جست‌وجوی استاد و پژوهشگر

Elliott SoRelleمشاهده پروفایل

استادیار

• Epstein-Barr Virus (EBV) Research
• Host-Virus Interactions
• Epigenetic Regulation
• +۴ مورد دیگر

Elliott SoRelle, PhD, is an Assistant Professor in the Department of Microbiology and Immunology at the University of Michigan Medical School. His laboratory focuses on understanding Epstein-Barr Virus (EBV)-host interactions at high resolution, with a particular emphasis on epigenetic regulation, cellular reprogramming during lytic reactivation, and spatial landscapes of virus-associated diseases. Dr. SoRelle employs cutting-edge techniques such as single-cell RNA sequencing, spatial transcriptomics, and advanced microscopy to investigate EBV-driven pathologies like lymphomas and autoimmune diseases. Dr. SoRelle holds a PhD from Stanford University School of Medicine (2018), a BS and BA from Rice University (2012), and completed postdoctoral training at Duke University School of Medicine (2024). His research bridges fundamental virology with translational goals, aiming to inform treatments for EBV-associated diseases. Recent work includes defining EBV's role in reprogramming B cell fate via the EBNA3A/3C-EZH2 axis, dissecting lytic reactivation's impact on cancer stemness, and leveraging spatial biology to map tumor microenvironments. Collaborations with clinicians at U-M and beyond drive translational applications of these findings.

Yanhai Yinمشاهده پروفایل

استاد

• Plant Biology
• Brassinosteroid Research
• Molecular Biology
• +۳ مورد دیگر

Yanhai Yin is a Professor and Chair at Iowa State University, specializing in plant steroid hormone research, particularly focusing on brassinosteroids' roles in plant growth, stress responses, and crop improvement. His work integrates genetics, genomics, and computational methods using model plants like Arabidopsis. Collaborations include researchers at the Plant Sciences Institute (PSI), NSF, and NIH. He holds a B.S. from Sichuan University, an M.S. from the Chinese Academy of Sciences, and a Ph.D. from The Scripps Research Institute. Research interests center on brassinosteroid signaling pathways, autophagy regulation, FERONIA receptor kinases, and crop applications. Key projects include developing automated phenotyping tools (e.g., ROAD system) and understanding crosstalk between brassinosteroids and other pathways. His lab explores mechanisms linking hormone signaling to stress tolerance and yield enhancement in crops like wheat and maize. Articles highlight brassinosteroid-regulated gene networks, autophagy modulation, and FERONIA's role in immunity. He has pioneered methods for identifying target genes via ChIP-seq and RNA-seq. Grants from NIH, NSF, and PSI support his work. No specific awards are listed, but his contributions to plant biology are extensive.

Wentao Liمشاهده پروفایل

استادیار

• DNA Damage and Repair
• Mutagenesis
• Genomics
• +۳ مورد دیگر

Dr. Wentao Li is an Assistant Professor in the Department of Environmental Health Science at the University of Georgia's College of Public Health. His research focuses on mechanisms of DNA damage, repair, and mutagenesis across organisms from yeast to humans, employing genomics, biochemistry, bioinformatics, and machine learning. He leads the Li Laboratory, actively recruiting postdoctoral researchers and graduate students in bioinformatics and molecular biology. Dr. Li's work has been recognized with prestigious awards, including the 2024 SOT/AACT Outstanding Young Toxicologist Award and the 2023 James A. Swenberg Carcinogenesis Merit Award. Research interests include understanding how DNA repair processes interact with 3D genome organization, mitochondrial DNA fragmentation under UV damage, and the role of xenophagy in pathogen infections. His lab collaborates on projects involving aflatoxin-induced damage, transcription-coupled repair mechanisms, and comparative repair dynamics in bats versus humans. Publications highlight contributions to nucleotide excision repair mapping, UV damage effects, and computational models like Gp-gpt for gene-phenotype mapping. Awards also include the 2023 EMGS Newly Independent Investigators Engagement Program and a 2024 Presidential Graduate Fellowship for student Shan Jiang. Dr. Li oversees lab operations at the Paul D. Coverdell Center, with a focus on mentoring over a dozen students and technicians.

