جست‌وجوی استاد و پژوهشگر

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

• Stem Cell Biology
• Genetic Engineering
• Epigenetics
• +۵ مورد دیگر

Konstantinos Anastassiadis is a Professor at the Center for Molecular and Cellular Bioengineering (CMCB) of Dresden University of Technology , leading the Stem Cell Engineering group at the Biotechnology Center (BIOTEC) . His research focuses on unraveling molecular pathways regulating stem cell self-renewal and lineage commitment, with a strong emphasis on genetic engineering tool development and epigenetic mechanisms during cellular reprogramming. The lab utilizes mouse and human embryonic stem cells, neural stem cells, mesenchymal stromal cells, and induced pluripotent stem cells (iPSCs) in their investigations. Core Research Areas: Molecular regulation of stem cell fate Epigenetic mechanisms (e.g., UTX/UTY histone demethylases) Genetic engineering tool development (Flp, Dre, Vika recombinases, CRISPR protocols) Conditional immortalization systems for rare cell expansion Publications highlight his contributions to understanding: Role of histone methyltransferases (MLL1, MLL2, Setd1b) in hematopoiesis and cancer Epigenetic regulation during mouse development and spermatogenesis Genetic tools for protein tagging, transposon-mediated BAC transgenesis Interactions between stem cells and niche microenvironments Transcriptional and mechanical markers during reprogramming Collaborations span immunology , developmental biology , and bioinformatics . The lab actively participates in teaching activities at CMCB and maintains a focus on translational applications of stem cell research.

Simon Schäferمشاهده پروفایل

استاد

• Neuroscience
• Developmental Biology
• Stem Cell Research
• +۴ مورد دیگر

Prof. Dr. Simon Schäfer leads the Schäfer Lab at the Technische Universität München , focusing on engineering advanced organoid systems to study human brain development, disease modeling, and repair mechanisms. His work bridges stem cell biology, gene editing, and bioengineering to develop personalized therapies for brain disorders. Stem Cell & Organoid Technology Neurodevelopmental Mechanisms Neurodegenerative Disease Models Gene Editing & Neuroimmune Interactions Translational Neuroscience Recent research emphasizes brain organoid development, microglia phenotypes, and neurodevelopmental timing anomalies in autism. His team’s work also explores zika virus interactions with glioblastoma stem cells and neuronal plasticity in psychiatric disorders. Scientific awards and funding include support from the Deutsche Forschungsgemeinschaft (DFG), Brain & Behavior Research Foundation (BBRF), and Munich Cluster for Systems Neurology (SyNergy). Collaborations span institutions like the TUM Center for Organoid Systems. Advises 6 students (2 PhD, 1 MSc, 3 associated) Labs include Schäfer Lab, COS@TranslaTUM Contact: simon.schafer@tum.de

Andrew Bassettمشاهده پروفایل

پژوهشگر

• Genome Engineering
• Neurodegenerative Diseases
• Stem Cell Research
• +۵ مورد دیگر

Dr. Andrew Bassett serves as Head of the Cellular and Gene Editing Research group at the Wellcome Sanger Institute, where he develops cutting-edge genome engineering techniques using human pluripotent stem cells to investigate neurodegenerative diseases including Alzheimer's and Parkinson's. His work focuses on scaling genetic screening approaches and improving CRISPR specificity for modeling complex disease mechanisms. His academic training includes: PhD at the MRC Laboratory of Molecular Biology (MRC-LMB) with Andrew Travers on chromatin remodelling in heterochromatin formation Postdoctoral research with David Baulcombe at the University of Cambridge studying small RNA roles in chromatin modification Additional postdoctoral work with Chris Ponting at the MRC Functional Genomics Unit (MRC-FGU) in Oxford, where he pioneered CRISPR applications in Drosophila Bassett's research program centers on developing advanced genome engineering methodologies for precise modulation of gene expression networks during development and neurodegeneration. His group specializes in creating complex editing events (SNPs, paired knockouts, enhancer perturbations) within iPSC-derived models, with particular emphasis on epigenetic regulation and transcriptional control. Current projects integrate single-cell 'omics and phenotypic assays to decode genetic causes of neurodegenerative disorders through the OpenTargets consortium. Analysis of his 15 most recent publications reveals dominant trends in CRISPR technology development (35%), neurodegenerative disease modeling (30%), and single-cell functional genomics (25%). His work consistently bridges methodological innovation with disease mechanism studies, increasingly incorporating multi-omics approaches and expanding into cancer immunology and infectious disease applications since 2022. As group leader, Bassett mentors postdoctoral researchers and PhD students while securing major funding for genome engineering initiatives. His team operates within the Sanger Institute's Cellular Operations division and maintains critical partnerships with the OpenTargets consortium for therapeutic target validation. The laboratory specializes in high-throughput screening platforms using iPSC-derived neural and microglial models, with recent methodological advances including scSNV-seq and ONE-STEP tagging systems that significantly enhance precision genome editing capabilities.

