جست‌وجوی استاد و پژوهشگر

H. Steven Wileyمشاهده پروفایل

پژوهشگر

• Systems Biology
• Cellular Signaling Networks
• Cancer Biology
• +۵ مورد دیگر

H. Steven Wiley serves as a Lead Scientist in Systems Biology at Pacific Northwest National Laboratory (PNNL), where he is affiliated with the Environmental Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. With over 200 scientific publications including more than 130 peer-reviewed journal articles, Dr. Wiley has established himself as a leading figure in systems biology research. Dr. Wiley's research focuses on understanding the systems-level design principles underlying regulatory networks in both prokaryotic and eukaryotic cells, with particular emphasis on how these networks become dysfunctional in diseases like cancer. His recent work leverages CRISPR-based technologies combined with proteomics, gene expression, and biochemical assays to build improved mechanistic models of signaling and metabolic networks. This research requires developing scalable computational infrastructure for integrating multidimensional datasets and advancing analytical technologies. His publication record shows a consistent focus on cellular signaling pathways, particularly the EGFR-MAPK pathway, with recent work expanding into single-cell analysis, cancer heterogeneity, and drug resistance mechanisms. The evolution of his research demonstrates a trajectory from fundamental signaling mechanisms toward increasingly complex systems-level questions with translational implications. Award for Distinguished Technical Communication (2011) Faculty of 1000 Member for Cell Biology (2011) Elected AAAS Fellow (2005) R&D 100 Award for designing single-chain antibody library in a yeast-display system (2004) Laboratory Fellow, Pacific Northwest National Laboratory (2000) National Institutes of Health Research Career Development Award (1988–1993) Dr. Wiley has served as an associate editor of Frontiers in Genetics and sits on the editorial boards of The Scientist and BMC Biology. He has reviewed for more than 30 scientific journals, demonstrating his significant contributions to scientific discourse. His work at PNNL's EMSL facility positions him at the intersection of cutting-edge experimental technologies and computational modeling approaches.

Valeria Cavalliمشاهده پروفایل

استاد

• Axon Regeneration
• Peripheral Nervous System
• Central Nervous System
• +۴ مورد دیگر

Valeria Cavalli, PhD, is the Robert E. and Louise F. Dunn Professor of Biomedical Research and Professor of Neuroscience at Washington University School of Medicine. Her research focuses on axon regeneration mechanisms in sensory neurons and the role of satellite glial cells in sensory function and dysfunction. She leads the Cavalli Lab, which investigates molecular pathways in peripheral and central nervous system repair using biochemistry, cell biology, in vivo imaging, and single-cell sequencing approaches. Education: BS and Master in Biochemistry, University of Geneva, Switzerland (1987-1992) Predoctoral Research, University of Rome "La Sapienza" (1991-1994) Predoctoral Research, Biozentrum, Basel, Switzerland (1994-1995) PhD in Biochemistry, University of Geneva, Switzerland (1995-2000) Research Interests: Dr. Cavalli's work centers on intrinsic mechanisms of axon regeneration, satellite glial cell contributions to neural repair, and therapeutic strategies for CNS injuries. Her lab studies neurodevelopmental disorders (e.g., Fragile X syndrome), aging-related sensory decline, and multicellular interactions in dorsal root ganglia. Key projects include epigenetic reprogramming after injury, endothelin receptor pathways, and macrophage-mediated regeneration. Publication Trends: Her recent articles (2021-2024) emphasize single-cell transcriptomics of sensory neurons, glial-neuronal interactions in pain/regeneration, and interventions for neurodevelopmental/aging models. Dominant themes include chromatin remodeling, receptor signaling (e.g., Endothelin B, GABAa), and cross-species molecular conservation. Awards: Robert E. and Louise F. Dunn Professorship (2021) NINDS Research Program Award (R35, 2020) Stein Innovation Award (2019) Jack Griffin Plenary Lecture (2019) Distinguished Investigator Award (2014) Advising & Grants: Dr. Cavalli mentors 19+ trainees (PhD/Master's students and postdocs) and secured major funding including an R35 award for "Multicellular Mechanisms Driving Axon Regeneration." Her lab collaborates with WashU departments (Genetics, Neurology, Anesthesiology) and external institutions like Weizmann Institute. Lab & Team: The Cavalli Lab comprises postdoctoral fellows, staff scientists, and undergraduates. Current members include Sarah Rosen (neuroimmunology), Irshad Ansari (membrane trafficking), and Brent Trauterman (lab operations). Alumni hold positions at universities and industry worldwide.

