جست‌وجوی استاد و پژوهشگر

Markus Heiligمشاهده پروفایل

استاد

• Addiction Neuroscience
• Alcohol Dependence
• Neuropharmacology
• +۴ مورد دیگر

Markus Heilig is a Professor of Psychiatry and Head of the Department of Biomedical and Clinical Sciences (BKV) at Linköping University. He serves as Director of the Center for Social and Affective Neuroscience (CSAN), integrating basic and clinical neuroscience to address addictive and affective disorders. His work bridges neuropharmacology, molecular psychiatry, and clinical trials. Linköping University (Current) Center for Social and Affective Neuroscience (CSAN) (Director) Wallenberg Center for Molecular Medicine (Collaborator) His research focuses on alcohol dependence mechanisms, stress-neurotransmitter interactions (e.g., CRF, substance P, endocannabinoids), and personalized medicine approaches. Using animal models and human neuroimaging (fMRI), his lab explores epigenetic changes in frontal lobe and amygdala neurons that drive compulsive alcohol use. Recent publications highlight his work on endocannabinoid modulation for PTSD treatment, neural correlates of reward choices, and pharmacological interventions targeting GABA and opioid receptors. His studies often combine brain imaging, behavioral analysis, and pharmacology. Scientific awards include the 2019 Wallenberg Clinical Scholar grant and 2017 CAN/Nordic Drugs prizes. Heilig's research is supported by Vetenskapsrådet (SEK 57 million center funding) and international donations like the Andrew J. Bock Memorial Fund.

Eric W. Schmidtمشاهده پروفایل

استاد

• Natural Products Chemistry
• Biosynthesis
• Synthetic Biology
• +۵ مورد دیگر

Eric W. Schmidt is a Distinguished Professor of Medicinal Chemistry at the University of Utah, with adjunct appointments in Biological Sciences and Chemistry. His research focuses on natural products chemistry, biosynthesis, synthetic biology, and pharmaceutical applications of marine animal microbiomes. University of California, San Diego (BS, PhD) Research areas include: Biosynthesis in animals and their microbiomes Synthetic biology approaches to chemical engineering Drug design from marine natural products Metagenomic analysis of symbiotic relationships Neuroactive compound discovery Antibiotic development against resistant pathogens His lab has pioneered methods for: Biosynthetic gene cluster identification Heterologous expression in E. coli Enzymatic modification of peptides Chemical analysis of marine invertebrates Recent publications highlight discoveries in: Marine animal chemical defense mechanisms Evolution of biosynthetic pathways Antibiotic resistance profiling Ionic channel-targeting compounds Peptide macrocyclization techniques Lipid-polyketide biosynthesis continuum Email: ews1@utah.edu Honors include: Distinguished Professor recognition

• Marine Natural Products
• Drug Discovery
• Chemical Ecology
• +۴ مورد دیگر

Raymond Andersen is a Professor in the Faculty of Science at the University of British Columbia, affiliated with the Department of Earth, Ocean & Atmospheric Sciences and the Department of Chemistry . His research focuses on the isolation and structural elucidation of bioactive natural products from marine and terrestrial organisms, with applications in drug discovery and chemical ecology. He has contributed to breakthroughs in anticancer agents, antiviral compounds, and inhibitors of Mycobacterium tuberculosis. Education: B.Sc. (University of Alberta, 1969), M.Sc. (Berkeley University, 1970), Ph.D. (University of California San Diego, 1975), followed by postdoctoral training at MIT (1975-76). Awards include the Killam Research Prize (1987), Rutherford Medal in Chemistry (1988), and Fellow of the Chemical Institute of Canada. Research interests span marine invertebrate-derived metabolites, phytoplankton toxins, and plant defensive compounds. His lab investigates antitumor agents, HIV latency reversal, and novel pharmacophores for cancer and infectious diseases. Recent work includes antiviral agents targeting SARS-CoV-2 and inhibitors of androgen receptor signaling in prostate cancer. Co-developed clionamine B, an autophagy-stimulating compound effective against latent tuberculosis. Identified sintokamides as androgen receptor antagonists for prostate cancer therapy. Advanced genome-mining techniques for discovering nonribosomal peptides. Overseen numerous graduate students, including notable theses on natural product synthesis, SAR studies, and bioactivity screening. Active in collaborative drug discovery projects, with patents on androgen receptor modulators, SHIP1 activators, and antiviral agents. Labs/Teams: Leads the Andersen Research Group at UBC, focusing on marine natural products and chemical genetics. Collaborates with the Pacific Museum of Earth and Bamfield Marine Sciences Centre for field studies.

