جست‌وجوی استاد و پژوهشگر

• Cephalopod Biology
• Evolutionary Developmental Neurobiology
• Genomics
• +۵ مورد دیگر

Clifton Ragsdale is a Professor in the Department of Neurobiology at the University of Chicago . His research focuses on evolutionary biology of brain organization , particularly in cephalopods and the neocortex. The Ragsdale Laboratory combines genomics , molecular cell biology , and genetic manipulation to study evolutionary novelties in octopuses, including their immense nervous system, prehensile arms, and adaptive coloration system. Current research areas: comparative cephalopod genomics , octopus arm regeneration , nervous system organization , neuroendocrinology of octopus reproduction/death , and evolutionary developmental neurobiology of the neocortex . The lab's 2015 Nature publication on the Octopus bimaculoides genome (with UC-Berkeley) remains a landmark study with 225 citations. Recent NIH-funded work explores octopus motor control, steroid hormone regulation of maternal behavior, and neuronal segmentation in cephalopod arms. Publications span journals like Nature Communications , Science , and Current Biology , emphasizing evolutionary neuroscience and developmental mechanisms . Key research trends include: cephalopod genome analysis , neuroendocrine systems , regenerative medicine , comparative neuroanatomy , and evolution of neural complexity . The lab maintains active scientific engagement through Twitter and collaborative networks in evolutionary biology , neurogenetics , and developmental neuroscience . NIH grants : R03HD064887 (2013-2015), R03HD056094 (2008-2010), R01EY016838 (2006-2011), R01NS035680 (1998-2006) Lab members include co-authors like Caroline Albertin and Joshua Rosenthal , with physical neighbors and collaborators at the University of Chicago. Altmetric scores indicate significant media coverage and academic discussion, particularly for studies on octopus regeneration and neocortex evolution .

Esther Klinglerمشاهده پروفایل

مدرس

• Developmental Neuroscience
• Molecular Neurobiology
• Emotional Circuit Development
• +۳ مورد دیگر

Esther Klingler serves as a Lecturer in the Department of Neuroscience at KU Leuven's Faculty of Medicine and leads the Laboratory for Emotional Circuit Development at the VIB-KU Leuven Center for Brain and Disease Research since September 2023. She holds additional memberships in the VIB-KU Leuven Center for Brain Research, KU Leuven Brain Institute (LBI), and KU Leuven Institute for Single Cell Omics (LISCO). Her academic foundation includes a PhD from Université Pierre & Marie Curie (Paris) investigating cytoskeleton-associated proteins in axon guidance using transgenic mice, followed by postdoctoral research at the University of Geneva under Prof. Denis Jabaudon where she pioneered the ConnectID barcoding method for neuronal projection mapping. Dr. Klingler's research focuses on developmental mechanisms of emotional circuits , examining how intrinsic genetic programs and environmental experiences shape neuronal diversity in the amygdala and prefrontal cortex. Her lab integrates cutting-edge experimental techniques (transgenic models, single-cell sequencing) with computational approaches to identify neural cell types vulnerable in disorders like autism spectrum disorder (ASD) and dementia, with particular emphasis on sensorimotor connectivity governed by genes such as Sox11. Analysis of her 15 most recent publications reveals dominant trends in single-cell and spatial transcriptomics applied to cortical development, with increasing emphasis on cross-species data integration (via pipelines like humous.org) and multi-omics approaches to model human brain diseases. Her work consistently bridges molecular identity with neural connectivity, uncovering principles of developmental timing and regional specification in emotional circuit formation. Dr. Klingler has not received any publicly listed scientific awards according to available information. She actively mentors three doctoral students, one master's student, and one postdoctoral researcher while securing substantial grant funding as promoter or co-promoter on seven active projects including Building Fear Circuits (2025-2028), Addressing Synaptic Dysfunction in Dementia (2025-2031), and Role of Amygdala in ASD Etiology (2024-2026), demonstrating strong leadership in both basic and translational neuroscience research. The Laboratory for Emotional Circuit Development employs innovative methodologies including ConnectID barcoding, MAPseq, and scRNA-Seq to investigate how genetic and environmental factors interact during emotional network development, with current work exploring the developmental origins of anxiety-related behaviors and neural circuit vulnerabilities in neurodevelopmental disorders.

