جست‌وجوی استاد و پژوهشگر

Barbara Guerraمشاهده پروفایل

دانشیار

• Protein Kinases
• Cancer Biology
• Cell Signaling
• +۷ مورد دیگر

Barbara Guerra is an Associate Professor in the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, Faculty of Science. She leads the Barbara Guerra Lab, which is part of the Translational Biology research section, focusing on the role of protein kinases in human disease, particularly cancer. She also serves as Head of the PhD School at the Faculty of Science since 2020, demonstrating strong leadership in academic training and research supervision. Her research expertise lies in protein kinase CK2, a key regulator of cell survival, growth, and differentiation. Her laboratory investigates CK2-mediated signaling pathways in cancer, DNA damage response, lipid metabolism, and cell cycle regulation. She has contributed extensively to understanding CK2's role in oncogenesis and its potential as a therapeutic target. Her recent publications reveal a consistent focus on CK2 in cancer metabolism, hypoxia signaling (e.g., HIF-1α), autophagy, and the development of kinase inhibitors. Themes include pharmacological targeting of CK2, regulation of metabolic enzymes like SCD-1, and modulation of tumor suppressors such as p27KIP1. She frequently collaborates on interdisciplinary studies involving drug delivery systems and natural product-based inhibitors. Barbara Guerra has received recognition for her teaching excellence, including a Faculty of Natural Science teaching prize in 2006. She serves on the editorial boards of Oncology Reports and Pharmaceuticals , contributing to scientific peer review and dissemination. She has supervised over 100 undergraduate, Master’s, and PhD students, as well as six postdoctoral researchers, indicating a strong commitment to mentoring the next generation of scientists. Her research is supported by numerous projects and she plays a central role in PhD education at the university level. Her lab is actively involved in translational research, bridging basic molecular mechanisms with potential clinical applications in oncology and metabolic disorders.

• Molecular Biology
• Genetics
• DNA Repair
• +۳ مورد دیگر

Kaima Tsukada serves as a Postdoctoral Researcher in the Department of Cellular and Molecular Medicine within the Faculty of Health and Medical Sciences at the University of Copenhagen. She holds dual appointments as a Guest Researcher in the Ochs Group and participates in the Molecular Aging Program. Her work focuses on DNA repair mechanisms and genome stability maintenance. Her research interests center on molecular mechanisms of DNA repair, particularly involving Bloom syndrome complex functions, replication fork dynamics, and double-strand break resolution. Key areas include Okazaki fragment processing, Holliday junction dissolution, and RPA-coated DNA sensing pathways. Her work bridges structural biology, cancer genetics, and cellular response to replication stress. Recent publications demonstrate significant contributions to understanding BLM helicase functions and BRCA1-BARD1 coordination in DNA repair. Her 2021 Nature Communications paper has garnered 55 citations and 120 Mendeley readers, while her 2022 PNAS article on Bloom syndrome complex assembly shows substantial academic impact with 15 citations and 45 readers. Dr. Tsukada maintains active collaborations across international research networks, with significant co-authorship ties to institutions in the United Kingdom and Australia. Her laboratory work occurs at dual campus locations: Blegdamsvej 3 and Ole Maaløes Vej 5 in Copenhagen, utilizing advanced molecular biology facilities within the BRIC (Biotech Research & Innovation Centre) and Department of Cellular and Molecular Medicine infrastructure.

