جست‌وجوی استاد و پژوهشگر

Keren Laskerمشاهده پروفایل

استادیار

• Membraneless Organelles
• Biomolecular Condensates
• Phase Separation
• +۴ مورد دیگر

Keren Lasker, PhD, is an Assistant Professor at Scripps Research (Department of Integrative Structural and Computational Biology) with joint appointments in Immunology & Microbiology and the Skaggs Graduate School of Chemical and Biological Sciences. Her research focuses on membraneless organelles (MLOs) in bacteria, leveraging phase separation principles to engineer synthetic MLOs in higher organisms for therapeutic and biotechnological applications. Education: PhD in Computer Science (Tel-Aviv University, 2012), M.Sc. and B.Sc. in Computer Science/Mathematics (Tel-Aviv University, 2006/2000). Research Interests : Biomolecular condensates, phase separation dynamics, bacterial cell polarity, synthetic MLO engineering, and applications in human disease. Her lab combines high-resolution imaging, genetics, and computational modeling to study PopZ protein-driven condensates in α-proteobacteria and their synthetic uses in human systems. Notable Awards : 2023 Faculty Scholar Program (Baxter Foundation), 2013 EMBO Fellowship, 2012 Best Paper Award (3DSig), and multiple early-career recognitions from Tel Aviv University and the Charles Clore Foundation. Grants : Supported by the Baxter Foundation, Burroughs Wellcome Fund, and NIH grants for MLO research. Labs/Teams : Lasker Lab at Scripps Research focuses on structural biology and synthetic biology of MLOs, collaborating with institutions like Stanford, Caltech, and the University of California.

Lucy Shapiroمشاهده پروفایل

استاد

• Developmental Biology
• Molecular Genetics
• Bacterial Cell Biology
• +۳ مورد دیگر

Lucy Shapiro is a Professor in the Department of Developmental Biology at Stanford University's School of Medicine, where she holds the Virginia and D. K. Ludwig Chair in Cancer Research. She serves as Director of the Beckman Center for Molecular and Genetic Medicine and maintains affiliations as a senior fellow at the Hoover Institution. Her professional roles extend to advisory positions at the Pasteur Institute, Ludwig Institute for Cancer Research, and Lawrence Berkeley National Labs. Shapiro also founded the anti-infectives discovery company Anacor Pharmaceuticals and serves on its board of directors. Shapiro's research focuses on the fundamental mechanisms of bacterial cell biology, particularly using Caulobacter crescentus as a model system to understand cellular organization, differentiation, and signaling. Her work has increasingly centered on biomolecular condensates and their role in spatial regulation of cellular processes, bacterial cell cycle control, and asymmetric division. She has pioneered the application of advanced imaging techniques including cryogenic super-resolution microscopy to visualize molecular organization within bacterial cells at unprecedented resolution. Analysis of her recent publications reveals a sophisticated integration of biophysical principles with cellular biology, particularly examining how biomolecular condensates function as regulatory hubs in bacterial cells. Her work demonstrates how phase separation mechanisms govern kinase signaling, cellular differentiation, and chromosome organization. The progression from studying individual molecular components to understanding their collective physical properties represents a significant conceptual shift in bacterial cell biology. Her distinguished honors include: Election to the American Academy of Arts and Sciences Election to the National Academy of Sciences 2005 Selman A. Waksman Award from the National Academy of Sciences 2009 Gairdner Award 2009 John Scott Award 2010 Abbott Lifetime Achievement Award 2020 Dickson Prize in Science As Director of the Beckman Center for Molecular and Genetic Medicine, Shapiro oversees a major research institution focused on understanding fundamental biological processes at the molecular level with implications for human health. Her leadership has fostered interdisciplinary research connecting basic science with medical applications, particularly in cancer research through her Ludwig Chair position. Her founding of Anacor Pharmaceuticals demonstrates her commitment to translating basic research into therapeutic applications, specifically in the anti-infectives space.

Brian Stevensonمشاهده پروفایل

استاد

• Molecular Microbiology
• Bacterial Gene Regulation
• Pathogenesis
• +۴ مورد دیگر

Brian Stevenson, PhD is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of Kentucky College of Medicine . His research focuses on molecular mechanisms of Borrelia burgdorferi gene regulation during vector-borne transmission cycles. Education: B.S. & M.S., Utah State University Ph.D., Stony Brook University Postdoctoral Fellow, Yale University School of Medicine IRTA Fellow, NIH Rocky Mountain Laboratories Research explores how Lyme disease spirochetes use c-di-GMP signaling , nucleoid-associated proteins , and environmental sensing to coordinate virulence factor expression across tick-mammal transitions. Key projects include NIH-funded investigations of PlzA , BpuR , and DnaA regulatory systems. Publications reveal expertise in bacterial surface protein regulation (e.g., OspC, Erp adhesins), operon control mechanisms, and spirochete genome evolution. Current work examines genomic diversity in Canadian B. burgdorferi strains. Lab welcomes undergraduate researchers and maintains collaborative networks across Lyme disease research communities. Social media presence at microscopist.net shares research updates and educational content.

