جست‌وجوی استاد و پژوهشگر

• Neurodegeneration
• Prion Disease
• Alzheimer's Disease
• +۹ مورد دیگر

Emiliano Biasini is an Associate Professor at the University of Trento, affiliated with the Department of Cellular, Computational and Integrative Biology (CIBIO) and the Centre for Medical Sciences (CISMED). His research focuses on neurodegenerative diseases, particularly Alzheimer's and prion-related disorders, with a strong emphasis on protein misfolding, aggregation, and drug discovery. He employs zebrafish models and advanced biochemical techniques to investigate mechanisms underlying neurodegeneration and develop novel therapeutic strategies. His expertise spans biomolecules, enzymology, and amyloid biochemistry, with contributions to understanding copper toxicity in Wilson disease and the functional roles of prion proteins. Teaching responsibilities include courses on biochemistry and macromolecular technologies, emphasizing protein structure-function relationships and proteomic analysis. Recent research highlights include identifying modulators of prion proteins, developing anti-prion compounds, and exploring the structural basis of protein aggregation. His work bridges fundamental biology with translational medicine, aiming to translate molecular insights into clinical applications.

Lars Tebbeمشاهده پروفایل

عضو هیئت علمی

• Biomedical Engineering
• Ophthalmology
• Genetic Disorders
• +۳ مورد دیگر

Lars Tebbe is a Research Assistant Professor in the Department of Biomedical Engineering at the University of Houston. His work focuses on retinal biology, genetic disorders, and ciliopathies, with an emphasis on understanding disease mechanisms and developing therapeutic strategies. Research Interests: Retinal degeneration mechanisms Gene therapy approaches for ocular diseases Protein trafficking in photoreceptors Ciliary dysfunction in genetic disorders siRNA delivery systems Recent work highlights include studies on hyaluronic acid nanospheres for gene delivery, syntaxin proteins' role in retinal health, and the impact of usherin mutations on auditory and visual systems. He is affiliated with the Science & Engineering Research Center (SERC), located at 3517 Cullen Blvd, Houston TX. His research contributes to both basic science and translational medicine in ophthalmology.

Joseph Carrollمشاهده پروفایل

استاد

• Ophthalmology
• Visual Neuroscience
• Retinal Imaging
• +۵ مورد دیگر

Joseph Carroll is the Richard O. Schultz, MD / Ruth Works Professor of Ophthalmology and Professor in the Departments of Ophthalmology & Visual Sciences, Biophysics, and Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin (MCW). He directs the Advanced Ocular Imaging Program (AOIP), a resource for high-resolution retinal imaging technologies like adaptive optics and optical coherence tomography. His research focuses on structural-functional relationships in the visual system, with emphasis on retinal degeneration mechanisms, comparative color vision, and foveal development. Dr. Carroll received his BS in Human Biology from UW-Green Bay and PhD in Cell & Developmental Biology from MCW, followed by a postdoctoral fellowship in adaptive optics imaging at the University of Rochester. Key research areas include applying advanced imaging to study human retinal structure-function correlations, analyzing inherited retinal diseases (e.g., achromatopsia, Usher syndrome), and developing translational imaging tools. Current projects involve longitudinal studies of cone photoreceptor mosaic integrity in genetic retinal disorders and assessment of adaptive optics-based visual acuity metrics. Funding comes from NIH grants, research foundations, and private donors through AOIP collaborations. His lab’s work bridges basic science and clinical application, with recent studies examining retinal structure-visual function relationships in macular diseases, rodent models of cone-dominant vision, and evaluating novel imaging technologies for disease monitoring. Dr. Carroll also contributes to peer review standards in ophthalmic journals and has pioneered FAZ analysis tools for OCT angiography.

Jangwook Jungمشاهده پروفایل

دانشیار

• Tissue Engineering
• Regenerative Medicine
• Biomaterials
• +۲ مورد دیگر

Dr. Jangwook Jung is an Associate Professor at Louisiana State University's Department of Biological and Agricultural Engineering. His research focuses on developing advanced biomaterials and tissue engineering strategies for regenerative medicine applications. Research explores: Engineering biomaterials for tissue regeneration Stem cell differentiation and extracellular matrix optimization Antioxidant and oxygen-releasing scaffolds for wound healing Recent publications (2021-2025) demonstrate innovations in lignin-based composites, stem cell fusion mechanisms, and ocular drug delivery systems. Core themes include diabetic wound healing, cardiac tissue engineering, and nanoparticle-based therapies. Teaches courses including BE 4335 Tissue Engineering and BE 4337 Regenerative Medicine. Leads research on lignin composites for medical applications and develops educational tools like 3D surgical simulators.

