جستجوی استاد راهنمای دانشگاهی

Manu Sharmaمشاهده پروفایل

دانشیار

• Neuroscience
• Neurodegenerative Diseases
• Synaptic Transmission
• +۵ مورد دیگر

Manu Sharma is an Associate Professor of Neuroscience at the Brain and Mind Research Institute , Weill Cornell Medical College (2024–present). His research focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly tauopathies and synucleinopathies (e.g., Alzheimer’s and Parkinson’s diseases), synaptic transmission, and protein aggregation. Education: Ph.D., University of Toronto (2005) B.Sc., University of Toronto (1998) Research Interests: Dr. Sharma investigates how physiological and pathological modifications of tau and α-synuclein proteins contribute to neurodegeneration. His work explores synaptic vesicle dynamics, chaperone-mediated protein stabilization, and the role of lysosomal pathways in disease progression. Grants: He has secured major funding as Principal Investigator and Co-Investigator from the National Institute on Aging and National Institute of Neurological Disorders & Stroke (2024–2029) for studies on tau proteostasis, synucleinopathies, and small molecule inhibitors targeting neurodegenerative pathways. Labs & Teams: Affiliated with the Brain and Mind Research Institute, Dr. Sharma collaborates on multidisciplinary projects involving synaptic biology, protein quality control, and neurodegeneration models.

• Synaptic Plasticity
• Long-Term Potentiation (LTP)
• Neuroscience
• +۳ مورد دیگر

Thomas J. O’Dell is a Professor of Physiology and Associate Director of the Brain Research Institute at the University of California, Los Angeles (UCLA). His research focuses on synaptic plasticity mechanisms, particularly long-term potentiation (LTP) and depression (LTD), in the hippocampus. He investigates β-adrenergic signaling, NMDA receptor dynamics, and astrocyte calcium signaling in learning and memory processes. O’Dell’s work bridges molecular neurobiology with behavioral neuroscience, emphasizing how synaptic changes underlie cognitive functions. Research Interests: Neuronal plasticity mechanisms in hippocampal circuits Role of NMDA receptors in synaptic function and disease β-Adrenergic modulation of LTP Calcium signaling in astrocytes and its impact on synaptic transmission Grants & Funding: NIH R21MH115404 (Mechanisms of homeostatic plasticity) NIH R01NS060677 (Astrocyte calcium signaling in striatum) NIH R01MH060919 (NMDA receptor signaling in LTP) Labs/Teams: O’Dell leads a lab at the UCLA Brain Research Institute, collaborating on projects involving synaptic physiology, proteomics, and behavioral neuroscience.

• Immunology
• Lipid Metabolism
• Infectious Diseases
• +۳ مورد دیگر

Dijin Xu is an Associate Research Scientist in the Department of Microbial Pathogenesis at Yale School of Medicine, Yale University. His research focuses on lipid metabolism, immunology, and molecular mechanisms underlying metabolic disorders and host-pathogen interactions. He holds a PhD from Tsinghua University (2016). Education: PhD in Microbiology, Tsinghua University, 2016 Research Interests: Dr. Xu’s work spans immunology (e.g., B cell biology and somatic hypermutation), lipid metabolism (lipid droplet dynamics and adipose tissue homeostasis), and virology (antiviral defense mechanisms against SARS-CoV-2). His studies integrate cellular biology, molecular genetics, and biochemical approaches to understand disease processes. Publications Overview: His recent work explores mechanisms of lipid droplet regulation, metabolic disorder prevention, and immune system function. Notable contributions include studies on Rab GTPases in lipid storage and ELOF1’s role in antibody diversification. Labs & Affiliations: He is affiliated with the West Campus Integrative Science & Technology Center at Yale University, focusing on interdisciplinary research in cellular and molecular biology.

