جستجوی استاد راهنمای دانشگاهی

Julia Chamot-Rooke is a Principal Investigator and Researcher at the Institut Pasteur in Paris, France, affiliated with the Department of Structural Biology and Chemistry and the Mass Spectrometry for Biology unit (UTechS MSBio), a joint CNRS service and research unit (USR2000). She leads multiple projects in advanced proteomics and is the PI for the Institut Pasteur in the European Proteomics Infrastructure Consortium providing access (EPIC-XS). Her research focuses on developing innovative methods in top-down proteomics , cross-linking mass spectrometry , and structural proteomics to study intact proteins, post-translational modifications, and protein complexes. Her work has applications in microbiology, infectious diseases, and host-pathogen interactions. She has developed the ProteoCombiner software to integrate proteomics data for improved proteoform characterization. The recent publications reflect a strong emphasis on structural and functional proteomics , particularly in microbial systems and immune interactions. Trends include the use of advanced mass spectrometry techniques (HDX-MS, cross-linking MS, top-down MS) to investigate protein structure, dynamics, and interactions in pathogens and host systems. There is also a growing focus on software and tool development to enhance data analysis and reproducibility in proteomics. Principal Investigator, EPIC-XS at Institut Pasteur Coordinator, Joint Research Activity on Future and Emerging Proteomics Technologies Lead Developer, ProteoCombiner software She supervises PhD students and research engineers and collaborates widely on projects involving bacterial pathogenesis, immune evasion, and structural biology. Her lab is equipped with state-of-the-art Orbitrap mass spectrometers and participates in transnational access programs, providing cutting-edge proteomics services to the European research community.

• Proteomics
• Structural Biology
• Mass Spectrometry
• +۷ مورد دیگر

Benoit Arcangioli is a Researcher and Principal Investigator at the Institut Pasteur, affiliated with the Genomes and Genetics Department and the Genome Dynamics unit in Paris, France. He leads research projects on genome stability in quiescence and DNA methylation, using fission yeast as a model organism. Research Interests: His work focuses on understanding how DNA damage is repaired and how mutations arise in non-dividing (quiescent) cells, a state relevant to aging, cancer, and neurodegenerative diseases. He investigates epigenetic mechanisms such as DNA methylation and heterochromatin regulation, particularly in the context of cellular quiescence and genome dynamics. Publication Trends: His recent publications (2017–2023) reveal a strong focus on genome stability, mutagenesis in quiescent cells, epigenetic regulation, and DNA repair mechanisms in fission yeast. His research bridges molecular biology, genetics, and evolutionary biology, with implications for human aging and disease. Scientific Awards: No scientific awards mentioned in the provided text. Advising and Grants: Dr. Arcangioli has mentored several PhD students and postdoctoral fellows, including Célia Raimondi, Samia Miled, Rostyslav Makarenko, and Balveer Singh. He leads funded research projects such as 'Genome stability in quiescence' and 'Dynamics and biological function of deoxycytosine methylation' at the Institut Pasteur. Labs and Teams: He is part of the Genome Dynamics team within the Genomes and Genetics Department at the Institut Pasteur. His laboratory investigates the molecular mechanisms of quiescence, DNA repair, and epigenetic inheritance using *Schizosaccharomyces pombe* as a model system.

