جست‌وجوی استاد و پژوهشگر

Spilianakis Charalamposمشاهده پروفایل

دانشیار

• 3D Epigenetics
• Genome Architecture
• Chromosomal Interactions
• +۵ مورد دیگر

Charalampos Spilianakis is an Associate Professor at the University of Crete with a research affiliation at the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation for Research and Technology - Hellas (FORTH). His work focuses on the three-dimensional organization of the genome and its critical role in gene regulation within immune cells, particularly T cells. Dr. Spilianakis earned his PhD in 2003 from the University of Crete in Biochemistry, Molecular Biology, Cellular and Developmental Biology. His academic career has been dedicated to understanding how nuclear architecture influences cellular function and gene expression patterns. His research program investigates both cis and trans regulatory mechanisms of gene expression, with particular emphasis on how protein complexes generate and maintain long-range chromosomal interactions in immune cell populations. His laboratory employs an integrated approach combining biocomputing, molecular techniques, biochemical assays, advanced imaging, and genetic analyses to explore the field of 3D epigenetics. This work has significant implications for understanding immune cell differentiation and function. Analysis of Dr. Spilianakis' publication record reveals a consistent research trajectory focused on chromatin architecture and transcriptional regulation in immune cells. His contributions include developing protocols for chromosome conformation capture in primary T cells, elucidating SATB1's role in shaping the 3D enhancer network during T cell development, and investigating the nuclear periphery's role in microRNA gene localization. His work bridges molecular biology, immunology, and genomics to advance spatial genomics understanding. Based at IMBB-FORTH (Office A251, Lab A204), Dr. Spilianakis leads a research group that serves as an important hub for investigating the relationship between nuclear architecture and gene expression in the immune system. His laboratory combines cutting-edge molecular and imaging technologies to address fundamental questions about genome organization and its functional consequences in health and disease.

Joan Steitzمشاهده پروفایل

استاد

• RNA Processing
• Molecular Biophysics
• Biochemistry
• +۳ مورد دیگر

Joan Steitz is the Sterling Professor of Molecular Biophysics and Biochemistry at Yale University and an Investigator at the Howard Hughes Medical Institute. She holds affiliations with the Yale School of Medicine, the Center for RNA Science and Medicine, and the Yale Cancer Center. Her career includes roles such as Department Chair and leadership in organizations like the American Society for Cell Biology. Education: PhD in Biochemistry from Harvard University (1967); BS from Antioch College (1963). Postdoctoral training at the MRC Laboratory of Molecular Biology, Cambridge. Research focuses on RNA-protein complexes, particularly snRNPs and their roles in RNA processing, viral oncogenesis, and gene expression. Notable discoveries include defining mRNA splicing mechanisms and characterizing noncoding RNAs in herpesviruses. Publications highlight advancements in RNA biology, viral RNA interactions, and stress-induced transcription. Over 300 peer-reviewed articles span molecular biology, virology, and biochemistry. Awards include the Wolf Prize (2021), Lasker Award (2018), and membership in the National Academy of Sciences (1983). Her lab at Yale explores RNA structure-function relationships and viral RNA mechanisms.

Peter Wrightمشاهده پروفایل

استاد

• Protein Structure and Dynamics
• Nuclear Magnetic Resonance (NMR) Spectroscopy
• Intrinsically Disordered Proteins
• +۳ مورد دیگر

Peter Wright, PhD, is a Professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute (TSRI). He holds the Cecil H. and Ida M. Green Investigator endowed chair. Wright’s research focuses on protein structure, dynamics, and interactions using techniques like NMR spectroscopy. His work emphasizes intrinsically disordered proteins, protein folding/misfolding mechanisms, and amyloid aggregation. He has pioneered studies on transthyretin aggregation linked to amyloid diseases and the dynamics of enzymes like dihydrofolate reductase. Education: B.S., M.S., and Ph.D. in Chemistry from the University of Auckland (1968–1972). Postdoctoral training at the University of Oxford (1972–1976). Professional roles include Chair of TSRI’s Department of Molecular Biology (1987–2012) and leadership in collaborative projects with Ashok Deniz (single-molecule FRET) and Ian Wilson (X-ray crystallography). Research interests span intrinsically disordered proteins’ roles in cellular signaling, zinc finger nucleic acid recognition, and protein dynamics. His lab combines NMR, X-ray crystallography, and computational methods. Awards include the NIH Merit Award, National Academy of Sciences membership, and multiple honorary doctorates. Key grants include NIH funding for amyloidosis research. His lab’s innovations include intein labeling technologies and NMR relaxation dispersion techniques to study protein excited states. Collaborations include work on muscleblind RNA recognition and Kaiso DNA binding mechanisms.

