جست‌وجوی استاد و پژوهشگر

Pierre Chymkowitchمشاهده پروفایل

دانشیار

• Transcription
• Chromatin
• Cellular Differentiation
• +۵ مورد دیگر

Pierre Chymkowitch is an Associate Professor at the University of Oslo , affiliated with the Section for Biochemistry and Molecular Biology . His research focuses on the transcriptional and epigenetic regulation of cell fate and the dynamics of SUMOylation in chromatin remodeling during adipocyte differentiation . He employs advanced techniques such as ChIP-seq, RNA-seq, and confocal microscopy to study human and murine adipose stem cells, linking these mechanisms to obesity-related diseases like diabetes and cancer. Academic Rank: Associate Professor Institution: University of Oslo Section: Biochemistry and Molecular Biology Email: pierre.chymkowitch@ibv.uio.no Research Interests Transcriptional regulation in cellular differentiation SUMOylation-mediated chromatin dynamics Adipose tissue biology and obesity-related diseases Cell cycle and transcriptional homeostasis Epigenetic mechanisms in carcinogenesis Publication Trends Chymkowitch's recent work (2025) explores SUMOylation inhibition as a therapeutic target for metabolic disorders via TAK-981. Earlier studies (2023-2011) span mitotic chromatin resetting , Cdk1 regulation of transcription , and sumoylation in ribosomal gene expression , with a strong emphasis on interdisciplinary approaches bridging molecular biology and clinical applications. Laboratory & Team He leads the Chymkowitch group at the University of Oslo, collaborating on high-throughput genomic methods and classical biochemistry to unravel SUMOylation networks in developmental and disease contexts.

Helen Murphyمشاهده پروفایل

دانشیار

• Evolutionary biology
• Genetics
• Microbial ecology
• +۳ مورد دیگر

Helen Murphy is the Class of 1953 Distinguished Associate Professor of Biology at the College of William and Mary. Her research focuses on evolutionary biology, genetics, and microbial ecology, with a particular emphasis on yeast species and their evolutionary mechanisms. She joined the university in 2014 after serving as a Research Associate at Duke University (2013–2014), Visiting Assistant Professor at William & Mary (2010–2012), and Research Associate at Wake Forest University (2006–2010). Dr. Murphy holds a B.S. in Biology Sciences and Environmental Sciences from SUNY Buffalo (1999) and a Ph.D. in Biology from the University of Pennsylvania (2006). Her work explores topics such as prezygotic isolation in yeast species, mutator alleles in clinical strains, and the role of sexual selection in microbial evolution. She has published extensively in high-impact journals, with notable contributions to understanding biofilm formation, quorum-sensing mechanisms, and microbial competition. Her scientific achievements include the prestigious Class of 1953 Distinguished Professor title. While no grant details or lab affiliations are explicitly mentioned, her research spans experimental evolution, population genetics, and microbial ecology, reflecting a commitment to advancing evolutionary theory through empirical studies.

Ronald Thomas Hayمشاهده پروفایل

استاد

• Ubiquitin proteasome system
• SUMO modification
• Ubiquitin E3 ligases
• +۳ مورد دیگر

Ronald Thomas Hay is a Professor of Molecular Biology at the University of Dundee, College of Life Sciences, Division of Gene Regulation and Expression, since 2005. Previously, he held academic positions at the University of St Andrews (1985–2005), including Professor of Molecular Biology (1994–2005), Reader (1991–1994), and Lecturer (1985–1991). B.Sc. in Biochemistry, Heriot-Watt University (1975) Ph.D. in Virology, University of Glasgow (1979) His research focuses on the ubiquitin proteasome system , SUMO modification , and their roles in transcriptional regulation , DNA damage response , and quantitative proteomics . He pioneered SUMO modification as a key regulatory mechanism in eukaryotes. Recent work highlights trends in SUMO-ubiquitin crosstalk , poly-SUMO conjugates , and stress response proteomics . His lab investigates enzymes like RNF4 and SENP7 to elucidate mechanisms of protein degradation and post-translational regulation. Fellow of the Royal Society Novartis Medal and Prize (2012) Over 14,000 citations; h-index 62 Hay has trained 17 PhD students and over 40 postdoctoral fellows. He receives funding from organizations including CR-UK , MRC , and Wellcome Trust for studies on SUMO-specific ubiquitin ligases and proteases. He is also an honorary member of the Scottish Institute for Cell Signaling (SCILLS) .