Lisa R. Merlinمشاهده پروفایل

استاد آموزشی

• Epilepsy Research
• Neurophysiology
• Neuropharmacology
• +۴ مورد دیگر

Lisa R. Merlin is a Teaching Professor at SUNY Downstate Health Sciences University , affiliated with the Department of Physiology and Pharmacology . Her research spans epileptogenesis , GABA and glutamate receptor dynamics , and medical curriculum reform . Education : MD (Medical Doctorate) Research Interests : Merlin investigates the basic mechanisms of epileptogenesis , focusing on group I metabotropic glutamate receptors and α4βδ GABAA receptors in adolescent seizure susceptibility. Her work aims to identify preventive strategies for post-trauma/post-stroke epilepsy and educational innovations in neuroscience. Article Trends : Recent collaborations center on systematic reviews in neurology , antiplatelet therapy , and longitudinal cognitive studies , reflecting her dual focus on clinical neuropharmacology and medical education . Scientific Awards : Clerkship Director Innovation Award Grants & Collaborations : Work with NIH study sections , Bob Wong , and Sheryl Smith on receptor pathways and curriculum development. No explicit grants mentioned. Labs & Teams : Collaborates with neurology and pharmacology teams at Downstate, including Peter Bergold and Michaelangelo Fuortes , on hippocampal excitability and epileptogenesis.

Anthony Brownمشاهده پروفایل

دانشیار

• Cancer Biology
• Wnt Signaling
• Stem Cells
• +۷ مورد دیگر

Anthony Brown is an Associate Professor in the Department of Cell and Developmental Biology at Weill Cornell Medical College, part of the Graduate School of Medical Sciences. He has been a faculty member since 1987 and currently serves as Director of the Office of Medical Student Research. Education: B.A. in Natural Sciences (Genetics), University of Cambridge, 1977 M.A., University of Cambridge, 1980 Ph.D. in Molecular Biology, University of Edinburgh, 1982 Postdoctoral Fellow, University of California, San Francisco (with Harold Varmus) Postdoctoral Fellow, University of Strasbourg (with Pierre Chambon) Dr. Brown's research focuses on the Wnt family of signaling proteins and their roles in tissue development, homeostasis, and cancer. His work has significantly advanced the understanding of both canonical and non-canonical Wnt pathways, particularly in breast and colorectal cancers. He has shown that Wnt signaling contributes to oncogenesis through mechanisms involving stem-like cells, epithelial-to-mesenchymal transition, and crosstalk with other signaling cascades such as TGFβ. His research employs diverse models including cell culture, organoids, mouse models, and patient-derived tissues. His recent publications reveal a strong emphasis on Wnt signaling in cancer stem cells, metastasis, and signal transduction mechanisms. Trends include the role of Wnt in tumor microenvironments, regulation of ribosomal DNA, and therapeutic targeting of multiple pathways simultaneously. His work frequently appears in high-impact journals such as PNAS, Cancer Research, and Development. Scientific Awards: Royal Society European Science Exchange Fellowship Medical Research Council (U.K.) Travelling Fellowship Cornell Scholars Award Andrew W. Mellon Teacher-Scientist Award Pew Scholar in the Biomedical Sciences Irma T. Hirschl Career Scientist Award WCM Awards for Teaching Excellence WCM Awards for Excellence in Medical Education Dr. Brown has been actively involved in grant-funded research, including as a Co-Investigator on the Clinical and Translational Science Center (UL1) grant awarded by the National Center for Advancing Translational Sciences (2022–2027). He collaborates with a broad network of co-investigators across disciplines. He also mentors students and contributes to medical education, reflecting his dual commitment to research and teaching. His laboratory investigates Wnt signaling mechanisms and their implications for cancer therapeutics.

