Paolo Medini

Paolo Medini is an Associate Professor at Umeå University, affiliated with the Department of Medical and Translational Biology and the Center for Transdisciplinary AI. His research focuses on cortical microcircuits, sensory processing, and brain recovery mechanisms.

• Neuroscience
• Neurophysiology
• Cortical Plasticity
• Optogenetics

His lab investigates how sensory information is processed by distinct cell types in cortical circuits and how these circuits adapt after brain lesions or sensory deprivations. Research spans both adaptive and maladaptive plasticity, aiming to differentiate molecular mechanisms for targeted interventions. Recent publications highlight applications of all-optical interrogation strategies and multisensory integration in the neocortex.

Paolo Medini's group employs advanced techniques such as in vivo patch clamp recordings, two-photon calcium imaging, and optogenetics. They use genetically modified strains to study cell-type-specific responses and circuit reorganization post-lesion. Their work is critical for developing therapies in neurodegenerative diseases and cortical repair.

• Environmental enrichment for brain recovery (Nature Neuroscience)
• Cortical microcircuit organization (Neuron)
• Post-stroke plasticity (Journal of Physiology)