• Ribosome biogenesis
• Molecular Biology
• Genetics
• +۵ مورد دیگر

Dr. Dieter Kressler is a Senior Researcher at the Department of Biology , Faculty of Science and Medicine , University of Fribourg. Holding a PhD and serving as head of the proteomics platform , his work focuses on the molecular mechanisms of eukaryotic ribosome biogenesis. Email: dieter.kressler@unifr.ch ORCID: 0000-0003-4855-3563 Contact: +41 26 300 8645 Location: PER 05 building, Fribourg Research Interests include: Dedicated chaperones for ribosomal proteins Co-translational regulation of ribosomal protein expression Ubiquitin signaling in ribosome assembly RNA helicase roles in pre-ribosomal particles Structural dynamics of ribosome maturation Stress response coupling to translational control His 15 most recent publications (2025-2016) reveal a consistent focus on ribosome biogenesis, with key articles in eLife , Nature Communications , and Nucleic Acids Research . Research spans from thermal avoidance circuits in C. elegans to ubiquitin fusion mechanisms in yeast ribosomes , integrating structural biology, genetics, and biochemical approaches.

Tabithia Rossمشاهده پروفایل

مدرس

• Microbiology
• Virology
• Biomedical Science

Tabithia Ross is a Visiting Instructor in Biology at the University of West Florida, recognized with the 2024 Adjunct Teaching Excellence Award. She holds an M.S. in Biomedical Science from Mercer University and M.Ed. in Higher Education Administration from Georgia Southern University. Ross teaches microbiology lecture and lab courses, emphasizing practical skill development and student mentorship. Her research background includes viral oncology, focusing on Epstein-Barr virus mechanisms and sumoylation pathways. Award: Adjunct Teaching Excellence Award (UWF, 2024)

Christian Bassiمشاهده پروفایل

مدرس

• Cancer Biology
• DNA Damage Response
• PTEN Signaling
• +۷ مورد دیگر

Dr. Christian Bassi is a Lecturer in Cancer Biology and Group Leader at the University of Leeds, Faculty of Biological Sciences. He holds a PhD from the University of Toronto and has conducted postdoctoral research at the Campbell Family Institute for Breast Cancer Research and the Institute of Cancer Research, London. His research focuses on synthetic lethality and SUMOylation in cancer and neuronal differentiation. Research Interests: His work centers on uncovering novel synthetic lethality interactions through CRISPR-based screening of the SUMO pathway, with therapeutic implications in cancer. He also investigates SUMO dynamics on chromatin during neuronal differentiation using advanced CUT&RUN technology. These interdisciplinary approaches bridge molecular oncology, epigenetics, and cell signaling. Publication Trends: His recent research publications reflect a strong focus on tumor suppressor regulation, particularly PTEN, and its role in DNA damage response and cancer progression. The methodologies involve molecular genetics, cell-based assays, and high-throughput screening, indicating a translational research orientation with implications for targeted therapies. Scientific Awards: Cancer Research Institute Irvington Postdoctoral Fellowship Program Advising and Grants: As a Group Leader, Dr. Bassi supervises research in his laboratory and leads independent projects. He is currently funded by the BBSRC IPA Tranche 2 (2024) for a project titled "Investigating the Role of SUMOylation in Neural Differentiation using CUT&RUN." This supports his innovative work at the intersection of chromatin biology and cellular differentiation. Labs and Teams: Dr. Bassi leads his own research group at the University of Leeds, focusing on cancer biology and synthetic lethality. He previously contributed to research teams at the Campbell Family Institute and the Institute of Cancer Research, and has industry experience in assay development within a global pharmaceutical CDMO.

