جست‌وجوی استاد و پژوهشگر

Donald H. Burkeمشاهده پروفایل

استاد

• Ribozyme Mechanism and Evolution
• Antiviral RNA Aptamers
• Origin of Life Studies
• +۵ مورد دیگر

Donald H. Burke is a Professor at the University of Missouri with appointments in Molecular Microbiology & Immunology , Biochemistry , and Bioengineering . His work spans four decades, focusing on RNA biochemistry, antiviral therapies, and the origin of life. Major research areas: Ribozyme evolution , HIV reverse transcriptase inhibition , RNA aptamer engineering , and RNA world hypothesis . Key methodologies: SELEX (Systematic Evolution of Ligands by Exponential Enrichment), chimeric SELEX , and FASTAptamer , a bioinformatic toolkit he developed. His lab investigates RNA-protein interactions in HIV-1 replication, RNA-small molecule binding (e.g., S-adenosyl methionine), and RNA catalysis for phosphorylation reactions. Recent work explores RNA-based gene therapy and metabolic engineering using synthetic ribozymes. Collaborations include X-ray crystallography , clinical virology , and synthetic chemistry . The lab trains future scientists through PhD programs in Molecular Pathogenesis and Therapeutics , Biochemistry , and Genetics .

Barbara Müllerمشاهده پروفایل

استاد مدعو

• Retrovirology
• HIV-1 Assembly and Maturation
• Viral Replication Mechanisms
• +۵ مورد دیگر

Barbara Müller is an Adjunct Professor at the Department of Virology , Heidelberg University, leading the Müller Lab at the Center for Integrative Infectious Disease Research (CIID) . Her research focuses on HIV-1 assembly, maturation, and post-entry mechanisms , using advanced imaging techniques such as super-resolution microscopy and fluorescence labeling. She also contributed to pandemic response efforts through SARS-CoV-2 antibody assays and epidemiological studies. Research interests include retroviral dynamics , viral capsid structure-function relationships , and host-cell interactions during HIV replication . Key projects investigate HIV-1 proteolytic maturation, capsid uncoating, and nuclear import. Her lab pioneered fluorescently labeled HIV derivatives to track viral processes in real-time. Recent work includes studies on HIV-1 spacer peptide 2 (SP2) in maturation, SARS-CoV-2 transmission in households, and post-acute sequelae of COVID-19. Collaborations with bioinformaticians and clinicians expanded her team’s capabilities in multiplex serology and population-based studies . Advising includes PhD students and postdocs in virology and immunology. The Müller Lab is part of CIID’s interdisciplinary environment, emphasizing translational research in infectious diseases.

Joel Palefskyمشاهده پروفایل

استاد

• Human Papillomavirus (HPV) Infection
• HIV/AIDS
• Anal Cancer
• +۳ مورد دیگر

Joel Palefsky is a Professor at the University of California San Francisco (UCSF) and a leading expert in Human Papillomavirus (HPV) infection, particularly in HIV-infected populations. He founded the HPV Working Group of the NCI AIDS Malignancy Consortium and chairs the ANCHOR study, an NIH-funded clinical trial preventing anal cancer in HIV patients. As director of the Anal Neoplasia Clinic at UCSF, he trains global clinicians in high-resolution anoscopy and anal biopsy techniques. International research in India, Costa Rica, and Thailand Over 275 publications and multiple NIH grants Current president of the International Papillomavirus Society Founder of the UCSF Doris Duke Clinical Research Fellowship Program His research spans HPV-related cancers, molecular biology, and clinical trial design, with a focus on HIV co-infection. Recent publications examine anal and cervical HPV dynamics, vaccine immunogenicity, and microbiome interactions in cancer progression. Notable scientific awards include election to the American Society for Clinical Investigation (2003), multiple teaching awards at UCSF, and recognition as a Top Doctor in Infectious Diseases. Palefsky leads numerous NIH-funded studies including CAMPO Center for HPV-related Cancer Prevention (U54CA242646), anal HPV vaccine trials (R01CA217715), and investigations into HPV-HIV interactions (R21CA206352).