• DNA repair
• Genome stability
• Cellular quiescence
• +۷ مورد دیگر

Daniela Rotin is a Professor at the University of Toronto, affiliated with the Temerty Faculty of Medicine, and holds appointments in the Department of Biochemistry and the Department of Physiology. She is a senior scientist in the Cell Biology Program at The Hospital for Sick Children (SickKids) in Toronto, where her research focuses on ubiquitin ligases, particularly the Nedd4 family, and their roles in cellular regulation, epithelial physiology, and disease. Her research interests include cell biology, physiology, ubiquitylation, endocytosis, cystic fibrosis, autophagy, epithelial biology, ion channel regulation, and protein trafficking. She has made significant contributions to understanding the regulation of the epithelial sodium channel (ENaC) by ubiquitin ligases such as Nedd4-2, and the discovery of primate-specific splice isoforms like Nedd4-1(NE), which regulates autophagy in response to nutrient availability. Her recent publications highlight a strong trend in molecular mechanisms of ubiquitin ligase activity, stress signaling (e.g., p38-MAPK, WNK kinases), and cellular responses to osmolarity and ion imbalances. Her work integrates cell biology, biochemistry, and physiology to uncover novel regulatory pathways in health and disease, with implications for cystic fibrosis, hypertension, epilepsy, and cancer. Dr. Rotin has not been noted to have received specific scientific awards in the provided text, but her high citation metrics (h-index 33, i10-index 48, over 4,700 citations) reflect significant scholarly impact. She collaborates extensively with researchers at SickKids, the University of Toronto, and international institutions. She advises a research team studying ubiquitin-mediated proteostasis, and her lab has secured funding for projects on ENaC regulation, autophagy, and organoid models of epithelial disease. She leads a research group that utilizes advanced techniques including CRISPR-Cas9, proteomics, and iPSC-derived organoids. Dr. Rotin is actively involved in research through her laboratory at SickKids, where she investigates the molecular basis of protein trafficking, cellular stress responses, and the pathophysiology of epithelial disorders. Her team includes postdoctoral fellows, graduate students, and research associates working on ubiquitin ligases and their roles in development and disease.

• Cell Biology
• Physiology
• Ubiquitylation
• +۹ مورد دیگر

Sebastian Amigorena is a CNRS Research Director and Research Team Leader at Institut Curie, Paris , heading the Immune Responses and Cancer team (Unit: Immunity and Cancer, U932). His career spans fundamental immunology, cell biology, and translational cancer research. PhD in Paris (1990) Postdoctoral fellowship at Yale University Founded INSERM AVENIR group (1995) Research Focus : Interdisciplinary work at immunology-cell biology interfaces, pioneering antigen presentation and cross-presentation mechanisms in dendritic cells, T cell exhaustion dynamics, and transposable elements' role in anti-tumor immunity. His team uses cutting-edge approaches like RNAseq, ChIP-Seq, intravital microscopy, and mouse models. Publication Trends : Recent work emphasizes transposable elements, tumor immunity, and epigenetic regulation of T cell memory and exhaustion. Earlier studies established foundational knowledge in IgG receptor functions and dendritic cell phagocytosis. Scientific Recognition : 2025: Franco-Brazilian chair for CellAction's cell therapy platform 2021: Two RHU program awards for innovative cancer research Collaborations & Grants : Key partnerships with Mnemo Therapeutics (75M€ spin-off funding), CellAction platform, and CNRS. His team includes permanent researchers, engineers, and PhD student Darawan Tabtim-on . Laboratory : Investigates dendritic cell membrane transport, chromatin organization in T cell differentiation, and transposable elements' impact on tumor immunity. Technologies span proteogenomics, single-cell RNA-seq, and in vivo CRISPR screens.

• Immunology
• Cell Biology
• Antigen Presentation
• +۶ مورد دیگر

Sebastian Baumgarten is the Head of the 'Parasite RNA Biology' Group at the Institut Pasteur, France, a position he has held since June 2021. He is affiliated with the Department of Biology of Host-Parasite Interactions. Previously, he was a post-doctoral researcher at the same institute from 2016 to 2021. His educational background includes a Ph.D. (2013–2016) and MSc (2012–2013) from the Red Sea Research Center at King Abdullah University of Science and Technology, Saudi Arabia, and a BSc (2009–2012) from the University of Tübingen, Germany. His research centers on RNA biology in malaria parasites, particularly focusing on RNA modifications such as m6A and tRNA methylation, epigenetic regulation, and post-transcriptional gene control in Plasmodium falciparum . He employs advanced genomic techniques including CRISPR, RNAseq, and ChIPseq to study gene regulation and immune evasion mechanisms in protozoan parasites. His recent publications reveal a strong trend in understanding how RNA modifications influence parasite development, stress response, and antigenic variation. His work bridges molecular parasitology with epitranscriptomics, contributing significantly to the understanding of gene regulation in malaria parasites. Notable scientific contributions include studies published in Nature Microbiology , mBio , EMBO Reports , and Life Science Alliance , focusing on m6A methylation, RUF6 ncRNA interactions, and cohesin-mediated gene repression. He has supervised or collaborated with several researchers including post-doctoral fellows, PhD students, and technicians within his team. His group is actively involved in uncovering the molecular mechanisms of parasite survival and immune evasion, with potential implications for antimalarial drug and vaccine development. The 'Parasite RNA Biology' group operates within the Institut Pasteur's ecosystem, leveraging interdisciplinary platforms for genomics, imaging, and functional analysis to advance understanding of malaria parasite biology.