Fabeha Fazalمشاهده پروفایل

دانشیار

• Pulmonary Medicine
• Cell Biology
• Molecular Pathology
• +۴ مورد دیگر

Fabeha Fazal, Ph.D. is an Associate Professor in the Department of Pediatrics at the University of Rochester Medical Center. Her research focuses on understanding the molecular mechanisms of Acute Lung Injury (ALI)/ARDS pathogenesis, particularly how endothelial cell dysfunction and inflammation contribute to disease progression. Current lab projects explore the role of endoplasmic reticulum BiP and mitochondrial GRP75 in ALI, as well as the link between endothelial cytoskeletal dynamics and inflammatory gene expression. She employs in vitro and in vivo models, including LPS-induced sepsis and thrombin-induced inflammation , to identify novel therapeutic targets for ALI. Her publications reveal expertise in NF-κB signaling , actin cytoskeleton regulation , and organelle crosstalk in inflammatory lung disorders. She has received NIH R01 grants for studying "Regulation of Endothelial-Neutrophil Interaction and Lung Vascular Permeability in Sepsis." Education: PhD in Biochemistry, A.M. University (1992) MSc in Biochemistry, A.M. University (1987) BSc in Chemistry, A.M. University (1985) Scientific Recognition: University Gold Medal for top M.S. Examination (1987) University Gold Medal for top B.S. Examination (1985) Lab Personnel: Collaborates with Principal Investigator Dr. Arshad Rahman and post-doctoral researchers like Dr. Pei Yi Su. Lab technicians and trainees include Antony Leonard (Technical Associate) and previous graduate researcher Moyinoluwa D Adenuga.

Michael G. Turnerمشاهده پروفایل

استاد

• Criminological Theory Testing
• Campus Risky Behaviors
• Resiliency and Desistance Research
• +۳ مورد دیگر

Dr. Michael G. Turner is a Professor and Chair in the Department of Criminal Justice and Criminology at the University of North Carolina at Charlotte. He holds a Ph.D. (2000) from the University of Cincinnati, along with M.S. (1994) and B.S. (1991) degrees from the same institution and Bowling Green State University. His research focuses on three core areas: testing criminological theories (particularly self-control development), analyzing campus-related risky behaviors (e.g., sexual victimization and binge drinking), and studying resiliency mechanisms against delinquency. Recent work includes a U.S. Department of Education grant for an intervention to reduce binge drinking on campuses. His scholarly contributions span over two decades, with a strong emphasis on longitudinal data analysis using the National Longitudinal Survey of Youth. Education: Ph.D. in Criminology, University of Cincinnati (2000) M.S. in Criminal Justice, University of Cincinnati (1994) B.S. in Psychology, Bowling Green State University (1991) Research Interests: Self-control theory: exploring developmental sources and life-course stability Rational Choice perspectives on cheating behaviors among college students Sexual victimization prevalence and intervention strategies on campuses Resiliency pathways influenced by racial/sex disparities in protective factors Grants and Interventions: U.S. Department of Education grant for binge drinking reduction programs Longitudinal studies funded via grants to analyze self-control and desistance Labs/Teams: No specific lab or team name mentioned, though his work involves collaborative research networks focused on criminological theory and applied interventions.