• Ophthalmology
• Anatomy
• Cardiology
• +۳ مورد دیگر

Falk Schrödl is a University Professor (Univ.-Prof.) and medical doctor serving as a Research Associate at the Institute of Anatomy and Cell Biology at Paracelsus Medical University in Salzburg. With an extensive research career spanning from 1997 to the present, he has produced 115 research outputs and led or contributed to 17 research projects, demonstrating significant contributions to ophthalmology, anatomy, and cardiology research. Research Interests: Ocular physiology with focus on the choroid and its role in vision Molecular mechanisms of melanopsin and gasotransmitter signaling in the eye Ultrastructural analysis of the choroid-sclera interface Cardiovascular physiology, particularly calcium handling in cardiac hypertrophy Relationships between eye growth, refractive development, and retinal signals Publication Trends: Professor Schrödl's publication record reveals a consistent focus on choroidal anatomy and physiology, with recent publications emphasizing molecular mechanisms like melanopsin signaling and hydrogen sulfide functions in the choroid. His work demonstrates an interdisciplinary approach that bridges ophthalmology with cardiovascular physiology, particularly in calcium signaling pathways. The research spans from basic science investigations of ocular structures to translational studies with potential clinical applications in vision science and cardiology. Research Projects: MYOTREAT (2023-2026) - Further contributor Vision, eye growth rhythms and retinal signals in refractive development (2021-2024) - Principal Investigator Development of a specific airway-trainer for airway management in MPS-patients (2020-2021) - Principal Investigator Ultrastructural analysis of the choroid-sclera interface (2020-2021) - Principal Investigator Impact of intrinsic choroidal neurons for emmetropization (2020-2022) - Principal Investigator Collaborations: Professor Schrödl maintains extensive collaborations with researchers including Kaser-Eichberger, Trost, Platzl, and others. His work suggests involvement in both ocular research teams focused on choroid anatomy/physiology and cardiovascular research groups investigating cardiac hypertrophy mechanisms.

• Medical Laboratory Science
• Immune System
• Angiogenesis Inhibitors
• +۳ مورد دیگر

Lesley Devine, PhD is a Technical Director at the Yale Flow Core Facility and Scientific Director of the Cancer Center Immune Monitoring Laboratory at Yale School of Medicine. She holds a PhD in Immunology from University College (1995) and a BS in Biochemistry & Immunology from the University of Strathclyde (1991). Her research focuses on immune system mechanisms, cancer biology, and medical laboratory science, with particular expertise in CD8 receptor biology, immune monitoring, and translational research in oncology. She has authored over 20 peer-reviewed articles, including seminal work on CD8-MHC interactions and immune profiling in cancer therapies. Dr. Devine leads core facilities supporting flow cytometry and immune monitoring for Yale's research community. Her recent work includes quantitative DNA repair biomarker studies in colorectal cancer (2023), metabolomic analysis of influenza vaccine responses (2022), and immunological markers in sickle cell disease (2018). She collaborates frequently with oncologists, immunologists, and data scientists at Yale to advance precision medicine and immune-based therapies. Dr. Devine's labs provide cutting-edge technical resources for multidisciplinary research teams across Yale Medicine.