• Tissue Engineering
• Antimicrobial Materials
• Biomaterials

Ying Deng serves as an Associate Professor in the Department of Biomedical Engineering at the University of South Dakota, Sioux Falls, where she has held faculty positions since 2008. Her academic journey includes postdoctoral research at Tsinghua University (2001-2003) and Rice University (2004-2007). Her research focuses on Tissue Engineering, antimicrobial materials, and biomaterials development , with specific emphasis on creating orthopedic implants that resist bacterial infection while promoting bone growth, and nanofibrous scaffolds for spinal disc repair. Current projects address critical challenges in medical device-related infections through innovative material science approaches. Professor Deng leads active NSF EPSCoR grants (2019-2024) for bioengineering innovation and multicellular life research. Her publication record includes significant contributions to biofilm research in medical devices and localized drug delivery systems, reflecting consistent expertise in biomaterials science despite limited recent publications listed in the source material. She teaches graduate courses in Tissue Engineering and Biomedical Engineering, along with undergraduate Biomedical Technology courses, bridging theoretical knowledge with practical medical applications through her experimental design expertise.

Eva Liebauمشاهده پروفایل

استاد

• Glutathione metabolism
• Oxidative stress response
• Parasitic nematodes
• +۵ مورد دیگر

Prof. Dr. Eva Liebau is a Professor and Group Leader at the Institute for Integrative Cell Biology and Physiology, University of Münster, Germany, specializing in Molecular Physiology. She leads an active research group investigating glutathione metabolism, oxidative stress response, and parasitic nematodes, with significant involvement in the SãMBio German-Brazilian double degree program with the University of São Paulo. Her research focuses on the molecular mechanisms of genetic adaptation to xenobiotic compounds and oxidative stressors, using Caenorhabditis elegans as a model organism. Her work spans environmental stress response, thiol-based redox signaling, glutathione-related enzymes, regulation of translation, and the secretome of parasitic nematodes. She has made significant contributions to understanding the UFM1 cascade, a posttranslational modification system highly conserved in multicellular organisms. Prof. Liebau's recent publications reveal a strong trend toward anthelmintic drug discovery using natural compounds and plant extracts, with particular emphasis on understanding the mechanisms of action against parasitic nematodes. Her work bridges basic molecular research with applied parasitology, contributing to both fundamental understanding of stress responses and potential therapeutic applications. She actively supervises PhD and MSc students including Emma Schröder and Luka Ressmann, and collaborates extensively with international partners including the Institute of Biomedical Sciences at the University of São Paulo, the Institute of Pharmaceutical Biology and Phytochemistry at the University of Münster, and the Redox Homeostasis Group at the Institute of Biomedicine of Seville. Prof. Liebau is affiliated with multiple research networks including Cells in Motion, CRC 1009 (Breaking Barriers), CRC 1348 (Dynamic Cellular Interfaces), CRC 1459 (Intelligent Matter), and CRC 944 (Physiology and Dynamics of Cellular Microcompartments), and participates in several PhD programs including CiM-IMPRS, IRTG Graduate School, and SP BioSciences.

• Intercellular Signaling
• Biomimetic Microenvironments
• Developmental Toxicology
• +۶ مورد دیگر

Dr. Brian P. Johnson is an Assistant Professor at Michigan State University, jointly appointed in the Department of Pharmacology & Toxicology and the Department of Biomedical Engineering. His interdisciplinary research focuses on designing biomimetic microenvironments to study intercellular signaling in development and disease, particularly using 3D printing and CNC machining for high-throughput cancer models and endocrine disruption studies. Ph.D. in Molecular and Environmental Toxicology, University of Wisconsin Postdoctoral training in Biomedical Engineering, University of Wisconsin His work addresses: Chemical mixtures disrupting epithelial-mesenchymal signaling in orofacial development Mechanisms of cancer treatment resistance via multicellular models Computational modeling of thyroid homeostasis perturbations Translational strategies for precision disease treatment Articles highlight trends in microtissue engineering, computational endocrinology, and cancer-immune microenvironment interactions.

• Evolutionary Biology
• Microbial Evolution
• Multicellularity
• +۲ مورد دیگر

Roberta May Fisher is an Academic Research Staff member at the Natural History Museum of Denmark within the University of Copenhagen's Faculty of Science. Her research centers on evolutionary transitions to multicellularity, using microbial model systems to investigate fundamental biological principles. Her core research interests include Evolutionary Biology , Microbial Evolution , and Multicellularity , with specific focus on Saccharomyces cerevisiae as an experimental model. She examines how group formation, division of labor, and environmental constraints drive the evolution of complex multicellular traits, integrating theoretical frameworks with empirical approaches to understand cooperation and relatedness in biological systems. Analysis of her 2017-2022 publications reveals consistent investigation into evolutionary mechanisms governing multicellular complexity. Her work demonstrates interdisciplinary integration of experimental evolution, theoretical biology, and microbial genetics, with recurring emphasis on clonal systems and fitness trade-offs. Key methodological approaches include controlled laboratory evolution experiments and mathematical modeling of social dynamics in yeast populations. Dr. Fisher's research appears in high-impact venues including Proceedings of the Royal Society B and Proceedings of the Biological Sciences , with publications accumulating significant citations (e.g., 27 Scopus citations for her 2020 paper) and substantial Mendeley readership, indicating active engagement within the evolutionary biology community.

