جست‌وجوی استاد و پژوهشگر

• Plant Biology
• Plant Signal Transduction
• Plant Gene Regulation
• +۴ مورد دیگر

Assoc Prof Ma Wei is an Associate Professor at the School of Biological Sciences, Nanyang Technological University (Singapore), specializing in plant molecular biology and lipid metabolism. He holds a PhD in Plant Science from the University of Connecticut (USA) and completed postdoctoral training at Michigan State University (USA). His lab focuses on understanding plant signal transduction, gene regulation, and lipid biosynthesis mechanisms, with a particular emphasis on improving seed oil yields through genetic engineering. He was promoted to Associate Professor with Tenure in 2024 and recognized as an EMBO Global Investigator in 2024. Education: PhD in Plant Science, University of Connecticut (USA) Postdoctoral Training, Michigan State University (USA) Research Interests: His research integrates molecular genetics, biochemistry, and systems biology to study plant lipid metabolism pathways. Key themes include: Transcriptional regulation of seed oil biosynthesis (e.g., WRINKLED1 regulatory networks) Protein engineering for enhanced oil production Crosstalk between lipid metabolism and plant signaling pathways Awards: EMBO Global Investigator (2024) Grants & Lab Activities: Current grants support projects on seed oil metabolic engineering and plant stress responses. His lab collaborates internationally to advance applications in biofuel production and sustainable agriculture. No listed advising students are currently visible. Labs/Teams: Maintains an active research group focused on plant lipidomics and genetic improvement strategies.

• Nanotechnology
• Single-Molecule Imaging
• Neurodegenerative Diseases
• +۳ مورد دیگر

Dr. Juan Varela is an Associate Professor and Reader at the School of Physics and Astronomy, University of St Andrews. He leads a research group funded by an ERC Starting Grant, focusing on nanotechnology and single-molecule imaging to combat neurodegenerative diseases. His work bridges physics, biology, and medicine, with applications in disease mechanisms and diagnostic tools. Education: BSc in Physics (Uruguay), PhD in Bio-Nano Interactions from University College Dublin. Postdoctoral research at Bordeaux’s Interdisciplinary Institute for Neurosciences and Cambridge’s Department of Chemistry. Research interests include nanotechnology-based diagnostics, single-molecule analysis of neurodegenerative proteins, and imaging techniques for brain cell studies. Recent work highlights protein aggregation mechanisms, extracellular matrix dynamics, and early-stage disease biomarkers. Publications span topics like aquaporin dynamics, amyloid detection probes, and brain extracellular space imaging, demonstrating cross-disciplinary impact. His lab (Neurophotonics Research Group) actively pursues translational research with clinical relevance. Supervises PhD students in neurodegeneration and nanomedicine. No awards explicitly listed but has secured major grants. Active in lab leadership and collaborative projects across institutions.

Matthew Benskeyمشاهده پروفایل

استادیار

• Neurodegenerative Diseases
• Neuroimmunology
• Parkinson’s Disease
• +۵ مورد دیگر

Matthew Benskey, PhD, is an Assistant Professor in the Department of Translational Neuroscience at Michigan State University’s College of Human Medicine. His research focuses on neuroimmunological mechanisms underlying Parkinson’s and Alzheimer’s diseases, particularly the roles of alpha-synuclein and tau proteins in neuroinflammatory responses. He leads studies on how glial cells (microglia/astrocytes) contribute to neuronal degeneration, using viral vector technologies for gene delivery and disease modeling. Education: B.S. in Psychology/Neuroscience, Central Michigan University (2008) Ph.D. in Neuroscience, Michigan State University (2013) Postdoctoral Fellowship in Translational Neuroscience, Michigan State University (2013–2016) Research Highlights: Dr. Benskey combines molecular, cellular, and animal model approaches to dissect proteinopathy-driven pathology. His lab pioneered viral vector tools for studying Parkinson’s-related mechanisms, including enteric nervous system targeting. Recent work explores microglial responses to alpha-synuclein aggregates and tau-induced neurodegeneration. Publications: His 2024 studies revealed microglial resistance to CSF1R inhibitors and identified neuroinflammatory gene signatures in Parkinson’s models. Earlier work (2017) uncovered asparagine endopeptidase’s role in alpha-synuclein toxicity. Labs/Teams: Directs the Benskey Lab at the Grand Rapids Research Center, focusing on translational neurobiology of neurodegenerative diseases.

