جست‌وجوی استاد و پژوهشگر

• Microbiology
• Immunology
• Bacterial Vaccines
• +۵ مورد دیگر

James B. Kaper is a Professor and Chair of the Department of Microbiology & Immunology at the University of Maryland School of Medicine. He serves as Vice Dean for Academic Affairs and previously held leadership roles as Senior Associate Dean (2014–2019) and Chair (2007–present). His research focuses on the molecular pathogenesis of diarrheagenic Escherichia coli and Vibrio cholerae , including vaccine development and bacterial-host interactions. Education: BS (1973) and PhD (1979) in Microbiology from University of Maryland; Postdoc in Molecular Pathogenesis at University of Washington (1979–1981) Dr. Kaper’s work has led to the creation of live attenuated cholera vaccines, including CVD 103-HgR, the first licensed recombinant bacterial vaccine. His lab investigates bacterial genetics, intestinal colonization, and immune system activation, particularly TLR5 response to V. cholerae flagellin. He has authored 303 peer-reviewed articles and 68 book chapters. His research has been funded continuously by NIAID since 1982. Key publications include foundational work on V. cholerae vaccines (1984), genomic structure (1998), and quorum sensing in EHEC/EPEC (1999). His lab’s recent studies focus on phosphotyrosine proteomics (2013) and pathogenicity island regulation (2007). Scientific awards: Fellow, American Academy of Microbiology (1994); NIH Merit Award (2004); ASM DC White Award (2019) Editorial roles: Editor-in-Chief, EcoSal (2006–present); Associate Editor, International Journal of Medical Microbiology (2000–present) As an academic leader, Dr. Kaper has mentored over 60 graduate students and postdoctoral fellows. He holds multiple patents for cholera vaccines and E. coli diagnostics, including U.S. Patents 4,935,364; 5,399,494; and 6,204,004. His lab at UMSOM combines basic science with translational applications for enteric disease prevention.

Ning Zhangمشاهده پروفایل

استادیار

• Plant Defense Mechanisms
• Genome Editing Technologies
• Crop Improvement
• +۳ مورد دیگر

Ning Zhang is an Assistant Professor in the Biology Department at James Madison University (JMU), joining in 2024. Her research focuses on enhancing crop resilience through molecular and biochemical studies of plant defense mechanisms against bacterial pathogens, alongside developing genome editing technologies for trait improvement. She holds a PhD in Horticulture and Crop Science from The Ohio State University (2016), an MS in Silviculture from Zhejiang Agriculture and Forestry University (2011), and a BS in Landscape Architecture from Shandong Agricultural University (2008). Research Interests: Dr. Zhang's lab investigates plant immunity pathways, CRISPR/Cas9 genome editing applications, and engineering crops for disease resistance. Her work integrates molecular biology, genetics, and biochemistry to tackle challenges posed by climate change and biotic/abiotic stresses. Recent Trends in Publications: Her articles concentrate on MAPK signaling pathways, NLR protein interactions, PP2C phosphatase regulation, and bacterial effector mechanisms in tomato and other crops. Key themes include immune system activation, pathogen recognition diversity, and transgenic plant development. Lab Information: The Zhang Lab at JMU is part of the Department of Biology, focusing on plant biotechnology solutions for agricultural sustainability. They collaborate on projects involving CRISPR-based gene editing and stress tolerance research.

• RNA Biology
• Bioinformatics
• Plant Molecular Biology
• +۴ مورد دیگر

Peter Brodersen is a Professor at the Department of Biology, University of Copenhagen , specializing in Bioinformatics and RNA Biology . His research focuses on RNA modification (m6A), YTHDF proteins, and small RNA pathways in plants. Recent research trends from his group include: (1) molecular mechanisms of ARGONAUTE-small RNA interactions, (2) m6A-YTHDF regulatory systems in plant development, and (3) RNAi-independent roles of DICER-LIKE proteins in antiviral defense. Collaborations span Denmark and international institutions. Publications highlight cross-disciplinary work bridging computational biology and experimental plant genetics. Key subfields include RNA structure, epigenetic regulation, and antiviral immunity.