• RNA modifications
• Parasitology
• Malaria
• +۱۲ مورد دیگر

Laurence Murillo is a Lecturer at the University of La Rochelle, attached to the AMARE research team and affiliated with the INEE institute. His academic rank corresponds to Lecturer in the CNU 65 research section. His primary research interests include energy metabolism, cellular adaptation mechanisms, environmental factors, pesticides, and marine organisms. His publications focus on environmental impacts on marine species, pesticide neurotoxicity, metabolomics, and ion channel regulation. Recent studies explore AI applications in port ecosystem monitoring, metal contamination effects on bivalves, and pesticide synergy mechanisms. As coordinator of supervised projects since 2015, he mentors students including DUT intern T. Maunier. His research spans coastal ecology, neurotoxicology, and molecular biology, with no scientific awards mentioned in the provided texts.

• Energy metabolism
• Cellular adaptation mechanisms
• Environmental factors
• +۴ مورد دیگر

Prof. Jean-Louis Guéant is a Professor of Biochemistry-Molecular Biology at Université de Lorraine and Head of the Department of Biochemistry-Molecular Biology and Nutrition at the University Regional Hospital of Nancy. He specializes in Hepato-Gastroenterology and holds roles in national academic committees, including President of the National Commission of Medical Biology and a member of the National Academy of Medicine. His research focuses on vitamin metabolism (particularly B12 and folate), epigenetics, metabolic disorders, and their clinical implications in diseases like cancer, inherited metabolic disorders, and COVID-19 pathogenesis. Education: MD, PhD, DSc in Hepato-Gastroenterology. He has organized major international conferences, including FASEB SRC events, and serves on editorial boards for journals like Hum Genet and Nutrients . His work has led to over 450 PubMed publications (H-index 71), with a focus on one-carbon metabolism, epigenetic mechanisms, and clinical applications. Research interests include fetal programming effects of nutrient deficiencies, mechanisms of vitamin B12/folate transport, and epigenetic modifications in diseases. He discovered the 'Epi-cblC' disorder, an epigenetic mutation affecting MMACHC gene expression. His lab explores therapeutic strategies targeting SIRT1 for metabolic disorders and investigates biomarkers for hepatocellular carcinoma and drug hypersensitivity. He has received major awards including the Sigrid Juselius Distinguish Scientist Award and AGAF Award. Grants include European projects (HDHL, DrNanoDall) and ANR initiatives totaling ~€2.5M. Lab activities involve collaborations in molecular biology, bioinformatics, and clinical research.