Patrick Onckمشاهده پروفایل

استاد

• Biophysics
• Mechanics of Biological Materials
• Molecular Biomechanics
• +۳ مورد دیگر

Patrick Onck is a Full Professor of Micromechanics at the Zernike Institute for Advanced Materials, University of Groningen. His research focuses on understanding the mechanical and functional behavior of biological materials using computational techniques like molecular dynamics and finite element modeling. He leads a team studying transport through the nuclear pore complex, protein phase separation in neurodegenerative diseases, and bio-inspired soft robotics. Onck holds a PhD in Applied Mechanics from Delft University of Technology (1998) and completed postdoctoral research at Harvard University. He has held positions at TU Delft and the University of Groningen since 2001, advancing to Full Professor in 2012. His work bridges atomistic and macroscopic scales, with applications in medicine and materials science. Key research areas include: Biophysical mechanisms of cellular transport Mechanics of disordered proteins in ALS and Huntington’s disease Magneto-responsive soft materials for microfluidics and robotics His recent articles explore magnetic soft robotics, artificial cilia, and nuclear pore dynamics. He serves on editorial boards of Extreme Mechanics Letters and International Journal of Molecular Sciences , and is an active member of IUTAM. Awards include KNAW Research Fellowships (1998–2000 and 2001–2002). Labs/Groups: Onck Research Group at the Zernike Institute focuses on multiscale modeling and bio-inspired design. Collaborations include the UMCG in Groningen for neurodegenerative disease studies.

Edmund Ellsworthمشاهده پروفایل

استاد

• Drug Discovery
• Cancer Therapeutics
• Medicinal Chemistry
• +۳ مورد دیگر

Edmund Ellsworth, PhD, is a Professor (Fixed-Term) and Director of the Medicinal Chemistry Facility at Michigan State University (MSU), affiliated with the Department of Pharmacology & Toxicology within the College of Osteopathic Medicine. His research focuses on drug discovery, particularly in cancer therapeutics, antibacterial agents, and HIV protease inhibitors. He leads efforts in developing novel small molecules for anti-tumor efficacy, gene expression modulation in mammary tumors, and anti-fibrillization treatments for neurodegenerative diseases. Ellsworth’s work spans from preclinical cancer models (e.g., HER2+ breast cancer, KRAS-driven lung cancer) to tuberculosis drug development targeting Mycobacterium tuberculosis signaling pathways. His research also explores innovative drug delivery systems, such as lipid-based self-microemulsions for hepatocellular carcinoma treatment. Notable contributions include the discovery of RXR agonists (e.g., MSU-42011) and structural studies of enzyme inhibitors like ornithine decarboxylase. Ellsworth’s interdisciplinary approach integrates computational modeling (e.g., machine learning for cocaine addiction mechanisms) with synthetic chemistry to address complex biological challenges. As Facility Director, he oversees medicinal chemistry resources supporting MSU’s Drug Discovery initiatives. While no formal awards are listed, his extensive publication record (spanning 1988–2024) underscores his sustained impact in drug development and organic chemistry. His research also extends to ecological studies, such as identifying spermine as a sex pheromone in sea lampreys, highlighting cross-disciplinary interests.

