معرفی
Dr. Deborah Goberdhan is an Associate Professor at the University of Oxford, affiliated with the Department of Physiology, Anatomy and Genetics (DPAG). She leads an independent research group investigating amino acid sensing, mTORC1 signaling, and exosome-mediated communication in cancer progression using both human cancer cells and Drosophila models. She serves on the Cancer Research UK Oxford Centre Research Committee, teaches Medical and Biomedical Sciences undergraduates, and acts as Academic Public Engagement Lead for her department.
Her research focuses on cell growth regulation through Proton-assisted Amino acid Transporters (PATs), which function as 'transceptors' modulating mTORC1 activity. This work has expanded to examine exosome heterogeneity and therapeutic delivery mechanisms with support from BBSRC and Cancer Research UK. She co-founded Oxosome, the Oxford extracellular vesicle interest group, to foster interdisciplinary collaboration.
Key research areas include
- Cancer cell communication via exosomes
- Amino acid signaling in tumor progression
- Drosophila as cancer model system
- Clinical collaborations with Prof Adrian L Harris, Prof Freddie C Hamdy, and Prof Clare Verrill
Recent publications highlight her group's contributions to exosome biogenesis (2023), brain-targeted siRNA delivery (2021), and nutrient stress responses in cancer (2020). She actively promotes scientific communication through ISEV social media initiatives.