• DNA Replication
• Chromosome Condensation
• Genome Stability
• +۴ مورد دیگر

Kenneth J. Marians is a Professor and holds the William E. Snee Chair at the Gerstner Sloan Kettering Graduate School of Biomedical Sciences, part of Memorial Sloan Kettering Cancer Center. His research focuses on understanding DNA replication mechanisms and chromosome dynamics. Education: B.S., Chemistry, Polytechnic Institute of Brooklyn, 1972 Ph.D., Biochemistry, Cornell University, 1976 Postdoctoral, Biochemistry, Albert Einstein College of Medicine, 1976-1978 Dr. Marians' research centers on the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and the mechanisms by which chromosomes are condensed and separated during cell division. His laboratory uses systems reconstituted with purified replication proteins and specialized templates to study these processes. Notably, he has recently shifted his primary focus from using bacterial proteins to using human proteins to develop these in vitro systems. His work has revealed important insights into replication fork stalling, lesion bypass, replication restart, and chromosome compaction mechanisms. His research on chromosome condensation and segregation utilizes a combination of biochemical, cell biological, and molecular genetic approaches. Scientific Awards: William E. Snee Chair, 1998 National Institute of General Medical Sciences MERIT Award, 2006 Fellow, American Association for the Advancement of Science, 2006 Member, American Academy of Arts and Sciences, 2015 National Institute of General Medical Sciences Outstanding Investigator Award, 2018 Memorial Sloan Kettering Medal for Outstanding Contributions to Biomedical Research, 2019 D. Sc., honoris causa, Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, 2019 Member, American Academy of Microbiology, 2021 Dr. Marians has mentored numerous graduate students and postdoctoral researchers who have gone on to successful careers in science. His laboratory has received continuous funding from the National Institutes of Health, including prestigious MERIT and Outstanding Investigator Awards. His current research explores how the human replisome deals with replication obstacles, with implications for understanding genome instability in cancer and other diseases.

• Genetics
• Cancer Mechanisms
• DNA Replication
• +۴ مورد دیگر

Ryan M Baxley is a Researcher at the University of Minnesota, affiliated with the Genetics Mechanisms of Cancer program within the Office of Academic Clinical Affairs. His work focuses on understanding the molecular mechanisms underlying genome stability and DNA replication processes, with direct implications for cancer biology and therapeutics development. Dr. Baxley's research program centers on critical genome maintenance pathways, with particular emphasis on: Minichromosome Maintenance (MCM) proteins and their regulation in DNA replication Proliferating Cell Nuclear Antigen (PCNA) post-translational modifications Ubiquitin-mediated regulation of DNA repair pathways Mechanisms of replication stress response Genomic instability in specialized cell types including natural killer cells Interplay between DNA replication and repair machineries Analysis of Dr. Baxley's recent publications (2023-2025) reveals a sophisticated research program examining how ubiquitin modifications of key replication proteins regulate genome maintenance. His work demonstrates how proteins like RAD18, RNF4, and USP7 coordinate to prevent hyper-recombination and maintain replication fidelity, with several studies investigating these mechanisms in differentiated cell types. This research has significant implications for understanding cancer development and identifying potential therapeutic targets in DNA repair pathways. Dr. Baxley maintains an active collaborative network within the University of Minnesota's cancer research community, consistently working with principal investigator Anja Bielinsky and colleagues including Liang Wang, Mark Schmit, and Jeffrey Miller. His research group appears well-integrated within the university's cancer research infrastructure, contributing to UN Sustainable Development Goal 3 (Good Health and Well-being) through fundamental discoveries in cancer mechanisms.

• DNA Damage and Repair
• Structural Biology
• Genomic Instability
• +۴ مورد دیگر

Stephen Smerdon serves as Professor of Structural Biology within the Cancer and Genomic Sciences department at the University of Birmingham's College of Medical and Dental Sciences. His research focuses on molecular mechanisms of DNA damage response and genomic instability, with particular expertise in protein phosphorylation networks and kinase signaling pathways. Current research examines the structural basis of DNA repair machinery and its implications for cancer development. His research interests span multiple interconnected domains of molecular oncology and structural biology: DNA damage response mechanisms and repair pathways Protein kinase signaling in genome maintenance Structural characterization of DNA repair complexes Molecular basis of genomic instability disorders Protein hydroxylase functions in replication stress Analysis of his recent publications reveals a consistent focus on structural mechanisms underlying genome integrity, with particular emphasis on protein modifications (phosphorylation, acetylation, hydroxylation) that regulate DNA repair processes. His work bridges basic structural biology with clinical implications for cancer and developmental disorders. Smerdon currently leads multiple major research initiatives funded by UK research councils: Principal Investigator for 'Structural Biology of DNA-damage signalling' at The Francis Crick Institute (2020-2023) Co-Investigator on 'Defining a role for DNA phosphorylation in maintaining replication fork stability' funded by BBSRC (2025-2028) Co-Investigator on 'Dissecting Hydroxylase Biology Implicated in Development Disorders and Cancer' funded by MRC (2024-2027) Collaborator on instrumentation development for structural biology His research group maintains active collaborations across multiple institutions, with recent work generating significant scholarly attention including news coverage and substantial social media engagement around findings related to genome instability disorders.

