جست‌وجوی استاد و پژوهشگر

• Neurology
• Pain Disorders
• Molecular Biology
• +۶ مورد دیگر

Sulayman Dib-Hajj is a Professor of Neurology at Yale School of Medicine and holds affiliations with the Center for Neuroscience and Regeneration Research and the Center for Restoration of Nervous System Function at the Veterans Administration Connecticut Healthcare System. He earned his B.S. and M.S. from the American University of Beirut and his Ph.D. from Ohio State University in 1990. His research focuses on the role of voltage-gated sodium channels in pain disorders, particularly their modulation by genetic mutations, post-translational modifications, and cellular interactions. Key areas include inherited channelopathies (e.g., erythromelalgia, insensitivity to pain) and acquired neuropathic pain. He serves on editorial boards for journals like Frontiers in Pharmacology of Ion Channels and Molecular Pain , and has been a member of the VA Merit Review Panel. His work combines genetic, biochemical, and electrophysiological approaches to study sodium channel trafficking, phosphorylation, and interactions with auxiliary proteins (e.g., CAP-1A, FGF11-14). Recent advancements include real-time imaging of axonal membrane proteins and identifying Nav1.7 as a central pain mediator. Collaborations with researchers like Stephen Waxman and Sidharth Tyagi highlight interdisciplinary efforts in pain biology. His contributions span drug discovery targets, electrophysiology techniques, and translational studies for pain therapies. No specific scientific awards are listed, but his service roles reflect academic leadership. His lab is part of broader initiatives at Yale to advance neuroscience and regenerative medicine.

• Membrane Trafficking
• Cell Biology
• Molecular Biology
• +۳ مورد دیگر

Michael Hanna is an Associate Research Scientist in the Department of Neuroscience at Yale School of Medicine, Yale University. His work focuses on membrane trafficking, organelle dynamics, and protein transport mechanisms. He holds a BA in Chemistry from Baldwin Wallace University (2011) and a PhD in Pharmacology from the University of Wisconsin-Madison (2017). His research investigates molecular mechanisms governing early secretory pathway dynamics, including COPII vesicle biogenesis, Golgi complex organization, and lipid transfer protein functions. Key areas include the role of VPS13 proteins in organelle interfaces, Sar1 GTPase-independent trafficking, and mutations linked to neurodegenerative disorders such as hereditary spastic paraplegia. Publications highlight contributions to understanding membrane traffic regulation at endosome-Golgi interfaces, ER-mitochondria contacts, and novel lipid transfer proteins like SHIP164 and BLTP3A. Methodological innovations include supported tubulated bilayer systems to study membrane remodeling processes.

Anne Ephrussiمشاهده پروفایل

استاد

• Developmental Biology
• RNA transport
• Localized translation
• +۳ مورد دیگر

Anne Ephrussi is a distinguished researcher and leader at the European Molecular Biology Laboratory (EMBL), where she has served as Head of the Developmental Biology Unit since 2007. She also coordinated the EMBL International Center for Advanced Training (EICAT) starting in 2005 and previously served as Dean of Graduate Studies for the EMBL International PhD programme from 2005-2008. Her career at EMBL spans over three decades, beginning as a Group Leader in 1992 and progressing through increasingly significant leadership roles. Dr. Ephrussi's educational background includes: PhD from Massachusetts Institute of Technology (1985) Postdoctoral work at Harvard University Postdoctoral fellowship at the Whitehead Institute, MIT Her research focuses on fundamental mechanisms of developmental biology, particularly RNA transport and localized translation. She has made seminal contributions to understanding how mRNA localization controls embryonic patterning in Drosophila , with her work on the oskar gene representing landmark discoveries in the field. Her research integrates molecular, cellular, and genetic approaches to investigate how spatial regulation of gene expression establishes body patterns during development. Analysis of her publication record reveals consistent contributions to understanding RNA localization mechanisms, with particular emphasis on Drosophila oogenesis and embryogenesis. Her work spans molecular characterization of RNA-protein interactions, cytoskeletal transport mechanisms, translational control, and the coupling of nuclear processing with cytoplasmic mRNA localization. The progression of her research shows increasing sophistication in methodology while maintaining focus on fundamental questions of developmental patterning. Her distinguished career has been recognized with numerous prestigious awards: 2024 Member, German National Academy of Sciences (Leopoldina) 2015 Chevalier de la L\u00e9gion d'Honneur 2011 Chevalier dans l'Ordre National du M\u00e9rite 2010 Member of the Academia Europaea 2008 Elected member French Acad\u00e9mie des Sciences 2000 International Union of Biochemistry and Molecular Biology, E.C. Slater Lecture 1995 Elected member European Molecular Biology Organisation (EMBO) As Dean of Graduate Studies for the EMBL International PhD programme and through her leadership of the Developmental Biology Unit, Dr. Ephrussi has played a significant role in mentoring and training the next generation of scientists. Her laboratory has been consistently supported by competitive research funding, enabling her team to pursue innovative approaches to understanding developmental mechanisms. She has established EMBL as a major center for research in RNA biology and developmental genetics. At EMBL Heidelberg, Dr. Ephrussi leads the Developmental Biology Unit, which investigates the origin, development, and evolution of organisms. Her laboratory has been instrumental in developing approaches to study mRNA localization and translational control in the context of developmental patterning, creating a vibrant research environment that attracts scientists from around the world.

