جست‌وجوی استاد و پژوهشگر

Haissi Cuiمشاهده پروفایل

استادیار

• RNA Maturation
• Protein Synthesis
• Inflammation Biology
• +۵ مورد دیگر

Haissi Cui is an Assistant Professor in the Department of Chemistry at the University of Toronto. Her research focuses on understanding RNA maturation and decoding processes in disease contexts, combining chemical tools, protein engineering, and cell biology. She leads the Cui Lab, which explores how RNA and protein localization impact inflammation, neurological diseases, and developmental disorders. Education: PhD (Dr. rer. nat.) in Experimental Medicine from Technical University of Munich, with postdoctoral training at Scripps Research Institute and Technical University of Munich. Affiliations: Principal Investigator at University of Toronto, Department of Chemistry. Research interests include aminoacyl-tRNA synthetases, tRNA regulation, and nuclear organization. Her lab has developed chemical tools to study mRNA splicing and metabolic pathways linked to disease. Recent work highlights the role of arginyl-tRNA synthetase in inflammatory processes and RNA splicing. Key achievements include a Nature Cell Biology paper on arg-tRNA synthetase’s role in inflammation, and a cover article on metabolic regulation of mRNA splicing. Awards include Human Frontiers Science Program and Deutsche Forschungsgemeinschaft fellowships. Scientific Awards: CIHR Postdoc Fellowship, Paul Schimmel Scholarship, Ontario Graduate Scholarship, NSERC USRA. Lab Members: Includes PhD students (Noha, Santiago, Samuel, Qingyu, Colette), postdocs (Jamie), and undergraduates across multiple projects. Grants & Funding: Supported by fellowships and institutional grants for interdisciplinary research initiatives. Collaborative efforts include work on non-viral mRNA delivery and structural biology. The lab emphasizes diversity and outreach through initiatives like ChemClub and Women in Science programs.

Furqan M Fazalمشاهده پروفایل

استادیار

• RNA biology
• Mitochondrial gene expression
• Nuclear membrane-less organelles
• +۵ مورد دیگر

Furqan M Fazal is an Assistant Professor and CPRIT Scholar in Cancer Research at Baylor College of Medicine in Houston, Texas. He leads the Fazal Lab within the Department of Biochemistry and Molecular Pharmacology , focusing on RNA subcellular localization mechanisms and their implications in disease. His work bridges biochemical, genomic, and computational approaches to decode RNA organization. Core member of the Therapeutic Innovation Center (THINC) Faculty member at Dan L Duncan Comprehensive Cancer Center Affiliated with Chemical, Physical & Structural Biology and Cancer & Cell Biology Graduate Programs Research Interests center on: Transcriptome-wide RNA subcellular localization Regulation of mitochondrial gene expression RNA localization in nuclear membrane-less organelles Local translation mechanisms and RNA modifications Key Publications reveal trends in: APEX-seq technology for spatial RNA mapping Mitochondrial RNA interactions in disease RNA structural dynamics across compartments Scientific Awards : CPRIT First-time Tenure-track Faculty Award ($2M) NIH K99/R00 Pathway to Independence Award Welch Research Grant Education : Postdoctoral Fellowship (2021-present), PhD (Stanford 2015), MS (Stanford 2010), BA (Amherst College 2008)

• Hematology
• Oncology
• Immunology
• +۵ مورد دیگر

Krzysztof Giannopoulos is a Professor at the Department of Experimental Haematooncology, Faculty of Medicine, Medical University of Lublin. His expertise lies in hematology and oncology, focusing on leukemia, immunotherapy, and molecular mechanisms of cancer. He leads research in chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), and multiple myeloma, emphasizing treatment resistance, immune modulation, and translational medicine. Research Interests: Immunological aspects of hematological malignancies Targeted therapies and immune checkpoint inhibitors Genetic and microbiome factors in cancer prognosis Novel therapeutic approaches in refractory diseases Clinical trials evaluating drug efficacy and patient outcomes Recent Publications Highlight Trends in: Molecular mechanisms of treatment resistance (e.g., PD-1/PD-L1, HLA-G) Impact of microbiota composition on cancer progression Development of T-cell engager therapies Prognostic biomarkers in CML and CLL Labs/Teams: Active in the Department of Experimental Haematooncology, collaborating internationally on clinical studies like the POMOST and SEQUOIA trials. His work integrates genomic, proteomic, and immunological approaches to advance cancer care.

