Xiaolong Jiang

Xiaolong Jiang is an Associate Professor at Baylor College of Medicine, jointly affiliated with the Department of Neuroscience and Department of Ophthalmology. His research focuses on cortical microcircuit organization in both healthy and pathological states, with particular emphasis on epilepsy and autism spectrum disorders.

• Expertise: Multi-cell patch recording (up to 12 simultaneous), single-cell RNA sequencing, optogenetics, machine learning
• Diseases Studied: Rett syndrome, Tuberous Sclerosis Complex (TSC), absence epilepsy, mesial temporal lobe epilepsy (mTLE)
• Key Techniques: Patch-seq, in vivo whole-cell recordings, two-photon calcium imaging, CRISPR genetic models

Research spans cross-species comparisons (mouse, macaque) to uncover evolutionary principles of circuit organization. His work addresses how genetic lesions impact cortical circuit development and how aberrant circuitry (connectopathies) contributes to neuropsychiatric conditions.

Current projects include deciphering primate prefrontal cortex microcircuits (NIMH R01 MH120404), TSC cortical tuber circuit mechanisms (DOD W81XWH-19-1-0079), and absence epilepsy circuit deficits (NINDS R01 NS102609-01A1).