جست‌وجوی استاد و پژوهشگر

• Cardiovascular Immunology
• Monocyte and Macrophage Biology
• Hematopoiesis
• +۵ مورد دیگر

Filip Swirski, PhD is a Professor at the Icahn School of Medicine at Mount Sinai, Department of Medicine, with cross-appointments in Immunology, Microbiology, and Neuroscience training areas. His research laboratory investigates the intersection of immunology and cardiovascular disease with particular focus on myeloid cell biology. Dr. Swirski's research interests span three major areas: Monocytes and Macrophages in Cardiovascular Disease - investigating how these cells participate in atherosclerosis and myocardial infarction, including his discovery of sleep's protective role against atherosclerosis by limiting monocyte production Hematopoiesis and Growth Factors - studying survival, proliferation, and differentiation of hematopoietic cells, including his work on GM-CSF-producing B cells and IL-3 in sepsis Systemic Inflammatory Networks and Inter-Organ Communication - examining how inflammatory networks connect cardiovascular and metabolic processes, including splenic monocyte production and iron recycling mechanisms His publication record demonstrates significant contributions to understanding immune mechanisms in cardiovascular disease, with research trends showing increasing focus on neuro-immune interactions and translational applications of basic findings. His work bridges immunology, cardiology, and neuroscience with growing emphasis on lifestyle interventions and circadian regulation of immune function. Dr. Swirski's scientific achievements have been recognized with numerous prestigious awards including: 2020 ESC William Harvey Lecture on Basic Science from the European Society of Cardiology 2016 NIH Outstanding Investigator Award 2017 Established Investigator Award from the American Heart Association Multiple distinguished lectureships and research scholar awards His research has been continuously funded by major NIH mechanisms, reflecting the significance of his work on monocyte biology in cardiovascular disease. Dr. Swirski maintains an active laboratory at the Hess CSM Building on the Mount Sinai campus where his team investigates fundamental mechanisms of immune cell function in cardiovascular health and disease.

Alex Kuanمشاهده پروفایل

استاد

• Neuroscience
• Neuroinflammation
• Microglia
• +۷ مورد دیگر

Alex Kuan, M.D., Ph.D., is a Professor in the Department of Neuroscience at the School of Medicine, University of Virginia. He is a primary faculty member with an active research profile focused on neuroinflammation, microglial function, and cerebrovascular regulation. Research Interests: Dr. Kuan's research spans neuroscience, immunology, and cell biology, with a focus on microglia, neuroinflammation, autophagy, and cerebral ischemia. His work investigates how immune cells in the brain regulate vascular function and respond to injury, particularly in neonatal and ischemic conditions. Publication Trends: His recent publications (2021–2025) emphasize the role of microglia and monocytes in neurovascular coupling, ectonucleotidase signaling, and inflammatory responses. A recurring theme is the interplay between immune activation and brain metabolism, especially through purinergic pathways. Scientific Awards: No awards listed in the provided text. Advising and Grants: While specific students and grants are not mentioned, Dr. Kuan's extensive publication record and collaborative work suggest active mentorship and research funding. He frequently collaborates with experts in microglial biology and neuroimmunology. Labs and Teams: Although no lab name is provided, Dr. Kuan is part of the University of Virginia's neuroscience research community, contributing to initiatives in neurodegeneration and brain injury.

Xin Liuمشاهده پروفایل

استادیار

• Immunometabolism
• Innate Immunity
• Host-Pathogen Interactions
• +۷ مورد دیگر

Xin Liu, PhD is an Assistant Professor in the Department of Biochemistry at the School of Medicine, Case Western Reserve University. Their research focuses on the intersection of immunology and metabolism, particularly in the context of lung infections and cancer. Research Interests: The lab investigates how metabolic pathways regulate the function of innate immune cells such as macrophages and monocytes. Specific areas include metabolic reprogramming during infection, host factor roles in immune modulation, and cell-cell communication at the immune-metabolic interface. The overarching goal is to manipulate immune-metabolic networks to improve treatments for infectious diseases and cancer. Publication Trends: Dr. Liu's recent work, published in journals like Cell Host & Microbe and The Journal of Immunology , centers on innate immune responses to pathogens such as Legionella and influenza viruses, with a strong emphasis on metabolic regulation and signaling pathways including RIG-I and MyD88. Scientific Awards: No awards mentioned in the provided text. Advising and Grants: While no specific students or grants are listed, Dr. Liu leads an independent research laboratory focused on immunometabolism. Their work likely involves extramural funding, though details are not provided. Labs and Teams: Dr. Liu directs a research lab that studies immunometabolic regulation in disease contexts, collaborating with experts in microbiology, immunology, and pulmonary biology.