Justin Kinneyمشاهده پروفایل

دانشیار

• Biophysics
• Machine Learning
• Sequence-Function Relationships
• +۱ مورد دیگر

Justin Kinney is an Associate Professor at Cold Spring Harbor Laboratory and Interim Chair of the Simons Center for Quantitative Biology. His research combines mathematical theory, machine learning, and experiments to study gene regulation mechanisms. Research Focus: The Kinney Lab develops DNA sequencing tools to dissect biophysical mechanisms of gene regulation, with applications in bacterial transcriptional regulation and alternative mRNA splicing in humans. This work has implications for understanding diseases like Spinal Muscular Atrophy and Cancer. Key Methods: Massively Parallel Reporter Assays (MPRAs), information theory approaches, and machine learning algorithms for analyzing multiplex assays of variant effect (MAVEs). Education: Ph.D. in Physics from Princeton University B.A. in Physics and Mathematics from Cornell University Publication Trends: Recent work focuses on developing interpretable machine learning models for genomic data, biophysical modeling of sequence-function relationships, and mechanistic studies of splice-modifying drugs. Articles demonstrate strong cross-disciplinary integration of physics, computational biology, and molecular genetics.

Erika Tse-Luen Weeمشاهده پروفایل

عضو هیئت علمی

• Fluorescence Imaging
• Microscopy Technology Development
• 4D Imaging
• +۵ مورد دیگر

Erika Tse-Luen Wee is a Research Assistant Professor and Director of the Microscopy Shared Resource at Cold Spring Harbor Laboratory (CSHL). She specializes in developing advanced fluorescence imaging techniques to study cellular and tissue mechanisms in cancer, neuroscience, and plant biology. Her work focuses on 4D live-cell imaging, 3D tissue imaging, and super-resolution microscopy. She also provides training in advanced microscopy modalities and software for image analysis. Education: Ph.D. in Biomedical Sciences from National Tsing Hua University (2009). Professional roles include prior positions as Manager of the Microscopy Shared Resource, Manager & Microscopy Specialist at McGill University (2013-2019), and academic appointments in Canada and the U.S. She leads efforts in standardizing microscopy quality assurance protocols and collaborates on imaging-based cancer and neuroscience research. Research Interests: Development of cutting-edge microscopy tools for quantifying molecular interactions, protein localization, and cell-cell signaling. Her technical expertise spans live-cell imaging, organoid analysis, and high-resolution 3D imaging. She emphasizes reproducibility and optimization of imaging techniques to minimize phototoxicity and enhance data accuracy. Key Contributions: Pioneered protocols for microscope quality management, developed imaging standards for 3D tissue analysis, and advanced understanding of cellular adhesion dynamics and synapse remodeling. Her work bridges technological innovation with biological discovery, particularly in cancer metastasis and neurodegenerative processes. Labs/Teams: Directs the Microscopy Shared Resource and oversees the Wee Laboratory at CSHL, providing infrastructure and training for imaging-based research across multiple disciplines.

• Developmental Neurobiology
• RNA Regulation
• Hox Gene Function
• +۴ مورد دیگر

Claudio Alonso is a Professor of Developmental Neurobiology at the University of Sussex's School of Life Sciences. He leads the Alonso Lab, focusing on molecular mechanisms controlling gene function in neural development, particularly RNA regulation of Hox genes. His research explores how RNA processing (e.g., splicing, polyadenylation, microRNA regulation) shapes neural circuits and behavior in model organisms like Drosophila. Academic roles include Head of the Department of Neuroscience (2022–2023), Chair of the Neuroscience Subject Group (2017–2022), and prior positions at the University of Cambridge (2005–2007) and Sussex (2008–2023). His work spans over 48 publications, with recent focus on microRNA roles in embryonic movement and post-developmental behavior. Research interests include: RNA regulation's role in neurodevelopment, Hox gene function across development, and mechanisms linking gene expression to complex behaviors. Major contributions include defining microRNA-Hox gene modules controlling movement and uncovering post-developmental roles of Hox genes in adult behavior. Grants include £2.4M from BBSRC (2024–2028) for Hox gene function studies and MRC funding (2016–2023) for Drosophila models of Huntington's disease. He teaches the 'Principles of Neuronal Function' course and supervises an international team of PhD students/postdocs in molecular genetics and neurobiology. Labs/teams: The Alonso Lab integrates biochemistry, genetics, and computational approaches to study RNA regulation's impact on neural circuit formation and behavior.