Anneke den Hollanderمشاهده پروفایل

استاد

• Ophthalmology
• Disease modeling
• Functional genomics
• +۸ مورد دیگر

Anneke den Hollander is currently Head of Functional Genomics and Cellular Genomics at the Genomic Research Center in Cambridge, MA, USA. Previously, she served as Full professor (90% Ophthalmology, 10% Human Genetics) at Radboudumc, Nijmegen, Netherlands from 2014 to 2021, and Associate professor from 2009–2014. Her research focuses on ophthalmology, functional genomics, and inherited retinal dystrophies. Education: PhD (cum laude) in Human Genetics from Radboud University (2002), MSc in Biomedical Sciences from Leiden University (1996). Research Interests: Disease modeling, genomics, age-related macular degeneration, and serum biomarkers. Her work bridges clinical ophthalmology with genomic technologies to understand inherited eye disorders and develop diagnostic tools. Awards: Includes the 2023 President’s Award (AbbVie), 2017 VICI Award (NWO), and 2015 Cogan Award (ARVO). She has secured over €5.2M in personal research funding and contributed to €14.9M as co-applicant. Leadership & Grants: Founded Radboudumc’s Expert Center for Hereditary Blindness (2015). Served on NWO’s Translational Adult Stem Cell Research review committee and editorial boards for PLoS ONE and Molecular Vision . Organized international conferences on genetic eye diseases and therapeutic developments. Labs/Teams: Leads the Functional Genomics team at Genomic Research Center and previously directed ophthalmogenetic research at Radboudumc. Supervised 15 completed PhD students (2 cum laude) and currently advises 9 doctoral researchers.

• Glaucoma Management
• Ophthalmic Surgery
• Optic Nerve Biomechanics
• +۳ مورد دیگر

Nicholas Strouthidis is a Clinical Professor in Clinical Ophthalmology and Eye Health at the University College London (UCL), affiliated with the Faculty of Medicine and Health. He is a consultant ophthalmic surgeon at Moorfields Eye Hospital in London, specializing in complex glaucoma management and cataract surgery. His research focuses on optic nerve biomechanics, clinical trials for glaucoma treatments, and surgical innovations for corneal disorders like keratoprosthesis. He has held leadership roles including Director of Glaucoma Service (2015-2018) and Executive Medical Director (2018-2021) at Moorfields. Research Interests: Optic nerve imaging and biomechanics Clinical trials for glaucoma therapies New treatments for complex glaucomas Management of glaucoma in corneal disease Artificial intelligence in ophthalmic imaging His recent work includes studies on aqueous shunt surgery outcomes, air pollution's role in glaucoma incidence, and deep learning algorithms for OCT image enhancement. He has contributed to over 40 peer-reviewed publications since 2015, addressing surgical techniques, biomechanical modeling, and clinical decision-making in glaucoma. Professional Activities: NIHR Biomedical Research Centre, Moorfields/UCL UK Biobank collaborative studies Moorfields Safer Surgery techniques Labs/Teams: Active in the NIHR Moorfields-UCL BRC Glaucoma Research Group and collaborates with the UCL Institute of Ophthalmology on biomechanical and AI-driven imaging projects.

Paul Parkمشاهده پروفایل

دانشیار

• Retinal Degeneration
• GPCR Biology
• Photoreceptor Cell Biology
• +۳ مورد دیگر

Paul Park, PhD, is an Associate Professor in the Department of Ophthalmology and Visual Sciences at Case Western Reserve University's School of Medicine. His primary appointment is in Ophthalmology, with secondary appointments in Pharmacology and Biochemistry. His research focuses on photoreceptor cell biology, rhodopsin structure-function relationships, and molecular mechanisms underlying retinal degeneration. He investigates G protein-coupled receptors (GPCRs), particularly rhodopsin mutations linked to inherited vision disorders such as retinitis pigmentosa. Key Research Areas: Rhodopsin dysfunction, membrane protein organization, protein aggregation, and retinal disease mechanisms. Techniques: Atomic force microscopy (AFM), Förster resonance energy transfer (FRET), cryoelectron tomography, and biochemical/biophysical assays. His lab explores how rhodopsin mutations cause structural instability and aggregation, leading to photoreceptor cell death. Recent work includes studying nanoscale organization of rhodopsin in rod outer segment membranes and the role of palmitoylation in receptor stability. Publications highlight structural analysis of rhodopsin mutants, oligomerization dynamics, and disease models. No scientific awards explicitly listed in provided texts. Labs/Teams: The Park Lab at Case Western Reserve University focuses on translational research bridging molecular mechanisms to therapeutic strategies for retinal diseases.