Michelle Hawkinsمشاهده پروفایل

مدرس ارشد

• DNA Replication
• Microbiology
• Genetics
• +۳ مورد دیگر

Dr. Michelle Hawkins is a Senior Lecturer in Microbiology at the University of York, Department of Biology. She specializes in DNA replication mechanisms, focusing on bacterial systems and obstacles encountered during replication. Her research employs genetics, biochemistry, and structural biology techniques, with current emphasis on termination processes and replication fork challenges. Education: MBiol (Honours) from University of Bath (2001-2005), PhD in Genetics from University of Nottingham (2005-2009). Prior roles include Postdoctoral Research Associate at York (2013-2018) and Research Fellow at Nottingham (2009-2013). Teaching involves lectures on DNA replication, interactive journal clubs, and tutorials on bioethics. She mentors final-year students in lab research and science communication projects. Active in grants: Co-investigator in the C-Trap for the North East (BBSRC-funded, 2024-2025) and Principal Investigator for 'Obstacles to replication: uncovering mechanisms of macromolecular collisions' (BBSRC, 2023-2026). Collaborations include structural biology and cryo-EM projects.

Anja Grothمشاهده پروفایل

استاد

• Molecular Cell Biology
• Epigenetics
• DNA Repair
• +۳ مورد دیگر

Anja Groth, 43 years old, is a full professor at the Biotech Research and Innovation Centre (BRIC) under the University of Copenhagen's Faculty of Health Sciences. Her research centers on molecular cell biology, epigenetics, DNA repair, and genome stability, with significant contributions to understanding how cells maintain functional memory during division—a critical process for both human development and cancer progression. Education: MSc in Biochemistry, University of Copenhagen PhD in Cancer Biology, University of Copenhagen (2004) Postdoc at Institut Curie, Paris (3 years) Her groundbreaking work on DNA repair mechanisms revealed a protein critical for cancer cell survival through error-free DNA repair. This discovery is paving the way for novel cancer therapies that block this protein. Using advanced molecular biology and interdisciplinary collaboration, she has published in top journals like Nature and secured two major ERC grants. Key Research Themes: Epigenetic memory and chromatin replication DNA damage repair pathways Histone dynamics and inheritance Replication fork stability Protein networks in genome maintenance Articles show a consistent focus on histone chaperones, ubiquitination pathways, and chromatin assembly factors. Her 2016 discovery of H4K20me0 marks and the TONSL–MMS22L complex has had lasting impacts on DNA repair research. Awards & Grants: EliteForsk Award (2018) EMBO Investigator Heirloom Award for Women Scientist Leaders ERC Starting Grant ERC Consolidator Grant As leader of a diverse research group of 15 international scientists (primarily women), Groth emphasizes collaborative innovation and trust-building in scientific environments. She advocates for sustainable lab practices and flexible research strategies that allow unexpected discoveries.

Ellen Vernonمشاهده پروفایل

پژوهشگر

• Transcriptional Regulation
• Biochemistry
• Molecular Biology
• +۵ مورد دیگر

Ellen Vernon is a Researcher affiliated with the North Wales Medical School and previously held roles at the School of Health Sciences. She completed her PhD in Biochemistry at the University of Bristol (1998) and holds BSc and HND degrees from the University of the West of England, Bristol. Her research focuses on DNA replication mechanisms, genome stability, and molecular biology processes, particularly involving MRE11, MRNIP, and replication stress responses. Recent studies explore CDK4/6 inhibitor effects on cellular senescence and the role of Translin in RNA processing under genomic stress. Key collaborations include work on nucleoside analog metabolism and replication fork protection. She has contributed to high-impact journals like Nucleic Acids Research and Molecular Cell .

