جست‌وجوی استاد و پژوهشگر

John A. Copland, IIIمشاهده پروفایل

استاد

• Cancer Biology
• Molecular Carcinogenesis
• Translational Research
• +۳ مورد دیگر

Dr. John A. Copland III is a Professor of Cancer Biology and Biochemistry & Molecular Biology at Mayo Clinic in Jacksonville, Florida. He leads the Cancer Biology and Translational Research Laboratory, focusing on molecular mechanisms of carcinogenesis, tumor progression, and development of targeted cancer therapies. Education: PhD in Physiology & Endocrinology (Medical College of Georgia), MS in Endocrinology (Medical College of Georgia), BS in Chemistry (Columbus College), with postdoctoral training at University of Texas Medical Branch. Research interests center on: Identifying tumor suppressor genes (e.g., RhoB, TBR3, GATA3) and oncogenes (e.g., FOXO3a, SCD1, NPTX2). Developing patient-derived xenografts and live cell models for personalized medicine. Designing SCD1 inhibitors via in silico modeling for clinical trials. Recent publications highlight his work on SCD1 inhibition in leukemia and thyroid cancer ImmunoPET imaging of thyroid tumors CRISPR-identified drug synergies in cholangiocarcinoma Patient-specific combination therapies using xenograft models

Xian Wuمشاهده پروفایل

استادیار

• Developmental Toxicology
• Stem Cell Models
• Neurotoxicology
• +۵ مورد دیگر

Xian Wu, Ph.D., serves as a Research Assistant Professor in the Department of Pharmacology & Toxicology at East Carolina University's Brody School of Medicine. Her research leverages human stem cell models to investigate developmental vulnerabilities to environmental contaminants in cardiovascular and neural systems, with emphasis on epigenetic mechanisms and disease modeling. Dr. Wu's academic credentials include: Ph.D. in Toxicology from the University of Georgia M.S. in Biomedicine from East China Normal University B.S. in Biotechnology from Anhui University Her postdoctoral training comprised a Fellowship at the National Institute of Environmental Health Sciences and an ORISE Fellowship at the U.S. Food and Drug Administration. Research focuses on creating human stem cell-derived organoid systems to model developmental toxicology, particularly examining cardiac and neural development under chemical exposure. The laboratory employs fluorescence reporter systems and RNA-seq to identify critical vulnerability windows during early development, with recent work targeting Parkinson's disease mechanisms through dopaminergic neuron models and cardiac fibrosis via advanced organoids. Methodological innovations include high-content imaging for neurogenesis quantification and epigenetic pathway analysis. Publication trends (2016-2025) demonstrate consistent advancement in stem cell-based toxicology testing, with increasing emphasis on micro/nanoplastics risk assessment, arsenic neurotoxicity mechanisms, and doxorubicin cardiotoxicity modeling. The work bridges environmental health, epigenetics, and regenerative medicine through interdisciplinary approaches. Scientific recognition includes: 2025 SPARC Award (ECU) 2024 Top Abstract Award (Developmental Origins of Health and Disease Society) 2024 NIEHS P30 Center Travel Award 2023 ECU Research and Creative Activity Award Dr. Wu actively mentors graduate researchers including Ph.D. candidate Cate Duncan and M.S. students Kamilah Muhammad and Bailey Skeen, alongside undergraduate Bryce Tilghman. Former trainees McKyrah Brown and Monica Cross completed honors theses in the laboratory. Current grants include ECU's SPARC Award funding stem cell model development for environmental contaminant testing. The BSOM 6S-11 laboratory maintains specialized capabilities in cardiac and cerebral organoid generation, fluorescence-based toxicity screening, and RNA-seq epigenetic analysis. Collaborative networks include the National Institute of Environmental Health Sciences and ECU's Center for Human Health and the Environment, supporting translational research on developmental vulnerability periods.