Dennis Paulsمشاهده پروفایل

استاد پژوهشی

• Neurobiology
• Behavioral Physiology
• Memory Mechanisms
• +۶ مورد دیگر

Dennis Pauls is a Research Professor in the Department of Animal and Behavioral Physiology at the Institute of Biology, University of Leipzig. He leads his own research group (PAULS LAB) focusing on neurobiological mechanisms underlying behavior, memory formation, and decision-making processes, primarily using Drosophila as a model organism. His work bridges molecular neuroscience, behavioral physiology, and systems neuroscience to understand fundamental neural processes. Dr. Pauls completed his biology studies (Diplom) at the University of Gießen and University of Würzburg (2001-2006), followed by a PhD (Dr. rer. nat.) at the University of Fribourg, Switzerland (2006-2010). He conducted postdoctoral research at the University of Marburg (2010-2011) before becoming a scientific staff member and later group leader at the Theodor-Boveri Institute, University of Würzburg (2011-2019). Since July 2019, he has been a group leader at the University of Leipzig, and completed his Habilitation (Dr. rer. nat. habil, PD) in December 2020. His research focuses on two primary areas: (1) the integration of time in memories, investigating how essential information is encoded as lasting physical changes through synaptic plasticity, and (2) the neurometabolic mechanisms underlying poor food decisions, exploring how animals overcome innate aversions to potentially harmful foods under hunger conditions. His laboratory employs neuro- and optogenetic approaches, electrophysiology, behavioral analyses, and high-resolution light microscopy to address these questions. Analysis of Dr. Pauls' recent publications reveals a strong emphasis on octopamine signaling in learning and memory circuits, time integration mechanisms in neural systems, and the metabolic regulation of feeding behavior. His work demonstrates how neuromodulators influence memory formation, how temporal information is incorporated into neural representations, and how metabolic states affect decision-making processes in Drosophila models. Dr. Pauls currently leads three major DFG-funded research projects: (1) The function of octopamine in reward processing in Drosophila larvae (2019-2023), (2) Neurobiological foundations of integrating time into memories (2023-2026), and (3) Metabolic signatures and neurophysiological mechanisms of poor food intake decisions (2024-2027). He collaborates extensively with the Kittel Lab and other neuroscience groups at the University of Leipzig, contributing to the NeuroTune Graduate School and other interdisciplinary initiatives focused on brain dynamics and neurological disorders. His laboratory is part of the Integrated Research and Treatment Center (IFB) for Adiposity-Related Disorders for his research on food decision-making, demonstrating the translational potential of his basic neuroscience research. Dr. Pauls' work provides fundamental insights into neural circuit function with implications for understanding memory disorders and eating behaviors in humans.

Paolo Mediniمشاهده پروفایل

دانشیار

• Neuroscience
• Neurophysiology
• Neurobiology
• +۵ مورد دیگر

Paolo Medini is an Associate Professor at Umeå University, affiliated with the Department of Medical and Translational Biology and the Center for Transdisciplinary AI. His research focuses on cortical microcircuits, sensory processing, and brain recovery mechanisms. Neuroscience Neurophysiology Cortical Plasticity Optogenetics His lab investigates how sensory information is processed by distinct cell types in cortical circuits and how these circuits adapt after brain lesions or sensory deprivations. Research spans both adaptive and maladaptive plasticity, aiming to differentiate molecular mechanisms for targeted interventions. Recent publications highlight applications of all-optical interrogation strategies and multisensory integration in the neocortex. Paolo Medini's group employs advanced techniques such as in vivo patch clamp recordings, two-photon calcium imaging, and optogenetics. They use genetically modified strains to study cell-type-specific responses and circuit reorganization post-lesion. Their work is critical for developing therapies in neurodegenerative diseases and cortical repair. Environmental enrichment for brain recovery (Nature Neuroscience) Cortical microcircuit organization (Neuron) Post-stroke plasticity (Journal of Physiology)