• Computational Biology
• Tissue Organization
• 3D Image Analysis
• +۴ مورد دیگر

Luis María Escudero Cuadrado is a Full Professor in the Department of Cell Biology at the University of Seville, where he leads research in computational biomedicine. His work bridges biology, mathematics, and computer science to understand tissue organization and develop diagnostic tools for neuromuscular diseases. He is affiliated with the Instituto de Biomedicina de Sevilla (IBiS) and heads Research Group CTS-594 Neuronal Maintenance Mechanisms. His research focuses on: Computational modeling of tissue organization and epithelial morphogenesis Development of 3D image analysis tools for biological applications Geometric principles in biological systems (notably the discovery of "scutoids") Neuromuscular disease diagnostics through computational methods Neurodegeneration and age-related changes in neural tissues Professor Escudero Cuadrado's recent publications demonstrate a strong focus on developing computational approaches to understand biological tissue organization. His most cited work describes "scutoids," a novel geometric shape that explains 3D packing in curved epithelia. His lab has developed several computational tools including CartoCell and EpiGraph for high-content image analysis of biological tissues. His research spans from fundamental biophysical principles to clinical applications in neurodegeneration and neuromuscular diseases. His scientific contributions include: Discovery of scutoids as a geometric solution for 3D epithelial packing Development of computational tools for biological image analysis Patent for neuromuscular disease diagnostic methods Multiple high-impact publications in journals like Nature Communications Professor Escudero Cuadrado actively mentors students and has directed doctoral theses on computational approaches to tissue organization. His laboratory maintains strong collaborations across disciplines and continues to push the boundaries of computational biomedicine through ongoing research projects and tool development. Professor Escudero Cuadrado leads the Computational Biomedicine Group (http://www.scutoids.es), which focuses on applying mathematical and computational approaches to biological problems. The lab combines expertise in cell biology, biophysics, computer science, and mathematics to develop innovative solutions for understanding tissue organization and disease mechanisms.

Xinhui Anمشاهده پروفایل

پژوهشگر

• Plant Cell Wall Biosynthesis
• Carbon Allocation
• Synthetic Biology
• +۳ مورد دیگر

Dr. Xinhui An is a Researcher at the Institute for Plant Cell Biology and Biotechnology, Heinrich Heine University Düsseldorf, focusing on fundamental mechanisms of plant performance optimization through interdisciplinary approaches bridging development, metabolism, and synthetic biology. Her core research areas include: Plant Cell Wall Biosynthesis and carbon allocation pathways Synthetic and Reconstruction Biology for pathway engineering Metabolomics and data-driven modeling of plant systems Edaphic adaptation through plant-microbiota metabolic networks Dr. An's current work reconstructs plant cell wall polysaccharide biosynthesis in cyanobacterial and eukaryotic CO 2 -fixing systems to overcome limitations of multicellular plant models, with emphasis on identifying regulatory factors for carbon partitioning. Her methodology integrates theoretical plant biology with advanced imaging and metabolomics platforms. No scientific awards or student advisement details are documented in the provided materials. Research infrastructure utilization includes the Plant Metabolism and Metabolomics Facility, Imaging Platform, and CEPLAS Data resources for comprehensive plant performance analysis.

• Cell Biology
• Molecular Biology
• Protein Structure and Function
• +۳ مورد دیگر

