Muscle Tone Dysfunction Professors and Supervisors

Sandra T Davidgeمشاهده پروفایل

استاد

University of Wisconsin-MadisonUnited States

Sandra T Davidge is a Professor in the Department of Obstetrics & Gynaecology and an Adjunct Professor in the Department of Physiology at the University of Alberta, Faculty of Medicine & Dentistry. She serves as the Executive Director of the Women and Children’s Health Research Institute (WCHRI), where she leads a multidisciplinary team focused on maternal and perinatal cardiovascular health. Her work bridges basic science and clinical translation, aiming to improve outcomes for women and children affected by pregnancy complications. Her research is centered on understanding the pathophysiology of pregnancy complications such as preeclampsia and intrauterine growth restriction. She investigates how these conditions lead to long-term cardiovascular risks in both mothers and offspring, exploring mechanisms like oxidative stress, endothelial dysfunction, and fetal programming. Her lab uses advanced techniques including vascular myography, cell culture, and molecular analysis in animal models to uncover novel therapeutic targets. Dr. Davidge's recent publications highlight a strong focus on vascular dysfunction in preeclampsia, intergenerational cardiovascular effects, and interventions targeting oxidative stress and the renin-angiotensin system. Her work spans both preclinical models and human translational studies, emphasizing prevention and treatment strategies for at-risk populations. She has been recognized with numerous honors, including: Fellow of the Royal Society of Canada (FRSC) Fellow of the Canadian Academy of Health Sciences (FCAHS) Fellow of the International Union of Physiological Sciences (IUPS) Former Canada Research Chair Tier 1 in Maternal and Perinatal Cardiovascular Health (2007–2021) Dr. Davidge actively mentors undergraduate and graduate students and postdoctoral fellows, maintaining a vibrant training environment. Her research is supported by major funding agencies including the Canadian Institutes of Health Research (CIHR), Heart and Stroke Foundation of Canada, Alberta Innovates, Canada Foundation for Innovation, and partner foundations through WCHRI. She leads collaborative projects across Canada and internationally, including the EINSTEIN/HeLTI initiative in India. Her laboratory is embedded within the Women and Children’s Health Research Institute, a hub for interdisciplinary research dedicated to improving maternal and child health outcomes through innovation, collaboration, and knowledge translation.

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Xiang Liمشاهده پروفایل

عضو هیئت علمی

University of HoustonUnited States

Xiang Li is a Research Associate Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy. Their research focuses on vascular pathobiology, particularly the cellular and molecular mechanisms underlying atherosclerosis, hypertension, and arterial stiffness associated with obesity, aging, and chronic kidney disease. M.D. in Clinical Medicine, Peking University M.S. in Pharmacology & Toxicology, Medical College of Wisconsin Ph.D. in Molecular Biology, University of Duisburg-Essen Research interests include epigenetic regulation, lipid biology, redox signaling, vascular inflammation, cell senescence, and progenitor cell dynamics. Their work utilizes gene knockout models, surgical interventions, and adenoviral gene delivery techniques to investigate disease mechanisms. Recent publications highlight trends in lysosome biogenesis, inflammasome activation, TFEB signaling, and acid sphingomyelinase roles in vascular dysfunction. Key themes span atherosclerosis, diabetes-related vascular complications, and inflammatory pathways. National Heart Lung Blood Institute Early Stage Investigator (2021) DFG Predoctoral Fellowship (2008-2010) Forschungstag Posterpreis (2008) Contact: xli59@uh.edu

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Julio A. Chirinosمشاهده پروفایل