John Goudreauمشاهده پروفایل

استاد

• Parkinson's Disease
• Neurology
• Pharmacology
• +۷ مورد دیگر

John Goudreau, DO PhD, is a Professor and Associate Dean of Clinical & Translational Science at Michigan State University's College of Osteopathic Medicine. He holds a joint appointment in the Department of Pharmacology & Toxicology, with a focus on neurology and neurodegenerative disorders. His research primarily centers on Parkinson's disease, dopamine metabolism, and translational therapies. Key areas of investigation include genetic factors influencing disease progression, clinical trials of neuroprotective agents, and mechanisms underlying motor and cognitive impairments in PD patients. Dr. Goudreau’s work integrates basic science and clinical research, with a strong emphasis on translating findings into clinical practice. His studies often involve preclinical models (e.g., rodent and equine systems) to explore dopamine pathways and neuroprotective strategies. He has led or contributed to pivotal trials such as the SURE-PD series evaluating urate elevation and the BouNDless trial for levodopa-carbidopa infusion therapy. His research also addresses practical interventions for PD symptoms, including bracing techniques for postural instability and novel drug delivery systems. Notably, he has explored the role of genetic polymorphisms (e.g., BDNF, dopamine receptor variants) in tailoring treatment outcomes, advancing the field of personalized medicine in neurology. Dr. Goudreau’s contributions span academic leadership, clinical innovation, and mentorship within the College of Osteopathic Medicine. His laboratory and collaborations focus on advancing our understanding of PD pathophysiology and developing evidence-based therapeutic approaches.

Guorong Wuمشاهده پروفایل

استادیار

• Neuroscience
• Machine Learning
• Alzheimer’s Disease
• +۵ مورد دیگر

Guorong Wu is an Assistant Professor at the University of North Carolina at Chapel Hill, holding joint appointments in the Department of Psychiatry and Computer Science within the UNC School of Medicine. His research focuses on computational neuroscience, machine learning, and neurodegenerative diseases, particularly Alzheimer’s disease. He develops advanced mathematical and computational models to understand brain functional dynamics, neural pathway propagation, and spatiotemporal progression of neuropathological events. Key research interests include graph theory applications to brain networks, optimal transport models for disease progression, and interpretable AI frameworks for medical diagnosis. His work spans interdisciplinary collaborations, integrating neuroimaging data with machine learning to uncover mechanisms of Alzheimer’s pathology, tau propagation, and amyloid-beta dynamics. His recent publications emphasize spatiotemporal modeling of neurodegenerative diseases, hub identification in brain networks, and the development of tools like PainFace for standardized mouse grimace analysis. While no specific grants or awards are mentioned, his contributions align with cutting-edge computational neuroscience and medical AI applications.

Adriana Beltranمشاهده پروفایل

دانشیار

• Genome engineering
• Stem cells
• Cancer research
• +۴ مورد دیگر

Adriana Beltran, PhD, is an Associate Professor in the Department of Genetics at the University of North Carolina School of Medicine and Director of the Human Pluripotent Cell Core. She holds adjunct roles in Pharmacology and collaborates extensively with the Lineberger Comprehensive Cancer Center (LCCC). Her research focuses on engineering cellular models to study neurodevelopmental disorders and cancer, particularly leveraging induced pluripotent stem cells (iPSCs) and organoids. Key contributions include developing breast cancer organoid biobanks and elucidating transcriptional adaptations to cancer therapies. Beltran earned her PhD in Marine Biotechnology from CICESE (Mexico) and completed postdoctoral training in Pharmacology at UNC. She has secured grants including the ELEVATE Award (2025) and Faculty Research Support Grant (2021). Her mentorship excellence was recognized through the Nova Award (2023) and Mentoring Awards from the Office of Graduate Education. Research interests span genome engineering, stem cell differentiation, and precision medicine. Notable projects include studying shared genetic variants across psychiatric disorders and investigating mechanisms underlying drug resistance in triple-negative breast cancer. She actively trains graduate students like Sonja Mihailovic (GMB program), who advances bioentrepreneurial ventures in pluripotent stem cell applications. Beltran's lab integrates genomic, transcriptomic, and epigenetic data to uncover therapeutic targets. Recent work highlights the predictive role of early cell cycle genes in cortical organoid models and the synergistic effects of BAZ2/BRD9 inhibitors in breast cancer. Her interdisciplinary approach bridges basic science with clinical translation through partnerships across UNC's medical and data science communities.

