Maxime Rousseaux

Maxime W Rousseaux is an Assistant Professor in the Department of Cellular and Molecular Medicine at the Faculty of Medicine, University of Ottawa. His research focuses on neurodegenerative diseases, particularly Parkinson’s disease and ALS, with an emphasis on protein mislocalization, regional vulnerability in the brain, and translating genetic variance into therapeutic strategies.

• Position: Assistant Professor
• Institution: University of Ottawa
• Department: Cellular and Molecular Medicine
• School: Faculty of Medicine

Rousseaux's laboratory investigates:

• Mechanisms of protein mislocalization (alpha-Synuclein, TDP-43) in neurodegeneration
• Regional vulnerability differences in neurodegenerative diseases using epitope-tagged knockin mice
• Functional validation of genetic variants through cellular models to inform drug development

His work employs cutting-edge techniques like immunoprecipitation, mass-spectrometry, and CRISPR screens to discover pharmacologically tractable targets.

Recent publications highlight trends in CRISPR-based discovery, SUMOylation dynamics, and cell-type-specific protein pathology. Key subfields include autophagy, neurotoxicity, and brain region-specific interactomes.

Lab affiliations and collaborations focus on neurogenetics and neurodegenerative disease modeling, leveraging mouse models and molecular tools to dissect disease mechanisms.