• Neuroscience
• Cell Signaling
• Neurodegenerative Diseases
• +۵ مورد دیگر

Jose Ramon Bayascas Ramirez is an Associate Professor in the Department of Biochemistry and Molecular Biology at the Universitat Autònoma de Barcelona's Institute of Neuroscience. With a Ph.D. in Biological Sciences from the University of Barcelona (1998), he completed postdoctoral training at the University of Lleida (1998-2002) and University of Dundee, Scotland (2002-2007) before joining UAB in 2007 as a Ramon y Cajal Fellow, becoming a Serra Húnter Associate Professor in 2014. His research focuses on the neurodevelopmental functions of the $$\text{PDK1}$$ signaling network and its implications for neurodegenerative and mental illnesses. His laboratory specializes in the $$\text{PI3K}$$/$$\text{Akt}$$ signaling pathway, utilizing brain-specific conditional knock-in mice with engineered $$\text{PDK1}$$ mutations (K465E and L155E) to study how these affect neuronal development and disease processes. The K465E mutation selectively impairs $$\text{Akt}$$ activation, while the L155E mutation abolishes activation of most $$\text{PDK1}$$ effectors except $$\text{Akt}$$. His work has revealed that reduced $$\text{Akt}$$ activation in $$\text{PDK1}$$ K465E mice protects against neurodegenerative insults, while the exclusive $$\text{Akt}$$ activation in $$\text{PDK1}$$ L155E mice causes severe mental disorders resembling human schizophrenia. His recent publications span molecular insights into $$\text{PDK1}$$ structure, behavioral studies in Alzheimer's models, and investigations into lysine crotonylation and metabolic homeostasis. His research has been recognized with a Ramon y Cajal Fellowship, and he has led multiple research projects including: "Assaig de l'inhibidor d'$$\text{Akt}$$ MK-2206 pel tractament de la Malaltia d'Alzheimer" (2022-2023) "Implicació de la ruta de senyalització $$\text{PI3K}$$/$$\text{PDK1}$$/$$\text{Akt}$$ en la Malaltia d'Alzheimer" (2019-2022) "Participació de $$\text{PDK1}$$ en les respostes a $$\text{PI3K}$$ durant el desenvolupament neuronal" (2015-2018) His group has published 53 research outputs with significant citations, demonstrating impactful contributions to understanding the molecular mechanisms underlying brain pathology and potential therapeutic targets for neurodegenerative and mental disorders.

Shreya Aryaمشاهده پروفایل

مدرس

• Geometry
• Topology
• Data Science

Shreya Arya is a Hans Rademacher Instructor of Mathematics at the University of Pennsylvania, affiliated with the Department of Mathematics. Her research interests intersect geometry, topology, and data science, with a focus on interdisciplinary applications in biological systems. She contributes to academic administration through editorial roles. Although specific educational background details are not provided, her work bridges mathematical methodologies with biomedical research. Key research areas include skin immune homeostasis, molecular signaling pathways in keratinocytes, and transcriptional regulation in epidermal development. Her publications explore topics ranging from HIV therapeutics to the role of DLX3 and CTIP2 in skin biology and carcinogenesis. Notably, her work on DLX3-dependent signaling networks and CTIP2’s role in epidermal regeneration highlights her expertise in molecular mechanisms underlying skin health and disease. No scientific awards or grants are explicitly mentioned in the provided texts. She has not listed advisees or students, suggesting a focus on independent research or early-career roles. Lab or team affiliations are not detailed here.

Daniel Levyمشاهده پروفایل

استاد

• Nuclear Biology
• Cellular Organelle Size Regulation
• Cancer Biology
• +۴ مورد دیگر