Jussi Taipaleمشاهده پروفایل

استاد

• Gene regulation
• Transcription factors
• Systems biology
• +۴ مورد دیگر

Jussi Taipale is a Professor of Medical Systems Biology at Karolinska Institutet and holds professorships at University of Helsinki. His research focuses on transcription factor binding mechanisms , cancer genomics , and gene regulatory networks . The interdisciplinary Taipale Lab operates across three international locations: Wellcome Sanger Institute (UK), Karolinska Institutet (Sweden), and University of Helsinki (Finland), with over 20 members including senior scientists, postdoctoral fellows, and graduate students. Ph.D., University of Helsinki (1996) Postdoctoral training: University of Helsinki, Johns Hopkins University Research spans transcription factor cooperativity , epigenetic regulation , chromatin accessibility , and noncoding mutation analysis . Key methodologies include HT-SELEX , CUT&RUN , ATI assays , and CRISPR-based functional genomics . The lab has significantly advanced understanding of Myc-driven oncogenesis , TF-nucleosome interactions , and dinucleotide specificity mechanisms . Notable discoveries include chromatin context-dependent enhancers , water-mediated DNA recognition , and novel composite transcription factor motifs . The group maintains active collaborations across Europe and has trained numerous alumni now leading academic and industry positions worldwide.

Kirk W. Deitschمشاهده پروفایل

استاد

• Malaria Biology
• Plasmodium falciparum Pathogenesis
• Gene Regulation
• +۵ مورد دیگر

Kirk W. Deitsch is a Professor of Microbiology and Immunology at Weill Cornell Medicine , where he leads research on Plasmodium falciparum pathogenesis. His work focuses on gene regulation and antigenic variation through the var gene family, which enables immune evasion by malaria parasites. Department of Microbiology and Immunology, Weill Cornell Medicine Research spans molecular mechanisms of var gene switching and immune avoidance Investigates genome plasticity via DNA repair and telomere dynamics His laboratory explores how chromatin structure and DNA double-strand break repair contribute to antigenic diversity. Recent studies highlight the role of transcriptional plasticity and epigenetic memory in malaria pathogenesis. Key findings include insights into mitotic recombination and environmental sensing for immune evasion. Notable article trends include: 2025 work on scRNA-seq for var gene plasticity 2024 analysis of var gene evolutionary importance 2023 studies on sexual differentiation epigenetics and environmental response 2022 reviews of antigenic variation mechanisms 2021 investigations into telomere dynamics His research team has secured multiple National Institute of Allergy & Infectious Diseases grants to study transcriptional switching networks and genome diversification. The lab also examines Plasmodium -host interactions and applications of CRISPR-Cas9 in malaria genetics.

Rafael Pinilla Redondoمشاهده پروفایل

استادیار

• Bacterial Immunity
• CRISPR-Cas Systems
• Molecular Evolution
• +۴ مورد دیگر

Rafael Pinilla-Redondo is an Assistant Professor in the Department of Biology at the University of Copenhagen's Faculty of Science, where he leads the Bacterial Immunity research group within the Section of Microbiology. His laboratory, located at Universitetsparken 15 in Copenhagen, focuses on the molecular mechanisms of bacterial defense systems against phages. His research interests center on bacterial immunity, particularly how CRISPR-Cas and other bacterial immune systems evolve and function. He investigates the molecular mechanisms driving these complex systems to answer fundamental biological questions and develop novel biotechnologies. His work spans phage biology, molecular evolution, molecular biology, and genetics, with a specific emphasis on bacterial defense mechanisms against viral threats. Dr. Pinilla-Redondo's recent publications demonstrate significant contributions to understanding bacterial immune systems, particularly CRISPR-Cas variants, retrons, and other defense mechanisms. His research shows strong trends in structural biology approaches to understanding immune system function, with increasing focus on the supramolecular organization of defense complexes and their evolutionary implications. Villum Young Investigator grant (2023) His laboratory maintains active collaborations across multiple institutions, as evidenced by the international authorship on his publications. The lab has developed specialized software tools including CRISPR-Cas Typer for automated identification of CRISPR-Cas loci, Plasmid Network for exploring the global plasmidome, and Hoodini (coming soon) for genome neighborhood visualization. His work has received significant attention, with multiple papers picked up by news outlets, blogged about, and widely shared on social media platforms. The Pinilla-Redondo Lab is part of the vibrant microbiology research community at the University of Copenhagen, focusing on the evolutionary arms race between bacteria and their viral predators.

