Heidi Hehnly

Heidi Hehnly is an Associate Professor in the Department of Biology at Syracuse University's College of Arts & Sciences. She serves as Associate Director of the BioInspired Institute and Director of the Blatt Imaging Center. Her research focuses on cellular mechanisms connecting cytoskeletal dynamics, membrane transport, and centrosome function to control essential cellular processes such as cell division, fate, and polarity.

Education:

• Ph.D., Molecular Physiology and Biophysics, University of Iowa (2009)
• B.S., Biochemistry and Biophysics, University of Rochester (2003)

Dr. Hehnly's laboratory investigates the interface between cytoskeletal dynamics and membrane transport, with particular focus on how these systems co-regulate one another during cellular processes. Her research program addresses the fundamental question: how are ciliated tissues assembled during tissue development? Using zebrafish, mammalian tissue culture, C. elegans, and murine models, her lab employs cell biology, biochemistry, live cell imaging, and high-resolution imaging techniques to study centrosome function, Rab GTPases, and their roles in cellular organization. A major focus is understanding how membrane trafficking events controlled by Rab11 interact with the centrosome to regulate cellular processes.

Analysis of Dr. Hehnly's recent publications reveals a consistent focus on the relationship between membrane trafficking (particularly Rab GTPases) and centrosome function. Her work has increasingly incorporated advanced imaging techniques and expanded into studying cellular mechanics, particularly the role of vimentin intermediate filaments. Key themes include the coordination of lumen and cilia formation during development, mechanisms of centrosome positioning, and the role of pericentriolar matrix integrity in cell division.

Scientific Awards:

• Renée Crown Professor in the Sciences & Mathematics, Syracuse University (2022-2025)
• Inaugural member of the Women in Leadership Cohort, Syracuse University (2022)
• James K. Dual-Agyeman Award for Outstanding faculty (2022)
• New Investigator Idea award, DOD (2020)

Dr. Hehnly has mentored numerous graduate students, postdoctoral researchers, and undergraduate students, many of whom have gone on to prestigious medical and graduate programs. Her research is supported by multiple significant grants including an NSF NRT-URoL grant (2024-2029) as Co-PI, and several NIH grants as PI including 'Cell Cycle Dependent Mechanisms Triggering Lumen Formation in vivo' (2021-2025) and 'Four-Dimensional Prediction and Quantification of How Physical Forces Impact Organogenesis in Zebrafish' (2020-2025). She has also pioneered BioArt initiatives at Syracuse University, including the CHIMERA Art and Science Exhibition Programming.

The Hehnly Laboratory, established in 2015, operates the Blatt Imaging Center at Syracuse University. The lab brings together researchers from diverse backgrounds to study cellular mechanisms using cutting-edge techniques including live cell imaging, optogenetics, and biosensor assays. The lab has developed novel methodologies for in vivo experimentation and maintains strong collaborative relationships with researchers across disciplines to gain novel perspectives on centrosome protein interactions during development.