استاد

University of PennsylvaniaUnited States

Julio A. Chirinos, MD, PhD is a Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania and the Perelman School of Medicine. He serves as an Attending Physician at the Hospital of the University of Pennsylvania (HUP), Adjunct Faculty at the Center for Magnetic Resonance and Optimal Imaging, and Co-Director of the Training Program in Cardiovascular Biology and Medicine within the Clinical/Translational Science department. Dr. Chirinos earned his MD from the Catholic University of Santa Maria School of Human Medicine in 1995, followed by a PhD in Biomedical Sciences from the same institution in 1999. He also completed additional training at the University of Ghent in 2012. His research expertise focuses on non-invasive cardiac imaging, arterial stiffness/hemodynamics, ventricular-vascular interactions, and the cardiovascular consequences of obstructive sleep apnea. His clinical expertise includes echocardiography and cardiac MRI, positioning him at the intersection of cardiovascular imaging and physiology. Analysis of his recent publications reveals a strong focus on cardiovascular imaging, arterial stiffness, proteomics in heart failure, and hemodynamic analysis. His work spans multiple methodologies including Mendelian randomization studies, advanced imaging techniques, and proteomic analyses, with particular emphasis on heart failure with preserved ejection fraction (HFpEF), aortic geometry, and vascular aging. Dr. Chirinos actively mentors students and fellows through his role as Co-Director of the Training Program in Cardiovascular Biology and Medicine, though specific advisees are not listed in the available information. His research program appears to be well-funded, given the extensive publication record spanning multiple high-impact journals. He maintains his clinical practice at the Perelman Center for Advanced Medicine (South Tower, Room 11-138) and leads research activities through the Cardiovascular Division at the University of Pennsylvania, contributing significantly to both the clinical and research missions of the department.

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Michael Winderمشاهده پروفایل

استاد

University of GothenburgSweden

Michael Winder is a Professor in Pharmacology at the Institute of Neuroscience and Physiology, University of Gothenburg. His research focuses on autonomic neuroscience, particularly the role of nitric oxide signaling, neurotransmitter interactions, and smooth muscle physiology in pathological conditions such as chronic pelvic pain syndrome, cystitis, and Parkinson's disease-related bladder dysfunction. Affiliation: Department of Pharmacology, Institute of Neuroscience and Physiology, University of Gothenburg Research Group: Autonomic Neuroscience Unit His research explores mechanisms of bladder overactivity, cross-organ sensitization between the prostate and bladder, and the therapeutic potential of soluble guanylate cyclase activators like BAY 60-2770. He investigates how inflammation, neurodegeneration, and pharmacological interventions affect smooth muscle contractility and neurotransmission in urological and gastrointestinal systems. Publications highlight trends in nitric oxide dependency, purinergic/cholinergic interactions, and drug combination therapies for bladder disorders. His work spans preclinical models, receptor signaling, and translational pharmacology. Email: michael.winder@pharm.gu.se Visiting Address: Medicinaregatan 11, 41390 Göteborg Postal Address: Box 430, 40530 Göteborg Winder collaborates extensively within the Autonomic Neuroscience Unit and with researchers in urology, neuroscience, and pharmacology. He has contributed to conferences like the International Continence Society meetings and journals such as Neurourology and Urodynamics and European Journal of Pharmacology .

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Lawrence Sinowayمشاهده پروفایل

