecular mechanisms of biofilm formation and resistance , including the role of efflux pumps, extracellular matrices, adhesins, and interspecies interactions. His studies span microbial physiology , structural biology , environmental microbiology , and host-microbe interactions , often using advanced techniques like liquid-cell electron microscopy and transcriptomic analysis. He has not been explicitly associated with any scientific awards in the provided text. Prof. Ghigo actively mentors students and postdoctoral researchers, including Yankel Chekli , Anne-Aurélie Lopes , Julie Le Bris , and others. His lab collaborates extensively within the Institut Pasteur and with external partners. He has developed widely used genetic tools and in vivo models for studying biofilms. His research is supported by institutional funding and collaborative grants, contributing to the development of novel strategies to combat biofilm-related infections. His laboratory includes specialized spaces such as a biofilm room , zebrafish room , cell culture room , and microscopy facilities , enabling multidisciplinary research on bacterial communities and host interactions.

Alessandra Pieraniمشاهده پروفایل

استاد

• Cortical Development
• Neurological Disorders
• Neuronal Migration
• +۳ مورد دیگر

Alessandra Pierani is a Professor leading a research team focused on understanding the genetics and development of the cerebral cortex, particularly the role of Cajal-Retzius cells in neural circuit formation. Her work bridges developmental neuroscience, evolutionary biology, and clinical applications, with affiliations at Institut Imagine (Paris) and the Institute of Psychiatry and Neurosciences of Paris (IPNP). Her research investigates how transient neuronal populations influence cortical architecture, with implications for neurological disorders like autism, schizophrenia, and epilepsy. Key areas include neuronal migration, synaptic gene regulation, and the evolutionary origins of higher-order cortical functions. Her team employs mouse and primate models to study developmental mechanisms linking early brain formation to later-onset psychiatric conditions. Recent projects emphasize translational research, collaborating with clinicians and geneticists to develop mouse models for cortical abnormalities and improve diagnosis of neurodevelopmental diseases. The team includes 22 members from 7 nationalities, with associated labs at both institutes.

Florent Ginhouxمشاهده پروفایل

پژوهشگر

• Myeloid Cell Biology
• Cancer Immunology
• Tumor Microenvironment
• +۴ مورد دیگر

Florent Ginhoux is a Researcher at Gustave Roussy 's Tumor Immunology and Cancer Immunotherapy Program (U1015). He leads the Florent Ginhoux Laboratory (ginhouxlab.com), focusing on myeloid cell biology in cancer progression and immunotherapy development. His team integrates spatial transcriptomics (Visium HD, Xenium), single-cell RNA sequencing , and MACSIMA spatial proteomics to dissect tumor-immune interactions. His research spans pediatric oncology (brain tumors, neuroblastomas, sarcomas) and adult cancers (pancreatic, head/neck carcinomas). Key projects include Developing iPSC-derived macrophages for patient-specific tumor modeling Characterizing TREM2+ multinucleated macrophages as prognostic indicators Creating MoMac-VERSE and DC-VERSE compendiums for cross-tissue myeloid cell analysis His lab collaborates with pediatric oncologists and bioinformaticians on projects funded by 2024 Fight-Kid Cancer grant ( MiMiC-Kids ) 2024 ANR Excellence Chair ( MATCH ) 2024 Horizon HIT-GLIO grant 2021 INCa PEDIAHRG High-Risk/High-Gain program

Glenda Comaiمشاهده پروفایل

پژوهشگر

• Developmental Biology
• Stem Cell Biology
• Muscle Development
• +۴ مورد دیگر

Glenda Comai is a Permanent Researcher (CRCN CNRS) at the Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, where she has worked since 2016 in Prof. Shahragim Tajbakhsh's laboratory. She serves on the Advisory Board of the French Society of Developmental Biology (SFBD) since 2019 and recently obtained her HDR (Habilitation à diriger des Recherches) from Université Paris Saclay in 2024. Her research focuses on understanding the mechanisms underlying tissue patterning during development, with special emphasis on craniofacial muscles. Using 3D-imaging, mouse genetics, and single cell/single nuclear omics approaches, she investigates how heterogeneity at the level of stem cells and myofibers is established and how this impacts muscular genetic disorders. Her work reveals significant differences between extraocular muscle stem cells and those from limb muscles, particularly in their regenerative capacity and molecular signatures. Analysis of her recent publications shows a strong trend toward understanding the transcriptional and epigenetic regulation of muscle stem cell identity, particularly how anatomical location influences stem cell behavior. Her research spans developmental biology, stem cell biology, and muscle physiology, with particular emphasis on craniofacial development and muscle regeneration mechanisms. AFM PRC Grant (2024-2026) ANR JCJC Grant (2021-2024) AFM Trampolin Grant (2020-2021) As Principal Investigator, Dr. Comai leads two major research projects: AFM-Trampolin: Cellular and genetic basis for robustness of cranial myogenic populations (ENCRYPT) and ANR-JCJC: Mechanisms defining functional heterogeneity of anatomically distinct myogenic populations (MUSE). Her laboratory employs advanced techniques including bioimage analysis, confocal microscopy, stem cell culture, and various molecular biology methods to investigate muscle development and regeneration.

