معرفی
Thomas Melia is a Professor of Cell Biology at the Yale School of Medicine, part of Yale University. He leads the Melia Lab, focusing on autophagosome biogenesis and membrane dynamics during autophagy. His research integrates cell-based assays with advanced imaging techniques like electron cryo-microscopy. Key areas include understanding membrane sources for autophagosomes, lipid transport mechanisms, and organelle formation under cellular stress.
- Education: PhD in Biochemistry from Baylor College of Medicine (1999), BS in Biological Sciences from Carnegie Mellon University (1992)
- Research Interests: Autophagy, lysosomal biology, membrane trafficking, and protein aggregate clearance
- Lab Affiliations: Collaborates with departments like Biochemistry, Quantitative Biology, and Molecular Cell Biology
Melia's work bridges molecular mechanisms with cellular function, particularly in how cells respond to starvation or pathogen invasion by degrading cytosolic components. Recent studies highlight roles for dynamin-like proteins in nuclear autophagy and lipid transfer proteins in organelle biogenesis.