• Bacterial pathogenesis
• Gastrointestinal microbiology
• DNA supercoiling and gene regulation
• +۷ مورد دیگر

Associate Professor Tadhg Ó'Cróinín is a microbiologist based at the School of Biomolecular and Biomedical Science , University College Dublin (UCD) . Since 2008 he has held academic appointments rising to Associate Professor in June 2023. He served as Head of Microbiology (2016-2022) and Associate Dean for Study Abroad (2011-2016) and currently chairs the UCD Student Finance Committee . Education BA (Moderatorship) in Microbiology, Trinity College Dublin (1995) PhD in Paediatrics, University College Dublin (1999) Professional Diploma in University Teaching & Learning, University College Dublin Research Interests Dr Ó’Cróinín’s group investigates the molecular basis of bacterial virulence, focusing on gastrointestinal pathogens such as Campylobacter jejuni , Salmonella enterica and Helicobacter pylori , as well as biofilm-forming pathogens on medical devices including Staphylococcus aureus and Pseudomonas aeruginosa . A unifying theme is the role of DNA supercoiling as a global regulator of virulence gene expression, biofilm formation and antibiotic resistance. The laboratory employs in vitro cell-culture models, 3-D intestinal spheroids, in vivo infection models, high-content imaging and genome-scale analyses to dissect these processes. Publication Themes Recent publications (2024-2025) reveal three major strands of work: (i) elucidating how DNA-relaxation in C. jejuni triggers an invasive phenotype and tight-junction disruption; (ii) developing antifouling and antimicrobial bioresorbable coatings for orthopaedic titanium implants to combat MRSA and P. aeruginosa biofilms; and (iii) genomic and phenotypic characterisation of novel yeast species from Irish soils. Earlier seminal studies established the role of DNA supercoiling and nucleoid-associated proteins (Fis, HU, Lrp) in regulating motility, invasion and intracellular survival across Salmonella , E. coli and Bordetella . Honours & Awards College of Science Teaching Award (2018) College of Science Teaching Award (2024) Chair, Professional Development Committee, Microbiology Society (2018-2021) Council Member, Microbiology Society (2018-2021) Grants & Supervision Since 2008 Dr Ó’Cróinín has been PI or Co-PI on >12 competitively funded grants from Science Foundation Ireland, EMBO, NIH, and industry partners, totalling in excess of €1.5 M. He has successfully supervised 7 PhD and 3 Master’s research students , mentoring them through projects spanning bacterial pathogenesis, antibiotic resistance and biofilm biology. Laboratory & Collaborations Research is conducted within the Microbiology Research Laboratory at UCD’s Health Sciences Centre. The group maintains active collaborations with clinical (Our Lady’s Children’s Hospital), materials-science (AMBER, CRANN) and international partners (NIH Bethesda, VU Amsterdam) to translate insights into infection control and biomaterial innovation.

• Tuberculosis
• Non-tuberculous mycobacteria
• Drug development
• +۳ مورد دیگر

Dr. Andréanne Lupien is an Assistant Professor in the Department of Microbiology and Immunology at McGill University and a Junior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC), affiliated with the Centre for Translational Biology and the Infectious Diseases and Immunity in Global Health Program. Her academic and research roles are centered on addressing critical challenges in infectious diseases, particularly tuberculosis and non-tuberculous mycobacterial infections. Research Interests: Development of novel treatments against Mycobacterium tuberculosis and non-tuberculous mycobacteria Mechanisms of drug resistance in mycobacteria Optimization of tuberculosis preventive therapies for latent infections Drug discovery from hit identification to pre-clinical validation Molecular biology of mycobacterial pathogenesis Her work spans the entire drug development pipeline, from identifying new chemical scaffolds to validating their efficacy in pre-clinical models. She employs molecular biology, genomics, and proteomics approaches to dissect resistance mechanisms and identify vulnerable drug targets in mycobacteria. Publication Highlights: Dr. Lupien's research output is prolific, with 15+ recent publications in leading journals such as PLoS Pathogens , Cell Reports , Nature Communications , and Antimicrobial Agents and Chemotherapy . Her work consistently addresses urgent global health needs, including multidrug-resistant tuberculosis and emerging mycobacterial pathogens. A recurring theme across her articles is the integration of genomic and proteomic data to inform therapeutic strategies. Laboratory and Affiliations: She conducts her research within the RI-MUHC's state-of-the-art facilities, leveraging the institute's containment level 3 tuberculosis labs and advanced molecular imaging platforms. Her team collaborates extensively with international partners, including the University of Zurich and the Swiss Tropical and Public Health Institute.

• Molecular Microbiology
• Bacterial Chromosome Replication
• Antimicrobial Resistance
• +۳ مورد دیگر

Anders Løbner-Olesen is a Professor in the Department of Biology at the University of Copenhagen, affiliated with both the BASP (Biotech Research and Innovation Centre) and the Functional Genomics research group. His laboratory is located at Ole Maaløes Vej 5 in Copenhagen, Denmark, where he maintains an active research program focused on bacterial molecular mechanisms. Professor Løbner-Olesen's research primarily centers on bacterial chromosome replication, DNA replication initiation, and antimicrobial resistance mechanisms. His laboratory investigates fundamental processes in Escherichia coli and Staphylococcus aureus , with particular emphasis on the DnaA protein that initiates chromosome replication. His team has developed innovative approaches using peptide-PNA conjugates to target bacterial replication machinery, representing novel strategies against antibiotic-resistant pathogens. His recent publication trends (2022-2025) demonstrate strong focus on antimicrobial peptide development, bacterial resistance mechanisms, and DNA replication control. The research spans fundamental molecular microbiology through to therapeutic applications, with significant contributions to understanding how bacteria regulate their cell cycles and develop resistance to antimicrobial agents. Professor Løbner-Olesen maintains active collaborations across multiple institutions, as evidenced by his extensive co-authorship network and research output metrics showing substantial Mendeley readership and social media engagement. His laboratory appears to be well-integrated within both national and international microbiology research communities.