• RNA structure and function
• RNA splicing mechanisms
• RNA enzymes
• +۶ مورد دیگر

Anna Marie Pyle is a Sterling Professor at Yale University in the Departments of Molecular, Cellular and Developmental Biology and Chemistry. She is a Howard Hughes Medical Institute Investigator since 1997 and has held leadership roles including President of the RNA Society and Chair of the NIH MSFA Study Section. Her research focuses on RNA structure, RNA remodeling enzymes, and innate immune receptors. She has authored over 190 publications and mentored over 40 students/postdocs. **Education:** B.S. in Chemistry (Princeton University), Ph.D. in Chemistry (Columbia University, 1990). Postdoctoral training at the University of Colorado with Thomas Cech. Joined Yale in 2002. **Research:** Pioneered structural studies of group II introns and the spliceosome. Her lab investigates RNA tertiary structures, viral RNA biology, and RIG-I signaling. Key contributions include understanding RNA helicases, antiviral immunity, and lncRNA structural biology. Collaborates with industry (e.g., Arrakis Therapeutics) on RNA-based therapeutics. **Awards:** HHMI Investigator, National Academy of Sciences member, AAAS Fellow. Recognized for innovations in RNA structure-function relationships. **Grants & Labs:** Leads the Pyle Lab at Yale, funded by NIH and HHMI. Active in developing RIG-I agonists for cancer immunotherapy and antifungal drugs targeting RNA splicing.

• Microbiology
• Microbial Biotechnology
• Yeast Biotechnology
• +۷ مورد دیگر

Martin Altvater is a researcher at the Institute of Microbiology and Microbial Biotechnology within the Department of Biotechnology and Life Sciences at the University of Natural Resources and Life Sciences, Vienna (BOKU). He holds a Dr. sc. from ETH Zurich and a Dipl.-Biol., and his work focuses on microbial biotechnology, particularly yeast-based systems for sustainable bioproduction. His research spans ribosome assembly, fermentation technologies, and metabolic engineering for lactic acid production. His research interests include Microbiology, Microbial Biotechnology, Yeast Biotechnology, Ribosome Assembly, Sustainable Bioproduction, Lactic Acid Fermentation, Synthetic Biology, Industrial Biotechnology, Bioart, and Metabolic Engineering . These areas reflect a strong interdisciplinary focus on using microbial systems for industrial and environmental applications, particularly in the context of bioeconomy and sustainability. The trends in his recent publications highlight a dual focus: one on fundamental molecular mechanisms in yeast ribosome biogenesis and nuclear export, and another on applied biotechnological innovations for sustainable lactic acid production. His work integrates systems biology, metabolic engineering, and process optimization, often using Saccharomyces cerevisiae as a model and industrial host. A notable recent direction includes bioart collaborations, emphasizing science communication and public engagement. Scientific Awards: No specific awards or fellowships are listed in the available data. Advising and Grants: There is no public record of supervised theses or doctoral students. No research projects are currently listed under his name as principal investigator. However, he actively contributes to the scientific community as a reviewer for journals including Biotechnology Journal , Essays in Biochemistry , Bioengineering , BMC Biotechnology , and FEMS Microbiology Letters . Labs and Research Teams: Martin Altvater is affiliated with the Institute of Microbiology and Microbial Biotechnology at BOKU, where he conducts research in microbial systems and bioprocesses. He collaborates closely with leading researchers such as Diethard Mattanovich and Michael Sauer, known for their work in industrial biotechnology and systems biology. His work is embedded in a larger research ecosystem focused on sustainable bioproduction and synthetic biology.