• Vitamin Metabolism
• Epigenomics
• Metabolic Disorders
• +۴ مورد دیگر

Didier Mazel is a Researcher and Head of the Plasticity of the Bacterial Genome unit at the Institut Pasteur in Paris, France, within the Genomes and Genetics Department. He leads a research team investigating bacterial genome dynamics, particularly in the context of antibiotic resistance and evolution. His research focuses on integrons—natural genetic systems that capture and express genes, notably those conferring antibiotic resistance—and the unique two-chromosome genome of Vibrio cholerae . His team employs genetic and post-genomic approaches to study gene recombination, stress responses, and chromosome maintenance. Key research areas include the molecular mechanisms of integron recombination, the impact of sub-inhibitory antibiotic concentrations on bacterial stress responses, and the coordination of dual chromosome replication in Vibrio species. They have also developed novel antimicrobial technologies targeting resistant pathogens. Dr. Mazel’s recent publications (2024–2025) reveal significant insights into integron function as biobanks of antiphage defense systems, the mechanical regulation of recombination efficiency, toxin-antitoxin control of gene cassette dynamics, and tRNA modifications linked to antibiotic tolerance. His work bridges fundamental molecular biology with applied antimicrobial strategies. He is actively involved in teaching, contributing to the Pasteur Institute’s genome analysis course and a MOOC on antibacterial resistance. He mentors several PhD students and postdoctoral researchers and leads multiple research projects, including Definbank, Chromintevol, and studies on Vibrio genome plasticity. His research is supported by institutional and national funding, and he collaborates within interdisciplinary programs such as Labex IBEID and INCEPTION, focusing on emerging infectious diseases and integrative biology. His laboratory is equipped with advanced imaging and molecular analysis tools.

• Bacterial Genome Plasticity
• Antibiotic Resistance
• Integrons
• +۱۲ مورد دیگر

Philippe Bouvet is a Professor at École normale supérieure de Lyon (ENS de Lyon) and a CNRS researcher, with dual roles as a scientific adviser at the National Research Agency (ANR). His research focuses on molecular biology, cancer mechanisms, nucleolin functions, and ribosome biogenesis. He earned his PhD from the University of Rennes, followed by postdoctoral studies at NIH. Key contributions include nucleolin targeting in pancreatic cancer, RNA stability studies, and innovations in super-resolution microscopy. Bouvet leads CRCL cancer research and chairs ANR’s biochemistry evaluation committees. He was honored as an Institut universitaire de France member (2005). Research interests span nucleolin’s role in cancer immunosuppression, ribosome alterations under drug treatments, and epigenetic regulation via histone variants like MacroH2A1. His work integrates nanomedicine for targeted drug delivery and advanced imaging techniques like dSTORM. Collaborations include CRCL, Joliot Curie Lab, and ANR initiatives. Recent articles highlight nucleolin-based therapies, ribosome-drug interactions, and fluorescent probe development.

• Molecular Biology
• Cell Biology
• Cancer Research
• +۳ مورد دیگر

Hirai Kenji is an Associate Professor at Hokkaido University's Research Institute for Electronic Science and Graduate School of Information Science and Technology, where he leads research in nanomaterials, photonics, and strong coupling phenomena. He also holds a Visiting Associate Professor position at National Yang Ming Chiao Tung University's Department of Applied Chemistry in Taiwan. His interdisciplinary work bridges chemistry, materials science, and photonics to develop novel functional materials and devices. Ph.D. in Synthetic Chemistry and Biological Chemistry, Kyoto University (2013) Master's in Synthetic Chemistry and Biological Chemistry, Kyoto University (2010) Bachelor's in Industrial Chemistry, Kyoto University (2008) Professor Hirai's research focuses on vibrational strong coupling and polaritonic chemistry , exploring how molecules interact with optical cavities to alter chemical reactivity and material properties without external light sources. His work demonstrates that placing molecules in optical cavities creates hybrid light-matter states (polaritons) that can significantly modify chemical reactions, self-assembly processes, and crystal polymorphism. This innovative approach has opened new pathways for controlling molecular behavior at the quantum level, with applications ranging from selective chemical synthesis to advanced optical devices. His recent publications show a clear evolution toward polaritonic chemistry, with increasing emphasis on cavity quantum electrodynamics applications. The research spans from fundamental studies on vibrational strong coupling effects to practical applications in plasmonics, photonic memory devices, and biomedical sensing. A notable trend is the integration of strong coupling phenomena with nanoscale materials engineering, particularly in graphene-based systems and metal-organic frameworks. Photonics Encouragement Award, Japan Society of Applied Physics (2022) New Chemical Technology Research Encouragement Award (2020) Reaxys Ph.D. Prize 2013 Finalist Multiple poster and presentation awards at coordination chemistry and colloid science symposia Professor Hirai leads multiple significant research projects, including the JSPS Transformative Research Areas grant 'Strong Coupling at Meso-Hierarchy' (2023-2028) and the JSPS Grant-in-Aid for Scientific Research 'Enhancement of ionic conductivity using quantum optical phenomena with optical resonators' (2021-2024). He serves on the Early Career Advisory Board for ChemPlusChem and as an editor for the Japan Society of Applied Physics' Organic Molecules and Bioelectronics Division. His international collaborations span institutions in Belgium, the United States, and Taiwan, reflecting the global impact of his research in cavity quantum electrodynamics and materials chemistry. His laboratory at Hokkaido University focuses on developing experimental platforms for studying strong coupling phenomena at multiple length scales, from single molecules to mesoscale assemblies. The research group combines expertise in nanofabrication, optical spectroscopy, and materials synthesis to create novel photonic and electronic devices based on quantum optical effects.