Douglas Phanstielمشاهده پروفایل

دانشیار

• 3D Chromatin Structure
• Genome Editing
• Cellular Differentiation
• +۷ مورد دیگر

Douglas Phanstiel, PhD is an Associate Professor in the Department of Cell Biology and Physiology at the University of North Carolina at Chapel Hill School of Medicine. His research focuses on understanding the molecular mechanisms of chromatin architecture and its role in cellular differentiation, particularly in diseases like rheumatoid arthritis, osteoarthritis, and Alzheimer’s Disease. He leads a lab utilizing genomic, proteomic, and computational tools to study DNA looping, epigenetic regulation, and CRISPR-based genome editing. Education: B.S., University of California, San Diego Ph.D., University of Wisconsin Postdoc, Stanford University Research Interests: 3D chromatin structure and its role in gene regulation Phase separation-driven chromatin looping in cancer Genome editing techniques for disease modeling Software development for genomic data analysis (e.g., Coral, Plotgardener) Recent Article Trends: Recent work highlights the lab’s focus on osteoarthritis mechanisms via chromatin accessibility and eQTL mapping, Alzheimer’s risk gene identification through 3D chromatin analysis, and CRISPR screening for cancer drivers. Tools like Coral enable kinome visualization, while Mariner aids Hi-C data exploration. Awards: 2024 HHMI Gilliam Fellow 2017 Junior Faculty Development Award 2015 K99/R00 Pathway to Independence Award 2012 Damon Runyon Fellowship Grants & Advising: Leads NIH-funded projects on osteoarthritis and Alzheimer’s, including a $2.5M NIAMS grant. Advises students like JP Flores (Gilliam Fellow) and Marielle Bond (F31 NIH grant recipient). Collaborates with labs at UNC and beyond to integrate genomics, proteomics, and computational biology. Labs & Teams: The Phanstiel Lab is part of UNC Lineberger Comprehensive Cancer Center and Thurston Arthritis Research Center. Projects include developing high-throughput CRISPR screens and analyzing chromatin dynamics in disease models.

John Kimمشاهده پروفایل

دانشیار

• MicroRNA Biology
• Small RNA Function
• Genome Regulation
• +۳ مورد دیگر

John Kim is an Associate Professor in the Department of Biology at Johns Hopkins University (Krieger School of Arts & Sciences), focusing on the biological functions of microRNAs and small RNAs. Previously, he held positions at the University of Michigan's Life Sciences Institute (2006–2015) and completed postdoctoral research at Harvard Medical School and MGH (2001–2006). His academic journey includes a PhD in Biochemistry and Molecular Biology from UC Davis (2000) and a B.S. in Molecular Biophysics and Biochemistry from Yale University (1990). His research explores how small RNAs regulate developmental processes, gene expression, and epigenetic mechanisms in organisms like C. elegans and Drosophila. Key themes include microRNA-mediated gene silencing, intergenerational RNA inheritance, and the role of small RNAs in chromatin dynamics. Notable contributions include studies on piRNA biogenesis, molting cycle regulation in C. elegans, and the formation of G bodies during hypoxia. Kim has received prestigious awards such as the Frederick C. Neidhardt Endowed Professorship (2013) and was a Pew Scholar in the Biomedical Sciences (2009–2013). His work integrates experimental and computational approaches, as seen in studies of transcriptome-wide RNA binding sites and gPAR-CLIP-seq methodologies. His lab investigates molecular mechanisms underlying RNA function in development and stress responses, with a focus on transgenerational epigenetic inheritance and metabolic adaptations. Collaborative efforts include projects on glycolytic enzyme compartmentalization and the role of RNAi in genome defense.