Marco Foianiمشاهده پروفایل

استاد

• Molecular Biology
• Molecular Oncology
• Computational Biology
• +۴ مورد دیگر

Marco Foiani is a Full Professor in Molecular Biology at the University of Milan and Scientific Director of IFOM (FIRC Institute of Molecular Oncology Foundation). He leads the 'Genome Integrity Laboratory' at IFOM since 2002 and holds positions at the European School of Molecular Medicine (SEMM) and the European Center for Nanomedicine (CEN). His research focuses on eukaryotic chromosome dynamics, DNA replication mechanisms, and genome integrity regulation. Key contributions include elucidating checkpoint-mediated control of stalled replication forks, CDK1's role in DNA damage response, and SUMOylation's function in replication fork protection. Education: PhD in Molecular Biology, University of Milan (1988) NIH Postdoctoral Fellowship under Dr. Alan Hinnebush, Washington DC (1989-1991) Research Interests: His work bridges molecular biology and oncology, addressing how DNA replication forks handle damage, transcription-replication conflicts, and telomere integrity. Recent studies highlight topoisomerase roles in replication topology and ATM-dependent regulation of terminal forks. Awards: EMBO Membership (2010) Italian Society of Biophysics & Molecular Biology Award Chiara D’Onofrio Prize Biotec Award (Amgen & Dompé) Professional Activities: Editor for Cell ; organizer of international conferences on DNA replication and chromosome dynamics. No grants explicitly listed in texts, though his lab's activities imply extensive funding support. Labs/Teams: Directs the Genome Integrity Laboratory at IFOM, collaborating with groups like the Branzei and Bermejo research teams on replication stress and repair mechanisms.

Ronald Thomas Hayمشاهده پروفایل

استاد

• Ubiquitin proteasome system
• SUMO modification
• Ubiquitin E3 ligases
• +۳ مورد دیگر

Ronald Thomas Hay is a Professor of Molecular Biology at the University of Dundee, College of Life Sciences, Division of Gene Regulation and Expression, since 2005. Previously, he held academic positions at the University of St Andrews (1985–2005), including Professor of Molecular Biology (1994–2005), Reader (1991–1994), and Lecturer (1985–1991). B.Sc. in Biochemistry, Heriot-Watt University (1975) Ph.D. in Virology, University of Glasgow (1979) His research focuses on the ubiquitin proteasome system , SUMO modification , and their roles in transcriptional regulation , DNA damage response , and quantitative proteomics . He pioneered SUMO modification as a key regulatory mechanism in eukaryotes. Recent work highlights trends in SUMO-ubiquitin crosstalk , poly-SUMO conjugates , and stress response proteomics . His lab investigates enzymes like RNF4 and SENP7 to elucidate mechanisms of protein degradation and post-translational regulation. Fellow of the Royal Society Novartis Medal and Prize (2012) Over 14,000 citations; h-index 62 Hay has trained 17 PhD students and over 40 postdoctoral fellows. He receives funding from organizations including CR-UK , MRC , and Wellcome Trust for studies on SUMO-specific ubiquitin ligases and proteases. He is also an honorary member of the Scottish Institute for Cell Signaling (SCILLS) .