Dr. Daniel Levy is a Professor in the Department of Molecular Biology at the University of Wyoming, affiliated with the College of Agriculture, Life Sciences and Natural Resources. His research focuses on nuclear size regulation, organelle scaling, and their roles in cancer and development. He leads the Levy Lab, which uses Xenopus models and microfluidic technologies to study cellular mechanisms. Research Interests: Mechanisms of nuclear size regulation in embryos and cancer cells Organelle scaling during development and disease Role of nuclear morphology in gene expression and oncogenesis Development of synthetic cell models using microfluidics Key Achievements: NIH-funded grants on nuclear morphology and organelle scaling (R35GM134885, R01GM113028) Identification of nuclear import factors (e.g., NTF2, nucleoplasmin) in size control Collaborative studies on epigenetic modulators and nuclear shape dynamics Lab Members: Current advisees include PhD students (Priscilla Phan, Haritha Prabha) and undergraduates (Ella Reed). Alumni have transitioned to postdocs at top institutions, including UT Southwestern and UC Berkeley. Awards: Recipient of the AES Early Career Research Award. Active in mentoring and interdisciplinary collaborations, including work with induced pluripotent stem cells and C. elegans models.

• Metabolic Disease
• Epigenetics
• Cardiovascular Disease
• +۳ مورد دیگر

Brad Ferguson is an Associate Professor in the Department of Environmental Sciences & Health at the University of Nevada, Reno. His research investigates the epigenetic mechanisms linking metabolic diseases like obesity and diabetes to cardiac remodeling, with a focus on histone deacetylases (HDACs), acetyltransferases (HATs), and dietary bioactives. Key techniques: bioinformatics, cell culture, animal models. Primary research themes: chromatin regulation, metabolic-cardiovascular crosstalk, microbiome-epigenome interactions. The lab emphasizes dietary epigenetic modifiers and translational approaches to develop therapies for cardio-metabolic disorders. Recent publications highlight intersections between: Epigenetic aging and caloric restriction HDAC inhibition in cardiac/hypertension models Muscle physiology and post-translational modifications Nutritional programming in livestock and human systems No scientific awards were explicitly documented in the provided materials.

Joseph P. Stainsمشاهده پروفایل

استاد

• Bone Biology
• Connexin43 Signaling
• Osteoblast Differentiation
• +۳ مورد دیگر

Joseph P. Stains, PhD, is a Professor in the Department of Orthopaedics with secondary appointment in Physiology at University of Maryland School of Medicine. He leads the Division of Musculoskeletal Science and maintains affiliations with multiple research centers including the Center for Research on Aging and Center for Stem Cell Biology. Education: B.S. in Molecular & Cell Biology (1994), PhD in Biochemistry (2000) from Penn State University Appointments: Postdoc at Washington University (2001-2004), then continuously at University of Maryland since 2004 Dr. Stains' research focuses on bone cell signaling through connexin43-containing gap junctions , examining how intercellular communication coordinates osteoblast differentiation and osteocyte mechanotransduction . His work mechanistically links cytoskeletal dynamics to sclerostin regulation via NOX2-ROS-TRPV4-CaMKII pathways. His lab has produced over 65 peer-reviewed publications with recent emphasis on microtubule rheostats and Ca²⁺-dependent bone remodeling . Funding includes NIH R01 grants (2013-2025), DoD , and Maryland Stem Cell Research Fund awards. Scientific Leadership: ASBMR Fellow (2020), NIH Study Section Member Academic Service: Graduate Council, School of Medicine Council, Course Director for GPLS 645

• Biomedical Engineering
• Tissue Engineering
• Microphysiological Systems
• +۵ مورد دیگر