Trond Vidar Hansenمشاهده پروفایل

استاد

• Organic Chemistry
• Biochemistry
• Pharmacology
• +۳ مورد دیگر

Trond Vidar Hansen is a Professor at the Department of Pharmacy, University of Oslo , and leads the LIPCHEM research group . He collaborates with institutions including the University of Bergen and Vestlandets Innovasjonsselskap through the VITADEL project, which recently received NOK 5,000,000 in verification support from the Research Council of Norway. His research focuses on the synthesis and biological evaluation of specialized pro-resolving lipid mediators derived from omega-3 fatty acids, with applications in inflammation resolution, neuroinflammation, and drug development. University : University of Oslo Department : Department of Pharmacy Research Group : LIPCHEM Collaborations : University of Bergen, Vestlandets Innovasjonsselskap Research Interests : H Hansen's work centers on the organic synthesis of bioactive lipid derivatives, particularly pro-resolving mediators from omega-3 polyunsaturated fatty acids. His team investigates their roles in inflammatory disease models , neuroinflammation , and PPAR receptor activation , aiming to develop therapeutic agents for conditions like chronic pain, diabetes, and neurodegenerative disorders. The research integrates stereoselective chemistry , biochemical profiling , and pharmacological evaluation to validate these mediators' clinical potential. Recent Awards : 2025: NOK 2,000,000 verification support from Research Council of Norway 2025: Co-leader of NOK 5,000,000 VITADEL project Publications : His articles (2015–2024) reveal a focus on stereoselective synthesis of resolvins, protectins, and maresins, with applications in anti-inflammatory and neuroprotective therapies . Key subfields include omega-3 metabolite profiling , PPAR agonist design , and biosynthetic pathway elucidation , often utilizing human cell models and mouse disease models . Collaborative projects emphasize commercialization of academic research and translational medicine .

• Obesity
• Energy balance
• Leptin signaling
• +۵ مورد دیگر

Maia Kokoeva, PhD, is a Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) and an Associate Professor in the Department of Medicine, Division of Endocrinology, at McGill University’s Faculty of Medicine and Health Sciences. She leads studies on obesity and neuroendocrine control of energy balance, focusing on leptin sensing and the role of NG2-glia in the hypothalamus. Research Interests: Neuroendocrine regulation of body weight Leptin signaling and sensing mechanisms Hypothalamic circuits controlling energy expenditure NG2-glia biology and adult neurogenesis Genetic mouse models of obesity and diabetes Her recent publications illuminate how NG2-glia in the median eminence mediate leptin entry into the hypothalamus, uncovering new cellular players that could be targeted to prevent age-related weight gain. Laboratory and Affiliations: Dr Kokoeva heads a laboratory within the Metabolic Disorders and Complications Program of the Centre for Translational Biology at RI-MUHC, leveraging state-of-the-art imaging and genetic tools to dissect hypothalamic control of metabolism.

Simon Arthurمشاهده پروفایل

استاد

• Immunology
• Cell Signalling
• Inflammation Biology
• +۳ مورد دیگر

Simon Arthur is a Professor of Immune Signalling at the University of Dundee, School of Life Sciences, within the Department of Cell Signalling and Immunology. His research focuses on understanding inflammatory processes, particularly the role of innate immune cells in coordinating inflammation and resolving immune responses. He holds a PhD from the University of Oxford (1995) and a BSc from Durham University (1990). Arthur is a Fellow of the Royal Society of Biology (2015) and serves on the editorial board of the Journal of Biological Chemistry . His teaching includes courses on Genetics, Cell Signalling, Immunology, and advanced topics in immunology and cell signalling. He supervises PhD projects on microglial phenotypes in brain ageing and immunomodulatory factors in helminth-host interactions. Arthur leads research projects funded by the Medical Research Council and other agencies, including studies on liver fibrosis, bile acid diarrhoea, and pulmonary fibrosis. Key research themes include cytokine regulation, macrophage function, and the molecular mechanisms underlying chronic inflammation. His work spans from fundamental biology to translational research, aiming to develop therapies for autoimmune and inflammatory diseases. Arthur collaborates internationally and has over 180 publications in high-impact journals.

