Darragh Duffy

Darragh Duffy is a Researcher in the Department of Genomes and Genetics at the Institut Pasteur in Paris, where he leads the Translational Immunology group focused on the Milieu Intérieur project. His work centers on understanding interindividual differences in immune responses through population immunology, cellular models, and clinical studies. He is deeply involved in research on innate and adaptive immunity, cytokine signaling, and immune biomarkers in autoimmune and infectious diseases.

The Milieu Intérieur project, which he coordinates, aims to define the range of immune variation in healthy populations and apply this knowledge to clinical immunology. His research integrates transcriptomics, systems immunology, and clinical data to uncover mechanisms of immune dysregulation in conditions such as dermatomyositis, systemic sclerosis, and HIV. He collaborates extensively with clinical and genetic research teams, including those led by Lluis Quintana-Murci.

His recent publications (2022–2025) reveal a strong focus on interferon pathways, autoantibodies against cytokines, and the impact of aging, sex, and lifestyle on immune function. These studies employ advanced techniques such as single-molecule array (SIMOA) assays and single-cell RNA sequencing. The research has significant implications for biomarker discovery and personalized treatment strategies in autoimmune diseases.

Darragh Duffy has mentored numerous PhD students, postdoctoral fellows, and research engineers, indicating an active and expanding research group. His leadership in the LabEx Milieu Intérieur underscores his role in large-scale collaborative science. There is no mention of awards in the provided text, but his publication record in high-impact journals such as Science Advances, The Lancet Neurology, and Journal of Experimental Medicine reflects significant scientific contributions.

He has not been described as part-time, retired, or deceased, and remains an active principal investigator at the Institut Pasteur.