Mark Mondrinos is an Assistant Professor of Biomedical Engineering at Tulane University, affiliated with the School of Science & Engineering. His research focuses on developing microphysiological systems and organoid-based models to study human tissues and diseases, with a particular emphasis on lung, muscle, and interstitial tissues. He integrates confocal microscopy and biochemical analysis to bridge translational gaps in preclinical therapy screening. Academic roles include teaching courses such as Microphysiological Systems (BMEN 6440) and Quantitative Physiology (BMEN 3070/6070). Education & Affiliations: Inaugural Fellow, Center for Engineering Mechanobiology at Penn (2017) Postdoctoral Fellow in Bioengineering, University of Pennsylvania (2014–2016) Postdoctoral Fellow, Temple University School of Medicine (2012–2014) Ph.D. in Biomedical Engineering, Drexel University (2011) B.Sc. Chemical Engineering & Biological Chemistry, Florida State University (2002) Research Focus: His lab engineers biologically-inspired models to study respiratory exposure injuries (e.g., vaping), fibrotic disorders, and muscle injury. Current projects include multi-organ microfluidic models for systemic effects of malignancies like cachexia. Key tools include organ-on-a-chip platforms and advanced imaging techniques. Publications: Recent work spans PKC-delta inhibition in sepsis, tumor microenvironment modeling, and vascularized lung scaffolds. These studies highlight translational applications in drug screening and disease mechanisms. Awards: 2013 Jeanette Piperno Memorial Award 2011 Drexel University Best PhD Dissertation Labs/Teams: His laboratory at Tulane specializes in tissue engineering and microphysiological systems, collaborating with institutions like the University of Pennsylvania's Mechanobiology Center. Ongoing projects aim to advance personalized medicine through organ-on-a-chip technologies.

Valerie Chappeمشاهده پروفایل

دانشیار

• Cystic Fibrosis
• Respiratory Physiology
• Molecular Genetics
• +۳ مورد دیگر

Valerie Chappe is an Associate Professor in the Department of Physiology and Biophysics at Dalhousie University's Faculty of Medicine. Her research focuses on cystic fibrosis (CF), specifically the role of vasoactive intestinal peptide (VIP), ion channel dysfunction, and CFTR trafficking. She leads the CHAPPE Lab, collaborating on molecular mechanisms and therapeutic strategies for respiratory diseases. Education: BSc, MSc, and PhD from University of Aix-Marseille II and University of Provence (France). Research Interests: Cystic fibrosis pathophysiology, VIP signaling in respiratory health, CFTR correction in epithelial cells, and CF-related diabetes. Collaborations include drug screening and epidemiological studies. Awards: CIHR New Investigator Award (2006-2011), CFI Leaders Opportunity Fund (2007), and DMRF New Investigator Award (2005). Active in professional societies like the American Physiological Society and Canadian Society of Biochemistry. Labs/Teams: Atlantic CFTR Group, focusing on CFTR dysfunction and therapeutic development. Collaborations with PhaseBio Pharmaceuticals Inc. and advocacy work with patients like Campbell Brown, a youth fundraiser for CF research.

Clyde Hodgeمشاهده پروفایل

استاد

• Neural Circuits
• Molecular Mechanisms of Addiction
• Alcohol and Neurodegenerative Disorders
• +۳ مورد دیگر

Clyde Hodge is a Professor in the Department of Psychiatry and Pharmacology at the University of North Carolina School of Medicine . As a member of the Bowles Center for Alcohol Studies , his research focuses on uncovering the neural circuits and molecular mechanisms underlying alcohol and drug addiction, with a particular emphasis on the role of the limbic system, amygdala, and glutamatergic signaling. University: University of North Carolina at Chapel Hill School: UNC School of Medicine Department: Psychiatry Affiliation: Bowles Center for Alcohol Studies Research Interests span multiple critical areas in addiction neuroscience: Neural mechanisms of alcohol reinforcement Glutamate AMPA receptor (AMPAR) and TARP γ-8 interactions Impact of alcohol on Alzheimer's disease pathology Protein kinase C-ε (PKC-ε) regulation of GABA-A receptors Adolescent alcohol exposure and long-term vulnerability Brain region-specific pharmacotherapies for addiction Publication Trends reveal a focus on preclinical models linking alcohol use to: Calcium signaling in reward pathways Tau propagation in neurodegeneration AMPA receptor modulation Neuroplasticity in the amygdala Translational pharmacology targets Sex-specific neural adaptations Lab Mission addresses two primary goals: Identify novel neural targets for alcohol addiction Investigate alcohol's role in neurodegenerative disorders His team employs a "discovery-to-mechanistic" approach combining: Proteomics and transcriptomics Pharmacological and genetic manipulations Behavioral assays in mouse models CRISPR/Cas9 and fiber photometry