Sebastian Baumgartenمشاهده پروفایل

پژوهشگر

• RNA modifications
• Parasitology
• Malaria
• +۱۲ مورد دیگر

Sebastian Baumgarten is the Head of the 'Parasite RNA Biology' Group at the Institut Pasteur, France, a position he has held since June 2021. He is affiliated with the Department of Biology of Host-Parasite Interactions. Previously, he was a post-doctoral researcher at the same institute from 2016 to 2021. His educational background includes a Ph.D. (2013–2016) and MSc (2012–2013) from the Red Sea Research Center at King Abdullah University of Science and Technology, Saudi Arabia, and a BSc (2009–2012) from the University of Tübingen, Germany. His research centers on RNA biology in malaria parasites, particularly focusing on RNA modifications such as m6A and tRNA methylation, epigenetic regulation, and post-transcriptional gene control in Plasmodium falciparum . He employs advanced genomic techniques including CRISPR, RNAseq, and ChIPseq to study gene regulation and immune evasion mechanisms in protozoan parasites. His recent publications reveal a strong trend in understanding how RNA modifications influence parasite development, stress response, and antigenic variation. His work bridges molecular parasitology with epitranscriptomics, contributing significantly to the understanding of gene regulation in malaria parasites. Notable scientific contributions include studies published in Nature Microbiology , mBio , EMBO Reports , and Life Science Alliance , focusing on m6A methylation, RUF6 ncRNA interactions, and cohesin-mediated gene repression. He has supervised or collaborated with several researchers including post-doctoral fellows, PhD students, and technicians within his team. His group is actively involved in uncovering the molecular mechanisms of parasite survival and immune evasion, with potential implications for antimalarial drug and vaccine development. The 'Parasite RNA Biology' group operates within the Institut Pasteur's ecosystem, leveraging interdisciplinary platforms for genomics, imaging, and functional analysis to advance understanding of malaria parasite biology.

Milena Hasanمشاهده پروفایل

پژوهشگر

• Single-cell transcriptomics
• Immunology
• Infectious disease research
• +۵ مورد دیگر

Milena Hasan is a Researcher at the Institut Pasteur in Paris, France, specializing in UTechS Single Cell Biomarkers unit. Her work focuses on cutting-edge single-cell transcriptomics , immune profiling , and cytometry data analysis across diverse conditions including viral infections, autoimmune diseases, and cancer immunotherapy. Lead investigator for multiple projects (TPAI, TTP, VARIANCE) involving single-cell technology training and advanced immune response analysis Key contributor to the Milieu Intérieur program studying immune system heterogeneity She actively develops tools for multi-omics data integration and leads courses on Single Cell Gene Expression and Beyond (2022, 2025) and Advanced Immunology (2025). Her research spans host-pathogen interactions , T cell dynamics , and inflammatory disease mechanisms through innovative technologies like spectral cytometry and single-cell proteomics.