Will Fullerمشاهده پروفایل

استاد

• Molecular Physiology
• Cardiac Diseases
• Protein Palmitoylation
• +۳ مورد دیگر

Professor Will Fuller is a Professor of Molecular Physiology and Director of Research at the University of Glasgow's School of Cardiovascular & Metabolic Health. He holds a formal academic role within the Department of Molecular Physiology. His research focuses on cardiac membrane proteins and microdomains, particularly palmitoylation processes and their impact on ion transporters, channels, and signaling pathways in cardiovascular diseases. He has advised students Samuel Adu and Eleanor Dickson-Murray and collaborates with Dr. David France in the School of Chemistry. Fuller completed his undergraduate and postgraduate degrees in Pharmacology at the University of Cambridge. After 8 years of postdoctoral training in the Cardiovascular Division at King’s College London, he established his research lab at the University of Dundee in 2006 before transferring to the University of Glasgow’s School of Cardiovascular & Metabolic Health (SCMH) in 2017. His work integrates subcellular fractionation, imaging, and biochemical techniques to study molecular physiology and therapeutic strategies. His research interests include palmitoylation regulation of Na+/Ca2+ exchangers (NCX1), voltage-sensitive potassium channels, NADPH oxidase, and zDHHC palmitoyl acyltransferases. Recent grants (2025–2030) from the BBSRC and British Heart Foundation fund studies on palmitoylation dynamics, Ca(v)1.2 channel regulation, and targeted degradation of palmitoylating enzymes. He also leads projects on insulin-induced NCX1 palmitoylation and SUMOylation impacts on cardiac relaxation. Notable achievements include pioneering studies on phospholemman’s role in cardiac Na/K-ATPase regulation and developing methods to study protein S-glutathiolation. His lab investigates therapeutic applications of palmitoylation modulation, such as PROTAC-mediated enzyme degradation and NCKX regulation. Key collaborators include Dr. Caglar Gök, Dr. David France, and teams in the Arrhythmias, Cardiac Remodelling, and Heart Failure research groups. His office is Room 415a in the Sir James Black Building on the Gilmorehill Campus, and he can be reached via Will.Fuller@glasgow.ac.uk (ORCID: 0000-0002-5883-4433).

• Cardiometabolic Syndrome
• Diabetes Research
• Cardiovascular Proteomics
• +۳ مورد دیگر

Melanie White is an Associate Professor and group leader at the Charles Perkins Centre, University of Sydney. Her research focuses on understanding how diabetes increases heart attack risk and poor outcomes post-cardiac events. She leads the Cardiometabolic Proteomics Group, using multi-omic techniques (mass spectrometry, bioinformatics) to study diabetic cardiomyopathy and ischemia. Key roles include Secretary of the Australasian Proteomics Society and editorial board member of the Journal of Molecular and Cellular Cardiology. Education and career milestones include NHMRC CJ Martin Fellowship (2006), DECRA (2012), and Heart Foundation Future Leader Fellowship (2019). Awards include the Paul Dudley White Award (2022) and FAHA fellowship (2022). Teaching roles include coordinating third-year pathology courses and integrating online education strategies during the pandemic. Research emphasizes post-translational modifications (e.g., phosphorylation, redox changes) in cardiovascular diseases. Her lab develops biomarkers using Langendorff perfusion and pre-clinical models. Collaborations with Sydney Mass Spectrometry aim to enrich protein modifications for disease analysis. Grants: Multiple NHMRC/ARC-funded projects on metabolic dysfunction and biomarker discovery. Labs/Teams: Cardiometabolic Proteomics Group, cardiovascular physiology lab with ex vivo perfusion expertise. Future Work: Expanding multi-omic approaches to hepatic-cardiac interactions and diabetes complications.

Jürgen Lassakمشاهده پروفایل

استاد پژوهشی

• Microbial Biochemistry
• Gene Regulation
• Translational Stress Response
• +۲ مورد دیگر

PD Dr. Jürgen Lassak is Head of the Working Group 'Microbial Biochemistry' at Ludwig Maximilian University of Munich's Biocenter, Department of Microbiology. His research focuses on microbial biochemistry including: Bacterial gene regulation and signal transduction Translational stress response mechanisms Post-translational modifications in bacteria Metabolism of non-canonical food sources Lassak investigates fundamental cellular processes in bacteria including translation elongation factors, ribosome stalling at polyproline sequences, and specialized modification systems. His work has applications in understanding bacterial adaptation and developing novel therapeutics.

Daniel Cifuentesمشاهده پروفایل

دانشیار

• RNA regulation
• Developmental biology
• Virology
• +۳ مورد دیگر

Dr. Daniel Cifuentes is an Associate Professor in the Department of Biochemistry at Boston University, where he leads the Cifuentes Laboratory. His research focuses on RNA regulation mechanisms in two primary model systems: zebrafish embryogenesis and RNA virus replication (e.g., Ebola and Lassa viruses). He integrates high-throughput genetic, genomic, and proteomic approaches to investigate post-transcriptional regulation in development and viral infection. PhD: University of Barcelona, Spain Postdoctoral Training: Yale University Research Interests Molecular mechanisms of RNA-binding proteins and microRNAs Role of RNA modifications in gene expression Transcriptional and translational control in filoviruses and arenaviruses Publications & Trends : His work spans RNA regulatory networks, with recent emphasis on computational approaches (sChemNET), viral RNA stabilization (Ebola), and chromatin organization in blood cell development (miR-144/Hmgn2 axis). Collaborations : Dr. Cifuentes collaborates with Prof. Mühlberger’s group at Boston University’s National Emerging Disease Laboratory (NEIDL) for RNA virus research. Laboratory Members : Owen Sanborn (PhD Student - RNA-Protein Interactions, microRNA) Annie Wen (PhD Student - Biochemistry, Virology)

