معرفی
Dennis Pauls is a Research Professor in the Department of Animal and Behavioral Physiology at the Institute of Biology, University of Leipzig. He leads his own research group (PAULS LAB) focusing on neurobiological mechanisms underlying behavior, memory formation, and decision-making processes, primarily using Drosophila as a model organism. His work bridges molecular neuroscience, behavioral physiology, and systems neuroscience to understand fundamental neural processes.
Dr. Pauls completed his biology studies (Diplom) at the University of Gießen and University of Würzburg (2001-2006), followed by a PhD (Dr. rer. nat.) at the University of Fribourg, Switzerland (2006-2010). He conducted postdoctoral research at the University of Marburg (2010-2011) before becoming a scientific staff member and later group leader at the Theodor-Boveri Institute, University of Würzburg (2011-2019). Since July 2019, he has been a group leader at the University of Leipzig, and completed his Habilitation (Dr. rer. nat. habil, PD) in December 2020.
His research focuses on two primary areas: (1) the integration of time in memories, investigating how essential information is encoded as lasting physical changes through synaptic plasticity, and (2) the neurometabolic mechanisms underlying poor food decisions, exploring how animals overcome innate aversions to potentially harmful foods under hunger conditions. His laboratory employs neuro- and optogenetic approaches, electrophysiology, behavioral analyses, and high-resolution light microscopy to address these questions.
Analysis of Dr. Pauls' recent publications reveals a strong emphasis on octopamine signaling in learning and memory circuits, time integration mechanisms in neural systems, and the metabolic regulation of feeding behavior. His work demonstrates how neuromodulators influence memory formation, how temporal information is incorporated into neural representations, and how metabolic states affect decision-making processes in Drosophila models.
Dr. Pauls currently leads three major DFG-funded research projects: (1) The function of octopamine in reward processing in Drosophila larvae (2019-2023), (2) Neurobiological foundations of integrating time into memories (2023-2026), and (3) Metabolic signatures and neurophysiological mechanisms of poor food intake decisions (2024-2027). He collaborates extensively with the Kittel Lab and other neuroscience groups at the University of Leipzig, contributing to the NeuroTune Graduate School and other interdisciplinary initiatives focused on brain dynamics and neurological disorders.
His laboratory is part of the Integrated Research and Treatment Center (IFB) for Adiposity-Related Disorders for his research on food decision-making, demonstrating the translational potential of his basic neuroscience research. Dr. Pauls' work provides fundamental insights into neural circuit function with implications for understanding memory disorders and eating behaviors in humans.