Meixia Zhaoمشاهده پروفایل

استادیار

• Genome Evolution
• Epigenetics
• Plant-Microbe Interactions
• +۴ مورد دیگر

Dr. Meixia Zhao is an Assistant Professor in the Department of Microbiology & Cell Science at the University of Florida. Previously, she held positions at Miami University (2018–2022) and was a postdoctoral researcher at Purdue University (2013–2017). She earned her PhD in Biochemistry and Molecular Biology from the Chinese Academy of Agricultural Sciences, with a visiting PhD in Plant Genetics at Purdue University. Her research focuses on using computational and functional genomic approaches to study genome evolution, epigenetic regulation of meiotic recombination, and plant-microorganism interactions in maize and soybean. Key areas include transposable element function, epigenetic silencing mechanisms, and disease resistance pathways. Her lab investigates mechanisms underlying maize and soybean immunity to pathogens like Phytophthora sansomeana , leveraging comparative genomics, epigenomics, and transcriptomics. Recent studies explore the role of DNA methylation, small RNAs, and histone modifications in regulating plant defense responses. She also examines sex-specific differences in meiotic recombination and the evolutionary consequences of polyploidization. Dr. Zhao has mentored over 20 graduate and undergraduate students, including those in the Plant Molecular and Cellular Biology (PMCB) program. Her work has been published in high-impact journals, focusing on topics like transposable element silencing, epigenetic variation, and crop disease resistance. The Zhao Lab collaborates with other groups to advance understanding of plant-microbe interactions and translational applications in agriculture.

• RNA structure and function
• RNA splicing mechanisms
• RNA enzymes
• +۶ مورد دیگر

Anna Marie Pyle is a Sterling Professor at Yale University in the Departments of Molecular, Cellular and Developmental Biology and Chemistry. She is a Howard Hughes Medical Institute Investigator since 1997 and has held leadership roles including President of the RNA Society and Chair of the NIH MSFA Study Section. Her research focuses on RNA structure, RNA remodeling enzymes, and innate immune receptors. She has authored over 190 publications and mentored over 40 students/postdocs. **Education:** B.S. in Chemistry (Princeton University), Ph.D. in Chemistry (Columbia University, 1990). Postdoctoral training at the University of Colorado with Thomas Cech. Joined Yale in 2002. **Research:** Pioneered structural studies of group II introns and the spliceosome. Her lab investigates RNA tertiary structures, viral RNA biology, and RIG-I signaling. Key contributions include understanding RNA helicases, antiviral immunity, and lncRNA structural biology. Collaborates with industry (e.g., Arrakis Therapeutics) on RNA-based therapeutics. **Awards:** HHMI Investigator, National Academy of Sciences member, AAAS Fellow. Recognized for innovations in RNA structure-function relationships. **Grants & Labs:** Leads the Pyle Lab at Yale, funded by NIH and HHMI. Active in developing RIG-I agonists for cancer immunotherapy and antifungal drugs targeting RNA splicing.

Mark Boldinمشاهده پروفایل

دانشیار

• Non-coding RNA Biology
• Immunology
• Cancer Genetics
• +۳ مورد دیگر

Mark Boldin, M.D., Ph.D., is an Associate Professor in the Department of Systems Biology at City of Hope. His research focuses on the control of inflammation and cancer through non-coding RNA mechanisms, particularly in hematopoietic disorders like leukemia and autoimmune diseases. The Boldin Laboratory investigates how microRNAs (miRNAs) such as miR-146a, miR-132, and miR-155 regulate immune system development and function. Research highlights include miR-146a's role as a molecular brake on inflammation and cancer via silencing TRAF6 and IRAK1 signaling proteins. Current work explores both small and long noncoding RNAs in immune cell signaling dysregulation, aiming to develop novel therapeutics for autoimmunity and cancer. The laboratory operates within the Duarte Cancer Center at City of Hope, with a mission to translate findings into clinical applications for devastating diseases.