Perry T. Kayeمشاهده پروفایل

استاد

• Medicinal Chemistry
• Synthetic Organic Chemistry
• Physical Organic Chemistry
• +۵ مورد دیگر

Professor Perry T. Kaye serves as a faculty member in the Department of Chemistry at Rhodes University, Grahamstown, South Africa. His academic profile remains active as documented in the university's staff directory updated January 2020. His research spans three interconnected domains: Medicinal Chemistry : Design and synthesis of novel compounds targeting anti-parasitic diseases (malaria, trypanosomiasis), HIV-1 viral enzymes (protease, integrase, reverse transcriptase), and tuberculosis, with evaluation through in silico and in vitro methodologies. Synthetic Organic Chemistry : Application of Baylis-Hillman reaction chemistry to construct benzanulated heterocyclic systems serving as precursors for biologically active molecules. Physical Organic Chemistry : Kinetic-mechanistic investigations of organic reaction pathways using spectroscopic analysis and computational modeling. No scientific awards were documented in the available records. Information regarding student supervision, research grants, and laboratory infrastructure was not provided in the source material.

Roger Hunterمشاهده پروفایل

استاد

• Synthetic Organic Chemistry
• Medicinal Chemistry
• Total Synthesis
• +۴ مورد دیگر

Professor Roger Hunter holds the Mally Chair of Organic Chemistry in the Chemistry Department at the University of Cape Town, South Africa, a position he has occupied since 2004 after serving as Associate Professor from 1989-2003. His research program bridges synthetic organic chemistry with medicinal applications through cutting-edge methodology development and drug discovery initiatives. His academic journey began with BSc Hons (1975) and PhD, DIC (1978) from Imperial College London, followed by EPSRC Post-Doctoral Research at University College London (1980-1982) and Royal Society Fellowship in Barcelona (1978-1980). He was awarded a US Fulbright Fellowship to Yale University in 2007. Hunter's research integrates synthetic organic chemistry across three major domains: total synthesis of bioactive alkaloids (Castanospermine, Tacamonine, Lepadiformine) using novel asymmetric catalysis techniques; medicinal chemistry targeting HIV through bifunctional reverse-transcriptase inhibitors developed with Yale collaborators; antimalarial agents active against chloroquine-resistant strains; and stable garlic-derived mimics with antimicrobial/anticancer properties. His group also pioneered practical methods for unsymmetrical disulfide synthesis using 1-chlorobenzotriazole. Publication analysis reveals consistent focus on therapeutic applications (HIV, malaria, cancer) coupled with innovative synthetic methodologies, demonstrating interdisciplinary collaboration with virologists, parasitologists, and oncologists to validate compound efficacy. The HIV bifunctional inhibitor project exemplifies his rational drug design approach. His scientific recognition includes: US Fulbright Fellow (2007) at Yale University Hunter leads multiple grant-funded projects through strategic collaborations with Professor Karen Anderson (Yale, HIV inhibitors), Professor Tim Egan (antimalarials), and Dr Catherine Kaschula/Professor Iqbal Parker (anticancer agents). His laboratory trains researchers in advanced organic synthesis while maintaining active partnerships with the Institute of Infectious Disease and Molecular Medicine (IDM) at UCT. The Hunter laboratory operates at the chemistry-biology interface, utilizing specialized instrumentation for complex molecule synthesis and mechanism-of-action studies. Current efforts focus on optimizing azaquaternary center formation for alkaloid synthesis, developing next-generation HIV therapeutics, and expanding the structure-activity database for garlic-derived anticancer compounds.

Annette Neumanمشاهده پروفایل

دانشیار

• Medicinal Chemistry
• Organic Chemistry
• Chemistry Education
• +۳ مورد دیگر

Annette Neuman serves as Associate Professor of Chemistry at Emory University's Oxford College. She holds a B.S. in Chemistry from Davidson College (2004) and a Ph.D. in Chemistry from Emory University (2013), with dissertation research focused on antiviral compound development for hepatitis C and HIV therapies. Dr. Neuman joined Oxford College in 2012 and serves as the campus pre-health advisor. B.S. in Chemistry, Davidson College (2004) Ph.D. in Chemistry, Emory University (2013) Her research spans two primary domains: developing novel synthetic methods for medicinally relevant heterocycles (triazoles and thiadiazoles) using C–H activation techniques, and innovating chemistry education through curriculum design focused on structure-function relationships. She employs backward design principles to create student-centered courses that help learners develop expert thinking patterns in organic chemistry. Her educational scholarship particularly targets non-science majors through integrated lab-lecture projects using natural medicinal sources. Dr. Neuman's scholarly output demonstrates consistent integration of synthetic organic chemistry with pedagogical innovation. Her publications reveal strong emphasis on translating complex medicinal chemistry concepts into accessible educational formats while maintaining rigorous synthetic methodology development. The recurring themes across her work include medicinal applications of heterocyclic compounds, student-centered curriculum design, and bridging pharmaceutical research with undergraduate education. As an educator, she has mentored ten undergraduate researchers through Oxford's Research Scholars and SURE programs, presenting collaborative work at regional ACS meetings. Her teaching portfolio includes Principles of Reactivity (Chemistry 202Q/L) and Advanced Reactivity (Chemistry 203Q/L) courses, along with the Discovery 101Q course 'From Peppermint Oil to Penicillin: Natural Sources of Medicine.' Outside academic duties, Dr. Neuman resides in Atlanta with her husband Rob, children Michael and Virginia, and their dog Biscuit, enjoying running and reading in her spare time.