Dieter Saurمشاهده پروفایل

استاد

• Translational Cancer Research
• Genetic Alterations in Cancer
• Personalized Medicine
• +۳ مورد دیگر

Prof. Dieter Saur is a Professor of Translational Tumor Research at the Technical University of Munich (TUM) and Head of the Department at the German Cancer Research Center (DKFZ). His research focuses on developing personalized cancer therapies through mechanistic studies of tumor-relevant genetic alterations, with a particular emphasis on pancreatic and gastrointestinal cancers. Education: Studied medicine at Ludwig Maximilian University of Munich, earned a doctorate in neurogastroenterology, completed specialist training in gastroenterology and gastrointestinal oncology, and habilitation in internal medicine. He became a senior physician at University Hospital rechts der Isar before his current roles at TUM and DKFZ. Research Interests: Translational cancer research, genetic drivers of tumor progression, early detection methods, and targeted therapies for pancreatic and gastrointestinal cancers. He uses genetically engineered mouse models and organoid systems to study tumor heterogeneity and therapeutic resistance. Awards: Recipient of prestigious grants like the ERC Consolidator Grant (2015) and awards such as the Martin Wienbeck Award (2014) and Rising Star Award (2006). His work bridges basic science and clinical translation, emphasizing interdisciplinary approaches. Labs/Teams: Leads the Translational Tumor Research group at TUM and collaborates with the DKFZ to advance preclinical and clinical cancer research. Key projects include exploring KRAS signaling pathways, tumor microenvironment dynamics, and immune checkpoint therapies.

Michael J. Zillerمشاهده پروفایل

استاد

• Functional Genomics
• Psychiatric Genetics
• Neurobiology of Mental Illness
• +۳ مورد دیگر

Michael J. Ziller is a Professor at the Faculty of Medicine, University of Münster, affiliated with the Department of Psychiatry and Psychotherapy. He leads the Lab for Functional Genomics in Psychiatry and participates in the "Cells in Motion" research commission. Research Focus: Functional genomics, molecular mechanisms of psychiatric disorders (schizophrenia, bipolar disorder), and computational strategies for personalized medicine. Projects: Decoding polygenic risk architectures, modeling neuronal hyperexcitability, and developing machine learning methods for patient stratification. Funding: BMBF (Project DINGS), EKFS Schlüsselproject. The lab utilizes iPSC models, ChIP-Seq, ATAC-Seq, HiC, single-cell RNA-Seq, and Perturb-Seq to bridge genetic associations with neurobiological insights, aiming to identify drug targets and optimize treatment for psychiatric diseases.

Thomas Langerمشاهده پروفایل

استاد

• Mitochondrial Biology
• Cellular Aging
• Age-related Diseases
• +۶ مورد دیگر

Prof. Dr. Thomas Langer leads the Department of Mitochondrial Proteostasis at the Max Planck Institute for Biology of Ageing. His research focuses on mitochondrial proteases, their role in cellular aging, and age-related diseases. He investigates how mitochondrial dynamics, lipid trafficking, and proteostasis impact neurodegeneration and metabolic disorders. Key Grants: DFG CRC 1218 & 1403, German-Israel MitoBalance, Marie Sklodovska-Curie ITN Remix Notable Awards: Humboldt Foundation & EMBO Postdoctoral Fellowships His work spans mitochondrial membrane dynamics, lipid homeostasis, calcium signaling, and stress responses. Recent studies highlight connections between OMA1 protease activation, ferroptosis, and cardiomyopathy, as well as prohibitin-mediated membrane organization in neurodegenerative diseases. Collaborative projects with institutions in Germany and Japan further expand his research impact. Publications show consistent contributions to journals like Nature , Cell Metabolism , and Nature Cell Biology , with recurring themes in mitochondrial fragmentation, metabolic reprogramming, and neuroprotection. His lab trains a large cohort of PhD students and postdocs, fostering next-generation scientists in mitochondrial biology.