Anthony Brownمشاهده پروفایل

دانشیار

• Cancer Biology
• Wnt Signaling
• Stem Cells
• +۷ مورد دیگر

Anthony Brown is an Associate Professor in the Department of Cell and Developmental Biology at Weill Cornell Medical College, part of the Graduate School of Medical Sciences. He has been a faculty member since 1987 and currently serves as Director of the Office of Medical Student Research. Education: B.A. in Natural Sciences (Genetics), University of Cambridge, 1977 M.A., University of Cambridge, 1980 Ph.D. in Molecular Biology, University of Edinburgh, 1982 Postdoctoral Fellow, University of California, San Francisco (with Harold Varmus) Postdoctoral Fellow, University of Strasbourg (with Pierre Chambon) Dr. Brown's research focuses on the Wnt family of signaling proteins and their roles in tissue development, homeostasis, and cancer. His work has significantly advanced the understanding of both canonical and non-canonical Wnt pathways, particularly in breast and colorectal cancers. He has shown that Wnt signaling contributes to oncogenesis through mechanisms involving stem-like cells, epithelial-to-mesenchymal transition, and crosstalk with other signaling cascades such as TGFβ. His research employs diverse models including cell culture, organoids, mouse models, and patient-derived tissues. His recent publications reveal a strong emphasis on Wnt signaling in cancer stem cells, metastasis, and signal transduction mechanisms. Trends include the role of Wnt in tumor microenvironments, regulation of ribosomal DNA, and therapeutic targeting of multiple pathways simultaneously. His work frequently appears in high-impact journals such as PNAS, Cancer Research, and Development. Scientific Awards: Royal Society European Science Exchange Fellowship Medical Research Council (U.K.) Travelling Fellowship Cornell Scholars Award Andrew W. Mellon Teacher-Scientist Award Pew Scholar in the Biomedical Sciences Irma T. Hirschl Career Scientist Award WCM Awards for Teaching Excellence WCM Awards for Excellence in Medical Education Dr. Brown has been actively involved in grant-funded research, including as a Co-Investigator on the Clinical and Translational Science Center (UL1) grant awarded by the National Center for Advancing Translational Sciences (2022–2027). He collaborates with a broad network of co-investigators across disciplines. He also mentors students and contributes to medical education, reflecting his dual commitment to research and teaching. His laboratory investigates Wnt signaling mechanisms and their implications for cancer therapeutics.

Stuart Allanمشاهده پروفایل

استاد

• Neuroinflammation
• Stroke Pathology
• Cytokine Signaling
• +۳ مورد دیگر

Stuart Allan is Professor of Neuroscience at the University of Manchester's Faculty of Life Sciences, Division of Neuroscience. His research focuses on neuroinflammation mechanisms in stroke and neurodegenerative diseases, with particular expertise in cytokine signaling (especially IL-1) and neuronal injury pathways. He leads projects targeting interleukin-1 for acute brain injury treatment and investigates stroke-immune mediated pathways in cognitive trajectory. Research Interests: Neuroinflammatory responses, cytokine-mediated neuronal injury, stroke pathophysiology, Alzheimer's disease mechanisms, and neurovascular coupling. His work bridges experimental paradigms (in vitro and in vivo) with clinical applications. Education: PhD Biomedical Sciences (University of Aberdeen, 1990-1993) BSc Pharmacology (University of Dundee, 1986-1990) Professional Appointments: Professor of Neuroscience (2012-present) Senior Lecturer (2008-2012) Lecturer (2002-2008) Postdoctoral Research Associate (1993-2002) Research Beacons & Institutes: Dementia@Manchester, Manchester Regenerative Medicine Network, Lydia Becker Institute, Christabel Pankhurst Institute, Manchester Institute for Collaborative Research on Ageing. Scientific Output: 179 research outputs including articles on cerebrovascular health, neurovascular coupling, and cytokine mechanisms in stroke models. Research demonstrates consistent focus on translational neuroscience and neuroinflammatory pathways.

George Hendersonمشاهده پروفایل

استاد

• Developmental Neuroscience
• Neurotoxicity
• Oxidative Stress
• +۳ مورد دیگر

George Henderson is a Professor at the Texas Tech University Health Sciences Center in the Department of Pharmacology & Neuroscience . His research focuses on the neurotoxic effects of ethanol and environmental toxins during development, particularly mechanisms of apoptosis and oxidative stress in the brain and placenta. Primary Affiliation: Texas Tech University Health Sciences Center Research Areas: Developmental neuroscience, neurotoxicity, oxidative stress, fetal alcohol spectrum disorder, nanoparticle drug delivery Research Trends: His publications from 1972–2023 show sustained expertise in ethanol-induced developmental damage, placental drug transport mechanisms, and antioxidant therapeutic strategies. Recent work (2023) explores chlorogenic acid as a neuroprotective agent via NFATc4/CSE pathways. Key Collaborations: Institute for One Health Innovation and translational neuroscience teams at TTUHSC.