Stephen J. Eylesمشاهده پروفایل

استاد

• Mass Spectrometry
• Protein Folding
• Hydrogen-Deuterium Exchange
• +۲ مورد دیگر

Stephen J. Eyles is Extension Professor and Director of the Mass Spectrometry Center at UMass Amherst. His research applies hydrogen/deuterium exchange mass spectrometry to study protein dynamics and folding, with emphasis on membrane protein complexes and biomolecular interactions. As center director, he develops analytical methods for campus researchers. Recent investigations characterize allosteric mechanisms in GPCR signaling, ER chaperone functions, and ubiquitin-proteasome regulation using advanced MS techniques.

Pascal Madeleineمشاهده پروفایل

استاد

• Ergonomics
• Sports Science
• Sports Technology
• +۵ مورد دیگر

Pascal Madeleine is a Professor at the Department of Health Science and Technology, Aalborg University, affiliated with The Faculty of Medicine. His research focuses on ergonomics, sports science, and biomedical engineering, particularly addressing musculoskeletal disorders and public health challenges related to aging. He has led multiple projects on occupational health, post-surgical pain management, and rehabilitation strategies for conditions like breast cancer and knee arthroplasty. Education: Completed AAU Pedagogical course. Key research areas include ergonomic interventions, pain mechanisms, and technology-driven solutions for workplace and clinical settings. He has supervised 13 PhD students and contributed to over 550 publications. Research interests emphasize translating novel methods into practical applications, such as wearable technologies for movement analysis and evidence-based treatments. Notable projects include investigating musculoskeletal pain in surgeons and developing rehabilitation protocols for chronic pain after knee replacements. Awards include the Lions Prize for innovative pain treatment research. His work aligns with UN Sustainable Development Goals, particularly in health and well-being (SDG 3) and decent work (SDG 8).

• Cell Biology
• Pharmacology
• Integrin Signaling
• +۵ مورد دیگر

David Calderwood is a Professor of Pharmacology and Cell Biology at Yale School of Medicine, where he also serves as co-Director of Graduate Studies for the Pharmacology Graduate Program. He holds primary appointments in the Department of Pharmacology and secondary appointments in Cell Biology, with additional affiliations across multiple interdisciplinary programs including Cancer Signaling Networks, Vascular Biology and Therapeutics, and Yale Cancer Center. Dr. Calderwood received his PhD from the University of Manchester in 1996. His research program focuses on molecular mechanisms of cell adhesion, particularly integrin receptor signaling and cytoskeletal dynamics. Key research interests include: Integrin activation mechanisms through talin and kindlin interactions Mechanical force transmission in cell-ECM adhesions Cytoskeletal regulation of cell migration and adhesion Structural basis of integrin-mediated signaling complexes His recent publications demonstrate a strong focus on mechanobiology and advanced imaging techniques, with recurring themes of integrin trafficking, cytoskeletal tension sensing, and molecular basis of adhesion complex assembly. The work frequently bridges structural biology with cellular biophysics, employing techniques from molecular modeling to live-cell imaging. Dr. Calderwood has received significant research funding, including a $1,390,200 NIH grant with Titus Boggon (2009) and a $1,356,968 NIGMS grant (2009). As co-Director of Graduate Studies, he oversees doctoral training in pharmacology while maintaining an active research laboratory investigating fundamental cell adhesion mechanisms relevant to cancer, immunology, and vascular biology.

