معرفی
Maria Fällman is a Professor at the Department of Molecular Biology at Umeå University, where she also serves as Deputy Head of Department. She is affiliated with Molecular Infection Medicine Sweden (MIMS), a leading research center for molecular infection medicine in Sweden.
Dr. Fällman's research focuses on understanding the molecular mechanisms behind bacterial adaptation to different environments, with particular emphasis on Yersinia pseudotuberculosis and Salmonella enterica Typhimurium. Her group investigates gene regulation critical for establishing and maintaining infections, bacterial stress responses, and the molecular mechanisms of the Type Three Secretion System (T3SS). The lab has developed advanced methods for RNA extraction from complex tissue samples and performs in vivo gene expression analyses.
Her publication record shows consistent contributions to understanding bacterial pathogenesis, with recent articles in high-impact journals including Nature Communications, Science, and PLOS Pathogens. Her work spans from fundamental molecular mechanisms of bacterial virulence to computational approaches for analyzing pathogen stress responses. A significant contribution is the PATHOgenex database (http://www.pathogenex.org), containing gene expression data of over 30 human pathogens exposed to different stress conditions.
Dr. Fällman leads the Maria Fällman Lab, which has made important discoveries including the finding that sub-lethal doses of Yersinia result in persistent infection in mice with reprogramming of bacterial gene expression. Current projects focus on stress response modeling and deciphering heterogeneous populations of infecting bacteria using single-cell RNA-seq.