David S. Cafisoمشاهده پروفایل

استاد

• Biochemistry
• Biophysics
• Biophysics & Structural Biology
• +۳ مورد دیگر

David S. Cafiso is a Professor in the Department of Molecular Physiology and Biological Physics at the University of Virginia. His research focuses on the molecular mechanisms of membrane transport and cell signaling, utilizing advanced techniques such as EPR spectroscopy, high-resolution NMR, and solid-state NMR. He has made significant contributions to understanding membrane protein structure and function, particularly in relation to synaptic vesicle exocytosis and bacterial nutrient transport. Education: AB, PhD in Biophysics from the University of California, Berkeley; Postdoctoral training at UC Berkeley and Stanford University His research interests span Biochemistry, Biophysics, Structural Biology, Neuroscience, and Microbiology. Recent work highlights conformational dynamics in membrane proteins, lipid-protein interactions, and the role of electrostatics in signaling. Publications emphasize PIP2 regulation, C2 domain function, and TonB-dependent transport systems, with applications in both bacterial physiology and neurosecretion. Professor Cafiso's laboratory investigates two primary areas: (1) Membrane protein attachment mechanisms critical for cell signaling, and (2) Solute transport across lipid bilayers in gram-negative bacteria. His studies often integrate biochemical, structural, and biophysical approaches to probe dynamic processes in membrane biology.

• Autophagy
• Cell Biology
• Membrane Biology
• +۳ مورد دیگر

Thomas Melia is a Professor of Cell Biology at the Yale School of Medicine, part of Yale University. He leads the Melia Lab, focusing on autophagosome biogenesis and membrane dynamics during autophagy. His research integrates cell-based assays with advanced imaging techniques like electron cryo-microscopy. Key areas include understanding membrane sources for autophagosomes, lipid transport mechanisms, and organelle formation under cellular stress. Education: PhD in Biochemistry from Baylor College of Medicine (1999), BS in Biological Sciences from Carnegie Mellon University (1992) Research Interests: Autophagy, lysosomal biology, membrane trafficking, and protein aggregate clearance Lab Affiliations: Collaborates with departments like Biochemistry, Quantitative Biology, and Molecular Cell Biology Melia's work bridges molecular mechanisms with cellular function, particularly in how cells respond to starvation or pathogen invasion by degrading cytosolic components. Recent studies highlight roles for dynamin-like proteins in nuclear autophagy and lipid transfer proteins in organelle biogenesis.

• Neurodegenerative Diseases
• Alzheimer's Disease
• Tau Protein Biology
• +۳ مورد دیگر

Dr. Charles Harrington is a Senior Research Fellow at the University of Aberdeen's School of Medicine, Medical Sciences and Nutrition. With a background in microbiology, he has transitioned to become a leading researcher in neurodegenerative diseases, particularly focusing on Alzheimer's disease and tau protein biology. His career spans over four decades, with significant contributions to understanding the molecular mechanisms of protein aggregation in neurodegenerative conditions. BSc (Hons) Microbiology, University of Glasgow (1977) PhD Microbiology, University of Glasgow (1980) Harrington's research interests center on the biology of tau protein in aging and Alzheimer's disease, with emphasis on diseases characterized by protein aggregation and methods to prevent these processes. His work has evolved from early studies on microbial cell walls to current investigations of tau pathology, demonstrating remarkable interdisciplinary expertise. He has developed assays for screening tau aggregation inhibitors and has extensively studied the therapeutic potential of hydromethylthionine. Analysis of his recent publications (2021-2025) reveals a strong focus on tau protein aggregation mechanisms, neuroinflammation, synaptic dysfunction in neurodegenerative diseases, and the therapeutic effects of tau aggregation inhibitors. His work frequently examines interactions between different therapeutic approaches, particularly how cholinesterase inhibitors might interfere with tau-targeting treatments. Harrington's research bridges molecular mechanisms with clinical applications, contributing significantly to the development of biomarkers and therapeutic strategies for Alzheimer's disease and related tauopathies. As Chief Scientific Officer for TauRx Therapeutics Ltd, Harrington oversees non-clinical activities for a company conducting phase 3 trials of hydromethylthionine. His collaborative work spans multiple international institutions, with numerous co-authors across neuroscience, biochemistry, and clinical research fields. While specific grant information isn't detailed in the provided text, his extensive publication record suggests substantial research funding support over his career. Harrington's laboratory work appears focused on tau transgenic mouse models, particularly investigating how tau pathology affects synaptic function, neurotransmitter systems, and behavioral outcomes. His research team has developed sophisticated methods for studying protein aggregation and its consequences in neurodegenerative disease models.