John Griffinمشاهده پروفایل

استاد

• Coagulation Pathways
• Neuroprotection
• Thrombosis
• +۵ مورد دیگر

John Griffin is a Professor in the Department of Translational Medicine at the Scripps Research Institute. His research focuses on the cytoprotective protein C pathway, coagulation mechanisms, and neuroprotection in ischemic stroke. He holds adjunct professorships in the Department of Medicine at the University of California, San Diego. Education includes a PhD in Biochemistry from Philipps University Marburg (1984) and an M.S. in Biology from Justus-Liebig University of Giessen (1980). Professional experience spans roles at Harvard Medical School, NIH, and the Centre d'Etudes Nucleaires in France before joining Scripps in 1974. Research interests include the structure-function relationships of activated protein C (APC), development of APC variants like 3K3A-APC for clinical trials, and mechanisms of PAR1 and EPCR receptors in anti-apoptotic signaling. His work bridges basic science, preclinical, and clinical studies with translational medicine applications. Key contributions include demonstrating APC's neuroprotective effects in stroke models and identifying protein S as a neuroprotectant with dual anticoagulant and anti-inflammatory roles. Recent studies explore APC's role in mitigating radiation injury and cardiac dysfunction. Awards include the 2005 ISTH Career Achievement Award and leadership roles in NIH review panels. He chairs scientific advisory boards for biotech firms focused on thrombosis therapies.

• Immunology
• Molecular Biology
• Chemokines
• +۴ مورد دیگر

Gerard Graham is a Professor of Molecular and Structural Immunology and Dean of Research at the MVLS College, University of Glasgow. His research focuses on chemokine biology, particularly the roles of chemokines and their receptors in inflammation, stem cell biology, and cancer. Key projects include studying the D6 decoy receptor's role in resolving inflammation, structural analysis of chemokine receptors, and therapeutic applications of chemokine-virus conjugates. Graham leads a laboratory investigating chemokine modulation in diseases like psoriasis and has contributed to understanding placental immune mechanisms. Holds dual roles in research leadership and academic administration Expertise spans immunology, molecular biology, and structural biology Collaborates internationally on projects involving chemokine signaling and receptor structure-function relationships Research interests emphasize translating basic immunology discoveries into therapeutic strategies targeting inflammatory and immune disorders. His lab's work on embryonic stem cells and inflammatory pathways has advanced understanding of hematopoietic stem cell mobilization and tissue repair mechanisms.

• Molecular Medicine
• Pharmacology
• Oncology
• +۳ مورد دیگر

Roman Perez Fernandez is a Professor at the Department of Physiology, University of Santiago de Compostela. He is affiliated with the Faculty of Medicine and Dentistry, and leads research at the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS) and the Strategic Grouping in Materials (AEMAT). His work focuses on designing bioactive compounds and materials , particularly vitamin D analogues and stem cell therapies. He holds a PhD from the University of Santiago de Compostela (1987) with a thesis on adrenal androgen physiology. Research interests include molecular mechanisms of cancer progression, anti-fibrotic therapies, and stem cell secretome applications. Notable areas include breast cancer metastasis regulation via POU1F1 transcription factor, and development of novel vitamin D-based drugs targeting oncologic and metabolic conditions. His studies also explore the therapeutic potential of human uterine cervical stem cells in regenerative medicine and anti-inflammatory treatments. Publications highlight advancements in: 1) Design of anti-cancer vitamin D analogs with reduced calcemic side effects; 2) Role of p63 in hepatic glucose metabolism and fibrosis; 3) Mechanisms of cancer stem cell reprogramming; 4) Anti-inflammatory effects of conditioned stem cell media in ocular and gastrointestinal disorders. His work bridges organic chemistry, molecular biology, and clinical applications. Awards and grants are not explicitly listed, but his extensive publication record (over 70 papers from 1987–2025) reflects sustained research excellence. He collaborates across disciplines including material science (AEMAT) and molecular medicine (CIMUS). Current projects involve optimizing drug delivery systems using hydrogels and cyclodextrin complexes for targeted therapies.