Christian Griesingerمشاهده پروفایل

استاد

• NMR Spectroscopy
• Structural Biology
• Biomolecular Dynamics
• +۷ مورد دیگر

Christian Griesinger is a Professor and Director of the Department of NMR-based Structural Biology at the Max Planck Institute for Multidisciplinary Sciences in Göttingen, Germany. He also serves as an Honorary Professor at the University of Göttingen's Department of Physical Chemistry. His research focuses on developing NMR methods to study biomolecular structure and dynamics, with applications to neurodegenerative diseases, membrane proteins, and drug-target interactions. Education: PhD in Chemistry from the University of Frankfurt (1986), postdoctoral training at ETH Zurich (1986–1989), Full Professor at Frankfurt University (1990–2000), and Director at the Max Planck Institute since 1999. Key awards include the Leibniz Prize (1998) and Otto Bayer Prize (2003). Research interests span NMR method development, structural biology of proteins/nucleic acids, and neurodegenerative disease mechanisms. His lab investigates phase separation in biomolecules, lipid fibrils, and amyloid pathology using interdisciplinary approaches combining NMR, X-ray crystallography, and chemical synthesis. Publications highlight advancements in NMR instrumentation, drug candidate characterization (e.g., anle138b), and biomolecular condensates. Collaborations involve institutions like the University Medical Center Göttingen and FAccTs GmbH. Technical expertise includes solid-state NMR and high-resolution structural analysis. Awards: Leibniz Prize (1998), Otto Bayer Prize (2003) Grants: Young Investigator Grant (1989), DFG funding Labs/Teams: Leads the NMR-based Structural Biology Department and collaborates with groups in computational biology (e.g., Markus Zweckstetter's team) and drug development.

• Proteomics
• Molecular Biophysics
• Biochemistry
• +۳ مورد دیگر

Sarah Slavoff is an Associate Professor of Chemistry and Molecular Biophysics & Biochemistry at Yale University, primarily affiliated with the Yale School of Medicine. She holds secondary appointments in Molecular Biophysics and Biochemistry and is associated with multiple interdisciplinary centers, including the Center for RNA Science and Medicine and the Institute of Biomolecular Design and Discovery. Her research focuses on understanding the roles of small and alternative open reading frame-encoded polypeptides (SEPs/microproteins) in cellular processes such as RNA metabolism, ribosome assembly, and stress responses. She pioneered techniques like MicroID and chemoproteomics to profile unannotated microproteins and their subcellular localizations. Her work bridges proteomics, biochemistry, and chemical biology, with notable contributions to understanding how microproteins regulate biomolecular condensates, RNA decapping mechanisms, and cellular signaling pathways. Key findings include the discovery of microproteins interacting with critical complexes like the mRNA decapping machinery and their roles in cancer pathways. Slavoff was honored as a 2016 Searle Scholar, recognizing her innovative research in this emerging field. Collaborators: Includes Ken Loh, David Schatz, Haomiao Su, and Matt Simon. Labs/Teams: Leads a lab focusing on microprotein discovery and function, with strong ties to the Yale Combined Program in the Biological and Biomedical Sciences (BBS). Publications: Over 25 peer-reviewed articles since 2011, with a focus on proteomic approaches and functional studies of uncharacterized proteins.

Jan Hendrik Spilleمشاهده پروفایل

استادیار

• Biophysics
• Cell Biology
• Fluorescence Microscopy
• +۷ مورد دیگر

Jan Hendrik Spille is an Assistant Professor in the Department of Physics at the University of Illinois at Chicago (UIC), with affiliations in Chemistry and Biomedical Engineering. His research focuses on biophysical principles of cellular organization using advanced fluorescence microscopy to study biomolecular condensates and nuclear architecture. The Spille Lab develops cutting-edge imaging tools combining super-resolution microscopy, live-cell imaging, and computational modeling to understand transcriptional regulation and chromatin dynamics. Education: Bachelor of Science in Physics (2007), Julius-Maximilians University Würzburg, Germany Master of Science in Physics (2009), Julius-Maximilians University Würzburg, Germany Doctor of Philosophy in Chemistry (2014), Rheinische Friedrich-Wilhelms University Bonn, Germany Research Interests: The lab explores how biomolecular condensates form and regulate transcription, employing interdisciplinary approaches spanning physics, chemistry, and biology. Current projects investigate chromatin organization in immune systems, super-resolution imaging of DNA/RNA/proteins, and CRISPR-based labeling technologies. Key collaborations include work with the Kenter lab (UIC Immunology) and Scialog-funded projects on biomolecular collective behavior. Awards & Funding: Scialog: Chemical Machinery of the Cell Award (2021, Gordon & Betty Moore Foundation) NIH NIAID R21 Award for chromatin topology studies Editorial role for Methods in Molecular Biology volume on Phase-Separated Biomolecular Condensates Teaching & Mentorship: Teaches PHYS 132 and advises over 15 students (undergraduates, graduates, and postdocs). Supports LASURI and Honors College thesis projects, emphasizing hands-on research in microscopy, modeling, and bioinformatics. Lab members have received LASURI awards, Honors College grants, and recognition at conferences like the Biophysics Research Day. Lab Infrastructure: Equipped with a Bruker Vutara super-resolution microscope and advanced computational tools. Hosts a bi-monthly interdepartmental Biophysics Seminar series.