• Epigenetics
• Bioinformatics
• Cancer Biology
• +۳ مورد دیگر

Helene Kretzmer is a Research Group Leader at the Max Planck Institute for Molecular Genetics and a faculty member of the International Max Planck Research School (IMPRS). Her work focuses on epigenetic regulation, particularly in the context of cell fate establishment and stabilization, with applications in early mammalian embryonic development and cancer biology. PhD in Bioinformatics from the University of Leipzig She utilizes advanced techniques such as single-cell RNA sequencing (scRNAseq) and whole-genome bisulfite sequencing (WGBS) to explore the molecular mechanisms underlying epigenetic changes. Her research contributes to understanding how epigenetic factors drive cellular differentiation and cancer progression. Helene joined Alex's research group in late 2017, bringing expertise in DNA methylation sequencing analysis developed during her involvement with the International Cancer Genome Consortium. Her lab, the Kretzmer Lab, is based in Berlin, Germany, where she investigates the intersection of computational biology, genomics, and developmental processes.

• Pharmaceutical Sciences
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Silvia Weiss is a researcher affiliated with the Faculty of Life Sciences at an unspecified institution, specifically within the Department of Pharmaceutical Sciences. Her work focuses on advanced drug delivery systems and genetic therapies. Research Interests: Utilizing splice-switching oligonucleotides for hepatic gene correction and developing degradable polypeptide architectures to enhance cellular uptake and biodistribution of therapeutic agents. Key areas include RNA processing, polymer science, and pharmacokinetics. Publications (2023-2025): Recent work explores endosomal escape mechanisms for efficient gene therapy and in vivo behavior of bottlebrush polypeptides. These studies contribute to pharmaceutical sciences, molecular biology, and biotechnology, with applications in hepatic disorders and targeted drug delivery.

• Biosensors
• Colloidal synthesis
• Diagnostics
• +۶ مورد دیگر

Laura Fabris is a Full Professor in the Department of Applied Science and Technology at the Polytechnic University of Turin. She serves as a member of the Interdepartmental Center PolitoBIOMed Lab - Biomedical Engineering Lab and leads research activities in the ERC Instrumental Chemical Analysis Laboratory. Her academic career spans cutting-edge research at the intersection of physics, chemistry, and biomedical engineering. Professor Fabris's research expertise focuses on plasmonic nanomaterials and their applications in advanced diagnostics. Her work centers on developing innovative biosensors using surface-enhanced Raman spectroscopy (SERS) with specialized metal nanoparticles. She investigates how light-matter interactions at the nanoscale can be harnessed for ultrasensitive detection of biological molecules, with particular emphasis on viral RNA detection and cancer biomarker identification. Her interdisciplinary approach combines principles from experimental physics, colloidal chemistry, and biomedical engineering to create next-generation diagnostic tools. Her publication record demonstrates significant contributions to the field of plasmonics and nanosensing, with influential review articles and original research on gold nanostar substrates, SERS mechanisms, and nanoparticle synthesis. Her work spans fundamental studies of plasmonic phenomena to applied research in medical diagnostics, establishing her as a leading expert in the field. STELLAR - SERS-based Technology for EarLy Liquid biopsy Analysis and Recognition (2025-2026) PHROGS - Hot Spot-Mediated Plasmonic Modulation of Viral RNA Polymerase Activity (2022-2027) ANFIBIO - ERC-2019-COG (2021-2026) NATIONAL TECHNOLOGY TRANSFER CENTER FOR ADVANCED TECHNOLOGIES FOR SUSTAINABILITY (2023-2035) Professor Fabris actively mentors six PhD students working on diverse projects related to plasmonic nanoparticles, biosensor development, and medical diagnostics. She also teaches Physics I for Automotive Engineering students across multiple academic years and participates in doctoral programs in Photoinduced Processes and Technologies and Bioengineering at both the Polytechnic University of Turin and the University of Perugia. Her laboratory research focuses on synthesizing and characterizing plasmonic nanomaterials, particularly gold nanostars, and applying them to solve critical challenges in medical diagnostics. Her team develops innovative approaches to modulate biological processes using light-activated nanomaterials, with potential applications ranging from early cancer detection to antiviral therapies.

