Clyde Hodge

Clyde Hodge is a Professor in the Department of Psychiatry and Pharmacology at the University of North Carolina School of Medicine. As a member of the Bowles Center for Alcohol Studies, his research focuses on uncovering the neural circuits and molecular mechanisms underlying alcohol and drug addiction, with a particular emphasis on the role of the limbic system, amygdala, and glutamatergic signaling.

• University: University of North Carolina at Chapel Hill
• School: UNC School of Medicine
• Department: Psychiatry
• Affiliation: Bowles Center for Alcohol Studies

Research Interests span multiple critical areas in addiction neuroscience:

• Neural mechanisms of alcohol reinforcement
• Glutamate AMPA receptor (AMPAR) and TARP γ-8 interactions
• Impact of alcohol on Alzheimer's disease pathology
• Protein kinase C-ε (PKC-ε) regulation of GABA-A receptors
• Adolescent alcohol exposure and long-term vulnerability
• Brain region-specific pharmacotherapies for addiction

Publication Trends reveal a focus on preclinical models linking alcohol use to:

• Calcium signaling in reward pathways
• Tau propagation in neurodegeneration
• AMPA receptor modulation
• Neuroplasticity in the amygdala
• Translational pharmacology targets
• Sex-specific neural adaptations

Lab Mission addresses two primary goals:

• Identify novel neural targets for alcohol addiction
• Investigate alcohol's role in neurodegenerative disorders

His team employs a "discovery-to-mechanistic" approach combining:

• Proteomics and transcriptomics
• Pharmacological and genetic manipulations
• Behavioral assays in mouse models
• CRISPR/Cas9 and fiber photometry