Heidi Hehnlyمشاهده پروفایل

دانشیار

• Cytoskeletal dynamics
• Membrane transport
• Cell division
• +۷ مورد دیگر

Heidi Hehnly is an Associate Professor in the Department of Biology at Syracuse University's College of Arts & Sciences. She serves as Associate Director of the BioInspired Institute and Director of the Blatt Imaging Center. Her research focuses on cellular mechanisms connecting cytoskeletal dynamics, membrane transport, and centrosome function to control essential cellular processes such as cell division, fate, and polarity. Education: Ph.D., Molecular Physiology and Biophysics, University of Iowa (2009) B.S., Biochemistry and Biophysics, University of Rochester (2003) Dr. Hehnly's laboratory investigates the interface between cytoskeletal dynamics and membrane transport, with particular focus on how these systems co-regulate one another during cellular processes. Her research program addresses the fundamental question: how are ciliated tissues assembled during tissue development? Using zebrafish, mammalian tissue culture, C. elegans, and murine models, her lab employs cell biology, biochemistry, live cell imaging, and high-resolution imaging techniques to study centrosome function, Rab GTPases, and their roles in cellular organization. A major focus is understanding how membrane trafficking events controlled by Rab11 interact with the centrosome to regulate cellular processes. Analysis of Dr. Hehnly's recent publications reveals a consistent focus on the relationship between membrane trafficking (particularly Rab GTPases) and centrosome function. Her work has increasingly incorporated advanced imaging techniques and expanded into studying cellular mechanics, particularly the role of vimentin intermediate filaments. Key themes include the coordination of lumen and cilia formation during development, mechanisms of centrosome positioning, and the role of pericentriolar matrix integrity in cell division. Scientific Awards: Renée Crown Professor in the Sciences & Mathematics, Syracuse University (2022-2025) Inaugural member of the Women in Leadership Cohort, Syracuse University (2022) James K. Dual-Agyeman Award for Outstanding faculty (2022) New Investigator Idea award, DOD (2020) Dr. Hehnly has mentored numerous graduate students, postdoctoral researchers, and undergraduate students, many of whom have gone on to prestigious medical and graduate programs. Her research is supported by multiple significant grants including an NSF NRT-URoL grant (2024-2029) as Co-PI, and several NIH grants as PI including 'Cell Cycle Dependent Mechanisms Triggering Lumen Formation in vivo' (2021-2025) and 'Four-Dimensional Prediction and Quantification of How Physical Forces Impact Organogenesis in Zebrafish' (2020-2025). She has also pioneered BioArt initiatives at Syracuse University, including the CHIMERA Art and Science Exhibition Programming. The Hehnly Laboratory, established in 2015, operates the Blatt Imaging Center at Syracuse University. The lab brings together researchers from diverse backgrounds to study cellular mechanisms using cutting-edge techniques including live cell imaging, optogenetics, and biosensor assays. The lab has developed novel methodologies for in vivo experimentation and maintains strong collaborative relationships with researchers across disciplines to gain novel perspectives on centrosome protein interactions during development.