Virginia Gaoمشاهده پروفایل

استادیار

• Movement Disorders
• Parkinson's Disease
• Gut-Brain Axis
• +۳ مورد دیگر

Virginia Gao, M.D., Ph.D., is an Assistant Professor of Neurology and Neuroscience at Weill Cornell Medical College, Cornell University, and a board-certified neurologist specializing in Movement Disorders at NewYork-Presbyterian Hospital. As the Louis and Rachel Rudin Clinical Scholar in Neurology, she directs clinical care at the Parkinson's Disease & Movement Disorders Institute while leading biomarker discovery research and medical education initiatives. Her educational background includes: B.A. in Neuroscience from Columbia University (2008) M.D. and Ph.D. from Mount Sinai School of Medicine (2018) Neurology Residency at Weill Cornell (Chief Resident) Movement Disorders Fellowship at Weill Cornell/Columbia Dr. Gao's research centers on the gut-brain axis in Parkinson's disease, investigating alpha-synuclein pathology in the enteric nervous system as an early biomarker. Her work bridges molecular neuroscience with clinical neurology to develop diagnostic tools and therapeutic targets for neurodegeneration. She directs an NIH-funded clinical trial focused on Parkinson's biomarker discovery. Her 15 most recent publications (2020-2025) reveal a concentrated focus on Parkinson's disease mechanisms, particularly the role of alpha-synuclein in synaptic dysfunction and gut-brain interactions. Key themes include enteric nervous system pathology as a diagnostic window, systemic influences on brain health in aging, and innovative approaches to biomarker validation through multi-omics techniques. Major recognitions include: 2025 Louis and Rachel Rudin Clinical Scholar in Neurology 2023 Emerging Scholar Award (American Neurological Association) 2022 Leon Levy Fellowship in Neuroscience 2021 McGraw Fellowship in Neurology Research 2012 Ruth L. Kirchstein National Research Service Award 2008 Fulbright Scholarship Dr. Gao serves as Co-Director for the Area of Concentration in Neurodegeneration for medical students and Associate Program Director for Research in the Neurology Residency Program. Her research is funded by the National Institutes of Health, Leon Levy Foundation, McGraw Fellowship, American Academy for Neurology, and the Clinical and Translational Science Center (NCATS UL1 grant 2022-2027). She leads the Parkinson's biomarker research team within the Neurology Department's Movement Disorders Institute.

• Membrane Biology
• Protein Folding
• Biophysics
• +۶ مورد دیگر

Yongli Zhang is a Professor of Cell Biology and holds a secondary appointment as an Associate Professor in Molecular Biophysics and Biochemistry at Yale University. His research focuses on molecular mechanisms of membrane fusion, protein folding dynamics, and the development of single-molecule biophysical tools. He earned a bachelor’s degree in applied physics from China, a master’s in theoretical physics from the Chinese Academy of Sciences, and a PhD in Molecular Biophysics and Biochemistry from Yale University. His postdoctoral training at UC Berkeley under Prof. Carlos Bustamante expanded his expertise in optical tweezers and molecular biophysics. Key areas of research include regulated SNARE protein assembly, membrane protein interactions, and instrumentation development. The Zhang Lab uses advanced optical tweezers and fluorescence microscopy to study molecular forces in biological processes like exocytosis and endocytosis. Recent work explores SNARE-mediated membrane fusion mechanisms and the role of mechanical forces in protein function. Awards include the Jane Coffin Childs Postdoctoral Fellowship and the Sinsheimer Scholar award. The lab is actively involved in training students and postdocs in biophysical techniques and interdisciplinary research. Collaborations span structural biology, neuroscience, and computational modeling to address fundamental questions in membrane biology and protein dynamics.

