SUMO2 Professors and Supervisors

Taejoon Wonمشاهده پروفایل

استادیار

University of Illinois Urbana-ChampaignUnited States

Taejoon Won is an Assistant Professor in the Department of Pathobiology at the University of Illinois. His research focuses on immune mechanisms underlying myocarditis, autoimmunity, and the role of programmed death ligand 1 (PD-L1) in inflammatory diseases. He investigates how immune checkpoint inhibitors contribute to cardiovascular adverse events and explores protective roles of specific macrophage subsets in arthritis and myocardial injury. Key research themes include T cell immunology, macrophage biology, and the interplay between cytokines and tissue-resident memory T cells. His work integrates lipidomics, single-cell analysis, and mouse models to study health-disease transitions in innate lymphoid cells and cardiovascular pathologies. Recent articles highlight discoveries such as myocarditis driven by myosin-specific T cells, protective roles of GATA6+ macrophages in pericarditis, and mechanisms of immune checkpoint inhibitor toxicity. Collaborations span cardiology, rheumatology, and immunology, with studies published in Circulation Research , Proceedings of the National Academy of Sciences , and Arthritis and Rheumatology .

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Niels Mailandمشاهده پروفایل

استاد

University of CopenhagenDenmark

Niels Mailand is a Professor and Group Leader at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, specializing in ubiquitin and ubiquitin-like modifier signaling in genome stability. His work bridges cell biology, biochemistry, and proteomics to unravel mechanisms behind DNA damage responses and replication stress. Key Positions: 2009–Present: Professor and Group Leader at University of Copenhagen; 2005–2009: Senior Scientist at Danish Cancer Society; 2004–2005: Postdoctoral Fellow at Cancer Research UK Education: PhD (2003, University of Copenhagen); MSc in Biochemistry (1999, University of Copenhagen) Mailand's research focuses on post-translational modifications, particularly ubiquitin and SUMO pathways, to safeguard genome integrity in human cells. His group's work has identified novel proteins involved in DNA repair and elucidated the role of ubiquitin chain types in cellular responses. Recent publications highlight his exploration of understudied ubiquitin chains (K29, K27), ubiquitin-SUMO crosstalk in DNA repair, and stress response pathways. His 2025 Molecular Cell study on CRAMP1 demonstrates histone H1 biogenesis in topoisomerase II tolerance, while 2024 works probe SUMO-targeted ubiquitin ligases and epigenome regulation via SUV39H1. Scientific Awards: Silver Medal, Royal Danish Academy of Sciences and Letters (2013) EMBO Young Investigator (2013) Hardiman-Redon Prize (2005) Young Elite Researcher Award (2008) Collaborations: Extensive international partnerships in proteomics, DNA repair, and ubiquitin signaling.

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Zac Sandyمشاهده پروفایل

پژوهشگر

The University of ManchesterUnited Kingdom

Zac Sandy is an academic researcher affiliated with the Manchester Cancer Research Centre, focusing on molecular mechanisms of DNA damage, cancer biology, and post-translational modifications. His work contributes to UN Sustainable Development Goals related to health and well-being. Education: BSc Biomedical Science (University of Liverpool, 2018), MRes Cancer Sciences (University of Birmingham, 2019) Research interests include interferon-stimulated genes, ubiquitin pathways, and their roles in DNA repair processes. His recent articles highlight advancements in protein interaction analysis via photo-crosslinking and microarray techniques, with implications for understanding cancer biology and genome stability. He has collaborated with institutions globally, contributing to peer-reviewed publications in journals like PLoS ONE and Biomolecules. No formal teaching role or student advisement is explicitly documented in the provided texts.

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Alex Garvinمشاهده پروفایل

مدرس

University of LeedsUnited Kingdom

Dr. Alex Garvin is a Lecturer in Cancer Biology at the School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds. His research is centered on the role of SUMOylation and deSUMOylating enzymes (SENPs) in DNA repair, genome stability, and cancer pathogenesis, particularly in Lung Squamous Cell Carcinoma (LUSC). His research interests include: SUMOylation and Ubiquitylation signaling DNA repair mechanisms Genome stability and chromatin dynamics Role of SENP enzymes in cancer Function of atypical SUMO family members (e.g., pseudoSUMO) Dr. Garvin's recent publications highlight a strong focus on the regulatory roles of SENP6, SENP7, and SENP2 in DNA damage response and cancer, with a notable 2025 paper identifying SUMO4 as a novel regulator of SENP1. His work bridges molecular mechanisms with therapeutic applications in oncology. Scientific awards include: Academy of Medical Sciences Springboard Award He leads the Garvin SUMO Biology Lab, which actively investigates the therapeutic potential of targeting SUMOylation in cancer. His lab collaborates with structural and cancer biologists and is funded by competitive national grants. He has advised or collaborated with researchers such as Rosie Wilkins and works alongside Elton Zeqiraj. His lab is involved in broader research networks, including the Astbury Biostructure Laboratory and Genome Damage and Stability research communities.

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Maxime Rousseauxمشاهده پروفایل

استادیار

University of OttawaCanada

Maxime W Rousseaux is an Assistant Professor in the Department of Cellular and Molecular Medicine at the Faculty of Medicine, University of Ottawa. His research focuses on neurodegenerative diseases, particularly Parkinson’s disease and ALS, with an emphasis on protein mislocalization, regional vulnerability in the brain, and translating genetic variance into therapeutic strategies. Position: Assistant Professor Institution: University of Ottawa Department: Cellular and Molecular Medicine School: Faculty of Medicine Rousseaux's laboratory investigates: Mechanisms of protein mislocalization (alpha-Synuclein, TDP-43) in neurodegeneration Regional vulnerability differences in neurodegenerative diseases using epitope-tagged knockin mice Functional validation of genetic variants through cellular models to inform drug development His work employs cutting-edge techniques like immunoprecipitation, mass-spectrometry, and CRISPR screens to discover pharmacologically tractable targets. Recent publications highlight trends in CRISPR-based discovery , SUMOylation dynamics , and cell-type-specific protein pathology . Key subfields include autophagy, neurotoxicity, and brain region-specific interactomes. Lab affiliations and collaborations focus on neurogenetics and neurodegenerative disease modeling , leveraging mouse models and molecular tools to dissect disease mechanisms.

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Joe Cassarمشاهده پروفایل

پژوهشگر ارشد

University of BirminghamUnited Kingdom

Joe Cassar is a Research Fellow in Integrative Structural Biology at the University of Birmingham , affiliated with the Cancer and Genomic Sciences department. His work focuses on molecular mechanisms underlying DNA repair and cancer resistance, particularly involving chromatin dynamics and ubiquitin signaling pathways. Cancer and Genomic Sciences Research Interests: Integrative Structural Biology Genomics Molecular Biology DNA Repair Protein Interactions Ubiquitin Signaling Recent Research Output: In 2025, he contributed to a groundbreaking article in Nature Communications analyzing how the PIN1-SUMO2/3 motif modulates RNF168 chromatin accumulation to promote ionizing radiation resistance. This work intersects structural biology, molecular oncology, and post-translational modification studies. Collaborations: Active in international networks, his research involves collaborations with experts in chromatin biology and ubiquitin signaling, with dataset contributions from University of Birmingham researchers.

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