Patricia Championمشاهده پروفایل

استاد

• Molecular Genetics
• Mycobacterial Pathogenesis
• Bacterial Genetics
• +۷ مورد دیگر

Patricia Champion is a Professor in the Department of Biological Sciences at the University of Notre Dame, where she holds the title of Notre Dame Collegiate Professor. Her research is centered on the molecular mechanisms of mycobacterial pathogenesis, with a focus on protein transport and virulence. She is affiliated with the Eck Institute for Global Health and the Center for Rare and Neglected Diseases. PhD in Molecular Biology, Princeton University (2003) B.S. in Biological Sciences, Carnegie Mellon University (1998) Her research interests lie in understanding how pathogenic mycobacteria, including Mycobacterium tuberculosis and M. marinum , cause disease through targeted protein secretion, particularly via the Type VII (ESX-1) secretion system. She investigates how secreted proteins function as effectors and regulate gene expression, and how post-translational modifications like acetylation influence virulence. Her lab employs an interdisciplinary approach combining genetics, molecular biology, proteomics, and transcriptomics. The recent publications highlight a strong focus on ESX-1-mediated secretion, identification of novel substrates, regulatory mechanisms (e.g., WhiB6, EspM), and post-translational modifications. The work spans fundamental bacterial physiology to host-pathogen interactions, contributing to the broader goal of identifying targets for anti-virulence therapeutics against tuberculosis. Her scientific recognition includes being named a Notre Dame Collegiate Professor, a distinguished honor reflecting her scholarly excellence. Dr. Champion leads an active research laboratory committed to fostering an inclusive and respectful environment, emphasizing core values such as integrity, teamwork, and excellence. Her lab's work is supported by ongoing research grants, though specific funding sources are not detailed in the text. The Champion Lab operates within the Department of Biological Sciences and collaborates with key institutes at Notre Dame focused on global and neglected diseases.

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

Chiu Ping Chengمشاهده پروفایل

استاد

• Molecular Biology
• Plant-Microbe Interactions
• Bacterial Pathogenesis
• +۵ مورد دیگر

Chiu Ping Cheng is a Professor in the Department of Biology at the University of Minnesota, USA, specializing in Molecular Biology and Plant-Microbe Interactions . With over two decades of research on Ralstonia solanacearum and its interactions with solanaceous crops, Dr. Cheng has pioneered studies on plant defense mechanisms against bacterial wilt, regulatory gene functions, and biocontrol agent applications. Current research: Plant-pathogen interactions Special techniques: Genomic screening, bacteriophage-derived proteins Key pathogens: Ralstonia solanacearum, Pectobacterium carotovorum His recent publications (2024) explore tomato cultivar resistance variation , NADPH oxidase-effector interactions , and phenylpropanoid metabolism in wild mungbean . Though no formal scientific awards are listed, his work has been featured in leading journals like Plant Cell & Environment and New Phytologist . Dr. Cheng operates from the Life Science Building R942 laboratory.

Shahid Siddiqueمشاهده پروفایل

دانشیار

• Plant-Nematode Interactions
• Agricultural Entomology
• Molecular Biology
• +۳ مورد دیگر

Shahid Siddique is an Associate Professor in the Department of Entomology and Nematology at the University of California, Davis. His research focuses on understanding molecular and applied aspects of plant-parasitic nematode interactions with host plants. He aims to develop sustainable strategies to mitigate nematode-induced crop losses through genetic, biochemical, and biotechnological approaches. His lab is particularly interested in host resistance mechanisms, nematode effector proteins, and biocontrol solutions. Education: MSc, Bahauddin Zakariya University, Multan, Pakistan PhD, University of Natural Resources and Life Sciences, Vienna, Austria Habilitation, University of Bonn, Germany Research Interests: Siddique’s work bridges basic and applied research, including cell surface signaling in plant-parasitic nematode interactions, functional characterization of secretory proteins, molecular diagnostics for nematodes, and biocontrol strategies. Current projects explore recombination hotspots in nematode genomes, CRISPR-based resistance engineering, and redox signaling mechanisms. Teaching: General Plant Nematology (NEM100) in Spring 2020 Labs/Teams: The Siddique Lab focuses on translating molecular discoveries into practical pest management solutions. Collaborations involve genomic analysis, proteomics, and field trials to address global agricultural challenges.