Matthew Gillمشاهده پروفایل

دانشیار

• Aging
• Genetics of Aging
• Insulin Signaling
• +۵ مورد دیگر

Matthew Gill is an Associate Professor in the Department of Genetics, Cell Biology and Development within the College of Biological Sciences at the University of Minnesota, Twin Cities. He leads the Gill Lab as part of the Masonic Institute on the Biology of Aging and Metabolism and the Medical Discovery Team on Aging, focusing on translational aging research since their 2017 founding. Dr. Gill's research employs C. elegans to dissect fundamental aging mechanisms through genetic, chemical, and biochemical approaches. His lab discovered a novel alternatively spliced insulin receptor (DAF-2B) that acts as a decoy to sequester insulin ligands and modulate aging, alongside identifying an endocannabinoid signaling system in nematodes. Current work investigates DAF-2B's splicing regulation and mammalian conservation, bridging developmental processes like dauer formation with lifespan extension pathways. Analysis of his publication record (2014-2023) reveals consistent focus on insulin signaling dynamics, alternative splicing events, and lipid-based neuromodulation in aging. His work demonstrates how conserved pathways—particularly insulin/IGF-1 signaling and stress responses—can be targeted to influence longevity, with implications for age-related metabolic disorders and neurodegenerative conditions. Scientific Awards: No specific awards were mentioned in the provided sources. Dr. Gill advises PhD students including Tom Hodder (co-advised with Chad Myers), who develops geroprotector screening methods, and mentors postdoctoral researchers like Bryan Martinez studying DAF-2B regulation. His research is institutionally supported through the Masonic Institute and Medical Discovery Team on Aging, indicating sustained funding for mechanistic aging studies. Current grants focus on insulin receptor splicing mechanisms and cross-species conservation of aging pathways. The Gill Lab operates from Nils Hasselmo Hall, leveraging C. elegans genetics to explore therapeutic targets for human aging. Ongoing projects examine how environmental stressors interact with genetic factors to influence aging, with future work directed toward mammalian validation of decoy receptor mechanisms and drug discovery for age-related decline.

Hye Yoon Parkمشاهده پروفایل

دانشیار

• Biomedical Technologies
• RNA Regulation
• Neuroscience
• +۵ مورد دیگر

Dr. Hye Yoon Park is an Associate Professor in the Department of Electrical and Computer Engineering at the University of Minnesota. Her research focuses on developing advanced biomedical technologies for studying RNA regulation at the single-molecule and single-cell levels in living tissues and organisms. Research Interests Real-time imaging of gene expression dynamics Activity-dependent transcription in neural networks RNA localization and transport mechanisms Development of fluorescent RNA labeling systems Key Techniques Live-cell and in vivo imaging Genetic engineering of mouse models Quantitative single-molecule analysis Computational modeling of RNA transport Her recent publications highlight interdisciplinary approaches combining RNA biology, neuroscience, and nanotechnology, with particular emphasis on Arc and β-actin mRNA dynamics in neurons, optogenetic control of RNA condensation, and novel diagnostic tools like nanoparticle-enhanced QuIC assays for Parkinson's disease. She actively seeks graduate students for research and has developed specialized software such as HybTrack for particle tracking analysis.

Amy K. Schmidمشاهده پروفایل

استاد

• Archaeal Molecular Biology
• Gene Regulatory Networks
• Microbial Stress Responses
• +۴ مورد دیگر