Krzysztof Palczewskiمشاهده پروفایل

استاد

• Genome Editing
• Vision Science
• Retinal Diseases
• +۵ مورد دیگر

Krzysztof Palczewski is a Donald Bren Professor and Distinguished Professor at the University of California, Irvine (UCI), School of Medicine, with joint appointments in Pharmacology, Ophthalmology, and Chemical Biology. His research focuses on the molecular mechanisms of vision, retinal diseases, and structural biology of G protein-coupled receptors (GPCRs). Education: Ph.D., Biochemistry, Technical University of Wrocław, Poland (1986) M.S., Chemistry, University of Wrocław, Poland Research Interests: His laboratory investigates photoreceptor function, visual signaling pathways, and retinal disease mechanisms. Key areas include: Genome editing for inherited retinal disorders Structure-function relationships of rhodopsin and GPCRs Chromophore recycling (visual cycle) Development of small molecule therapies for age-related macular degeneration Grants & Awards: NIH R01 grants (EY030873, EY09339, EY030912) Member of National Academy of Sciences (2022) and National Academy of Medicine (2019) Paul Kayser International Award for Retina Research (2018) Professional Roles: Director of the UCI Center for Translational Vision Research. Previously held leadership roles at Case Western Reserve University (Chair of Pharmacology) and the University of Washington (Professorships in Ophthalmology and Pharmacology). Labs & Collaborations: Leads a multidisciplinary team integrating structural biology, genetics, and pharmacology. Collaborates with the Infrared Neuroimaging (INP) and Chemical Biology programs at UCI.

Alison Binnsمشاهده پروفایل

مدرس

• Age-Related Macular Degeneration
• Early Detection of AMD
• Treatment of AMD
• +۵ مورد دیگر

Dr. Alison Binns is a Lecturer in the Division of Optometry and Visual Science at City St George's, University of London, where she has been conducting research and teaching since July 2013. Her primary academic focus is on the early detection and treatment of Age-Related Macular Degeneration (AMD), with particular expertise in electrophysiological characteristics of early AMD. She holds a BSc in Optometry and Vision Sciences and a PhD from Cardiff University. Dr. Binns' research program centers on developing sensitive clinical tools for AMD diagnosis and monitoring, as well as investigating treatments for early AMD. Her work includes evaluating low vision service provision, studying retinal adaptation using electrophysiology and imaging techniques, and identifying electrophysiological biomarkers of retinal disease. She has secured significant grant funding from organizations including the College of Optometrists, NIHR, Macular Society, and RNIB for projects such as the AMD light trial (ALIGHT) and development of retinal imaging densitometers. Her publication record demonstrates a consistent focus on AMD research, with numerous recent articles in high-impact ophthalmology journals. Her work often involves collaboration with Cardiff University, Bristol Eye Hospital, and various international partners through the MACUSTAR consortium. Dr. Binns has been instrumental in developing clinical tools for AMD assessment and has contributed significantly to understanding the relationship between retinal function and structural changes in AMD. Member, College of Optometrists Registered, General Optical Council As an educator, Dr. Binns teaches multiple clinical skills and eye disease modules. She has supervised numerous research students working on AMD-related topics and collaborates extensively with colleagues across institutions. Her work bridges clinical practice, research, and education in the field of optometry and visual science, with particular emphasis on improving outcomes for patients with AMD.

Alain Destexheمشاهده پروفایل

استاد پژوهشی

• Computational Neuroscience
• Dynamical Systems
• Electrophysiology
• +۵ مورد دیگر

Dr. Alain Destexhe serves as Research Director (DRCE) and Deputy Director of the NeuroPSI Institute (UMR9197) at CNRS, University of Paris-Saclay, and CEA Saclay Campus in France. As Editor-in-Chief of the Journal of Computational Neuroscience , he leads one of the premier publications in his field. His research program spans multiple international collaborations, with funding from major agencies including the ANR, EC, MRC, NIH, and HFSP. Destexhe's research lies at the interface between physics (dynamical systems) and neuroscience (electrophysiology), focusing on the stochastic activity of the cerebral cortex and its consequences on integrative properties and neuronal coding. His work explores collective dynamics of neuronal networks including oscillations and chaotic states, along with the development of computational methods for electrophysiology such as conductance extraction and analysis of multiple electrode recordings. His laboratory maintains an extensive website ( neurocompute.cnrs.fr ) featuring publications, simulations, and 3D morphological reconstructions. The recent publications reveal a strong emphasis on multiscale approaches connecting molecular mechanisms to large-scale brain activity, with particular focus on thalamocortical systems, slow-wave sleep dynamics, consciousness signatures, and the development of advanced neural network models. His work spans from single neuron dynamics to whole-brain modeling, demonstrating a consistent commitment to bridging different levels of neural organization. Destexhe actively participates in the organization of international conferences and summer schools, contributing to the training of the next generation of computational neuroscientists. His laboratory website provides extensive educational resources including simulation demos, computer-generated animations, and NEURON programs that reproduce figures from published articles.