Rutilio A. Frattiمشاهده پروفایل

استاد

• Membrane Biology
• Ion Channels
• Protein Dynamics
• +۵ مورد دیگر

Rutilio A. Fratti is a Professor of Biochemistry and Biophysics & Quantitative Biology at the University of Illinois, affiliated with the College of Liberal Arts & Sciences and the School of Molecular & Cellular Biology. His research focuses on protein-lipid interactions, membrane fusion, and lipid metabolism, particularly in the context of diseases like cancer, diabetes, and Alzheimer's. He earned his B.S. from California State University, Long Beach (1992), Ph.D. from the University of Michigan (2002), and completed postdoctoral work at Dartmouth Medical School (2002-2006). Key research interests include regulatory lipids (e.g., phosphatidic acid, phosphoinositides) and their roles in membrane microdomains, SNARE protein function, and drug discovery targeting fungal pathogens. His lab uses yeast vacuoles and synthetic vesicles to study lipid-protein interactions during membrane fusion. Publications highlight advancements in methods like Bio-Layer Interferometry, microscale thermophoresis, and spectroscopic techniques for studying lipid-protein interactions. Collaborations span drug discovery (e.g., SQ109 antifungal mechanisms) and mechanistic insights into Sec18 protein dynamics and Ypt7 regulation. Affiliated with the Center for Biophysics & Quantitative Biology, his work bridges fundamental lipid biology with translational applications in metabolic and infectious diseases.

• Molecular Biology
• Microbiology
• Biochemistry
• +۴ مورد دیگر

Stefan Irniger serves as a faculty member at a German-speaking academic institution, where he has supervised numerous doctoral candidates between 2004 and 2014. His academic position as a Privatdozent (PD) indicates he has completed the habilitation process, the highest academic qualification in the German system. Dr. Irniger's research spans multiple areas of molecular and cellular biology, with particular emphasis on: Microbial pathogenesis and host-pathogen interactions Fungal and yeast molecular genetics Protein regulation and post-translational modifications Enzyme structure and function Cellular metabolism and signaling pathways His doctoral students have published work examining diverse biological systems including Toxoplasma gondii, Saccharomyces cerevisiae, Aspergillus nidulans, and various plant-pathogen interactions. The publications demonstrate a consistent focus on molecular mechanisms underlying cellular processes, with particular attention to protein regulation, metabolic pathways, and host-microbe interactions. His students' work appears across multiple subdisciplines including parasitology, fungal genetics, enzymology, and membrane biology. Dr. Irniger has guided 18 doctoral students to completion, with dissertation topics spanning from 2004-2014. His students have investigated fundamental biological questions with implications for infectious disease, agricultural pathology, and basic cellular mechanisms. While specific awards are not documented in the available records, the breadth and quality of supervised research indicates significant scholarly contribution to his fields of expertise.

Mark Monroe Richمشاهده پروفایل

استاد

• Neuromuscular Disease
• Electrophysiology
• Neuromuscular Junction
• +۷ مورد دیگر