• Proteomics
• Plant Biology
• Molecular Biology
• +۶ مورد دیگر

Pratigya Subba is an Associate Research Scientist at Yale School of Medicine, specializing in proteomics, plant biology, and molecular mechanisms of stress responses. His research focuses on elucidating proteomic and phosphoproteomic networks in plants and pathogens under environmental stresses, with applications in crop improvement and disease understanding. He has contributed to studies on rice, chickpea, chili pepper, and sandalwood, addressing topics like salt tolerance, thermal adaptation, and pathogen interactions. His work integrates advanced proteomic techniques with bioinformatics to uncover novel regulatory pathways. Key research areas include plant stress signaling, protein post-translational modifications (e.g., crotonylation), and translational applications in agriculture and medicine. Recent studies involve SARS-CoV-2 proteome analysis for diagnostic tools and murine muscle stem cell proteomics. Subba’s publications reflect a multidisciplinary approach, bridging basic science and applied research. His articles highlight trends in proteogenomics, stress response mechanisms, and systems biology. Collaborative projects with Yale’s medical research community emphasize translational potential, though specific grants or lab affiliations are not detailed here. No awards or student advisement records are mentioned in the provided texts.

Robert Schneiderمشاهده پروفایل

استاد

• Epigenetics
• Chromatin
• Histone modifications
• +۵ مورد دیگر

Robert Schneider serves as Director of the Institute for Functional Epigenetics (IFE) at Helmholtz Zentrum München and Professor at the Faculty of Biology, LMU Munich. His academic career spans leadership positions at major European research institutions including IGBMC in Strasbourg and the Max Planck Institute for Immunobiology and Epigenetics in Freiburg. Dr. Schneider's research focuses on epigenetic mechanisms with particular expertise in chromatin biology, histone modifications, and transcriptional memory. His laboratory investigates the molecular basis of epigenetic reprogramming, environment-genome interactions, and metabolic signaling to chromatin. Current work explores how metabolic signals influence chromatin states and how epigenetic information is maintained through cell divisions. His publication record demonstrates consistent contributions to understanding histone modifications, particularly regarding less-studied modifications like propionylation and succinylation, as well as the role of linker histones in chromatin organization. Recent work connects metabolic pathways with epigenetic regulation, showing how cellular metabolites directly influence chromatin states and gene expression patterns. ERC Starting Grant (2007) HFSP Career Development Award (2005) Chaire Gutenberg awarded by Universite de Strasbourg (2011) Ligue Contre la Cancer, Equipe labelisée (2014) Membership of Epigenesys Network of Excellence (2011) As an active member of the epigenetics community, Schneider serves on multiple scientific boards including the Research Coordination Board of the German Center for Diabetes Research since 2017. He has organized numerous major conferences including the 2023 GRC on DNA and Histone Modifications and the annual Munich Epigenetics Spotlight series since 2016. His laboratory maintains strong collaborative networks across Europe through initiatives like the 'Epicrossborders' International Research School which he has led since 2019.

Norma Frizzellمشاهده پروفایل

استاد

• Mitochondrial Metabolism
• Protein Modification
• Redox Biology
• +۵ مورد دیگر

Norma Frizzell, Ph.D., is a Professor in the Department of Pharmacology, Physiology & Neuroscience at the University of South Carolina School of Medicine. Her research focuses on the chemical modification of proteins by mitochondrial metabolites, particularly the non-enzymatic succination of cysteine residues by fumarate. She has made significant contributions to understanding how metabolic alterations in mitochondrial disorders like Leigh Syndrome and in diabetes lead to pathological protein modifications. B.Sc. in Biochemistry, Queen's University of Belfast, Northern Ireland Ph.D. in Biochemistry, Queen's University of Belfast, Northern Ireland Postdoctoral Training, University of Ulster and University of South Carolina Her work investigates the role of fumarate and protein succination in mitochondrial encephalopathies and metabolic diseases. She was the first to document increased brainstem and olfactory bulb succination in a murine model of Leigh Syndrome and to study succination of adipocyte proteins in diabetes. Her research bridges redox biology, metabolism, and disease mechanisms, with implications for therapeutic interventions in neurodegenerative and metabolic disorders. Recent publications reveal her focus on mitochondrial stress, metabolic crosstalk, and the impact of oncometabolites. Her work spans proteomics, cell signaling, and disease models, with studies in diabetes, cancer, neuroinflammation, and infectious disease. She frequently collaborates on chemoproteomic and redox biology projects. Scientific contributions include: Pioneering research on protein succination in diabetes Discovery of mitochondrial-ER stress links via succination Elucidation of fumarate’s role in neurodegeneration and tumor suppression Development of chemoproteomic methods to profile oncometabolites Dr. Frizzell has mentored researchers such as Dr. Gerardo Piroli and collaborates with interdisciplinary teams. Her work is supported by ongoing publications in high-impact journals, indicating active research and funding. She has no listed awards in the provided text, but her publication record in journals like Nature , Redox Biology , and Cancer Research underscores her scientific impact. She leads a research laboratory focused on the succinated proteome and metabolic signaling, contributing to both basic science and translational applications in metabolic and neurological diseases.