Juha Saarikangas is an Assistant Professor at the Helsinki Institute of Life Science (HiLIFE) at the University of Helsinki. He holds multiple supervisory roles in doctoral programmes including Cellular Individuality, Brain & Mind, Integrative Life Science, and Microbiology and Biotechnology. His academic position is currently in its second term, indicating continued recognition of his contributions to the institution. Dr. Saarikangas' research spans multiple disciplines within cellular and molecular biology. His work focuses on protein structure and function, cellular aging mechanisms, cytoskeletal dynamics, and cellular individuality. His research bridges basic cellular processes with implications for neurological development and disease. He has established a productive research trajectory with consistent publications in high-impact journals across multiple domains of cell biology. His recent publications demonstrate a strong focus on cellular mechanisms related to protein homeostasis, cytoskeletal organization, and cellular aging. The research shows interdisciplinary connections between structural biology, cell biology, and neuroscience, with particular emphasis on how cellular processes contribute to developmental disorders and longevity. His work often employs advanced imaging and molecular techniques to uncover fundamental cellular mechanisms. Dr. Saarikangas currently leads multiple significant research projects funded by prestigious organizations including the Academy of Finland, Jane and Aatos Erkko Foundation, and Emil Aaltonen Foundation. These projects span from 2023 to 2029, indicating sustained research activity and funding support. His current projects focus on cellular aging mechanisms, compartmentalization of the synaptic ER, and microcephaly-linked protein research. Based at Biocenter 2 in Helsinki, Dr. Saarikangas operates within one of the leading life science research environments in Northern Europe. His position at HiLIFE provides access to state-of-the-art facilities and collaborative opportunities across multiple disciplines of life science research.

Ilya Nemenmanمشاهده پروفایل

استاد

• Theoretical biophysics
• Biological information processing
• Coarse-grained modeling
• +۷ مورد دیگر

Ilya Nemenman is the Samuel Candler Dobbs Professor of Physics and Biology at Emory University's College of Arts and Sciences. He is a theoretical physicist who has been instrumental in establishing Emory as a global leader in theoretical and modeling approaches to living systems, recognized as a 2021 Simons Investigator. His educational background includes a Ph.D. from Princeton University (2000), with additional education at Belarusian State University. He completed postdoctoral training at the NEC Research Institute and the Kavli Institute for Theoretical Physics. Nemenman's research focuses on understanding how biological systems learn from and respond to their environment through what he terms "biological information processing." He seeks to identify computational primitives employed by living organisms and determine if phenomenological, coarse-grained representations of biological processes can be functionally accurate. His work spans theoretical biophysics, coarse-grained modeling in systems biology and neuroscience, information transduction in biological systems, and learning and adaptation across molecular, neural, and evolutionary scales. Nemenman leads the Theory and Modeling of Living Systems (TMLS) initiative at Emory, which unites researchers from multiple departments and institutions to understand biology with precision comparable to physical sciences. His research group studies diverse systems including primate visual brain, neural signal transduction in C. elegans, cellular suicide dynamics, and multicellular effects in cellular signaling. Simons Investigator (2021) Winship Distinguished Research Professor of Physics and Biology (2017-2020) Fellow, American Physical Society (2016) General Member, Aspen Center for Physics (2015-2025) Phi Beta Kappa mentor recognition (2013, 2015) Chair Line, Division of Biological Physics, American Physical Society (2013-2017) McDonnell Foundation 21st Century Science Initiative Fellow Nemenman mentors postdoctoral researchers, including Audrey Sederberg who joined the faculty at the University of Minnesota, and Andrew Mugler who received the NSF CAREER Award and is now an assistant professor at the University of Pittsburgh. His research has been supported by significant grants including the Simons Foundation award providing $100,000 annually for five years. He is affiliated with multiple research initiatives including The New Mexico Consortium and The Center for Nonlinear Studies at LANL, and has collaborated extensively with experimental researchers to apply theoretical approaches to real biological systems.

Michael Elowitzمشاهده پروفایل

استاد

• Synthetic Biology
• Genetic Circuits
• Noise in Gene Expression
• +۴ مورد دیگر

Michael Elowitz is a Professor of Biology, Bioengineering, and Applied Physics at the California Institute of Technology (Caltech) and an HHMI Investigator, appointed since 2003 after completing his academic training. His educational background includes a Ph.D. in Physics from Princeton University (1999) and postdoctoral research at the Rockefeller University. Dr. Elowitz's research pioneers the quantitative analysis of genetic circuit design principles in living cells. He founded synthetic biology through the Repressilator—a three-gene repressor circuit generating clock-like oscillations in bacteria—and systematically investigated how stochastic noise governs cellular decision-making, differentiation, and developmental evolution. Current work integrates synthetic biology with multicellular signaling, memory mechanisms, and pattern formation dynamics. His major recognitions include: Packard Fellowship for Science and Engineering Searle Scholars Award MacArthur Fellowship ("Genius Grant") HFSP Nakasone Award for interdisciplinary life sciences As an HHMI Investigator, Dr. Elowitz directs substantial research funding toward innovative projects exploring fundamental biological principles. His laboratory at Caltech serves as a hub for quantitative systems biology, training researchers in experimental and theoretical approaches to genetic networks. The Elowitz Lab maintains active research programs in synthetic circuit engineering, noise quantification in gene expression, and developmental patterning mechanisms across bacterial and eukaryotic systems.