Antoine Gessainمشاهده پروفایل

استاد پژوهشی

• Virology
• Epidemiology
• Retrovirology
• +۱۲ مورد دیگر

Antoine Gessain is a leading medical virologist and Head of Structure at the Oncogenic Virus Epidemiology and Pathophysiology (EPVO) unit at the Institut Pasteur in Paris. He received his MD and PhD from Parisian universities and has been instrumental in advancing research on retroviruses and oncogenic viruses since the unit's founding in 2001. He leads multiple research projects and collaborates with international institutions across Central Africa, French Guiana, and Peru. His research interests include: Virology and molecular epidemiology of HTLV-1, HHV-8, and simian foamy viruses Zoonotic transmission of retroviruses from primates to humans Genetic diversity and global dissemination of oncogenic viruses Pathogenesis of HTLV-1-associated diseases such as myositis and neuromyelopathy Immunological responses to retroviral infections His recent publications (2022–2025) reflect a strong focus on emerging viral threats, structural virology, and the molecular mechanisms of viral entry and immune neutralization. Notably, his team has contributed key insights into the structure of foamy virus envelope proteins, seroreactivity to ebolaviruses in Central Africa, and the epidemiology of HTLV-1 transmission in rural populations. Dr. Gessain has received no explicitly mentioned scientific awards in the provided text. However, his role as principal investigator on multiple funded projects and his extensive publication record underscore his scientific impact. He is actively involved in mentoring researchers and post-doctoral fellows, though specific PhD advisees are not listed. His work is supported by long-term collaborations with the Réseau International des Instituts Pasteur, CIRMF in Gabon, and Peruvian academic institutions. He also contributes to teaching at the Institut Pasteur, co-directing courses in systematic virology and infectious disease circulation. His research unit operates at the intersection of basic virology, public health, and clinical applications, with strong links to hospital departments and animal care facilities for translational research.

Etienne Kornobisمشاهده پروفایل

پژوهشگر

• Bioinformatics
• Evolutionary Biology
• Transcriptomics
• +۸ مورد دیگر

Etienne Kornobis is a bioinformatician and researcher at the Institut Pasteur , affiliated with the Bioinformatics and Biostatistics Hub . He obtained his PhD in Biology from the University of Reykjavik in 2011 and has held postdoctoral positions in Spain before joining the Institut Pasteur in 2016. He became a member of the Bioinformatics and Biostatistics Hub in 2018, where he continues his work on transcriptomics and bioinformatics methodology. His research interests include bioinformatics, evolutionary biology, transcriptomics, population genetics, RNA splicing, genome analysis, reproducible research, workflow development, long-read sequencing, alternative splicing, and microbial genomics . His work emphasizes computational methods for analyzing complex biological data, particularly in non-model organisms and microbial systems. The recent publications of Etienne Kornobis span a broad range of topics in genomics and molecular biology, with a strong trend toward transcriptomic analysis, host-pathogen interactions, microbial genomics, and methodological development in bioinformatics . His work frequently involves high-throughput sequencing, alternative splicing, and data reproducibility, reflecting his expertise in computational biology and systems-level analysis. Scientific Awards: No awards mentioned in the provided text. Etienne Kornobis is actively involved in research mentoring and collaborative projects. He leads the Bioconda project and contributes to Bioconvert , both critical tools for bioinformatics software distribution and data format conversion. He has also taught courses on reproducible data analysis and Software Carpentry , indicating a strong commitment to training and open science. There is no mention of formal student advising or grant leadership in the text provided. Labs and Teams: Bioinformatics and Biostatistics Hub (current) Revive Consortium (past) Epigenetic Regulation unit (past) Expertise group: SysBio – Systems Bioinformatics (past) Biomics – Dry-Lab (past)

Natalia Pietrosemoliمشاهده پروفایل

پژوهشگر

• Bioinformatics
• Biostatistics
• Genomics
• +۶ مورد دیگر

Natalia Pietrosemoli is a Senior Bioinformatician at the Center for Bioinformatics, Biostatistics and Integrative Biology (C3BI) at Institut Pasteur in Paris, where she has been working since November 2015. She specializes in functional and pathway analysis at the genomic level, with expertise in integrative analysis of different omics data both at large-scale and for small datasets. Her work focuses on decreasing the complexity of biological systems by grouping genes and proteins into the pathways they are involved in to increase comprehension of these systems. Her research interests span bioinformatics, biostatistics, genomics, transcriptomics, systems biology, functional genomics, pathway analysis, and omics data integration. She has developed several bioinformatics tools including g-RITA (Gene Set Enrichment Analysis visualization), Sherpa (Transcriptomic Analysis tool), and coGSEA (Comparative Gene Set Enrichment Analysis tool). Her recent publications (2023-2025) demonstrate expertise in viral pathogenesis (particularly Lassa virus and SARS-CoV-2), bacterial biofilms (Leptospira), immunology, and bioinformatics methodology development. She actively participates in teaching and training programs, including the Bioinformatics program for PhD students at Institut Pasteur and the PHINDaccess courses in Comparative Genomics and Functional OMICs. She has collaborated on numerous interdisciplinary research projects, often working with experimental colleagues to provide bioinformatics support and insights. PhD in Computational Biology from Rice University's School of Bioengineering Postdoctoral fellowship at the Swiss Institute of Bioinformatics' Bioinformatics Core Facility Visiting scholar positions at the National Centre for Biotechnology (CNB-CSIC) and Spanish National Cancer Centre Master's degree in Modeling and Simulation of Complex Realities from ICTP and SISSA Dr. Pietrosemoli leads the PHINDaccess twinning initiative with the Institut Pasteur de Tunis and serves as Principal Investigator for several software development projects including g-RITA, Sherpa, and coGSEA. Her work bridges computational analysis with experimental biology, providing critical insights into complex biological systems through sophisticated bioinformatics approaches.