استاد

Pennsylvania State UniversityUnited States

Lawrence Sinoway, MD, is Distinguished Professor of Medicine in the Division of Cardiology at Pennsylvania State University College of Medicine, and a leading investigator within the Penn State Clinical and Translational Science Institute (CTSI) and Penn State Heart and Vascular Institute. Over a career spanning nearly five decades, he has produced 240 research outputs, secured 47 major NIH grants, and achieved an h-index of 55 with >9,000 citations. Education & Training: While the provided text does not enumerate his degrees, Dr Sinoway’s title of “MD” indicates medical training; additional academic credentials are likely but are not explicitly stated. Research Focus: Dr Sinoway’s work centres on cardiovascular autonomic control, with particular emphasis on muscle sympathetic nerve activity, baroreflex and chemoreflex regulation, exercise pressor reflex mechanisms, and peripheral arterial disease. His investigations range from cellular signalling to whole-human integrative physiology, leveraging translational approaches that align with the goals of the Penn State CTSI. Recent publications (2023-2025) demonstrate sustained productivity in: Pharmacologic optimisation of heart failure therapy (e.g., sacubitril/valsartan dosing) Mechanisms of autonomic dysfunction in peripheral arterial disease, heart failure with preserved ejection fraction, and diabetes mellitus Novel device-based haemodynamic modulation (e.g., HeartWare LVAD speed adjustment during exercise) Non-pharmacological interventions such as inspiratory muscle training and dietary nitrate supplementation These studies collectively advance understanding of neuro-cardiovascular coupling and inform evidence-based therapeutic strategies. Honours & Awards: Career Research Excellence Award – Penn State University (2017) Research Funding & Leadership: Dr Sinoway has served as Principal Investigator or Co-Investigator on 47 funded projects. Ongoing NIH support includes: Penn State CTSI (NCATS) – Co-PI (2016-2026) “The Human Cardiovascular Control: The Role of Limb Veins” – NHLBI Co-PI (2019-2024) Program Project “Acute and Chronic Afferent Engagement” – NHLBI PI/Co-PI (2017-2022) These grants foster multi-disciplinary collaborations across cardiology, physiology, endocrinology, and biomedical engineering. Laboratory & Teams: Dr Sinoway directs active research teams embedded within the Penn State Heart and Vascular Institute and the Clinical Research Center. His group employs state-of-the-art microneurography, Doppler ultrasound, and metabolic techniques to dissect autonomic mechanisms in health and disease.

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D. Walter Wrayمشاهده پروفایل

استادیار

University of UtahUnited States

D. Walter Wray is a Research Assistant Professor in the Division of Geriatrics at the University of Utah. He focuses on vascular and autonomic physiology, particularly in aging and age-related diseases like heart failure (HF). He co-founded the Utah Vascular Research Laboratory (UVRL), affiliated with the University of Utah's Departments of Internal Medicine and Nutrition and Integrative Physiology, and the Salt Lake City Veterans Administration Medical Center GRECC. Education: Postdoctoral Fellowship, University of California San Diego PhD, University of North Texas Health Science Center MSc, University of North Texas Health Science Center BSc, Abilene Christian University His research examines neurohumoral control of muscle blood flow during exercise and chronic sympathoexcitation in HF. Recent studies include the effects of antioxidants, BH4, and statins on vascular function. His work is extramurally funded and involves collaborations with the Veterans Administration. Notable projects include investigating adrenergic regulation, baroreflex dysfunction, and sympatholysis impairment in HF patients. He employs techniques like Doppler ultrasonography and peripheral sympathetic nerve recording. Key affiliations include: University of Utah Utah Vascular Research Laboratory (UVRL) Salt Lake City VAMC GRECC

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Andrea L. Kalinoskiمشاهده پروفایل

استاد

University of ToledoUnited States

Andrea L. Kalinoski, Ph.D. , is a Professor with Tenure at the University of Toledo , affiliated with the College of Medicine and Life Sciences and the Department of Surgery . She serves as the Director of Integrated Core Facilities , overseeing advanced resources like Advanced Microscopy & Imaging Center and Flow Cytometry . Her academic journey began with a B.A. in Biology (1994) and a Ph.D. in Medical Sciences (2003) from the University of Toledo, followed by postgraduate training at the University of Toledo Health Science Campus (2003–2009). Research Interests focus on molecular signaling mechanisms in vascular injury responses, specifically neointimal hyperplasia and arterial stiffness due to vascular tone dysregulation. Her work spans genetic factors in vascular disease , cancer biology (pancreatic and breast cancer), and adipose tissue metabolism , supported by NIH grants (e.g., R01CA169500, SPARC OT2OD023859). Publications in journals like PLOS One , Frontiers , and Science Advances highlight collaborations in medical imaging , genetic complementation , and neural circuit mapping . Labs & Facilities : As Director, she manages the UT Integrated Core Facilities , integrating Advanced Microscopy , Flow Cytometry , and Transmission Electron Microscopy to enable cutting-edge research. Her team's tools include 3D co-culture models for studying carcinogenesis and microwave-assisted synthesis for bioimaging materials.