Ben Montpetitمشاهده پروفایل

استادیار مدعو

• Molecular Biology
• Cell Biology
• RNA Biology
• +۳ مورد دیگر

Ben Montpetit is an Adjunct Assistant Professor in the Department of Viticulture & Enology at the University of California at Davis, College of Agricultural and Environmental Sciences. His research focuses on the molecular mechanisms of mRNA export through nuclear pore complexes (NPCs) and its implications in cellular stress responses and human diseases. Ph.D., University of British Columbia Research Interests Montpetit’s work investigates how NPCs regulate mRNA export at cellular, molecular, and atomic levels. His lab employs cell biology , biochemistry , structural biology , and single-molecule imaging in Saccharomyces cerevisiae to elucidate transport mechanisms. Future directions include expanding studies to mammalian systems to link mRNA export defects to diseases like cancer and neurodegenerative disorders. Publication Trends Montpetit's articles span RNA biology , nuclear transport , and protein-RNA interactions , with a focus on DEAD-box ATPases, nucleoporins, and stress-regulated export pathways. His work bridges basic cell biology and clinical relevance , particularly in disease mechanisms. Lab Members The Montpetit Lab collaborates with a multidisciplinary team of undergraduates, graduate students, postdocs, and staff, leveraging yeast and mammalian models to advance mechanistic understanding of RNA transport and processing. Contact Email: benmontpetit@ucdavis.edu Office: Department of Viticulture & Enology, UC Davis Phone: 530-752-9355

• DNA Repair
• Ubiquitin Signaling
• SUMO Modification
• +۴ مورد دیگر

Helle D Ulrich serves as Scientific Director of the Institute of Molecular Biology (IMB) and Professor of Biology at Johannes Gutenberg University Mainz, where she leads groundbreaking research in DNA repair mechanisms and genome stability. Her research program focuses on the molecular intricacies of post-translational modifications, particularly the roles of ubiquitin and SUMO in DNA damage response. Dr. Ulrich's work has established fundamental principles regarding: How PCNA modification regulates DNA damage tolerance pathways The crosstalk between different protein modification systems in genome maintenance Mechanisms of ubiquitin-dependent DNA damage bypass Regulation of mutagenesis through post-translational control Analysis of her publication history reveals an evolving research trajectory from characterizing individual components of DNA repair machinery to understanding integrated signaling networks. Her most recent work demonstrates continued innovation in molecular tools and approaches to study protein degradation systems, while maintaining her core focus on genome integrity mechanisms. The consistency and impact of her research across two decades highlight her position as a thought leader in molecular biology. As Scientific Director of IMB, Dr. Ulrich oversees one of Europe's premier molecular biology research institutions, fostering collaborative science and mentoring the next generation of researchers. Her laboratory maintains active collaborations with international research groups and continues to receive competitive funding for innovative projects at the intersection of DNA repair, protein modification, and cellular signaling pathways.

Niels Mailandمشاهده پروفایل

استاد

• Genome Stability
• Ubiquitin Signaling
• DNA Damage Response
• +۴ مورد دیگر

Niels Mailand is a Professor and Group Leader at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, specializing in ubiquitin and ubiquitin-like modifier signaling in genome stability. His work bridges cell biology, biochemistry, and proteomics to unravel mechanisms behind DNA damage responses and replication stress. Key Positions: 2009–Present: Professor and Group Leader at University of Copenhagen; 2005–2009: Senior Scientist at Danish Cancer Society; 2004–2005: Postdoctoral Fellow at Cancer Research UK Education: PhD (2003, University of Copenhagen); MSc in Biochemistry (1999, University of Copenhagen) Mailand's research focuses on post-translational modifications, particularly ubiquitin and SUMO pathways, to safeguard genome integrity in human cells. His group's work has identified novel proteins involved in DNA repair and elucidated the role of ubiquitin chain types in cellular responses. Recent publications highlight his exploration of understudied ubiquitin chains (K29, K27), ubiquitin-SUMO crosstalk in DNA repair, and stress response pathways. His 2025 Molecular Cell study on CRAMP1 demonstrates histone H1 biogenesis in topoisomerase II tolerance, while 2024 works probe SUMO-targeted ubiquitin ligases and epigenome regulation via SUV39H1. Scientific Awards: Silver Medal, Royal Danish Academy of Sciences and Letters (2013) EMBO Young Investigator (2013) Hardiman-Redon Prize (2005) Young Elite Researcher Award (2008) Collaborations: Extensive international partnerships in proteomics, DNA repair, and ubiquitin signaling.

