Erika Tse-Luen Wee

Erika Tse-Luen Wee is a Research Assistant Professor and Director of the Microscopy Shared Resource at Cold Spring Harbor Laboratory (CSHL). She specializes in developing advanced fluorescence imaging techniques to study cellular and tissue mechanisms in cancer, neuroscience, and plant biology. Her work focuses on 4D live-cell imaging, 3D tissue imaging, and super-resolution microscopy. She also provides training in advanced microscopy modalities and software for image analysis.

Education: Ph.D. in Biomedical Sciences from National Tsing Hua University (2009). Professional roles include prior positions as Manager of the Microscopy Shared Resource, Manager & Microscopy Specialist at McGill University (2013-2019), and academic appointments in Canada and the U.S. She leads efforts in standardizing microscopy quality assurance protocols and collaborates on imaging-based cancer and neuroscience research.

Research Interests: Development of cutting-edge microscopy tools for quantifying molecular interactions, protein localization, and cell-cell signaling. Her technical expertise spans live-cell imaging, organoid analysis, and high-resolution 3D imaging. She emphasizes reproducibility and optimization of imaging techniques to minimize phototoxicity and enhance data accuracy.

Key Contributions: Pioneered protocols for microscope quality management, developed imaging standards for 3D tissue analysis, and advanced understanding of cellular adhesion dynamics and synapse remodeling. Her work bridges technological innovation with biological discovery, particularly in cancer metastasis and neurodegenerative processes.

Labs/Teams: Directs the Microscopy Shared Resource and oversees the Wee Laboratory at CSHL, providing infrastructure and training for imaging-based research across multiple disciplines.