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Thomas Andrew Qvistgaard Jeppsمشاهده پروفایل

دانشیار

University of CopenhagenDenmark

Thomas Andrew Qvistgaard Jepps is an Associate Professor in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences, where he leads research on vascular physiology with a focus on circulation, kidney, and lung systems. He also holds a Guest Researcher position in the Department of Drug Design and Pharmacology within the Molecular and Cellular Pharmacology section. Dr. Jepps received his BSc (Hons.) in Biomedical Sciences from St. George's University of London (2005-2008), followed by a PhD from the same institution funded by the Biotechnology and Biological Sciences Research Council (2009-2013). His academic journey includes postdoctoral research at the University of Copenhagen and prestigious fellowships including a Marie Curie Independent Research Fellowship and a Carlsberg Foundation Research Fellowship. His research program centers on understanding vascular ion channel regulation, particularly potassium channels, and their role in hypertension and vascular diseases. Dr. Jepps investigates two primary areas: KCNE ancillary subunits and microtubules in smooth muscle cells, with additional projects on smooth muscle proliferation in atherosclerosis, novel ion channels in angiogenesis, and functional sympatholysis mechanisms. His laboratory employs advanced techniques including isometric tension recordings, electrophysiology, immunostaining, proximity ligation assays, and molecular biology approaches. Analysis of his recent publications reveals a strong focus on vascular tone regulation, with particular emphasis on microtubule function in hypertension, potassium channel modulation by novel compounds, and translational research connecting basic mechanisms to clinical applications such as colchicine for hypertension treatment and understanding drug-induced hypotension. Scientific Recognition: Selected for the 68th Lindau Nobel Laureate Meeting (2018) Multiple best presentation awards at international symposia (2009-2014) Widdicombe Prize in Physiology from St. George's University of London (2009) Regular invitations to present at international conferences and departmental seminars Dr. Jepps has supervised 2 ERASMUS students, 9 bachelor's project students, and 3 Master's students. His research is supported by significant grants including the Carlsberg Foundation Research Fellowship (1,178,053DKK), Lundbeck Foundation Postdoctoral Fellowship (700,000DKK), and a Marie Curie Postdoctoral Fellowship (€199,809). He has organized numerous scientific events including the First International Kv7 Channels Symposium and Cardiovascular Seminar Series at the University of Copenhagen. His laboratory maintains active collaborations with researchers across multiple institutions including Prof. Geoffrey Abbott at UC Irvine (KCNE subunits), Prof. Christian Aalkjær at Aarhus University (microtubules in arteries), and Prof. Anthony Heagerty at the University of Manchester (colchicine for hypertension treatment).

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David X. Zhangمشاهده پروفایل

دانشیار

Medical College of WisconsinUnited States

Dr. David X. Zhang is an Associate Professor in the Department of Medicine, Division of Cardiology at the Medical College of Wisconsin, where he is also a member of the Cardiovascular Research Center. His academic career bridges clinical medicine (MD) and basic science research (PhD), positioning him at the forefront of translational cardiovascular research. Dr. Zhang's research focuses on the molecular mechanisms of vascular function, with particular emphasis on endothelial physiology, ion channel regulation (especially TRP channels), and the signaling pathways that control vasodilation and vascular tone. His laboratory investigates how reactive oxygen species (NO, H2O2), calcium signaling, and various mediators regulate human microvascular function in both health and disease states. Key areas of investigation include the role of TRPV4 channels in vascular signaling, mechanisms of endothelial dysfunction in coronary artery disease, and the vascular consequences of inflammatory conditions including SARS-CoV-2 infection. Analysis of Dr. Zhang's recent publication record (2019-2025) reveals a consistent research trajectory focused on molecular vascular mechanisms with direct clinical relevance. His work frequently employs human tissue models, providing translational significance to his findings. The publications demonstrate expertise in multiple methodologies including human microvessel physiology, molecular signaling analysis, and structural biology approaches. His research has made significant contributions to understanding alternative vasodilator mechanisms, ion channel regulation in vascular tissue, and the molecular basis of endothelial dysfunction. Dr. Zhang maintains an active collaborative network, as evidenced by his numerous multi-institutional publications. His work has been published in high-impact journals including Nature Communications, Journal of Biological Chemistry, Arteriosclerosis Thrombosis and Vascular Biology, and Basic Research in Cardiology. While specific grant details aren't provided, the sustained productivity and sophisticated nature of the research suggest substantial ongoing funding support. For students and researchers interested in vascular biology, Dr. Zhang's laboratory offers opportunities to work at the intersection of basic science and clinical cardiovascular research, with emphasis on human vascular physiology and molecular signaling mechanisms that have direct relevance to cardiovascular disease pathogenesis and potential therapeutic targets.