Peter R. MacLeishمشاهده پروفایل

استاد

• Retinal Neuroscience
• Neural Regeneration
• Electrophysiology
• +۵ مورد دیگر

Peter R. MacLeish serves as Professor of Neurobiology at Morehouse School of Medicine's School of Medicine, where his laboratory in the Multidisciplinary Research Center (F-22614) investigates fundamental mechanisms of retinal function and regeneration. Education: Undergraduate: Bachelor of Engineering Science (Electrical) from University of Western Ontario Graduate: Doctor of Philosophy from Harvard University Postdoctoral Training: Neurobiology at Harvard Medical School Research Focus: Dr. MacLeish's program encompasses two interconnected domains. First, he characterizes functional properties of mature retinal neurons in salamanders and primates using electrophysiology and optical imaging to dissect phototransduction cascades, synaptic connectivity, and compartmentalized ionic conductances. Second, he investigates retinal regeneration mechanisms in adult newts, examining how retinal pigment epithelial (RPE) cells undergo depigmentation, proliferation, and differentiation to form functional retinas after injury. His innovative approaches include antibody-immobilized substrates to enhance neuronal adhesion for in vitro studies. Publication Trends: His 25-year publication record reveals consistent contributions to vision science, evolving from foundational studies on retinal development (1990s) to contemporary work on primate retinal circuitry (2010s), with his 2015 BRAIN Initiative paper highlighting leadership in large-scale neuroscience collaboration. The body of work demonstrates methodological progression from immunolabeling to advanced electrophysiological techniques across multiple model organisms. Scientific Recognition: Elected Member of the Institute of Medicine (National Academies) Dana Alliance for Brain Initiatives membership NIH BRAIN Initiative Working Group participant Research Operations: While specific grant details aren't provided, his laboratory maintains active research programs in retinal neuroscience with demonstrated capacity for multi-institutional collaboration as evidenced by the BRAIN Initiative publication. The absence of student listings suggests either independent research focus or unreported mentoring activities. Facilities: Research is conducted within the Multidisciplinary Research Center at Morehouse School of Medicine, utilizing specialized equipment for cellular electrophysiology and optical imaging of retinal tissues.

Deborah Goberdhanمشاهده پروفایل

دانشیار

• Cancer Biology
• Cell Growth Regulation
• mTORC1 Signaling
• +۵ مورد دیگر

Dr. Deborah Goberdhan is an Associate Professor at the University of Oxford , affiliated with the Department of Physiology, Anatomy and Genetics (DPAG) . She leads an independent research group investigating amino acid sensing , mTORC1 signaling , and exosome-mediated communication in cancer progression using both human cancer cells and Drosophila models . She serves on the Cancer Research UK Oxford Centre Research Committee , teaches Medical and Biomedical Sciences undergraduates , and acts as Academic Public Engagement Lead for her department. Her research focuses on cell growth regulation through Proton-assisted Amino acid Transporters (PATs) , which function as 'transceptors' modulating mTORC1 activity . This work has expanded to examine exosome heterogeneity and therapeutic delivery mechanisms with support from BBSRC and Cancer Research UK . She co-founded Oxosome , the Oxford extracellular vesicle interest group , to foster interdisciplinary collaboration. Key research areas include Cancer cell communication via exosomes Amino acid signaling in tumor progression Drosophila as cancer model system Clinical collaborations with Prof Adrian L Harris , Prof Freddie C Hamdy , and Prof Clare Verrill Recent publications highlight her group's contributions to exosome biogenesis (2023), brain-targeted siRNA delivery (2021), and nutrient stress responses in cancer (2020). She actively promotes scientific communication through ISEV social media initiatives.