• Nanomaterials
• Photonics
• Self-assembly
• +۷ مورد دیگر

Marc Fontecave is a distinguished Professor at the Collège de France, where he holds the Chemistry of Biological Processes Chair since 2008. He heads the Chemistry of Biological Processes Laboratory, a joint research unit of the Collège de France-CNRS-Sorbonne University. Previously, he was a professor at Grenoble's Joseph-Fourier University starting in 1988, where he created and ran the Laboratoire de chimie et biologie des métaux at CEA-Grenoble. His educational background includes being a former student of the École normale supérieure de l'enseignement technique, where he obtained the agrégation de sciences physiques, option chimie, in 1978. He earned his PhD in 1984 and completed a postdoctoral fellowship at the Karolinska Institute in Stockholm, Sweden (1985-1986). Professor Fontecave specializes in chemistry at the interface with biology, studying the structure and reactivity of complex enzymatic sites - metal centers within metalloenzymes and organic cofactors within flavoenzymes. His research encompasses metabolic and biosynthetic pathways such as cofactor biosynthesis and RNA modification. Through a bioinspired approach, he develops new molecular and solid catalysts for electrochemical solar energy storage technologies, including water decomposition into oxygen and hydrogen, and CO2 electrolysis. His recent publications and lectures focus on artificial photosynthesis, CO2 conversion to fuels, hydrogen production, and energy transition strategies. His work bridges fundamental biochemical research with practical applications for sustainable energy solutions. Winner of the Energy Transition Award 2024 Professor Fontecave actively advises students and researchers in his laboratory, guiding work on bioinspired catalysts, energy storage systems, and sustainable fuel production. His research has been supported by numerous grants from French and international funding agencies focused on energy transition and sustainable chemistry. He leads the Chemistry of Biological Processes Laboratory, which brings together interdisciplinary teams of chemists, biologists, and materials scientists working on the interface of biological processes and chemical applications for energy solutions.

• Bioinorganic Chemistry
• Artificial Photosynthesis
• Catalysis
• +۷ مورد دیگر

Nishana Mayilaadumveettil is an Assistant Professor at the School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram , focusing on chromatin organization, nuclear structure, and their roles in disease mechanisms. Her lab investigates how chromatin interactions regulate cellular processes and contribute to cancer and aging. Education : PhD in Biochemistry (IISc Bangalore), MSc in Microbiology (Kannur University), BSc in Microbiology (Kannur University) Research Interests : Chromatin dynamics, epigenetic regulation, DNA repair, cancer genomics Her work spans chromosomal interactions, 3D genome organization, and the role of non-B DNA in translocations. Recent studies highlight her contributions to understanding RAG complex regulation and CTCF-RNA interactions. Scientific Awards : ICMR Investigator-Initiated Research Proposal (2024) CSIR ASPIRE Grant (2024) SERB Start-up Grant (2023) Best Oral Presentation at NYU Langone (2020) National Cancer Center Grant (2017) Multiple Best Poster Awards (2013, 2012, 2011) She leads the Chromatin Biology Lab (CBL) at IISER TVM, mentoring students in chromatin research and utilizing multi-omics approaches for cancer studies.

