Panagiotis Politis

Panagiotis Politis serves as a Visiting Professor at the European University Cyprus (EUC) School of Medicine and Frankfurt, while maintaining his primary role as Principal Investigator at the Biomedical Research Foundation of the Academy of Athens (BRFAA) since 2015. His academic journey includes a PhD in Biochemistry from Oxford (2000) focusing on chromatin regulation in yeast, preceded by a NASA Planetary Biology Internship at the Salk Institute (1998) and BSc in Biology from Patras (1996).

His research qualifications include:

• PhD in Biochemistry, University of Oxford (2000)
• BSc in Biology, University of Patras (1996)

Dr. Politis's research program centers on neurodegenerative mechanisms, particularly Parkinson's disease pathophysiology, where he investigates long non-coding RNAs, nuclear receptor signaling, and neural stem cell dynamics. His work integrates molecular, cellular, and systems neuroscience approaches to dissect epigenetic regulation in neurodevelopment and neurodegeneration, with significant contributions to understanding transcription factor networks (Prox1, NR5A2) in neuronal fate decisions and disease progression. Current projects explore auto-antibody pathophysiology and RNA splicing mechanisms in brain development.

Analysis of his 2004-2019 publications reveals a consistent trajectory from chromatin biology toward neurological disease mechanisms, with increasing focus on human iPSC models, non-coding RNA networks, and translational applications in neurodegeneration and neuro-oncology. Key thematic clusters include transcriptional regulation in neural development (2010-2017), Parkinson's disease modeling (2017-2019), and cancer-related neural mechanisms (2013-2018).

His scientific distinctions include:

• Fulbright Research Scholar Fellowship (2008)
• NASA Planetary Biology Fellowship (1998)
• Multiple Oxford-based awards including Florey EPA studentship
• Young Scientist Travel Award from International Society of Biochemistry

Dr. Politis has secured €2M+ in research funding as Principal Investigator for 10+ projects from Greek Secretariat of Research (Excellence/SYNERGASIA schemes), Fondation Sante, and EU COST actions. His grants investigate Parkinson's mechanisms, neural development, and renal fibrosis, with recent focus on anti-GAD65 auto-antibodies (2017-present) and RNA splicing in brain development (2017-present). He actively mentors junior researchers through BRFAA's training programs and has organized major conferences including FENS symposia and Hellenic Neuroscience Society meetings.

His research is conducted through the BRFAA Molecular Neurobiology Laboratory, which employs advanced techniques in iPSC modeling, molecular genetics, and neuropathology to investigate neurodegenerative mechanisms and therapeutic targets.