Huiqing Zhouمشاهده پروفایل

استادیار

• Epitranscriptomics
• RNA Modifications
• Nucleic Acid Chemistry
• +۴ مورد دیگر

Huiqing (Jane) Zhou is an Assistant Professor of Chemistry at Boston College, affiliated with the Morrissey College of Arts and Sciences and the Chemistry Department. Her research focuses on developing technologies to map and modulate RNA chemical modifications (epitranscriptome) in mammalian systems. She employs interdisciplinary approaches including directed evolution, biochemistry, mass spectrometry, and structural biology to study the regulatory mechanisms of these modifications in gene expression and disease. Education: B.S., Nankai University Ph.D., Duke University Research Interests: Her lab explores how RNA modifications influence transcript stability, interactions, and expression, with applications in disease modeling and gene therapy. Key areas include base-resolution mapping of modifications, engineering tools for modification manipulation, and understanding dysregulated epitranscriptomes in diseases like Alzheimer’s. Publications: Her work spans publications in Nature Methods , Biochemistry , and Nucleic Acids Research , focusing on reverse transcriptase evolution, Hoogsteen base pairing dynamics, and RNA modification detection technologies. Awards: 2017 Chicago Fellows Fellowship. Lab & Funding: Supported by Boston College and grants from the National Institutes of Health (NIGMS, NCI). Her lab develops cutting-edge tools to visualize and modulate RNA modifications, aiming to identify novel drug targets and advance gene therapy strategies.

Jianming Huمشاهده پروفایل

استاد

• Virology
• Molecular Biology
• Hepatitis B Virus (HBV) Research
• +۳ مورد دیگر

Jianming Hu, MD, MS, PhD is a full-time Professor at the Penn State College of Medicine in the Department of Cell and Biological Systems . He is also affiliated with the Penn State Cancer Institute under the Mechanisms of Carcinogenesis Program. Research Focus: Virology, Molecular Biology, Hepatitis B Virus (HBV) assembly and replication Key Contributions: 104 research outputs, 5 NIH-funded projects since 1999 Techniques: Structural analysis of viral particles, computational modeling of HBV infection Recent Research Trends from 2023-2025 show increasing emphasis on: High-resolution structural characterization of HBV subviral particles Computational modeling of whole-cell viral infection dynamics cccDNA formation mechanisms Lipid bilayer interactions in viral assembly Scientific Awards: None explicitly mentioned, but demonstrates long-term NIH funding

• Transposable Elements
• LINE-1 Retrotransposition
• Genome Structure and Function
• +۵ مورد دیگر

John V. Moran is the Gilbert S. Omenn Collegiate Professor of Human Genetics and a Professor of Internal Medicine at the University of Michigan Medical School. His research focuses on the molecular mechanisms and genomic impacts of LINE-1 and SINE retrotransposition. Education: B.S. in Chemistry (Rochester Institute of Technology), M.S. in Molecular Genetics (The Ohio State University), Ph.D. in Biochemistry (University of Texas Southwestern Medical School) Postdoctoral Training: Damon Runyon Fellow at Johns Hopkins University and University of Pennsylvania Dr. Moran’s laboratory investigates how transposable elements shape genome evolution and disease. His work spans molecular biology, genomics, and computational approaches to analyze retroelement dynamics in somatic and germline cells. His recent research highlights include LINE-1 retrotransposition in neural tissues , interactions with DNA repair pathways , and roles in somatic mosaicism in schizophrenia . Collaborative efforts include the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Scientific Awards: 2013 Curt Stern Award AAAS Fellow Howard Hughes Medical Institute Alumnus Dr. Moran actively mentors students and postdoctoral fellows. He also contributes to genomic resource development and serves on advisory boards for biotech companies.