Hay Ronald Thomasمشاهده پروفایل

استاد

• Ubiquitin proteasome system
• SUMO modification
• Ubiquitin E3 ligases
• +۳ مورد دیگر

Ronald Thomas Hay is a Professor of Molecular Biology at the University of Dundee's College of Life Sciences, Division of Gene Regulation and Expression. Previously, he held professorial roles at the University of St Andrews (1994–2005) and was a Reader and Lecturer there from 1985 onward. He completed his B.Sc. (1st Class Honours in Biochemistry) at Heriot-Watt University and his Ph.D. at the University of Glasgow's Institute of Virology. His research focuses on the ubiquitin and SUMO systems, including their roles in DNA replication, stress responses, and protein dynamics. Key honors include the Novartis Medal (2012), the Danny Thomas Lecture (2008), and fellowships in the Royal Society, Royal Society of Edinburgh, and Academy of Medical Sciences. He has led major grants, including projects on SUMO modification and oncology, funded by GSK, Cancer Research UK, MRC, and EU initiatives. Over 40 postdoctoral researchers and 17 Ph.D. students have been trained under his supervision. He has held administrative roles such as Head of the Division of Cell and Molecular Biology at St Andrews and contributed to national and international research committees, including the Cancer Research UK Programmes Committee and the Biomedical and Therapeutic Research Committee of the Scottish Executive.

Margarita Vigodnerمشاهده پروفایل

استاد

• Cell Biology
• Reproductive Biology
• Cancer Research
• +۱ مورد دیگر

Dr. Margarita Vigodner is a Professor of Biology at Stern College for Women, Yeshiva University, where she directs a research laboratory focused on germ cell biology and molecular mechanisms in reproduction. Her research investigates spermatogenesis, SUMO protein functions, and testicular stress responses, with significant implications for understanding male fertility and testicular cancer. Her research interests include the role of post-translational modifications in germ cell development, molecular responses to environmental toxins like tobacco smoke, and the characterization of SUMOylation pathways in testicular function. She employs advanced techniques including confocal microscopy, flow cytometry, and molecular biology approaches. Dr. Vigodner's publications center on SUMO protein dynamics in reproductive biology, tobacco smoke effects on sperm function, and molecular diagnostics for male infertility. Her work demonstrates consistent themes of cellular stress responses, DNA damage repair mechanisms, and epigenetic regulation in germ cells. She has received substantial research funding including NIH and FAMRI grants. Her laboratory trains numerous undergraduate students and postdoctoral fellows in cellular and molecular biology techniques, contributing significantly to STEM education. Her team includes technicians and research associates who support ongoing projects in testicular cancer research and reproductive toxicology.

• Cell Biology
• Molecular Biology
• Developmental Biology
• +۳ مورد دیگر

Yicktung Ip is a Professor at the T.H. Chan School of Medicine , specializing in Program in Molecular Medicine at UMass Chan Medical School. His research bridges Drosophila melanogaster and human physiology to investigate intestinal stem cell repair mechanisms after tissue damage. Education: BS in Pharmacy from National Defense University, Taipei (1984); PhD in Biochemistry from University of Iowa (1989) Postdoctoral training: University of California, San Diego (1991-1994) His work focuses on intestinal stem cell biology , exploring how these cells respond to injury through insulin signaling and genetic pathways. By studying the simple cellular organization of Drosophila midgut , he identifies genes critical for stem cell division and tissue repair, offering insights into human conditions like inflammatory bowel disease and GI cancers. Key publication trends include genetic screens , signaling pathways , and immune response mechanisms . His studies on Toll receptors , Hippo pathway , and YAP/TAZ highlight cross-species regulatory networks. Scientific Awards : Hoffmann-LaRoche Fellow (1991-1994) Leukemia Society of America Scholar Award (1996-2001) Ip's lab offers rotation projects and postdoctoral positions to investigate genetic regulators of stem cell division and RNAi-based screens . His interdisciplinary collaborations span biochemistry , molecular biology , and cellular imaging .