Mark Monroe Rich is a Professor in the Department of Neuroscience, Cell Biology & Physiology and Professor of Clinical Neuroscience at Wright State University School of Medicine, with over 25 years of combined clinical and research expertise in neuromuscular diseases. His MD/PhD background includes specialized fellowship training in neuromuscular disorders, positioning him at the intersection of patient care and laboratory investigation. Dr. Rich's research program centers on electrophysiologic defects across the neuromuscular axis, with particular emphasis on peripheral nerve pathologies, neuromuscular junction dysfunction, and skeletal muscle excitability disorders. His lab actively investigates disease mechanisms in myasthenia gravis, Lambert-Eaton syndrome, critical illness neuropathies, spinal muscular atrophy, ALS, Huntington's disease-related myopathies, and chemotherapy-induced sensory deficits. Current work focuses on identifying druggable targets for rapid therapeutic translation, especially regarding muscle excitability dysregulation in genetic muscle diseases. Analysis of his 15 most recent publications reveals a consistent trajectory toward mechanistic studies of action potential abnormalities in disease models, with growing emphasis on Huntington's disease, myotonia congenita, and periodic paralysis. His work increasingly integrates transverse tubule ultrastructure, ion channel dysfunction, and neuromuscular junction plasticity to explain pathological phenotypes. Dr. Rich's contributions have been recognized through significant honors: Wright State Academy of Medicine Outstanding Senior Faculty Achievement Award (2019) University Professor designation (2019) Teaching excellence award, School of Medicine (2020 and 2022) His laboratory maintains continuous NIH funding exceeding 25 years, supporting both basic science investigations and therapeutic development. While specific student mentorship isn't detailed in available records, his extensive publication record (110+ articles) indicates active training of researchers through collaborative projects. The lab employs advanced electrophysiological and ex vivo preparation techniques to model disease states and evaluate potential interventions, operating within Wright State's neuroscience research infrastructure.

Axel Brungerمشاهده پروفایل

استاد

• Structural Biology
• Biophysics
• Synaptic Neurotransmission
• +۷ مورد دیگر

Axel Brunger is a Professor at Stanford University in the Department of Molecular and Cellular Physiology, Photon Science Directorate, Neurology & Neurological Sciences, and Structural Biology (by courtesy). He is an Investigator of the Howard Hughes Medical Institute (HHMI) since 1987 and a member of the National Academy of Sciences (2005) and American Academy of Arts & Sciences (2021). His research focuses on structural biology and biophysics of synaptic proteins, particularly SNAREs, complexin, and synaptotagmin, which mediate neurotransmitter release and membrane fusion. Education: Diplom in Physics (University of Hamburg, 1980) Ph.D. in Biophysics (Technical University of Munich, 1982) His groundbreaking work includes pioneering X-ray crystallography tools for structural calculation and cryo-EM studies of synaptic supercomplexes. Recent studies reveal mechanisms of NSF-mediated SNARE disassembly, α-synuclein's physiological role in synaptic vesicle clustering, and synaptic vesicle architecture via cryo-tomography. He discovered novel protein interactions like V-ATPase-synaptophysin and AMPA receptor-PSD networks, with implications for Parkinson's disease and neurotransmission disorders. His publications span Structural Biology , Neuroscience , Molecular Biophysics , and Biochemistry , with a focus on SNARE Complex Dynamics , Membrane Fusion Mechanisms , and Synaptic Vesicle Biogenesis . Key subfields include Cryo-EM Structural Analysis , Protein-Protein Interactions , Neurodegenerative Disease Models , ATPase Function , Synaptic Transmission , and Phase Separation in Neurons . Scientific Awards: Gregori Aminoff Prize (2003), Röntgen Prize (1995), DeLano Award (2011), Carl Hermann Medal (2014), Katz Award (2014), Trueblood Award (2016), and National Academy of Sciences membership (2005). Brunger mentors postdoctoral and doctoral students, including Liv Jensen , Yousuf Khan , and Jiahao Liang . He contributes to graduate programs in Biophysics, Molecular and Cellular Physiology, Neurosciences, and Structural Biology. His lab develops advanced protocols for studying synaptic vesicle fusion and protein interactions using single-vesicle assays and subtomogram averaging .