• Natural Products Drug Discovery
• Molecular Pharmacology
• HIV/AIDS Research
• +۴ مورد دیگر

Dr. Ghee T. Tan is an Associate Professor in the Department of Pharmaceutical Sciences at the Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo. She received her B.Sc. (Hons.) in Pharmacy from the National University of Singapore and her Ph.D. in Molecular Pharmacology from the University of Illinois at Chicago (UIC). Education: Ph.D. - University of Illinois at Chicago B.Sc., Pharmacy - National University of Singapore Her research focuses on natural products drug discovery for tropical diseases (HIV/AIDS, malaria, tuberculosis), cancer, and global health challenges. She has led NIH-funded projects, including the International Cooperative Drug Discovery Groups (ICBG) consortium in Vietnam and Laos, and authored reviews on natural products in book chapters. Key trends in her publications include bioactive compound isolation , structure-activity relationships , and solid-phase peptide synthesis . Recent work explores antileishmanial agents, antiviral plant sources, and endophytic fungi in Noni and Taxus species. Scientific Awards: Tuition Grant (NUS, 1983–1987) Kilmer Prize (1990) Phi Kappa Phi (1990–1998) Sigma Xi (1992–1998) NRSA AIDS Training Grant (1996–1998) UH Research Council Travel Award (2011) Teacher Recognition Award (GWIS, 2012) Dr. Tan has mentored 9 doctoral students and supervised postdoctoral, predoctoral, and undergraduate researchers internationally. Her grants include NIH R25 GM113747-01A1 for the Students of Hawaii Advanced Research Program (SHARP)/RISE (2016–2021).

• Virology
• HIV/AIDS
• Antiviral Resistance
• +۴ مورد دیگر

Dr. Daniel Armenia is an Associate Professor of Microbiology and Clinical Microbiology at the University of Rome Saint Camillus International University of Health Sciences. He holds a degree in Pharmaceutical Biotechnology from the University of Bologna and a PhD in Medical Microbiology and Immunology from the University of Rome Tor Vergata. His research focuses on virology, particularly HIV, hepatitis viruses (HBV/HCV), and mechanisms of antiviral drug resistance. He has conducted studies on viral evolution, resistance mutations, and treatment optimization in diverse patient populations, including pediatric and treatment-experienced individuals. His work spans Italy and Cameroon, addressing challenges in resource-limited settings. Dr. Armenia has authored numerous peer-reviewed articles and contributed to international conferences, emphasizing translational research and clinical outcomes. Education: Bachelor's in Pharmaceutical Biotechnology, University of Bologna PhD in Medical Microbiology and Immunology, University of Rome Tor Vergata Research Interests: Dr. Armenia’s work centers on antiretroviral resistance mechanisms, viral reservoirs in HIV, and the impact of treatment adherence. He investigates drug resistance dynamics in HBV/HCV and explores novel antiviral strategies. His research also evaluates viral tropism, genotypic/phenotypic resistance analysis, and the application of next-generation sequencing in clinical virology. Publications: His recent work includes studies on HIV DNA load correlations with resistance, viral reservoirs under long-acting therapies, and pediatric dolutegravir efficacy. He has contributed to understanding resistance mutations in integrase inhibitors and their clinical implications. Professional Experience: Dr. Armenia has held a research fellowship at the University of Rome Tor Vergata’s Virology department and collaborated internationally with clinical research centers and diagnostic companies.

• Functional Pharmacogenetics
• Epigenetics
• Drug Metabolism
• +۷ مورد دیگر

Aik Jiang Lau is an Associate Professor at the College of Pharmacy, Dalhousie University, specializing in Functional Pharmacogenetics, Epigenetics, and Drug Metabolism. His research bridges pharmacokinetics and pharmacodynamics to advance personalized pharmacotherapy. BSc (Honours) in Pharmacy, National University of Singapore PhD in Pharmaceutical Sciences, National University of Singapore Postdoctoral Fellowship in Pharmaceutical Sciences and Pharmacology, University of British Columbia His work focuses on genetic and non-genetic factors (e.g., drugs, food, microbiota) regulating drug metabolism and adverse reactions. Key areas include Aldehyde Oxidase Inhibition, Sulfotransferase Enzymology, and Steroid Receptor Pharmacology. From 2016–2022, his publications highlight interactions between drugs, nutraceuticals, and enzymes like CYP3A, SULT2A1, and PXR. Recent studies explore links between steroid hormones and cancer-related cognitive impairment. Postdoctoral Scientist Award - American Society for Pharmacology and Experimental Therapeutics (2012) Emil A. Pfitzer Postdoctoral Award - Society of Toxicology (2012) Best Presentation Award - International Society for the Study of Xenobiotics (2011) Dr. Lau's research team investigates mechanisms to improve drug efficacy and safety, with support from academic and institutional grants. He collaborates with international teams and supervises research trainees in pharmacogenomics and drug metabolism studies.