Zhihao Zhuangمشاهده پروفایل

استاد

• Protein Post-Translational Modification (PTM)
• Ubiquitin Biology
• Chemical Biology
• +۴ مورد دیگر

Zhihao Zhuang is a full-time Professor in the Department of Chemistry and Biochemistry at the University of Delaware (College of Arts & Sciences). His work bridges chemistry and biology , focusing on protein post-translational modification via ubiquitin (Ub) and ubiquitin-like proteins (ISG15, SUMO) in processes such as protein degradation , DNA damage tolerance , and mitophagy . He develops chemical approaches for protein ubiquitination , activity-based Ub probes , and PROTAC strategies for targeted protein degradation in neurological disorders (e.g., Parkinson’s disease) and cancer . Education : B.S. (1997) Sichuan University; Ph.D. (2003) University of New Mexico; Postdoctoral Fellow (2003–2007) Pennsylvania State University Research interests center on elucidating the function, structure, and catalysis of proteins involved in ubiquitination/deubiquitination, deISGylation, and protein homeostasis. His lab employs biochemical, synthetic, biophysical , and molecular/cell biology techniques at the molecular level. Publications highlight innovations in ubiquitin probe design , DUB inhibitor development , and structural analysis of ubiquitin-related enzymes . Recent work includes photocaged probes for temporal enzyme profiling (2020), triubiquitin probes for branched chain analysis (2023), and AlphaLISA DUB assay platforms (2017).

• Proteomics
• SUMO Biology
• Chromatin Dynamics
• +۵ مورد دیگر

Ivo Alexander Hendriks serves as an Associate Professor at the Novo Nordisk Foundation Center for Protein Research (CPR), part of the University of Copenhagen. He is affiliated with the Nielsen Group and maintains an active research profile with numerous recent publications in high-impact journals including Nature, Molecular Cell, and Nature Structural and Molecular Biology. Dr. Hendriks' research primarily focuses on protein post-translational modifications and their roles in cellular regulation. His work spans several interconnected areas including SUMO biology, chromatin dynamics, DNA repair mechanisms, and advanced mass spectrometry techniques. His laboratory investigates how protein modifications such as SUMOylation and citrullination regulate fundamental cellular processes, with implications for understanding cancer biology, autoimmune diseases, and genome maintenance. Analysis of Dr. Hendriks' recent publication record reveals a strong emphasis on developing and applying cutting-edge proteomics methodologies to map protein modifications with site-specific resolution. His work demonstrates how these modifications regulate DNA repair pathways, chromatin organization, and cellular responses to genotoxic stress, contributing significantly to our understanding of molecular mechanisms underlying genome stability. As an Associate Professor, Dr. Hendriks participates in academic mentoring and likely supervises graduate students and postdoctoral researchers. His extensive collaborative network, evident from his multi-author publications with international researchers, suggests active engagement in the global scientific community. Dr. Hendriks operates within the Nielsen Group at the Novo Nordisk Foundation Center for Protein Research, a world-class facility equipped with state-of-the-art mass spectrometry and molecular biology technologies. His laboratory environment fosters interdisciplinary research that bridges biochemistry, molecular biology, and proteomics to address fundamental questions in cellular regulation.

• Cellular stress responses
• Functional genomics
• Cell signaling
• +۵ مورد دیگر

Peter Thorlund Haahr is an Associate Professor in the Department of Cellular and Molecular Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences. His research program focuses on Transcription, RNA, and Gene Medicine, investigating fundamental cellular processes with implications for human disease. Dr. Haahr's primary research focuses on the molecular mechanisms of cellular stress responses and functional genomics. His laboratory aims to identify and characterize new genes that play important roles in human disease by studying basic mechanisms of cellular stress responses and gene expression. The lab employs a combination of unbiased proteome- and genome-wide screens as well as targeted molecular and cell biological approaches to understand how cellular stress responses function as dynamic signaling networks controlling adaptation mechanisms against environmental challenges. His recent publications demonstrate a strong focus on cellular stress response mechanisms, particularly how these responses interact with transcriptional and translational machinery. His work spans diverse areas including DNA damage response, protein synthesis regulation during stress, and the role of specific enzymes in cellular fitness. The research has significant implications for understanding and treating cancer and age-related neurodegenerative disorders. Dr. Haahr's laboratory combines targeted cell biology, biochemistry, and synthetic biology approaches with cutting-edge systems-wide screening strategies to elucidate cellular processes in human cells. Current research specifically investigates mechanisms of translation regulation during stress, SUMO-targeted ubiquitination in proteostatic stress responses, and genetic compensation by adaptive gene expression.