Konstantinos Anastassiadis

Konstantinos Anastassiadis is a Professor at the Center for Molecular and Cellular Bioengineering (CMCB) of Dresden University of Technology, leading the Stem Cell Engineering group at the Biotechnology Center (BIOTEC). His research focuses on unraveling molecular pathways regulating stem cell self-renewal and lineage commitment, with a strong emphasis on genetic engineering tool development and epigenetic mechanisms during cellular reprogramming. The lab utilizes mouse and human embryonic stem cells, neural stem cells, mesenchymal stromal cells, and induced pluripotent stem cells (iPSCs) in their investigations.

• Core Research Areas:
• Molecular regulation of stem cell fate
• Epigenetic mechanisms (e.g., UTX/UTY histone demethylases)
• Genetic engineering tool development (Flp, Dre, Vika recombinases, CRISPR protocols)
• Conditional immortalization systems for rare cell expansion

Publications highlight his contributions to understanding:

• Role of histone methyltransferases (MLL1, MLL2, Setd1b) in hematopoiesis and cancer
• Epigenetic regulation during mouse development and spermatogenesis
• Genetic tools for protein tagging, transposon-mediated BAC transgenesis
• Interactions between stem cells and niche microenvironments
• Transcriptional and mechanical markers during reprogramming

Collaborations span immunology, developmental biology, and bioinformatics. The lab actively participates in teaching activities at CMCB and maintains a focus on translational applications of stem cell research.