Xin Liمشاهده پروفایل

استاد

• Plant Innate Immunity
• Molecular Mechanisms of Plant Defense
• Pathogen-Plant Interactions
• +۵ مورد دیگر

Dr. Xin Li is a Professor at the University of British Columbia (UBC), affiliated with the Michael Smith Laboratories and the Department of Botany. She holds a Tier 1 Canada Research Chair in Plant Immunity and leads research on plant innate immunity mechanisms, focusing on molecular pathways in Arabidopsis thaliana. Her work explores how plants defend against pathogens through gene regulation, protein interactions, and signal transduction. Education: BSc in Genetics from Fudan University (1989), PhD in Plant Pathology from Oklahoma State University (1995), postdoctoral training at Duke University (1996-1999). Prior to UBC, she was a Scientist at Maxygen, Inc. (1999-2001). Research spans biochemistry, genomics, and proteomics, with a focus on regulatory components of plant disease resistance. Key areas include NLR immune receptors, salicylic acid signaling, and translational strategies for sustainable agriculture. Lab members include PhD students (e.g., Paul Kapos, Kevin Ao), MSc students (e.g., Nanbing Zhang), and postdocs (e.g., Tongjun Sun). The Li Lab collaborates internationally, notably through the PRoTECT training program funded by NSERC and DFG. Notable awards include the Tier 1 CRC nomination (2022) and grants supporting the PRoTECT initiative. Her research has led to over 70 peer-reviewed publications, advancing understanding of plant immunity and its applications in crop protection.

Maria Fällmanمشاهده پروفایل

استاد

• Molecular microbiology
• Bacterial pathogenesis
• Infection biology
• +۷ مورد دیگر

Maria Fällman is a Professor at the Department of Molecular Biology at Umeå University, where she also serves as Deputy Head of Department. She is affiliated with Molecular Infection Medicine Sweden (MIMS), a leading research center for molecular infection medicine in Sweden. Dr. Fällman's research focuses on understanding the molecular mechanisms behind bacterial adaptation to different environments, with particular emphasis on Yersinia pseudotuberculosis and Salmonella enterica Typhimurium. Her group investigates gene regulation critical for establishing and maintaining infections, bacterial stress responses, and the molecular mechanisms of the Type Three Secretion System (T3SS). The lab has developed advanced methods for RNA extraction from complex tissue samples and performs in vivo gene expression analyses. Her publication record shows consistent contributions to understanding bacterial pathogenesis, with recent articles in high-impact journals including Nature Communications, Science, and PLOS Pathogens. Her work spans from fundamental molecular mechanisms of bacterial virulence to computational approaches for analyzing pathogen stress responses. A significant contribution is the PATHOgenex database (http://www.pathogenex.org), containing gene expression data of over 30 human pathogens exposed to different stress conditions. Dr. Fällman leads the Maria Fällman Lab, which has made important discoveries including the finding that sub-lethal doses of Yersinia result in persistent infection in mice with reprogramming of bacterial gene expression. Current projects focus on stress response modeling and deciphering heterogeneous populations of infecting bacteria using single-cell RNA-seq.

Mehdi Kabbageمشاهده پروفایل

استاد

• Necrotrophic fungal pathogenesis
• Programmed cell death in plants
• Plant-microbe interactions
• +۴ مورد دیگر

Mehdi Kabbage is a Professor and Director of Graduate Studies in the Department of Plant Pathology at the University of Wisconsin-Madison . His research focuses on necrotrophic fungal pathogenesis, particularly the role of oxalic acid and programmed cell death (PCD) in plant-pathogen interactions. He teaches courses in fungal biology and plant-microbe interactions. Education : Ph.D. in Plant Pathology (Kansas State University), M.S. in Plant Pathology (Kansas State University), B.S. in Engineering (Ecole d'Ingénieurs de Purpan, France) Dr. Kabbage investigates how Sclerotinia sclerotiorum manipulates plant PCD through oxalic acid secretion and explores strategies to inhibit this process for crop protection. His work spans molecular mechanisms of fungal virulence, plant stress tolerance, and genetic resistance in soybeans. Recent publications highlight his research on fungal effector proteins, host-induced gene silencing, oxalic acid signaling, and autophagy-based resistance strategies. He collaborates extensively on soybean and dry bean pathosystems, with a focus on integrated disease management and climate resilience. His lab develops transgenic approaches for stress tolerance, studies BAG protein family functions in plant defense, and investigates fungal enzymatic virulence factors like alcohol oxidases and laccases. Current projects include chemical genomics for resistance pathway discovery and novel antifungal agents such as poacic acid.