Kif Liakath-Aliمشاهده پروفایل

مدرس

• Regulation of RNA Splicing
• Neurodegeneration
• Molecular Biology
• +۷ مورد دیگر

Dr. Kif Liakath-Ali is a Lecturer in Advanced Cell Biology at the University of Southampton's School of Biological Sciences and serves as a Principal Investigator at the Splice Lab. He was appointed in May 2024 and leads a research team focused on RNA splicing mechanisms and their implications in neurodegenerative diseases. His lab is located in Building 85 on the Highfield Campus. Prior to his current position, he earned a PhD from the University of Cambridge, where he studied skin biology and ribosome-rescue machinery in epidermal stem cells under Professor Fiona Watt. He then conducted postdoctoral research at Stanford University (2018–2024) under Nobel Laureate Thomas Südhof, investigating molecular neuroscience and synaptic splicing regulation. Dr. Liakath-Ali holds a Stanford Postdoctoral Teaching Certification and an Associateship of King's College London (AKC). He is dedicated to research rigor, reproducibility, and open science, reflected in his RaRe Researcher Award (2024) and Stanford Bio-X Mentor Award (2021). He is also an elected member of the UK Young Academy (2025). His teaching responsibilities include courses on genetic information flow (BIOL2010), neuroscience principles (BIOL2051/52), scientific thinking (BIOL1030), and advanced research projects (BIOL6013, BIOL6099). His research integrates molecular biology, biochemistry, genetics, microscopy, and computational tools to uncover RNA splicing roles in spliceopathies. Recent work includes studies on teneurin/latrophilin signaling in hippocampal development, GRK2's role in skin homeostasis, and cerebellin-neurexin interactions in synaptic plasticity. He collaborates with interdisciplinary groups such as the Precision Biosciences Innovation Hub and the UK Young Academy to advance therapeutic discovery and scientific practices. PhD Supervision: Accepting applications for PhD students. Awards: EMBO Fellowship (2018), Hillblom Fellowship (2020), RaRe Award (2024), Bio-X Mentor Award (2021), UK Young Academy Membership (2025). Grants & Advising: His research is supported by fellowships, and he advocates for reproducible science. The Splice Lab, under his leadership, actively explores RNA splicing's role in neurodegeneration and therapeutic applications. Visit www.splicelab.co.uk for more details.

Brendan Freyمشاهده پروفایل

استاد

• Machine Learning
• Bioinformatics
• Genomics
• +۳ مورد دیگر

Brendan Frey is a Professor in the Departments of Communications and Biomedical Engineering at the University of Toronto, cross-appointed in the Banting and Best Department of Medical Research, the Centre for Cellular and Biomolecular Research, and the Department of Computer Science. He holds the Edward S. Rogers Sr. Endowed Chair in Engineering and is a Canada Research Chair (Tier 1). His research focuses on developing machine learning algorithms for addressing challenges in genome biology, including gene expression analysis, alternative splicing inference, and computational modeling of biological systems. Notable contributions include the sum-product algorithm, affinity propagation, and image epitomes techniques. Frey’s awards include the John C Polanyi Award, NSERC Steacie Fellowship, and Fellowships from AAAS and IEEE. He advises six graduate students and two postdoctoral fellows, many of whom have become prominent academics and industry leaders. Education: Studies in Canada, United States, and United Kingdom (specific degrees not listed). Consulting: Technical Advisor to Microsoft Research India and consultant for international companies.

Susan A Martinisمشاهده پروفایل

استاد

• Enzymology
• Molecular Evolution
• Protein-Nucleic Acid Interactions
• +۷ مورد دیگر

Susan A. Martinis is the Vice Chancellor for Research and Innovation and holds the Stephen G. Sligar Professorship in Biochemistry at the University of Illinois. She is affiliated with the Chemistry department and Biomedical and Translational Sciences. Her research focuses on tRNA synthetases, RNA-protein interactions, and mechanisms underlying protein synthesis fidelity. Her work explores both enzymatic accuracy and novel roles of these ancient proteins in cellular processes like RNA splicing and muscle regeneration. Education: B.S. (1985, Washington State University), Ph.D. (1990, University of Illinois), Postdoc (1990, MIT). Her research spans enzymology, molecular evolution, and biotechnological applications of engineered amino acids. Notable collaborations include studies on SARS-CoV-2 transmission at universities and the role of leucyl-tRNA synthetase in skeletal muscle regeneration. Her articles address topics like RNA splicing mechanisms, extremophile enzyme adaptations, and clinical impacts of tRNA synthetase mutations. She leads a research group investigating the dual functions of tRNA synthetases in both protein synthesis and alternate cellular roles.