Marino Zerialمشاهده پروفایل

دانشگاهی

• Molecular Cell Biology
• Membrane Biology
• Endocytosis
• +۳ مورد دیگر

Marino Zerial is a leading academic and researcher in molecular cell biology, serving as Director of the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and Honorary Professor at the Medical Faculty of Technische Universität Dresden. He obtained his biology degree from the University of Trieste (Italy) in 1982 and conducted postdoctoral research at the Institut Jacques Monod (Paris) and EMBL (Heidelberg). His work has focused on understanding endocytosis mechanisms, particularly the role of Rab GTPases in membrane fusion and organelle biogenesis. Zerial has pioneered translational research in liver disease, 3D tissue modeling, and drug delivery systems. He leads the Zerial Group, which integrates molecular biology, biophysics, and computational modeling to study cellular organization at multiple scales. Education: Biology (University of Trieste, 1982) Postdoctoral Training: Institut Jacques Monod, EMBL Affiliations: MPI-CBG (Director), TU Dresden (Honorary Professor) His research interests span endocytic pathways, liver tissue biophysics, and molecular motor mechanisms. Zerial has received prestigious awards, including the Gottfried Wilhelm Leibniz Prize (2006) and election to the American Academy of Arts and Sciences (2021). The Zerial Group collaborates on projects like LiSyM (liver cancer research) and ENDOSCAPE (gene delivery technology), emphasizing interdisciplinary approaches to biological challenges.

Reinhard Jahnمشاهده پروفایل

استاد

• Membrane traffic
• Exocytosis
• Synaptic transmission
• +۳ مورد دیگر

Reinhard Jahn is a Professor at the University of Göttingen and Director of the Department of Neurobiology at the Max Planck Institute for Biophysical Chemistry. His work focuses on molecular mechanisms of membrane traffic, exocytosis, and synaptic transmission, particularly through the study of SNARE proteins and membrane fusion. With a PhD from the University of Göttingen (1981) and academic positions at institutions like Yale University and The Rockefeller University, his career spans both academic and research leadership roles. His research has significantly advanced understanding of neurotransmitter uptake and storage , synaptic transmission , and the molecular anatomy of trafficking organelles . The field of neuroscience has been enriched by his studies on SNARE complex dynamics and NSF/ATP-driven processes. Scientific Awards and Honors: Balzan Prize (2016) Foreign Associate Member, National Academy of Sciences, USA (2015) Heinrich Wieland Prize (2014) Eduard Buchner Prize (2013) Sir Bernhard Katz Award (2008) Ernst-Jung Prize for Medicine (2006) Gottfried-Wilhelm Leibniz-Prize (2000) Max-Planck Research Prize (1990) Reinhard Jahn’s publications, including 296 entries and a high H-index of 100, reflect his leadership in molecular neuroscience. His work on membrane fusion intermediates and helical extensions of SNARE complexes has shaped modern understanding of synaptic vesicle biology. He is a member of prestigious academies such as the German National Academy of Science (Leopoldina) and EMBO, underscoring his influence in the scientific community.

Jason Warnerمشاهده پروفایل

مدرس

• Membrane Fusion
• Biophysical Chemistry
• Cell Membrane Dynamics
• +۳ مورد دیگر

Jason Warner is a Lecturer in the Department of Chemical and Biological Engineering at Rensselaer Polytechnic Institute (RPI), located in Troy, New York. His work focuses on membrane fusion mechanisms, particularly the role of SNARE proteins and cholesterol in mediating cellular processes such as viral entry and lipid bilayer interactions. He is actively involved in teaching courses like Introduction to Engineering Analysis and Biotechnology and Bioprocessing Laboratory, contributing to foundational education in engineering and biochemical systems. Research interests span biophysical chemistry, cell membrane dynamics, and the interplay between proteins and lipid environments. His studies investigate how SNARE complexes generate forces for membrane fusion, the influence of cholesterol on pore stability, and the structural evolution of hemifusion intermediates. These efforts combine experimental techniques like pTIRFM microscopy with computational modeling to understand molecular-scale fusion processes. Jason Warner has contributed significantly to understanding fusion pathways through persistent investigations since 2007. His published works highlight advancements in quantifying pore dynamics, exploring cationic peptide membrane traversal, and modeling viral acidification mechanisms. While no scientific awards are listed, his research demonstrates a deep commitment to advancing membrane biophysics and its applications in biotechnology. No formal advisees or grant information are provided in the profile. He maintains a presence in the Ricketts Building at RPI, indicating active participation in departmental activities and access to research facilities associated with that location.