Amy K. Schmid is Professor of Biology at Duke University's Trinity College of Arts & Sciences, where she leads a research program focused on archaeal molecular biology and gene regulatory networks. She was promoted to full Professor in 2024 after serving as Associate Professor (2018-2024) and Assistant Professor (2009-2018). She is also Associate of the Duke Initiative for Science & Society since 2018. Research Interests: Dr. Schmid's laboratory investigates how microbial cells make decisions in response to environmental cues, with particular focus on molecular networks within free-living archaeal cells. Her work examines how these extremophiles regulate growth under optimal conditions and deploy damage repair systems during stress. She specializes in studying archaeal stress responses, particularly in hypersaline-adapted organisms that survive multiple extreme stressors. Her publication trends reveal a consistent focus on transcriptional regulation in archaea, with increasing emphasis on network evolution, cell decision-making, and the structural basis of regulatory mechanisms. Recent work has expanded into archaeal cytoskeleton, histone function, and metabolic regulation under extreme conditions. Awards & Recognition: NSF CAREER Award (2017-2022) Promoted to full Professor at Duke University (2024) Named to Endowed Bass Connections Professorship (2022) Grant Support: Dr. Schmid maintains an exceptionally strong funding record with multiple concurrent grants from NIH and NSF. Her current major projects include 'Structure, function, and evolution of gene regulatory networks in archaea' (NIH, 2025-2030), 'Transcription network evolution under extreme environmental selection' (NSF, 2024-2027), and 'Transitions: Modeling microbial community metabolic interactions under extreme conditions' (NSF, 2021-2026). She has served as mentor for multiple NIH training grants including the Cell and Molecular Biology Training Program. Research Environment: The Schmid Lab operates at the intersection of microbiology, systems biology, and extremophile research, utilizing cutting-edge genomic, proteomic, and computational approaches to understand fundamental principles of cellular decision-making in archaea.

Richard A. Youngمشاهده پروفایل

استاد

• Gene Expression Regulation
• Transcriptional Regulatory Circuitry
• Biomolecular Condensates
• +۵ مورد دیگر

Richard A. Young is a Professor of Biology at the Massachusetts Institute of Technology and a Member of the Whitehead Institute where he has been since 1984. His laboratory studies the regulation of gene expression in health and disease, with particular focus on transcriptional regulatory circuitry and biomolecular condensates that control cell identity and function. His work bridges fundamental molecular mechanisms with therapeutic applications in cancer and other diseases. Young received his PhD from Yale University in 1975. His research has fundamentally transformed our understanding of gene regulation, particularly through the discovery of super-enhancers and the role of biomolecular condensates in transcriptional control. His work has revealed how defects in these regulatory mechanisms contribute to cancer, neurodevelopmental disorders, and chronic diseases. Young's laboratory investigates several interconnected research areas including transcriptional regulatory circuitry that controls gene expression programs specifying different cell types, the protein and RNA machinery controlling gene expression during development, and the role of biomolecular condensates in gene regulation. His team discovered that gene regulation occurs within non-membrane-bound organelles called biomolecular condensates, which has changed our understanding of cellular organization and led to new therapeutic concepts for disease treatment. His research publications reveal a consistent trajectory focusing on gene regulation mechanisms, with recent work emphasizing the role of biomolecular condensates in health and disease. His laboratory has made significant contributions to understanding how transcription factors, RNA, and chromosomal architecture work together to control gene expression, with implications for cancer therapeutics, chronic disease mechanisms, and protein compartmentalization. Developed technology to map human genome regulatory circuitry Discovered core regulatory circuitry of human embryonic stem cells Recognized among top 50 leaders in science, technology and business by Scientific American (2006) Elected member of the National Academy of Sciences (2012) Elected member of the National Academy of Medicine (2019) Burroughs Wellcome Scholarship Chiron Corporation Biotechnology Research Award Yale's Wilbur Cross Medal Young has mentored numerous postdoctoral fellows and graduate students who have gone on to successful careers in academia and industry. His laboratory receives substantial funding for research on gene regulation mechanisms and their implications for disease. The lab maintains valuable collaborations with scientists across multiple disciplines including basic biology, chemistry, physics, computing, and medicine, with physician-scientists representing multiple clinical specialties who contribute to the lab's mission of translating basic science discoveries into patient care advancements. The Young laboratory consists of scientists with diverse backgrounds in basic biology, chemistry, physics, computing, and medicine. The team includes physician-scientists who conduct clinical care in Boston's major hospitals while contributing to the lab's research mission. The laboratory maintains extensive collaborations with other talented scientists across multiple institutions and has developed important technologies for mapping regulatory circuitry and understanding biomolecular condensates in cellular function.