Raven H Huangمشاهده پروفایل

استاد

• Bioinformatics
• Drug Discovery
• Enzymology
• +۹ مورد دیگر

Raven H Huang is a Professor in the Department of Biochemistry at the University of Illinois, with an affiliate appointment in Chemistry. His research focuses on molecular mechanisms of biological conflicts, particularly defensive systems employed by bacteria in conflicts both between organisms and between organisms and viruses. Education: B.S. and M.S. (1986) from Nankai University Ph.D. (1995) from University of Washington Postdoctoral training (1996-1999) at Harvard University Dr. Huang's research centers on bacterial defense mechanisms against biological threats. His work explores how bacteria employ offensive and defensive weaponry during conflicts for survival and competitive advantage. Specifically, his laboratory investigates RNA repair systems that allow bacteria to survive toxin attacks, as well as antiphage defense systems that bacteria use against viral infections. His research has revealed important insights into how protein translation machinery serves as a battlefield for these conflicts, with particular focus on ribotoxins, RNA repair mechanisms, and abortive infection systems. Analysis of Dr. Huang's recent publications reveals a strong focus on RNA biology within the context of bacterial defense systems. His work spans structural characterization of RNA repair enzymes, molecular mechanisms of antiphage defense, and the role of tRNA modifications in immune regulation. The research employs diverse methodologies including cryo-electron microscopy, biochemical characterization, and structural analysis to understand how bacteria defend themselves against biological threats at the molecular level. Dr. Huang's laboratory investigates the molecular basis of biological conflicts, with particular emphasis on: Discovery of new RNA repair systems Mechanistic understanding of RNA repair processes Identification of novel antiphage defense systems Characterization of bacterial suicide mechanisms during phage infection Analysis of how protein translation machinery serves as a battleground in biological conflicts

• Neuromuscular Disorders
• Genetic Diseases
• Molecular Biology
• +۳ مورد دیگر

Dr. Fran Evesson is a Senior Lecturer at the School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, affiliated with the Kids Neuroscience Centre. Her research focuses on understanding inherited neuromuscular disorders using cell and animal models to develop precision therapies for conditions lacking treatments. She coordinates courses including AMED3888 and contributes to SOMS4102 and AMED3003/3903 instruction. Her core research investigates protein dysfunction in skeletal muscle, genetic disease mechanisms (particularly splicing abnormalities), and therapeutic interventions. Key areas include neuromuscular pathology, molecular biology of muscle repair, and genotype-phenotype correlations in muscular dystrophies. Methodologies span cellular/molecular approaches, pathogenesis studies, and protein trafficking analysis. Her publications (2019-2025) demonstrate consistent focus on genetic basis of muscle disorders, with recurring themes in RNA splicing defects, animal model validation, and diagnostic genomics. Recent work emphasizes novel gene-disease associations and therapeutic target identification through advanced sequencing technologies. Dr. Evesson mentors Honours/PhD students and junior researchers at Kids Neuroscience Centre. She has secured research funding including: 2019 NHMRC Ideas Grant: 'A new class of genetic splicing variant underlying inherited disorders and cancer' 2018 Muscular Dystrophy Association grant: 'PYROXD1; a novel cause of congenital myopathy'

Tore Jahnsenمشاهده پروفایل

استاد

• cAMP-dependent protein kinases
• Protein kinases
• Sperm motility
• +۵ مورد دیگر