• Neuroscience
• Developmental Biology
• Molecular Biology
• +۳ مورد دیگر

Carina Hanashima is a Professor at the Faculty of Education and Integrated Arts and Sciences , Waseda University, Japan. Her research focuses on neuroscience , developmental biology , and molecular mechanisms underlying cortical development . She has held academic positions at Kobe University (2014.04-2018.03), RIKEN (2008.10-2017.03), Osaka University (2012.04-2015.03), and Nara Women's University (2007.09-2014.11). Research Interests Neuronal specification and cortical circuit formation Role of transcription factors (e.g., Foxg1, Robo1) in brain development Gene regulatory networks in neurogenesis Evolutionary origins of the neocortex Recent Trends in Publications : Her work explores transcriptional repression , axon guidance signaling , and developmental clock mechanisms in mammalian and non-mammalian models (chicks, mice). Key themes include neurodevelopmental disorders (e.g., autism, schizophrenia), angiogenesis , and cell migration . Scientific Awards : Poster Award, Asia-Pacific Developmental Biology Conference APDBC (2012.10) Grants and Projects : Japan Society for the Promotion of Science Grants-in-Aid (2016.06-2021.03, 2021.04-2022.03) RIKEN Joint Retreat Organizer (2011-2017) Labs and Collaborations : She leads the Hanashima Lab at Waseda University, focusing on spatiotemporal control in neuronal identity and neurovascular coupling . Her lab employs genetic lineage tracing , in situ hybridization , and in utero electroporation techniques.

Kei Itoمشاهده پروفایل

استاد

• Neuroscience
• Drosophila Brain Architecture
• Glial Cell Biology
• +۴ مورد دیگر

Prof. Dr. Kei Ito is a leading neuroscientist at the University of Cologne , specializing in Drosophila melanogaster brain architecture. His research focuses on mapping " terra incognita " regions of the brain, analyzing glial cell functions across development, and establishing standardized insect brain nomenclature through international collaboration. As AXA Chairholder and former HHMI Senior Fellow , he combines molecular genetics with 3D virtual reality visualization to unravel neuronal network organization . Academic Affiliation : University of Cologne (2016–present) Prior Positions : The University of Tokyo (2002–2017), National Institute for Basic Biology (1998–2002) Research Interests span multiple domains: "Terra Incognita" Analysis : Systematic mapping of previously uncharacterized brain regions (70% of brain volume) Glial Cell Biology : Classification and functional analysis from embryo to adult Connectome Research : Integration of electron microscopy data with genetic tools Neuronal Lineage Studies : 3D reconstruction of neuroblast progeny patterns Scientific Contributions include: Creation of 4,500 NP Gal4 driver lines (Japan consortium, 1998) Pioneering Split-Gal4 systems for precise neuron labeling Establishment of 6 distinct neuron naming schemes for EM data Leadership in Insect Brain Name Working Group (2007–2014) Advising Legacy features direct mentorship of 6 doctoral students and collaborative analysis of 3,777 neuron types in EM datasets. His lab maintains 1,000+ specific Split-Gal4 lines for terra incognita research.

• Neuroscience
• Molecular Biology
• Genetics
• +۴ مورد دیگر

Panagiotis Politis serves as a Visiting Professor at the European University Cyprus (EUC) School of Medicine and Frankfurt, while maintaining his primary role as Principal Investigator at the Biomedical Research Foundation of the Academy of Athens (BRFAA) since 2015. His academic journey includes a PhD in Biochemistry from Oxford (2000) focusing on chromatin regulation in yeast, preceded by a NASA Planetary Biology Internship at the Salk Institute (1998) and BSc in Biology from Patras (1996). His research qualifications include: PhD in Biochemistry, University of Oxford (2000) BSc in Biology, University of Patras (1996) Dr. Politis's research program centers on neurodegenerative mechanisms , particularly Parkinson's disease pathophysiology, where he investigates long non-coding RNAs, nuclear receptor signaling, and neural stem cell dynamics. His work integrates molecular, cellular, and systems neuroscience approaches to dissect epigenetic regulation in neurodevelopment and neurodegeneration, with significant contributions to understanding transcription factor networks (Prox1, NR5A2) in neuronal fate decisions and disease progression. Current projects explore auto-antibody pathophysiology and RNA splicing mechanisms in brain development. Analysis of his 2004-2019 publications reveals a consistent trajectory from chromatin biology toward neurological disease mechanisms, with increasing focus on human iPSC models, non-coding RNA networks, and translational applications in neurodegeneration and neuro-oncology. Key thematic clusters include transcriptional regulation in neural development (2010-2017), Parkinson's disease modeling (2017-2019), and cancer-related neural mechanisms (2013-2018). His scientific distinctions include: Fulbright Research Scholar Fellowship (2008) NASA Planetary Biology Fellowship (1998) Multiple Oxford-based awards including Florey EPA studentship Young Scientist Travel Award from International Society of Biochemistry Dr. Politis has secured €2M+ in research funding as Principal Investigator for 10+ projects from Greek Secretariat of Research (Excellence/SYNERGASIA schemes), Fondation Sante, and EU COST actions. His grants investigate Parkinson's mechanisms, neural development, and renal fibrosis, with recent focus on anti-GAD65 auto-antibodies (2017-present) and RNA splicing in brain development (2017-present). He actively mentors junior researchers through BRFAA's training programs and has organized major conferences including FENS symposia and Hellenic Neuroscience Society meetings. His research is conducted through the BRFAA Molecular Neurobiology Laboratory, which employs advanced techniques in iPSC modeling, molecular genetics, and neuropathology to investigate neurodegenerative mechanisms and therapeutic targets.