Alfonso Aixaمشاهده پروفایل

دانشیار

• Neuroscience
• Cell Biology
• Developmental Biology
• +۳ مورد دیگر

Alfonso Aixa, PhD, is an Associate Professor and Director of Undergraduate Studies in the Department of Biological Sciences at the University of Illinois Chicago (UIC), within the College of Liberal Arts and Sciences. His research focuses on understanding neuronal polarity and the molecular mechanisms governing synaptic vesicle trafficking and neuronal differentiation using the model organism Caenorhabditis elegans (C. elegans). He holds a BS from the University of Puerto Rico-Rio Piedras and a PhD from the University of Wisconsin-Madison. Dr. Aixa’s research has two primary areas: (1) the role of the clathrin adaptor protein UNC-11/AP180 in synaptic vesicle protein sorting and trafficking, and (2) the function of HLH-3, a basic helix-loop-helix transcription factor critical for sex-specific neuronal differentiation in C. elegans. His work bridges cell biology and developmental biology, with implications for understanding fundamental membrane trafficking processes and neurodevelopmental disorders. His publications span molecular mechanisms of synaptic vesicle biogenesis, neuronal circuitry development, and genetic modifiers of neurodegenerative processes. He has contributed to studies on α-synuclein, parkin, and DJ-1 in C. elegans models, linking these findings to mitochondrial dysfunction and Parkinson’s disease pathways. His lab’s findings on UNC-11 and HLH-3 have advanced understanding of clathrin-mediated endocytosis and transcriptional regulation of neuronal identity. Dr. Aixa’s academic leadership includes directing undergraduate studies in Biological Sciences at UIC, emphasizing student mentorship and curriculum development in life sciences. His research has been supported by grants focusing on C. elegans genetics and neuronal mechanisms, though specific grant details are not provided in the text. Key collaborations include work with institutions like UI Health and international teams studying molecular pathways in neurobiology. His lab’s future directions aim to further characterize HLH-3’s downstream targets and explore therapeutic applications of C. elegans models in neurodegenerative research.

• Protein biochemistry
• Molecular biology
• Biotechnology
• +۴ مورد دیگر

Paul Xiang-Qin Liu is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University's Faculty of Medicine. He has been a department member since 1989 and currently serves as Research Project Coordinator (2022-present). His research focuses on intein-catalyzed protein splicing and its applications in protein engineering, including site-specific modification, peptide cyclization, and artificial spider silk development. Dr. Liu holds a PhD from Cornell University. His work integrates molecular biology, protein biochemistry, and material science to develop innovative protein-based technologies. Key contributions include engineering split inteins for protein trans-splicing, optimizing spider silk protein production, and studying intein structure-function relationships. Recent publications (2012-2022) emphasize biomedical applications of engineered silks and protein splicing mechanisms. Notable findings include nerve growth-promoting silk films, structural insights into spider silk domains, and MDM2/MDMX protein interactions. His research bridges fundamental biology with practical applications in biomaterials and molecular tools. Awards: None explicitly listed. Active collaborations include work with Dr. J.K. Rainey on silk protein mechanics and Dr. Q. Meng on intein engineering. Research infrastructure includes advanced NMR, biophysical characterization, and recombinant protein production facilities.