Marcin Nowotnyمشاهده پروفایل

استاد

• Reverse transcriptases
• Structural biology
• Protein crystallography
• +۳ مورد دیگر

Marcin Nowotny is a Professor and Head of the Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology (IIMCB) in Warsaw, Poland, since 2008. He is also a Co-founder and Chief Scientific Officer of ProBiostructures, an IIMCB research service center for the pharmaceutical industry. His career includes postdoctoral research at the National Institutes of Health (2003-2008) and serving as Deputy Director for Science at IIMCB (2015-2018). Education: PhD in biochemistry (2002) from Nencki Institute of Experimental Biology, habilitation (2013) in Poland. Nowotny’s research focuses on structural biology and enzymology of nucleic acids, particularly reverse transcriptases, nucleases, and DNA repair mechanisms. His work bridges molecular biology and biotechnology applications. Scientific recognition includes EMBO membership (2019), multiple Jan Karol Parnas awards for outstanding Polish biochemical research, the Knight's Cross of the Order of Polonia Restituta (2013), and prestigious grants like the European Research Council Starting Grant (2011) and Wellcome Trust Senior Research Fellowship (2007, renewed 2012). He also received the Polish Prime Minister’s Award for scientific achievement (2012).

• RNA Biology
• Retrotransposons
• Protein Complexes
• +۶ مورد دیگر

John LaCava is a Research Associate Professor at the Laboratory of Cellular and Structural Biology, The Rockefeller University, and Managing Director of B13LOGY LLC. His research focuses on retrotransposon biology, protein complexes, and their roles in cancer, immunology, and inflammatory diseases. He holds editorial roles at Mobile DNA and has organized international conferences on mobile genetic elements. Key contributions include elucidating LINE-1 retrotransposon mechanisms and their implications in cancer immunology and autoimmune disorders. Affiliations: Rockefeller University, B13LOGY LLC Research Themes: Retrotransposons, Protein Interactomes, Immunogenicity, Neuroinflammation Notable Achievements: NCDIR Fellowship (2012), EMBO Long Term Fellowship (2005) His work bridges molecular biology with clinical applications, including developing diagnostic tools for cancer detection through retrotransposon expression profiling. Over 60 publications and 8 datasets demonstrate his contributions to proteomics and retrotransposon genomics.

• Machine Learning in Drug Design and Discovery
• Environmental Analysis
• Natural Product Chemistry
• +۳ مورد دیگر

Dr. Kassim Adebambo is a researcher at the Centre for Research in Mechanisms of Disease and Drug Discovery, part of the School of Life and Medical Sciences at the University of Hertfordshire. Previously, he held roles as a Teaching Fellow at the University of Aberdeen and lecturing positions at Nigerian universities, including Tai Solarin University of Education and Olabisi Onabanjo University. He has industry experience with Nitech Solution, focusing on optimizing crystallization processes and omega-3 extraction in fish oil using Continuous Oscillatory Batch Reactor techniques. Dr. Adebambo holds a B.Sc. (Hons) in Chemistry from Ondo State University (now Ekiti State University), an M.Sc. in Organic Chemistry (Natural Products) from the University of Ibadan, a PhD in Medicinal Chemistry from Heriot-Watt University, and an M.Sc. in Advanced Drug Delivery from the University of Strathclyde. His research interests span multiple areas: applying machine learning and data science to drug design and discovery, analyzing environmental contaminants like trace metals and PFAS in food and the environment, isolating and characterizing natural products' secondary metabolites, and developing smart drug delivery systems, particularly liposomal technologies. He has collaborated on studies involving molecular docking to investigate potential treatments for Alzheimer's disease, SARS-CoV-2, malaria, and HIV. Notably, his work includes computational studies on anti-inflammatory drugs against SARS-CoV-2 proteins and in silico investigations into novel Alzheimer's therapies. While no specific scientific awards are mentioned, his contributions to drug discovery and environmental analysis have been published in peer-reviewed journals. Dr. Adebambo's current affiliations and past roles reflect a career dedicated to advancing pharmaceutical research through interdisciplinary approaches, combining computational methods with practical applications in drug delivery and environmental chemistry.