• Neurosciences
• Developmental Biology
• Epigenetics
• +۶ مورد دیگر

Takashi Namba is a Senior Researcher at the Faculty of Medicine , University of Helsinki , affiliated with the Neuroscience Center . He serves as a Supervisor for the Doctoral Programme in Integrative Life Science and the Doctoral Programme Brain & Mind, while holding the title of Docent in Faculty Common Matters. His work bridges neuroscience and evolutionary biology, focusing on the metabolic and epigenetic regulation of neocortical development. Recent research outputs highlight his investigations into mitochondrial dynamics in radial glial cells, human-specific metabolic regulators , and genetic mechanisms underlying neurodevelopmental disorders. His 2024-2025 publications span journals like Nature Communications , Journal of Comparative Neurology , and Trends in Neurosciences , emphasizing interdisciplinary approaches. Namba leads the project Deciphering the role of evolutionarily adapted neural stem/progenitor cell metabolism in human neocortex development and neurodevelopmental disorders (2025–2029), funded by the Academy of Finland . Collaborations span subcellular imaging, metabolic regulation, and translational neuroscience, reflecting his integration of cellular and systems-level perspectives.

• Circadian Rhythms
• Molecular Neuroscience
• Pineal Gland Research
• +۴ مورد دیگر

Tenna Bering serves as Assistant Professor in the Department of Neuroscience within the Faculty of Health and Medical Sciences at the University of Copenhagen. Her research is conducted through the Rath Lab as indicated by her institutional website, with laboratory facilities located at Blegdamsvej 3 in Copenhagen. Her research focuses on molecular mechanisms of circadian rhythms across multiple brain regions. Specializing in clock gene regulation, she investigates how circadian oscillators function in the pineal gland, hippocampus, and cerebellum. Her work particularly examines the interplay between hormonal signals (especially corticosterone and triiodothyronine) and neural pathways in regulating rhythmic gene expression. Current projects explore astrocyte involvement in circadian proteome dynamics and transcription factor networks controlling melatonin synthesis. Analysis of her 11 publications from 2020-2023 reveals consistent focus on molecular chronobiology with particular emphasis on pineal gland function. Her research demonstrates sophisticated integration of in vitro and in vivo approaches, primarily using rodent models to investigate clock gene networks. The publications show strong collaborative patterns with the Rath Lab team and exhibit significant citation impact across neuroscience and endocrinology journals. While specific grant information isn't detailed in the provided text, her research output indicates active funding support through substantial publication volume in high-impact journals. Her work shows extensive collaboration with both national and international researchers, particularly in circadian biology and neuroendocrinology fields. Dr. Bering's laboratory work appears centered within the Rath Lab research group at the University of Copenhagen, focusing on molecular techniques for studying clock gene expression, protein profiling, and neural regulation of circadian systems. Her research infrastructure likely includes specialized facilities for rodent circadian studies, molecular biology assays, and potentially proteomics capabilities given her recent work.

• Cortex Functional Organisation and Development
• Neural Coding and Dynamics
• Neural Data Analysis
• +۷ مورد دیگر

Matthias Kaschube is a Professor in the Faculty of Computer Science and Mathematics at Goethe University Frankfurt and a Senior Fellow at the Frankfurt Institute for Advanced Studies (FIAS). His research group focuses on understanding how the brain forms efficient representations of sensory environments and internal states through dynamic neural processes. He maintains active collaborations with leading neuroscience institutions including the University of Minnesota, Max Planck Florida Institute for Neuroscience, and Technion. Dr. Kaschube completed his physics studies at Goethe University Frankfurt and Georg-August-University Göttingen, graduating in 2000 and earning his doctoral degree in physics in 2005. His doctoral work was conducted at the Max Planck Institute for Dynamics and Self-Organization under Fred Wolf and Theo Geisel. He then held a Bernstein Fellowship before becoming a Theory Fellow at Princeton University's Lewis Sigler Institute from 2006-2011. In 2011, he joined Goethe University as Professor for Computational Neuroscience. His research spans four primary areas: the developmental emergence of cortical representations, flexible representations underlying learning and creativity, cognitive maps and representational spaces, and analysis methods for neural data. His group combines dynamic models of neural circuit function with neural data modeling techniques in close collaboration with experimental groups, creating an interdisciplinary interface between computer science, physics, biology, and AI. Notably, his work has revealed highly structured cortical networks prior to sensory experience that share similar architectural principles across sensory and association cortices. Analysis of his recent publications shows a consistent focus on understanding how endogenous neural activity patterns develop into reliable cortical representations through experience. His work spans multiple scales from molecular and cellular mechanisms to whole-brain functional organization, with particular emphasis on developmental processes in visual and auditory cortices. His methodological contributions include advanced techniques for analyzing chronic imaging data, tracking chromatophores in cuttlefish, and characterizing latent spaces in deep neural networks. Lewis Sigler Theory Fellowship (2006-2011) Bernstein Fellowship (2005) Professor Kaschube actively mentors a large group of PhD students including Lorenzo Butti, Jonas Elpelt, Santiago Galella, Deyue Kong, Maurycy Miekus, Ana Pamela Osuna Vargas, and Sigrid Trägenap. His research has been supported by multiple grants including NIH grants EY011488 and EY026273, Bernstein Focus Neurotechnology grant 01GQ0840, and BMBF project D-USA-Verbund: SpontVision. His group currently pursues three major research directions: the origin of distributed modular activity in neocortex, quantitative growth models for cuttlefish based on physical models, and the role of self-organization in linking endogenous cortical networks to sensory input.