• Stem Cell Biology
• Neural Differentiation
• Neuroregeneration
• +۳ مورد دیگر

Oliver Brüstle is Professor at the University of Bonn's Institut für Rekonstruktive Neurobiologie and Steering Committee member of the Transdisciplinary Research Area (TRA) 'Life and Health'. Research focuses on human pluripotent stem cells for neuroregeneration and CNS disease modeling, employing iPSC reprogramming, neural differentiation, transcription factor-based forward programming, and somatic cell conversion. Key projects develop neuronal/glial subtypes for transplant strategies and study neurodegenerative/neuropsychiatric diseases using 2D/3D models. Selected publications (2017-2023) emphasize iPSC-derived neuron pathology mechanisms, microglia production techniques, and neural transplant mapping. Articles consistently integrate stem cell biology with translational neurology. Research methodology combines cellular reprogramming, electrophysiological analysis, and advanced imaging. Work contributes to both basic understanding of neural development and therapeutic applications for neurological disorders.

• Information Retrieval
• Machine Learning
• Recommendation Systems
• +۴ مورد دیگر

Chenliang Li is a Professor at the School of Computer Science and Engineering, Nanyang Technological University, Singapore. He holds a PhD in Computer Science from the same institution (2013). His research focuses on information retrieval, machine learning, recommendation systems, natural language processing, and social media analysis. He has published extensively in top-tier venues such as SIGIR, CIKM, ACL, and IEEE TKDE. Key contributions include advancements in sequential recommendation systems using diffusion models and transformers, knowledge graph reasoning with GNNs, and applications of pretrained language models in NLP tasks. His work bridges theory and practice, addressing challenges in data-driven decision making and large-scale systems. Recent publications (2023-2025) explore topics like cross-city POI recommendation, bias-agnostic recommender systems, and multimodal vision-language models. He collaborates widely with industry and academia, contributing to open-source projects like ModelScope-Agent.

Holm Zaehresمشاهده پروفایل

مدرس ارشد

• Stem Cell Engineering
• Induced Pluripotent Stem Cells (iPS)
• Neural Differentiation
• +۳ مورد دیگر

Holm Zaehres is a Senior Lecturer at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, leading the Stem Cell Engineering Laboratory . His work focuses on reprogramming somatic cells to pluripotency using transcription factors like OCT4, SOX2, and KLF4, with significant contributions to induced pluripotent stem (iPS) cell generation from neural and hematopoietic progenitors. Key Research Areas: Stem cell engineering, iPS cell differentiation, genome editing, and disease modeling (including Frontotemporal Dementia and Duchenne Muscular Dystrophy). Publications: Authored 10+ seminal works in Nature , Cell , and Stem Cells , establishing methods for efficient cellular reprogramming and organoid-based disease studies. Collaborations: Partnered with institutions like University of Bonn, German Cancer Research Center (DKFZ), and academic hospitals in neurology and hematology.

• Stem Cell Metabolism
• Mitochondrial Disorders
• Neurodegenerative Diseases
• +۷ مورد دیگر

Alessandro Prigione is a Professor at the Department of General Pediatrics, Heinrich Heine University Düsseldorf, leading the Stem Cell Metabolism research group. His work focuses on bridging human induced pluripotent stem cell (iPSC)-based neuronal disease modeling with mitochondrial metabolism to address neurodegenerative diseases in children. Key affiliations: University Children’s Hospital Düsseldorf, Heinrich Heine University Research Interests: Investigating mitochondrial disorders such as Leigh syndrome and Huntington’s disease in early-onset neurodegeneration. Utilizing patient-derived iPSCs to generate neuronal/glial cells and cerebral organoids for disease-specific modeling. Identifying therapeutic compounds through high-throughput screenings targeting mitochondrial and neuronal function. Integrating CRISPR/Cas9 genome engineering, mitochondrial assays, and high-content analysis for mechanistic studies. Lab & Collaborations: His lab develops innovative models for mitochondrial diseases, emphasizing metabolic coupling in human neurons and astrocytes. Collaborations include institutions like the Max Planck Institute for Molecular Genetics and Charité Universitätsmedizin Berlin.

Volker Busskampمشاهده پروفایل

استاد

• Retinal Degeneration
• Stem Cell Therapy
• Optogenetics
• +۲ مورد دیگر

Prof. Dr. Volker Busskamp holds the professorship for Degenerative Retinal Diseases at the University of Bonn's Department of Ophthalmology. His interdisciplinary research combines stem cell biology, neural engineering, and optogenetics to develop vision restoration strategies. Major innovations include transcription factor-based photoreceptor programming, holographic optogenetics for neural circuit analysis, and organoid models for retinal degeneration. His laboratory develops microphysiological systems to study neuronal networks under altered gravity conditions in collaboration with the German Aerospace Center. Awarded the Paul Ehrlich and Ludwig Darmstaedter Junior Award and ERC Starting Grant, Dr. Busskamp's patented technologies advance therapeutic approaches for inherited retinal diseases.