Tore Jahnsen is a Professor in the Department of Biochemistry at the University of Oslo. His research focuses on cAMP-dependent protein kinases (PKA), their regulation, structural biology, and roles in cellular processes such as sperm motility and signal transduction. He has collaborated widely, including with Professor Bjørn S. Skålhegg, and leads a research group of 9 members (technicians, students, and postdocs). He serves on the boards of Rheumatech AS and Spermatech AS. Education: Dr.med. (Ph.D.) in 1983 and Cand.med. (M.D.) in 1982 from the University of Oslo's Faculty of Medicine. His doctoral thesis examined adenylyl cyclases in rat testes. Research interests include PKA structure/function, phylogenetic analysis of catalytic subunits, heterogeneity in PKA genes (with implications for diagnostics/therapeutics), and human sperm metabolism/capacitation. His work spans biochemistry, molecular biology, and reproductive biology. Recent publications (2013–2007) highlight studies on PKA evolution, mutations in PKA genes, sperm glycolysis regulation, and roles of PKA in pre-mRNA splicing and T lymphocytes. His 1991 Anders Jahres Award recognized contributions to early-career science. Advising and grants: Supervises Ph.D. and master's students. Research group includes medical students and postdocs. Collaborates internationally on projects involving protein kinase signaling and reproductive biology. Research teams: Active in the 'cAMP and PKA' research group at the University of Oslo, exploring PKA's role across biological systems.

Florian Heydمشاهده پروفایل

استاد

• RNA Biochemistry
• Alternative Splicing
• Temperature-Dependent Regulation
• +۴ مورد دیگر

Florian Heyd is a Professor of RNA Biochemistry at the Freie Universität Berlin, part of the Department of Biochemistry within the Faculty of Biology, Chemistry and Pharmacy. His research focuses on RNA biochemistry, particularly the role of temperature in regulating alternative splicing and its implications for neurodegenerative diseases and cellular processes. Heyd earned his PhD from Essen University in 2006 and conducted postdoctoral research in Montreal and Dallas/Philadelphia before establishing his independent lab at Philipps-Universität Marburg with an Emmy-Noether Fellowship from the DFG in 2011. Since 2013, he has led the Heyd Group at FU Berlin, exploring topics such as molecular switches, mRNA structures, and therapeutic applications of splicing modulation. Research Interests: Temperature-dependent regulation of RNA splicing Mechanisms of neurodegeneration and neuroprotection Role of long non-coding RNAs in cell biology Development of RNA-based therapeutics Awards: Emmy-Noether-Fellowship from the German Research Foundation (DFG), 2011 Lab Activities: The Heyd Group investigates how environmental and physiological factors influence RNA processing, with a focus on translational research for neurological disorders. Current projects include studying RBM3 ASOs as potential neuroprotectants and exploring temperature-sensing mechanisms in splicing regulation.

Markus Wahlمشاهده پروفایل

استاد

• Structural Biochemistry
• RNA Biology
• Molecular Biology
• +۵ مورد دیگر

Prof. Markus Wahl is a Biochemistry Professor at the Department of Biology, Chemistry, and Pharmacy at Freie Universität Berlin. His research focuses on structural biochemistry, particularly RNA biology, molecular mechanisms of transcription, and protein interactions. His group investigates spliceosome dynamics, transcription termination factors, and the structural basis of bacterial resistance mechanisms. He leads the Wahl Group, which has produced significant contributions to understanding RNA processing, synaptic proteins, and drug design targeting clathrin-mediated endocytosis. Education details are not explicitly stated, but his career is centered at Freie Universität Berlin. Research interests include structural biochemistry, molecular inhibitors, and bacterial gene regulation. Recent work includes developing next-generation clathrin inhibitors and elucidating ρ factor inactivation mechanisms. Over 30 students have graduated under his supervision, many holding PhDs in biochemistry and molecular biology. His lab uses advanced structural biology techniques, including crystallography and cryo-EM, and collaborates with institutions like the Helmholtz-Zentrum Berlin. Current projects involve studying transcription complexes as RNA chaperones and the role of post-translational modifications in splicing regulation.

Kaijie Zhengمشاهده پروفایل

پژوهشگر ارشد

• Plant Proteomics
• Protein Processing
• Molecular Breeding
• +۳ مورد دیگر

Dr. Kaijie Zheng is a Postdoctoral Research Assistant at the Department of Biology, University of Oxford, affiliated with the van der Hoorn Group. His research focuses on plant proteomics, protein processing, and molecular breeding for agricultural applications. Research interests include: Secretory protein cleavage events in plants Proteome dynamics in Nicotiana benthamiana AI-driven approaches for soybean molecular design breeding Mechanisms of salt stress tolerance in Arabidopsis Trichome development regulation via MBW complexes Recent publications highlight his work on protein processing in plant expression systems, stress response signaling, and gene family evolution across species. Collaborations with Chinese soybean research teams underscore his interdisciplinary approach to modern agricultural challenges.