Junya Tomidaمشاهده پروفایل

پژوهشگر

• Molecular Biology
• Biochemistry
• Genetics
• +۳ مورد دیگر

Dr. Junya Tomida is a Researcher in the Department of Biological Sciences at UNC Charlotte's College of Liberal Arts & Sciences. He leads the Tomida Lab, focusing on DNA repair mechanisms and their implications in cancer biology, particularly in prostate, breast, and ovarian cancers. His work bridges biochemical, molecular, and genomic approaches with data from TCGA and ONCOMINE. Research interests include genome instability, DNA repair pathways, chemoresistance mechanisms, and the role of proteins like FAM35A, REV7, and BRCA1 in double-strand break repair and replication stress. His lab investigates how defects in DNA repair systems contribute to cancer progression and resistance to therapies such as PARP inhibitors. The 15 most recent publications highlight his contributions to DNA repair, Fanconi Anemia pathways, replication fork stability, and malaria genetics. Key themes include protein interactions in DNA damage responses, innate immune reactions to polymerase disruptions, and crosslink repair mechanisms. Funding includes the NIH/NCI R03 CA212556-01 grant, supporting his work on DNA repair and chemoresistance. The Tomida Lab is actively engaged in uncovering molecular determinants of repair pathway choice and genome stability.

Alicia K. Byrdمشاهده پروفایل

استادیار

• DNA Damage Response
• Helicase Enzymes
• G-quadruplex Structures
• +۳ مورد دیگر

Alicia K. Byrd serves as an Assistant Professor in the Department of Biochemistry and Molecular Biology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. She also holds an Associate Member position at the Winthrop P. Rockefeller Cancer Institute. Her research focuses on DNA damage response mechanisms, particularly the role of helicase enzymes in maintaining genomic stability. Dr. Byrd's research interests center on DNA repair pathways and genomic instability. Her laboratory investigates how helicases resolve secondary DNA structures like G-quadruplexes, which can cause chromosomal rearrangements leading to cancer or Fragile X Syndrome. Using biophysical, biochemical, and cellular techniques—including single-molecule kinetics, proteomics, and genomics—her team examines enzyme mechanisms both individually and within multi-protein complexes, with emphasis on post-translational modifications. Her publication analysis reveals strong specialization in G-quadruplex biology and helicase function across diverse systems from bacteriophage to human enzymes. Key trends include methodological innovations in DNA unwinding assays, structural analyses of helicase-DNA interactions, and exploration of helicase roles in replication fork dynamics. The research demonstrates consistent focus on fundamental mechanisms of DNA repair enzymes with translational implications for cancer and genetic disorders. Dr. Byrd leads an active research program in the Biomedical Research Center (B408), utilizing advanced techniques to study DNA-protein interactions. Her laboratory maintains collaborative relationships across multiple institutions as evidenced by co-authorship patterns in publications.

Daniel Georgeمشاهده پروفایل

استاد

• Medical Humanities
• Public Health
• Dementia Studies
• +۳ مورد دیگر

Daniel George, PhD is a Professor at Penn State College of Medicine with dual appointments in the Department of Humanities and Department of Public Health Sciences . His work spans Medical Humanities and Public Health , with a focus on Health Disparities , Dementia Studies , and Community Health initiatives. Research Interests : Medical Humanities Public Health Dementia and Alzheimer's Disease Health Equity Community-Embedded Services Medical Education Recent Publications highlight his interdisciplinary approach, combining Qualitative Methods with Policy Analysis to address systemic issues in healthcare. His Dean’s Award for Excellence in Teaching (2022) underscores his commitment to pedagogy, while collaborations with multidisciplinary teams reflect his role in advancing Penn State’s contributions to the UN Sustainable Development Goals , particularly Good Health and Well-Being .

• Bacterial Genetics
• Chromosome Replication
• Antimicrobial Peptides
• +۳ مورد دیگر