• Chromatin Biology
• Nuclear Organization
• Genomic Regulation
• +۴ مورد دیگر

Gilles Charvin is a Researcher at the University of Strasbourg, leading the Quantitative Biology of Cell Growth team within the Molecular Genetics, Genomics, and Microbiology (GMGM) department under the Faculty of Life Sciences. His work focuses on fundamental cellular processes regulating growth, stress adaptation, and replicative senescence using yeast as a model organism.

• Cell Biology
• Genetics
• Aging
• +۶ مورد دیگر

Vincent Cantagrel is a Research Professor and Lab Director (DR2 INSERM) at the Université Paris Cité, leading the Developmental Brain Disorders Laboratory affiliated with Necker Hospital and the Imagine Institute. His work focuses on genetic and molecular mechanisms underlying neurodevelopmental disorders, including intellectual disability, autism spectrum disorder, and cerebellar defects. He uses advanced genetic tools and animal models (zebrafish, mice, yeast) to identify disease-causing mutations and study their effects on brain development. Education: PhD in Human Genetics, postdoctoral training at UCSD with Prof. Joseph Gleeson. Collaborates closely with departments of Genetics, Neurology, and Pediatrics at Necker Hospital. His team includes 12+ researchers and clinicians, specializing in genetic screening, molecular biology, and neurobiology. Research interests emphasize cerebellar development, protein glycosylation defects, and genetic diagnostics. Key projects include identifying genes for cerebellar atrophy, studying N-glycosylation disorders, and translating findings into clinical diagnostics. Publications highlight discoveries in genes like SNX14, FRRS1L, and CACNA1G, linking genetic mutations to cognitive and motor impairments. The lab also develops diagnostic strategies using whole-exome sequencing and bioinformatics. Labs/Teams: Directs the Developmental Brain Disorders Laboratory, fostering interdisciplinary collaborations in Paris and internationally.

• Neurodevelopmental Disorders
• Genetics
• Molecular Biology
• +۳ مورد دیگر

Jessica Bryant is a Research Fellow in the Biology of Host-Parasite Interactions Unit within the Department of Parasites and Insect Vectors at the Institut Pasteur, Paris. She conducts cutting-edge research on epigenetic and transcriptional regulation in Plasmodium falciparum , the deadliest malaria parasite, focusing on the var multigene family and antigenic variation. Ph.D. in Cell and Molecular Biology, University of Pennsylvania (2008–2014) B.S. in Cellular Biology, University of Georgia (2004–2008) Her research expertise lies in chromatin biology, gene regulation, and CRISPR-based technologies in parasitology. She investigates how epigenetic mechanisms control virulence gene expression and immune evasion in malaria parasites. Her work integrates molecular biology, genomics, and functional assays to dissect transcriptional networks in Plasmodium . The recent publications highlight a strong focus on CRISPR applications, m6A mRNA methylation, noncoding RNA regulation, and chromatin remodeling in Plasmodium . These studies reveal complex regulatory layers controlling antigenic variation and stage-specific gene expression, with implications for malaria pathogenesis and therapeutic development. Scientific Awards and Fellowships: EMBO Long-term Postdoctoral Fellowship (2015–2017) Institut Pasteur Roux-Cantarini Postdoctoral Fellowship (2015–2016) Goldwater Scholar (2008) Biomedical Graduate Studies Travel Grant (2012, 2013) University of Pennsylvania Genetics T32 Training Grant (2010–2012) Jessica Bryant has contributed significantly to mentoring and scientific community building, having served as Departmental Postdoc Representative at the Institut Pasteur. She has taught epigenetics and next-generation sequencing courses at Sorbonne University and the University of Bern. She co-organized the international CRISPR in Parasitology Symposium, fostering collaboration across the field. Her research is supported by prestigious grants and conducted within a leading parasitology research unit, with no indication of retirement or former status.

• Parasitology
• Epigenetics
• Gene Regulation
• +۷ مورد دیگر