• Neuroscience
• Circadian Rhythms
• Molecular Neurobiology
• +۳ مورد دیگر

Professor Martin Fredensborg Rath serves as Head of Department in the Department of Neuroscience within the Faculty of Health and Medical Sciences at the University of Copenhagen. His research focuses on the photoneuroendocrine system regulating circadian rhythms, specifically investigating the suprachiasmatic nucleus, pineal gland, and retina through neuroanatomical and molecular biological approaches. His educational background includes an MSc in Human Biology (2005) and PhD in Medical Sciences (2009), both from the University of Copenhagen. His academic career progressed from Postdoc (2009-2013) to Assistant Professor (2013-2014), Associate Professor (2014-2020), and finally Professor of Experimental Neuroanatomy (2020-present). Rath's research centers on circadian rhythm mechanisms, particularly homeobox gene regulation in the pineal gland, clock gene function in neural tissues, and melatonin biosynthesis pathways. His work integrates molecular neurobiology with systems-level circadian physiology, emphasizing the neural regulation of peripheral clocks in the cerebral cortex and hippocampus. His publication portfolio shows consistent focus on pineal gland neurobiology, with recent articles examining GLP-1 receptor effects on intracranial pressure (2025), 3D ultrastructure of pinealocytes (2024), and diurnal proteome dynamics in cortical astrocytes (2023). The research demonstrates strong methodology in molecular techniques combined with neuroanatomical analysis. Rath has secured substantial funding from major Danish research foundations including the Lundbeck Foundation (multiple awards totaling over 10 million DKK), Novo Nordisk Foundation, Carlsberg Foundation, and Independent Research Fund Denmark. He leads the Rath Lab comprising a technician, postdocs, assistant professor, and graduate students. His international experience includes research at the NIH (2004/2007) and University of Oxford (2019), reflecting his global scientific engagement.

Christian Beltoft Brøchnerمشاهده پروفایل

دانشیار بالینی

• Neuroscience
• Developmental Biology
• Stem Cell Research
• +۵ مورد دیگر

Christian Beltoft Brøchner is a Clinical Associate Professor at the Department of Clinical Medicine, University of Copenhagen. His academic career spans both clinical medicine and research, with a focus on human brain development and stem cell research. Faculty: Faculty of Health and Medical Sciences, University of Copenhagen Department: Department of Clinical Medicine Academic Rank: Clinical Associate Professor Dr. Brøchner completed his Bachelor of Medicine (2002-2005), MD (2009), and has been pursuing PhD studies at the University of Copenhagen since 2011. His clinical background includes work as a General Practitioner and internships in Orthopedics and Neurology. His research centers on the developing human neocortex with particular focus on glycoprotein YKL-40, which appears in human embryonic stem cells, normal brain development, cancer forms, and inflammatory diseases. He also investigates stem cell differentiation compared to normal human development. Dr. Brøchner's 18 research outputs demonstrate expertise across neuroscience, developmental biology, cancer research, and immunology. His 2019 paper on astrogliogenesis has received significant attention with 55 Scopus citations, indicating substantial impact in the field. Highly cited work on brain development and cancer mechanisms Interdisciplinary research bridging clinical medicine and basic science Methodological expertise in microscopy and statistical analysis He serves as a Board member in the DASCS research network since 2012, demonstrating commitment to collaborative research. His work has been referenced in policy sources and discussed across social media platforms including X, Facebook, and academic networks like Mendeley. Proficient in Danish (fluent), English (fluent), and French (moderate), Dr. Brøchner maintains international research connections while contributing to the academic community through teaching and research supervision.