Lida Derevninaمشاهده پروفایل

پژوهشگر

• Plant Pathology
• Plant Immunity
• Molecular Plant Pathology
• +۳ مورد دیگر

Dr. Lida Derevnina is a leading researcher in plant-pathogen interactions and immune receptor networks at the University of Cambridge , affiliated with the School of Biological Sciences and the Department of Plant Sciences . She heads the Crop Pathogen Immunity Group at the Crop Science Centre , focusing on NLR (Nucleotide-binding and Leucine-Rich Repeat) immune receptor networks and pathogen effector functions to engineer durable crop resistance. Education: PhD in Plant Pathology and Phytopathology, University of Sydney (2008-2012) BSc in Agricultural Science, University of Sydney (2004-2007) Her research explores how pathogens evade plant immunity through effector proteins and how NLR networks can be bioengineered to counteract these mechanisms. This work bridges molecular biology, evolutionary genetics, and sustainable agriculture, with recent advances in resistosome activation models and effectorome characterization. Scientific awards include the Crop Science Centre Fellowship (2022) , Marie Skłodowska-Curie Individual Fellowship (2016) , and the Jeanie Borlaug Laube Women in Triticum Award (2012) . Her work has been published in top journals such as Science , Nature , and PLoS Biology . Dr. Derevnina is actively engaged in public outreach, including the Talking Biotech podcast and a YouTube video explaining plant immunity . Her laboratory collaborates on projects related to global food security and pathogen genomics.

Sarah Coulthurstمشاهده پروفایل

استاد

• Protein secretion systems
• Inter-bacterial competition
• Antimicrobial resistance
• +۵ مورد دیگر

Professor Sarah Coulthurst is the Chair of Microbial Interactions and a Wellcome Trust Senior Research Fellow at the University of Dundee's School of Life Sciences. Her research focuses on understanding how Gram-negative bacterial pathogens cause disease, with a focus on protein secretion systems (especially the Type VI secretion system), inter-bacterial competition, and antimicrobial resistance mechanisms. She leads a molecular microbiology group using genetics, proteomics, and non-mammalian virulence models. Education: PhD in Molecular Microbiology from the University of Cambridge (2005), MSci in Natural Sciences (2000), and BA in Natural Sciences (1999), all from the University of Cambridge. Research Focus: Her work investigates the molecular mechanisms of the Type VI secretion system (T6SS), bacterial competition strategies, and antimicrobial peptide production. Key projects include studying Serratia marcescens's T6SS-mediated attacks and the role of lifestyle switches in clinical pathogen adaptation. Recent Work: Recent publications highlight discoveries in T6SS effector proteins, pore-forming mechanisms, and genomic regulation of bacterial competition. She also contributes to understanding antimicrobial resistance and Serratia's role in polymicrobial communities. Awards: Includes Fellow of the Royal Society of Edinburgh (2024), Wellcome Senior Research Fellowship (2020), and multiple prizes for contributions to microbiology and teaching excellence. Teaching & Supervision: Module manager for Advanced Molecular Microbiology and supervisor for PhD projects on T6SS mechanisms and bacterial adaptation. She also engages in public outreach and educational initiatives. Lab & Collaborations: Collaborates with institutions like the University of Newcastle and Heriot-Watt University. Her lab integrates cutting-edge omics approaches with traditional microbiology to study pathogen interactions.

Jeff Danglمشاهده پروفایل

استاد

• Plant-microbe interactions
• Plant immune system
• Root microbiome
• +۴ مورد دیگر