Godefroid Charbon is an Associate Professor in the Department of Biology at the University of Copenhagen, specializing in Functional Genomics. His research primarily focuses on bacterial chromosome replication mechanisms, antimicrobial resistance, and developing novel peptide-based antimicrobial strategies that minimize resistance development. Based at Ole Maaløes Vej 5 in Copenhagen, he maintains an active research program with extensive collaboration networks. Dr. Charbon's research centers on the molecular mechanisms of bacterial chromosome replication, particularly in Escherichia coli and Staphylococcus aureus . His work investigates the DnaA protein's critical role in replication initiation, cell cycle control, and how bacteria regulate DNA synthesis. A significant portion of his research focuses on developing peptide-nucleic acid conjugates that target essential replication proteins, creating antimicrobial approaches with reduced resistance potential. His functional genomics work examines bacterial responses to replication stress and antimicrobial challenges, with implications for understanding fundamental bacterial physiology and developing next-generation therapeutics. Analysis of Dr. Charbon's publication record reveals a consistent focus on bacterial replication mechanisms and antimicrobial development over the past five years. His research demonstrates expertise in molecular genetics, bacterial physiology, and antimicrobial discovery, with particular emphasis on overcoming antibiotic resistance mechanisms. The work spans from fundamental studies of replication initiation to applied research on novel antimicrobial compounds, showing strong translational potential. His frequent collaborations with Løbner-Olesen and others highlight interdisciplinary approaches combining molecular biology, genetics, and pharmaceutical sciences to address complex challenges in bacterial pathogenesis. Dr. Charbon maintains active research collaborations across multiple institutions, as evidenced by his extensive publication record totaling 35 research outputs. His work has generated significant academic interest, with multiple publications appearing in high-impact journals and receiving attention across academic platforms including Mendeley, X (Twitter), and Bluesky. His research program demonstrates strong continuity with publications spanning from 2021 through 2025, indicating an active and productive academic career trajectory at the University of Copenhagen.

David Ruedaمشاهده پروفایل

استاد

• Single-molecule imaging
• DNA and RNA processing
• CRISPR/Cas9 mechanisms
• +۷ مورد دیگر

Professor David Rueda holds the Chair in Molecular and Cellular Biophysics at Imperial College London’s Department of Infectious Disease (Faculty of Medicine). He leads a research group developing single-molecule imaging techniques to study structural dynamics of biomolecules involved in DNA/RNA processing, chromatin remodelling, and gene editing. His work spans CRISPR/Cas9 off-target mechanisms, SMC complex dynamics, and RNA localization via fluorogenic aptamers. Affiliations: CDT in Chemical Biology (supervisor), Centre for Advanced Therapeutics, Institute of Chemical Biology, and Molecular Sciences Network Postgraduate Training: PhD (EPF Lausanne, 2001) and Postdoc (University of Michigan, 2001–05) Research focuses on: CRISPR/Cas9 off-target binding mechanisms under mechanical stress SWR1 complex-mediated histone variant incorporation Live-cell RNA imaging using Mango aptamers Cohesin’s role in DNA tethering and SMC complex dynamics His lab employs advanced microscopy (optical tweezers, super-resolution imaging) and collaborates with Prof. Dale Wigley (Imperial) and Prof. Peter Unrau (Simon Fraser) on chromatin and RNA studies. Recent work addresses DNA repair pathways and synthetic lethal targets in cancer.

Satya Prakashمشاهده پروفایل

استاد

• DNA Replication
• DNA Repair
• Translesion Synthesis
• +۳ مورد دیگر

Satya Prakash, PhD, is a Professor in the Department of Biochemistry & Molecular Biology at the University of Texas Medical Branch (UTMB). He holds a BSc in Biology and Chemistry from Meerut College, an MVSC in Genetics from the Indian Veterinary Research Institute, and a PhD in Genetics from Washington University. His postdoctoral training was at the University of Chicago. Dr. Prakash's research focuses on DNA replication and repair mechanisms, particularly translesion synthesis (TLS) and their role in cancer. His work has been recognized with awards such as the Merit Award from NCI, the Distinguished Faculty Research Award, and Fellowships from AAAS and the American Academy of Microbiology. His research interests include understanding how TLS polymerases facilitate replication through DNA lesions, the interplay between DNA repair and cancer evolution, and mechanisms underlying genome instability. Key findings include the discovery of Pol η's role in XPV syndrome and the elucidation of TLS's role in preventing tumorigenesis. Current studies aim to target error-prone DNA repair pathways for cancer therapy. Dr. Prakash has an extensive publication record spanning DNA repair, TLS mechanisms, and cancer biology. His work bridges biochemical, genetic, and structural approaches to uncover fundamental biological processes and their clinical implications.