Jeff Dangl

Jeff Dangl is the John N. Couch Professor and an HHMI Investigator at the University of North Carolina at Chapel Hill, where he leads research in the Department of Biology. He has been studying plant-microbe interactions since 1989, focusing on two main areas: the plant immune system and the root microbiome. His laboratory is located in the Genome Sciences Building on UNC's historic campus, which is part of the Research Triangle Park area, a leading hub for biotechnology research.

Dr. Dangl's research interests span several interconnected areas of plant-microbe interactions. His work examines how plants recognize pathogens through their two-tiered immune system consisting of extracellular pattern recognition receptors and intracellular NLR receptors. He also investigates how the plant immune system shapes the composition and function of the root microbiome. His lab uses Arabidopsis thaliana as a model system to study these interactions at multiple biological scales, from molecular and structural levels to small mesocosms.

The research trends in Dr. Dangl's recent publications indicate a strong focus on understanding the molecular mechanisms of plant immune receptors, particularly NLR proteins and their activation pathways. His work increasingly integrates microbiome research with plant immunology, exploring how commensal microbes interact with and potentially modulate the plant immune system. There's also significant emphasis on the structural and functional aspects of immune receptor complexes, as well as the evolutionary dynamics of plant-pathogen interactions.

• HHMI Investigator
• John N. Couch Professor

Dr. Dangl leads a diverse research group with members from several countries, emphasizing small team approaches to tackle complex problems in plant-microbe interactions. His students and postdocs benefit from access to multiple inputs about their work through this collaborative environment. His laboratory has developed expertise in genomics, ecological modeling, metabolic modeling, and both forward and reverse genetics to address questions about microbiome assembly and function.

The Dangl lab maintains strong connections with the broader scientific community through collaborations and participation in major research initiatives. They work within the rich research environment of the Research Triangle Park, which includes UNC, Duke University, North Carolina State University, the North Carolina Biotechnology Center, and numerous life-science companies.