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Seher Ülkerمشاهده پروفایل

مدرس

Alanya UniversityTurkey

Dr. Seher Ülker is a Lecturer in the Department of Physiotherapy and Rehabilitation at Alanya Alaaddin Keykubat University's Faculty of Health Sciences. She holds a PhD in Physiology from Akdeniz University (2018) and previously served as Research Assistant at Akdeniz University's Department of Physiology (2010-2018). Her academic appointments include multiple administrative roles: Deputy Head of Department (2021), Director of Research and Application Center (2020), and General Coordinator for Disabled Students (2019). Her research focuses on vascular physiology mechanisms , particularly carbon monoxide pathways in vascular tone regulation, exercise-induced vascular adaptations, and hypertension models. She investigates how aging, exercise training, magnesium supplementation, and 20-HETE inhibition affect vascular reactivity in resistance/conduction arteries using rodent models. Recent publications (2020-2024) demonstrate continued productivity in journals like Journal of Surgical Research and Turkish Bulletin of Hygiene . Dr. Ülker actively supervises graduate students with four recent theses (2023-2025) on rehabilitation topics including knee osteoarthritis, archery performance, temporomandibular dysfunction, and multiple sclerosis frailty. She teaches 8+ courses annually across undergraduate and graduate programs, covering physiology fundamentals, exercise physiology, and rehabilitation science. Key research contributions: Parabiosis effects on vascular aging (2022) Carbon monoxide regulation in hypertensive models (2020) Exercise adaptations in vascular tone (2019) Magnesium therapy mechanisms in hypertension (2015-2016) 20-HETE pathway in trained vasculature (2018) She has led 6 nationally funded research projects (2009-2018) including TÜBİTAK 1002 support. Dr. Ülker also contributes to rehabilitation literature through book chapters on temporomandibular dysfunction, sarcopenia, and exercise modalities.

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Frances Planeمشاهده پروفایل

دانشیار

University of AlbertaCanada

Frances Plane is an Associate Professor at the University of Alberta specializing in vascular biology and cardiovascular pharmacology. Her research targets endothelial dysfunction in metabolic diseases, focusing on endothelial-smooth muscle communication mechanisms critical for blood pressure regulation and tissue perfusion. Education: PhD Pharmacology, University of London, 1992 Her laboratory investigates how disruption of endothelial-derived factors like nitric oxide and myoendothelial gap junctions contributes to hypertension, atherosclerosis, and thrombosis in diabetes. Using functional, electrophysiological, and molecular approaches, her team identifies novel ion channel targets to restore vascular function. Current work emphasizes metabolic disease models and therapeutic strategies for endothelial repair. Recent publications (2018-2022) reveal strong thematic continuity in vascular pharmacology, with emphasis on endothelial ion channels, platelet-vascular interactions, and sex-specific responses. Key trends include oxidative stress mechanisms in metabolic disease, repurposing existing drugs for vascular conditions, and myoendothelial feedback pathways as therapeutic targets. Scientific Awards: NSERC Discovery Grant Research Grant from Marshall Eliuk Fund for Medical Research Dr. Plane actively mentors graduate students including MSc candidate Stephen Gust, while leading a research team with lab assistant Caleb McInroy. Her grants support investigations into vascular dysfunction biomarkers and novel interventions for diabetic vascular complications. She is affiliated with the Cardiovascular Research Institute and teaches PMCOL425 (Pharmacology). Her laboratory operates from the Medical Sciences Building (9-62), utilizing advanced techniques to study resistance artery physiology and endothelial signaling pathways in metabolic disease contexts.

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