• Machine Learning
• Computer Vision
• Data Compression
• +۳ مورد دیگر

Don Adjeroh is a Professor and Associate Chair in the Lane Department of Computer Science and Electrical Engineering at West Virginia University (WVU). He serves as Graduate Coordinator for CS programs and has led multiple NSF-sponsored projects including Bridges in Digital Health and Multi-Scale Integrative Approach to Digital Health . His research focuses span Machine Learning , Bioinformatics , Computational Biology , and Data Compression . NSF CAREER Award recipient Collaborated with institutions like University of Central Florida and University of Canterbury Led workshops on Plant Image Analysis and Long Non-Coding RNA research His academic contributions include co-authoring the book The Burrows Wheeler Transform: Data Compression, Suffix Arrays, and Pattern Matching (Springer, 2008) and developing software tools like BSMP and PSA for data compression and protein family modeling. He teaches graduate-level courses in String Algorithms and Information Theory , with former projects involving undergraduate and graduate students in DNA microarray image processing and 3D video compression research. Key Scientific Awards : NSF CAREER Award NASA-WV Space Consortium funding WV-EPSCOR grants NSF-CITeR support DOD-ONR/DHS/DOJ/NIJ/NHPRC sponsorships

David Nesbittمشاهده پروفایل

استاد

• Physical Chemistry
• Chemical Physics
• Spectroscopy
• +۵ مورد دیگر

David Nesbitt is a Professor at the University of Colorado Boulder and a Physicist at the National Institute of Standards and Technology (NIST). He holds affiliations with JILA, a joint institute of NIST and CU Boulder, where he serves as a Fellow. His research spans four areas: High-Resolution Laser Spectroscopy, Chemical Reaction Dynamics, Quantum Nanostructures, and Single-Molecule Biophysics. Dr. Nesbitt earned his Ph.D. from the University of Colorado in 1981 and completed a postdoctoral fellowship at the National Bureau of Standards. His expertise includes Physical Chemistry, Chemical Physics, Spectroscopy, and Biophysics, with a focus on molecular dynamics and nanomaterials. 2024: High-Pressure Single-Molecule RNA Folding Studies 2023: Advances in Hot Carrier Control and Gas-Liquid Interface Dynamics 2022: Molecular Crowding Analysis and Photonic Nanomaterials Research Dr. Nesbitt has received numerous accolades, including Fellowship in the American Academy of Arts and Sciences and the American Physical Society. His work integrates experimental and theoretical approaches to understand fundamental chemical and biophysical processes. His laboratory employs cutting-edge technologies such as ultrafast pulsed lasers, confocal microscopy, and quantum theoretical calculations. Current projects include biophysics of riboswitches, plasmonic nanostar photocathodes, and spectroscopic analysis of reactive chemical intermediates.

Scott Chandlerمشاهده پروفایل

استاد

• Neuroscience
• Neurophysiology
• Movement Disorders
• +۳ مورد دیگر

Scott Chandler is a Professor in the Department of Integrative Biology and Physiology at the University of California, Los Angeles (UCLA). His research focuses on understanding the central nervous system's control of rhythmic movements and neurodegenerative diseases like ALS. B.S., Neurobiology, University of California, Berkeley Ph.D., Physiology/Neurophysiology, University of California, Los Angeles (1979) Chandler's research explores how small brainstem neuronal networks generate rhythmic movements (e.g., mastication, respiration) and how ion channels contribute to these processes. His lab investigates early ALS-related neuronal dysfunction using transgenic mouse models, aiming to identify molecular targets for drug therapies. 2023 study on GABA inhibition and L-type calcium currents in ALS mouse jaw neurons 2020 work on single-cell RNA-seq in ALS brainstem analysis 2019 publications on resurgent sodium currents and circuit-specific ALS impairments 2015 studies on sensory neuron enrichment and membrane homeostasis in ALS 2007-2009 work on Kv1 channels and Nav1.6 sodium currents in trigeminal neurons Chandler's lab combines electrophysiological recordings, computational modeling, and bioinformatics to unravel the cellular mechanisms underlying movement control and neurodegeneration.