Mary Lauren Bentonمشاهده پروفایل

استادیار

• Computational Biology
• Gene Regulation
• Biomedical Informatics
• +۳ مورد دیگر

Dr. Mary Lauren Benton is an Assistant Professor in the Department of Computer Science at Baylor University's College of Engineering and Computer Science. She holds a Ph.D. and M.S. in Biomedical Informatics from Vanderbilt University (2020, 2018) and a B.S.I. in Bioinformatics from Baylor University (2015). Education: Ph.D. (Vanderbilt, 2020), M.S. (Vanderbilt, 2018), B.S.I. (Baylor, 2015) Her research focuses on computational biology and gene regulation, particularly how DNA sequences influence genome function and human disease risk through integrated datasets. Recent work explores enhancer-gene interactions, epigenetic mechanisms, and the application of graph neural networks to genomic problems. Selected publications highlight interdisciplinary trends across genomics (e.g., Cis-regulatory landscapes , CTCF motif accessibility ) and computer science (e.g., Dynamic graph attention , Node classification ).

Junco Warrenمشاهده پروفایل

استادیار

• Energy Metabolism
• Mitochondrial Bioenergetics
• Heart Failure Therapy
• +۳ مورد دیگر

Junco Warren, PhD, is an Assistant Professor at the Fralin Biomedical Research Institute and Virginia Tech’s Department of Human Nutrition, Foods, and Exercise. She holds an adjunct appointment at Kumamoto University, Japan. Her research focuses on metabolic reprogramming in heart failure, particularly mechanisms linking energy metabolism dysfunction to cardiac pathology. Key interests include mitochondrial bioenergetics, metabolomics, and epigenetic regulation in cardiac disease. Education: PhD in Pharmacology (SUNY Medical School, 2007), B.A. in International Economics (Aoyama-Gakuin University, 1997). Research Interests: Her work investigates how metabolic dysregulation drives heart failure progression, with emphasis on PERM1 and Smyd1 proteins. Projects include metabolomics-based biomarker discovery and therapeutic strategies targeting mitochondrial function. Awards: Notable recognitions include the 2023 Seale Innovation Award, 2016 BCVS Early Career Investigator Award, and multiple NIH and American Heart Association grants. Grants/Advising: Leads the Warren Lab, mentoring graduate and undergraduate students. Current projects involve PERM1 gene therapy in heart failure models and collaborations on mitochondrial dysfunction mechanisms. Lab Affiliations: Center for Vascular and Heart Research at Fralin, with international collaborations in Japan and the U.S.

• RNA Metabolism
• Alternative Splicing
• Molecular Oncology
• +۴ مورد دیگر

Prof. Maria Paola Paronetto is an Associate Professor at the Department of Human Motor Sciences and Health, University of Rome 'Foro Italico'. Her research focuses on RNA metabolism and alternative splicing, particularly in cancer and neurodegenerative diseases like Ewing Sarcoma and Amyotrophic Lateral Sclerosis (ALS). She investigates the roles of RNA binding proteins (RBPs) and signaling pathways in disease pathogenesis, with an emphasis on developing novel therapeutic targets. Research Areas: RNA processing, molecular oncology, neurodegeneration, splicing regulation Her work includes projects funded by grants such as the AIRC Investigator Grant (IG21877) and PRIN 202224MK8Z. Prof. Paronetto collaborates on international initiatives like the European Master's in Health and Physical Activity. She teaches courses in research methodology and general biology at the university. Key contributions include identifying the DHX9/KDM2B complex as a therapeutic target in Ewing Sarcoma and elucidating exercise impacts on ALS progression in mouse models. She is a member of review groups for international programs and contributes to translational research initiatives.