• Immunology
• Translational Immunology
• Innate Immunity
• +۱۲ مورد دیگر

Darragh Duffy is a Researcher in the Department of Genomes and Genetics at the Institut Pasteur in Paris, where he leads the Translational Immunology group focused on the Milieu Intérieur project. His work centers on understanding interindividual differences in immune responses through population immunology, cellular models, and clinical studies. He is deeply involved in research on innate and adaptive immunity, cytokine signaling, and immune biomarkers in autoimmune and infectious diseases. The Milieu Intérieur project, which he coordinates, aims to define the range of immune variation in healthy populations and apply this knowledge to clinical immunology. His research integrates transcriptomics, systems immunology, and clinical data to uncover mechanisms of immune dysregulation in conditions such as dermatomyositis, systemic sclerosis, and HIV. He collaborates extensively with clinical and genetic research teams, including those led by Lluis Quintana-Murci. His recent publications (2022–2025) reveal a strong focus on interferon pathways, autoantibodies against cytokines, and the impact of aging, sex, and lifestyle on immune function. These studies employ advanced techniques such as single-molecule array (SIMOA) assays and single-cell RNA sequencing. The research has significant implications for biomarker discovery and personalized treatment strategies in autoimmune diseases. Darragh Duffy has mentored numerous PhD students, postdoctoral fellows, and research engineers, indicating an active and expanding research group. His leadership in the LabEx Milieu Intérieur underscores his role in large-scale collaborative science. There is no mention of awards in the provided text, but his publication record in high-impact journals such as Science Advances , The Lancet Neurology , and Journal of Experimental Medicine reflects significant scientific contributions. He has not been described as part-time, retired, or deceased, and remains an active principal investigator at the Institut Pasteur.

Florian Mullerمشاهده پروفایل

پژوهشگر

• Bioimage Analysis
• Single-RNA Imaging
• Spatial Transcriptomics
• +۷ مورد دیگر

Florian Muller is a Group Leader and Researcher at the Photonic BioImaging (UTechS PBI) , Pasteur Institute, Paris. His work integrates advanced microscopy, image analysis, and single-RNA imaging to study spatial transcriptomics and gene regulation. Institution: Pasteur Institute Department: Photonic BioImaging (UTechS PBI) Role: Group Leader (Principal Investigator) His research focuses on quantitative imaging , spatial transcriptomics , and bioimage analysis , with an emphasis on developing computational tools for cell segmentation and RNA localization. He leads projects such as Fish&Chips and autoFISH , and develops open-source software including RNA2seg and Comseg . The recent publications highlight a strong trend in machine learning for image analysis , spatial omics , and high-throughput RNA imaging , particularly using smFISH and point cloud methods. His work bridges biology, computer science, and microscopy. He mentors a team including a PhD student and post-doctoral researchers, contributing to training and collaborative science at the Pasteur Institute.

Hervé Le Hirمشاهده پروفایل

استاد

• Molecular Biology
• RNA Biology
• Post-transcriptional Gene Regulation
• +۴ مورد دیگر

Hervé Le Hir is a Professor at the Department of Biology of École Normale Supérieure (ENS), leading a research team focused on post-transcriptional regulation of gene expression, particularly the Exon Junction Complex (EJC). His work integrates biochemistry, biophysics, and transcriptomics to study EJC assembly, dynamics, and roles in mRNA transport, translation, and quality control. He has contributed to resolving the EJC core structure, identifying its role in NMD and translational activation, and mapping its genome-wide binding sites in human cells. Research Themes: RNA-protein interactions, molecular motors, mRNA metabolism, EJC function, NMD pathway. Key Methods: Protein reconstitution, single-molecule biophysics, CLIP-seq, high-throughput sequencing. Recent studies include exploring EJC-dependent mRNA localization in ciliogenesis and characterizing UPF1 helicase activities. His lab actively recruits researchers and can be contacted directly for collaboration.