Yuuki Obataمشاهده پروفایل

استادیار

• Gut Microbiota Research
• Immune System Regulation
• Enteric Nervous System Development
• +۳ مورد دیگر

Dr. Yuuki Obata is an Assistant Professor in the Department of Immunology and Neuroscience at UT Southwestern Medical Center, USA. He holds an Investigator role at the O'Donnell Brain Institute. Previously, he served as a postdoctoral fellow at the Francis Crick Institute (2016-2021) and the University of Tokyo (2015-2016). His research focuses on how environmental signals (microbiota, diet, circadian rhythms) shape intestinal neural circuits and immune networks. He employs advanced techniques including imaging, viral tracing, gnotobiotic systems, and multi-omics approaches. Education: PhD in Immunology from Chiba University (RIKEN Joint Graduate School Program), Japan. Postdoctoral training included JSPS Superlative Postdoctoral Fellowships (Japan) and EMBO/HFSP fellowships (UK). Research interests span microbiota-immune interactions, enteric nervous system development, gut-brain axis communication, and epigenetic regulation of immune responses. His lab investigates mechanisms linking microbial metabolites to host physiology, particularly in metabolic and neural contexts. Key findings include microbiota's role in IgA responses, T cell differentiation, and neuronal programming. Collaborations emphasize inter-organ communication and translational applications in immunology and neuroscience. Laboratory: The Obata Lab at UT Southwestern employs interdisciplinary methods to address how environmental factors reprogram gut neural and immune systems. Future work includes exploring microbiota-based therapies and neuroimmune interactions in disease models.

Donald S Sakaguchiمشاهده پروفایل

استاد

• Stem Cell Biology
• Neuroscience
• Neurodegenerative Diseases
• +۳ مورد دیگر

Donald S. Sakaguchi is the Morrill Professor in the Department of Genetics, Development and Cell Biology at Iowa State University (ISU), and serves as Director of the Biology and Genetics Undergraduate Programs. He holds an adjunct professorship at the ISU College of Veterinary Medicine. His research focuses on regenerative and repair strategies for the nervous system, particularly using stem cells and biomaterials for neuroprotection and tissue repair. Dr. Sakaguchi earned his B.S. and Ph.D. in Biology/Neurobiology from SUNY Albany and completed postdoctoral training at UC San Diego. Education: B.S. Biology (SUNY Albany, 1979), Ph.D. Neurobiology (SUNY Albany, 1984), Postdoctoral Fellow (UC San Diego). Research Interests: Developing cell-based therapies for neurodegenerative diseases and injuries using mesenchymal stem cells (MSCs) and neural progenitor cells (NPCs). Key areas include: 1) Stem cell engineering for neurotrophic factor delivery, 2) Biomaterials for neural regeneration (e.g., 3D-printed conduits), 3) Peripheral nerve repair via transdifferentiation, and 4) In vitro models of traumatic brain injury. Collaborations span neuroscience, bioengineering, and veterinary medicine. Labs/Teams: Sakaguchi Lab at ISU, part of the Nanovaccine Institute and interdisciplinary programs in Neuroscience, MCDB, and Bioinformatics. The lab emphasizes diversity and inclusion, fostering training for undergraduate and graduate researchers.