Marc Thierمشاهده پروفایل

پژوهشگر

• Stem Cell Research
• Neural Reprogramming
• Clinical Translation
• +۳ مورد دیگر

Dr. Marc Thier is a Researcher at the German Cancer Research Center (DKFZ) and Heidelberg University, leading the Neural Reprogramming and Clinical Translation group. His work bridges stem cell biology, direct cellular reprogramming, and clinical applications in cancer and endocrinology. Key Research Themes: Stem Cell Engineering Neural Reprogramming Cancer Metastasis Mechanisms Hyperparathyroidism Surgery Outcomes Notable Collaborations: Prof. Frank Edenhofer, Prof. Andreas Trumpp, Dr. Michael Milsom Dr. Thier's recent publications focus on glioblastoma neuron-tumor interactions (2025), miRNA-driven reprogramming (2012), and stem cell dormancy models (2016). He has contributed to over 15 peer-reviewed studies since 2009. His laboratory develops protocols for converting somatic cells into expandable neural progenitors and investigates cancer stem cell dynamics. Current projects include retrograde tracing in glioblastomas and longitudinal metabolic studies in post-surgical endocrinology.

• Neurology
• Neurodegenerative Diseases
• Stem Cell Research
• +۳ مورد دیگر

Alexander Storch is a Professor of Neurology and the Director of the Clinic and Polyclinic for Neurology at Universitätsmedizin Rostock. He holds a W3 professorship in Neurology from the Medical Faculty Carl Gustav Carus, Technische Universität Dresden (since 2011). His academic journey includes habilitation in Neurology at the University of Ulm (2001) and a doctoral thesis (summa cum laude) from Johannes Gutenberg-Universität Mainz (1996). He specializes in neurodegenerative disorders, movement disorders, and stem cell research, with a focus on Parkinson’s disease and regenerative therapies. Education: 1990–1995: Medical studies at Johannes Gutenberg-Universität Mainz and Freie Universität Berlin 1996: Doctoral thesis (summa cum laude) in Molecular Neurobiology 2001: Habilitation (Neurology), University of Ulm Professional Roles: Since 2008: Associate Director, Department of Neurology, TU Dresden Since 2006: Member of Dresden International Graduate School for Biomedicine and Biotechnology Since 2004: Senior Neurologist and Head of Movement Disorder Section, TU Dresden His research focuses on neurodegenerative diseases, stem cell biology, and translational applications in neurological disorders. He has contributed to studies on coenzyme Q10 therapy for Parkinson’s disease and the differentiation of pluripotent stem cells. His work bridges clinical neurology with regenerative medicine, emphasizing cellular diversity and therapeutic interventions. Awards: Summa Cum Laude doctoral distinction (1996). Dr. Storch collaborates with research institutions like the DFG Cluster of Excellence ‘Center for Regenerative Therapies Dresden’ (CRTD) and serves on editorial boards for journals like Stem Cells . His labs focus on neural stem cell research and neurodegenerative disease mechanisms.

• Genetics
• Molecular Genetics
• Human Genetics
• +۷ مورد دیگر

Prof. Nilima Prakash is a Professor in the Department of Applied Genetics and Stem Cell Biology at Hamm-Lippstadt University of Applied Sciences. Her research focuses on regenerative medicine for Parkinson’s Disease, stem cell-based therapies, and developmental neurobiology. She leads the Human Stem Cell Research Group, developing protocols for midbrain dopaminergic neuron generation and studying ion channel roles in neurodegeneration. She holds certifications in genetic engineering safety and is an approved animal experimentation researcher. Her expertise spans molecular genetics, forensic genetics, and genetic engineering. She mentors in the TUM Mentoring Program and serves as a journal reviewer and co-editor for Frontiers in Neuroanatomy . Research interests include stem cell differentiation pathways, Wnt signaling, and neurodevelopmental mechanisms in neuropsychiatric disorders. Her work bridges basic science and translational medicine, with recent articles exploring calcium homeostasis in Parkinson’s models and CRISPR-based neuronal reprogramming. She collaborates on projects like the IDGenes database for mouse brain genetic interactions. Grants and funding support her studies on dopaminergic neuron survival and disease modeling. Prof. Prakash is affiliated with the ISSCR, German Genetics Society, and Stem Cell Network NRW. Her lab integrates cutting-edge techniques like live cell imaging and CRISPR-Cas9 engineering for stem cell analysis.