Keriayn Smithمشاهده پروفایل

دانشیار

• Non-coding RNA
• Genetics
• Epigenetics
• +۴ مورد دیگر

Keriayn Smith, PhD, is an Associate Professor in the Department of Genetics at the University of North Carolina School of Medicine and holds a concurrent appointment as an Associate Professor in the School of Data Science and Society. Her research focuses on non-coding RNAs, particularly long noncoding RNAs (lncRNAs), exploring their roles in cell identity, developmental processes, and disease mechanisms. She has received significant grants, including an NSF award ($665,786) for studying lncRNA functions in yeast and mammalian cells, and a Hypothesis Fund Seed Grant for investigating noncoding RNAs' roles in cell identity. Dr. Smith’s work emphasizes translational applications, such as leveraging lncRNA insights for regenerative medicine and personalized therapies. She leads initiatives like the RNA Discovery Center at UNC Lineberger Comprehensive Cancer Center, promoting diversity in RNA research. Notably, she chairs the Society for Scientific Advancement (SOSA), advocating for STEM accessibility in underserved regions and underrepresented groups. Her grants include a UNC Idea Grant for studying the oncogenic role of lncRNA Cyrano in neuroblastoma and supplemental funding during the pandemic to explore lncRNA roles in stem cell maintenance. Recent articles highlight her contributions to understanding lncRNA networks, epigenetic regulation, and interdisciplinary collaborations in genomics. Awards include the Junior Faculty Development Award from the UNC Provost’s Office, recognizing her project on comparative transcriptomics in ozone-exposure models. Dr. Smith’s research bridges basic science with clinical impact, addressing systemic risks to health through innovative, high-risk projects.

• Non-coding RNA research
• Computational Biology
• Genomics
• +۳ مورد دیگر

Sam Griffiths-Jones is a Professor of Computational Biology at the University of Manchester, affiliated with the Division of Evolution, Infection and Genomics within the Faculty of Life Sciences and Faculty of Biology, Medicine and Health. His research focuses on non-coding RNA (ncRNA) structure, function, and evolution, leveraging computational methods and databases such as Rfam and miRBase. He holds a PhD in Chemistry from the University of Nottingham (2000) and has held academic positions since 2007, including roles at the Wellcome Trust Sanger Institute. Research interests include ncRNA gene identification, microRNA regulation, and comparative genomics. Key contributions include curating miRBase and expanding Rfam to include viral and metagenomic families. His work bridges computational tools and biological insights, addressing questions about RNA diversity and evolutionary mechanisms. Education: BSc (Biochemistry) and PhD (Chemistry) from the University of Nottingham Labs/Teams: Leads a group focused on RNA computational biology and collaborates with global teams on Rfam/miRBase development Grants/Impacts: Impacts include tool development for microRNA research and pharmaceutical applications Teaching roles include Academic Admissions Officer for biosciences programs and courses in bioinformatics and genomics. Recent publications (2020-2025) highlight advancements in RNA sequencing, database resources, and functional studies in diverse organisms.

Paul Marshallمشاهده پروفایل

پژوهشگر

• Neuroscience
• Epigenetics
• RNA Biology
• +۳ مورد دیگر

Dr. Paul Marshall is a Researcher at the Queensland Brain Institute, The University of Queensland, supported by an NSERC Scholarship. His work focuses on neuroepigenetic mechanisms underlying learning and memory, with expertise in RNA biology, DNA structure dynamics, and fear extinction processes. He completed his PhD in 2020 at the Queensland Brain Institute, exploring dynamic DNA structure states and their role in memory. His research integrates cutting-edge technologies to study noncoding RNAs, epigenetic modifications (e.g., m6A, Z-DNA), and their impact on synaptic plasticity and cognitive functions. Key contributions include identifying the role of DNA G-quadruplex in transcriptional control, the function of long noncoding RNAs in fear extinction, and mechanisms linking RNA editing (via ADAR1) to memory consolidation. His findings bridge molecular biology with behavioral neuroscience, advancing understanding of how genetic and epigenetic factors influence cognitive processes. Publications highlight collaborations with Timothy Bredy and others, emphasizing interdisciplinary approaches to unravel neural mechanisms. No awards are explicitly listed, but his work is recognized in high-impact journals like Nature Neuroscience and Cell Reports .