Jeff Dangl is the John N. Couch Professor and an HHMI Investigator at the University of North Carolina at Chapel Hill, where he leads research in the Department of Biology. He has been studying plant-microbe interactions since 1989, focusing on two main areas: the plant immune system and the root microbiome. His laboratory is located in the Genome Sciences Building on UNC's historic campus, which is part of the Research Triangle Park area, a leading hub for biotechnology research. Dr. Dangl's research interests span several interconnected areas of plant-microbe interactions. His work examines how plants recognize pathogens through their two-tiered immune system consisting of extracellular pattern recognition receptors and intracellular NLR receptors. He also investigates how the plant immune system shapes the composition and function of the root microbiome. His lab uses Arabidopsis thaliana as a model system to study these interactions at multiple biological scales, from molecular and structural levels to small mesocosms. The research trends in Dr. Dangl's recent publications indicate a strong focus on understanding the molecular mechanisms of plant immune receptors, particularly NLR proteins and their activation pathways. His work increasingly integrates microbiome research with plant immunology, exploring how commensal microbes interact with and potentially modulate the plant immune system. There's also significant emphasis on the structural and functional aspects of immune receptor complexes, as well as the evolutionary dynamics of plant-pathogen interactions. HHMI Investigator John N. Couch Professor Dr. Dangl leads a diverse research group with members from several countries, emphasizing small team approaches to tackle complex problems in plant-microbe interactions. His students and postdocs benefit from access to multiple inputs about their work through this collaborative environment. His laboratory has developed expertise in genomics, ecological modeling, metabolic modeling, and both forward and reverse genetics to address questions about microbiome assembly and function. The Dangl lab maintains strong connections with the broader scientific community through collaborations and participation in major research initiatives. They work within the rich research environment of the Research Triangle Park, which includes UNC, Duke University, North Carolina State University, the North Carolina Biotechnology Center, and numerous life-science companies.

• Epigenetics
• Host-pathogen interactions
• Microbiology
• +۴ مورد دیگر

Monica Rolando is a researcher at the Institut Pasteur in Paris, France, specializing in the study of intracellular bacterial pathogens, particularly Legionella pneumophila , the causative agent of Legionnaires' disease. She is affiliated with the Biology of Intracellular Bacteria department and teaches in the Pasteur Microbiology Course, sharing her expertise in bacterial pathogenesis and host-pathogen interactions. Dr. Rolando obtained her PhD in Cellular and Molecular Biology from the University of Nice-Sophia Antipolis, where she studied bacterial toxins targeting the host endothelium. In 2009, she joined the laboratory of Carmen Buchrieser at the Institut Pasteur for postdoctoral training, shifting her focus to non-toxin-mediated aspects of host-pathogen interactions. Her research primarily focuses on how bacterial pathogens manipulate host cellular processes, with particular emphasis on epigenetic regulation. Dr. Rolando investigates how Legionella pneumophila employs bacterial effectors that target the host cell nucleus to modify epigenetic marks, thereby subverting host cell functions to facilitate bacterial replication. Her work explores the fascinating co-evolution between L. pneumophila and its eukaryotic hosts, which has led to the acquisition of proteins through horizontal gene transfer that allow the bacterium to mimic eukaryotic functions. Analysis of Dr. Rolando's recent publications reveals a strong focus on patho-epigenetics - the manipulation of host epigenetic machinery by bacterial pathogens. Her research spans molecular mechanisms of bacterial effectors, particularly histone-modifying enzymes like methyltransferases, and their role in subverting host defenses. A significant portion of her work examines how Legionella and related pathogens target chromatin structure and nuclear processes to promote intracellular survival and replication. Dr. Rolando has contributed to numerous collaborative research projects at the Institut Pasteur, working with various research teams investigating bacterial pathogenesis. Her work bridges molecular microbiology, cell biology, and epigenetics, providing novel insights into host-pathogen interactions at the molecular level. Her laboratory focuses on identifying and characterizing bacterial effectors that target host nuclear processes, with particular attention to how these effectors modify epigenetic marks to benefit bacterial replication. This research has important implications for understanding bacterial pathogenesis and potentially developing novel anti-infective strategies targeting pathogen epigenetic manipulation.

• Plant Genetics
• Rust Resistance in Cereals
• Cereal Cytogenetics
• +۳ مورد دیگر

Associate Professor Peng Zhang is affiliated with the School of Life and Environmental Sciences and the Plant Breeding Institute at the University of Sydney. She holds memberships in the China Studies Centre and Sydney Institute of Agriculture. Her educational background includes a BSc from Wageningen Agricultural University (Netherlands), MSc in Biotechnology (Wageningen), and PhD in Genetics from Kansas State University (USA). Her research focuses on molecular cytogenetics of wheat, introgression of rust resistance genes from wild relatives, and developing durable resistant germplasm. Key research interests include cereal crop improvement, rust pathogen resistance mechanisms, and genomic tools for plant breeding. Notable awards include the 2023 Sydney Research Accelerator (SOAR) Prize. Recent grants involve rust resistance mechanisms and hybrid wheat breeding programs in collaboration with international partners. Publications highlight work on resistance gene characterization, molecular mapping, and disease management strategies. Collaborative research with institutions like Kansas State University and international bodies underscores her global impact in agricultural science.