• Alzheimer's Disease Research
• Nutrigenomics
• Cellular and Synaptic Physiology
• +۷ مورد دیگر

Dr. J. Josh Lawrence is a Professor in the Department of Pharmacology and Neuroscience at Texas Tech University Health Sciences Center School of Medicine. His research program focuses on understanding the molecular and cellular mechanisms underlying Alzheimer's disease, with particular emphasis on nutrient-gene interactions and their impact on brain health. Dr. Lawrence's research interests span nutrigenomics, cellular and synaptic physiology of Alzheimer's disease, the role of excitation/inhibition balance in disease states, hippocampal learning and memory circuitry, GABAergic inhibition, cell type specificity of neuromodulation, antioxidant depletion over lifespan, neuroinflammation, and the effects of diet on healthy aging. His work uniquely bridges basic neuroscience with translational applications for neurodegenerative disorders. His recent publications reveal a strong focus on the connections between vitamin metabolism and neurodegeneration, with particular attention to how vitamin A and D homeostasis disruption contributes to Alzheimer's pathogenesis. Dr. Lawrence employs innovative multidisciplinary approaches combining behavioral neuroscience, single-cell transcriptomics, and circuit analysis to uncover novel therapeutic targets. NIH R01 Grant AG071859-01A1 ($1,872,220; 2022-2026): Transcriptional Dysfunction in Dentate Gyrus Cell Types NIH R01 Grant AG073826-01A1 ($3,158,615; 2022-2027): Hippocampal Dentate Gyrus in Aging and Alzheimer's Disease Dr. Lawrence actively mentors graduate students and collaborates with researchers across disciplines to advance understanding of neurodegenerative mechanisms and develop novel interventions for cognitive decline. His lab employs cutting-edge techniques in molecular neuroscience, bioinformatics, and behavioral assessment to address critical questions in Alzheimer's research.

James Noonanمشاهده پروفایل

استاد

• Embryonic and Fetal Development
• Epigenomics
• Molecular Evolution
• +۷ مورد دیگر

James Noonan is the Albert E. Kent Professor of Genetics and Professor of Neuroscience at Yale University School of Medicine, where he also serves as co-Director of Graduate Studies in Genetics. His primary appointment is in the Department of Genetics, with secondary appointments in the Department of Ecology & Evolutionary Biology and Neuroscience. He maintains extensive affiliations across Yale, including the Yale Cancer Center, Yale Center for Genomic Health, Yale Stem Cell Center, Wu Tsai Institute, and Kavli Institute for Neuroscience. Dr. Noonan's research focuses on understanding human-specific gene regulation and its role in evolution and development. His lab pioneered the discovery that Human Accelerated Regions (HARs) encode transcriptional enhancers with human-specific activity in the developing embryo. The lab has developed innovative approaches including humanized mouse models to study how HARs alter developmental gene expression and drive the evolution of novel phenotypes. They also pioneered massively parallel screening approaches to characterize gene regulatory functions in human brain development and evolution. The lab's recent publications reveal significant insights into how uniquely human sequence changes affect enhancer activity, how HARs contribute to cortical development, and how autism risk genes like CHD8 regulate neurodevelopmental pathways. Their work demonstrates that HARs have clear biological functions in neurodevelopment and has identified specific regulatory innovations contributing to the emergence of the mammalian neocortex. Mallinckrodt Foundation Fellowship (2008) Professor Noonan has mentored at least 11 PhD students to completion, with his most recent student (Atreyo Pal) defending in 2025. His lab maintains multiple active grants from NIH, SFARI, NOMIS Foundation, and other major funding agencies. Students in the lab gain training in cutting-edge genomic techniques including CRISPR genome editing, single-cell genomics, and comparative epigenomics. The lab's interdisciplinary approach provides students with opportunities to work across multiple departments and research centers at Yale, with recent students winning prestigious awards like the Carolyn Slayman Prize in Genetics. The Noonan Lab (noonanlab.org) maintains an active presence in the scientific community, regularly sharing research updates and engaging with broader issues affecting biomedical research. Their work continues to advance our understanding of what makes us uniquely human at the molecular level.