Christian Reinhardtمشاهده پروفایل

استاد

• Oncology
• Hematology
• B-cell Lymphoma
• +۱۳ مورد دیگر

Prof. Dr. Christian Reinhardt is a leading oncology researcher and clinician at the University of Duisburg-Essen, serving as Director of the Clinic for Hematology and Stem Cell Transplantation at University Hospital Essen. He is a key member of the West German Cancer Centre (WTZ) and the ZMB (Zentrum für Molekulare Biomedizin), where he leads research in the Oncology program. His work bridges clinical practice and molecular cancer research, with a focus on improving outcomes for patients with aggressive lymphomas and lung cancers. His research interests center on B-cell lymphomas , DNA damage response , transcription factor p53 , functional genomics , and cellular immunotherapy . He investigates mechanisms of therapy resistance, tumor evolution, and immune evasion, particularly in the context of CAR-T therapy and stem cell transplantation. His lab employs cutting-edge genomic and functional screening approaches to identify druggable vulnerabilities in cancer. The recent publications highlight a strong trend in understanding molecular drivers of aggressive cancers—particularly in lymphoma and small cell lung cancer . Themes include genomic instability , immune modulation , metabolic dependencies , and therapy resistance mechanisms . His work frequently appears in top journals like Nature , Cell , Blood , and Cancer Discovery , reflecting high impact and translational relevance. His scientific honors include: German Cancer Award 2023 (Deutscher Krebspreis) DKH-Exzellenzförderprogramm funding (1 million euros until 2028) Lead role in the TACTIC project (11.8 million euros from German Cancer Aid) Prof. Reinhardt leads a well-funded, dynamic research team with strong translational links to clinical oncology. He is actively recruiting MD, PhD, and postdoctoral candidates, indicating ongoing research expansion. His lab collaborates nationally and focuses on preclinical drug development, particularly targeting transcriptional addiction in cancer. He has no named students listed, but his leadership in large consortia and high-impact publications underscores his role as a principal investigator and mentor. He is affiliated with the following institutions and initiatives: Faculty of Medicine, University of Duisburg-Essen University Hospital Essen West German Cancer Centre (WTZ) ZMB – Zentrum für Molekulare Biomedizin TACTIC Project (Targeting Transcriptional Addiction in Cancer) German Cancer Aid (Deutsche Krebshilfe) funded programs

Matthias Gunzerمشاهده پروفایل

استاد

• Immunology
• In Vivo Imaging
• Neutrophil Biology
• +۷ مورد دیگر

Prof. Dr. Matthias Gunzer is a leading faculty member and Director at the Institute of Experimental Immunology & Imaging and the Center of Medical Biotechnology (ZMB) at the University of Duisburg-Essen, Faculty of Medicine. His research is centered on understanding immune cell dynamics, particularly neutrophil behavior, using advanced imaging technologies such as intravital two-photon and light-sheet microscopy. He leads a major research group with extensive funding, including a recent DFG grant for the development of the high-speed 'ComplexEye' microscope. His research interests span immunology, in vivo imaging, neutrophil biology, inflammation, and host-pathogen interactions. His work focuses on visualizing immune responses in real time within vital organs like the brain, lung, and bone marrow. He has made significant contributions to understanding neutrophil swarming, migration, and their roles in stroke, infection, and cancer. His recent publications (2023–2025) demonstrate a strong trend in high-impact journals, focusing on advanced imaging techniques, immune cell dynamics in disease, and the development of novel tools for immunological research. His work frequently appears in Nature , Science , Immunity , and Nature Communications . Prof. Gunzer has received significant research funding, notably from the German Research Foundation (DFG), including a grant of nearly 1.3 million euros for the development of next-generation microscopy to study immune responses. He collaborates with institutions such as ISAS Dortmund and leads a research group actively investigating immune responses in stroke, retroviral infections, and cancer. He is a principal investigator at the Institute for Experimental Immunology and Imaging, supervising postdocs, doctoral students, and research assistants. His team includes principal investigators like Dr. Vikramjeet Singh and Dr. Anja Hasenberg, indicating a large, collaborative research environment. He is also involved with the IMCES Light Microscopy & FACS Unit.

• Pharmacology
• Cardiovascular Research
• Inflammation
• +۳ مورد دیگر

Jennifer Irvine is a Lecturer in the Department of Pharmacology at Monash University. Her research focuses on cardiovascular pharmacology, particularly the role of nitroxyl (HNO) and angiotensin receptor agonists in regulating endothelial function, inflammation, and cardiomyocyte hypertrophy. She has contributed to studies on soluble guanylyl cyclase activation and its therapeutic implications in hypertension and cardiac remodeling. Her academic work aligns with UN Sustainable Development Goals related to good health and well-being (SDG 3). She is a member of the Monash Partners advisory panel (2018–2021), contributing to healthcare policy and academic partnerships. Her research integrates molecular biology, drug development, and translational cardiovascular science. Irvine’s publications explore anti-inflammatory effects of pharmacological agents, mechanisms of vascular dysfunction, and novel therapeutic targets for cardiovascular diseases. Her studies often involve in vitro and in vivo models to investigate cellular pathways involved in hypertension and heart failure.

Alex Wadleyمشاهده پروفایل

استادیار

• Exercise Immunology
• Exercise Metabolism
• Inflammation
• +۷ مورد دیگر

Dr. Alex Wadley is an Assistant Professor in Exercise Metabolism at the School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham. He is also an Academy of Medical Sciences Springboard Fellow and Academic Director of the Cellular Health and Metabolism Facility. His research explores the impact of exercise on immunity in clinical populations, including those with type-1 diabetes, lupus, and cancer. Education: BSc in Sport & Exercise Sciences (1st Class Honours), University of Birmingham PhD, University of Birmingham Post-Doctoral Researcher, Loughborough University (2013–14, 2017–19) and University of Worcester (2014–17) Research Interests: Dr. Wadley’s work focuses on the intersection of exercise, metabolism, and immune function. He investigates how regular physical activity modulates inflammation and disease progression in autoimmune conditions. His current clinical trials examine remotely monitored exercise interventions in type-1 diabetes and lupus, and intra-apheresis cycling to improve stem cell donation outcomes. His research bridges clinical application with mechanistic physiology. Publication Trends: His recent publications emphasize clinical exercise interventions, immune cell dynamics, inflammation modulation, and feasibility studies in chronic diseases. Topics include hematopoietic stem cell mobilization, monocyte behavior, and immune checkpoint molecules in response to exercise. Scientific Awards: Academy of Medical Sciences Springboard Fellowship Advising and Grants: Dr. Wadley supervises multiple PhD and Master’s students. He leads projects funded by the Academy of Medical Sciences, Lupus UK, and Rosetrees Trust, focusing on exercise interventions in autoimmune diseases. He actively mentors early-career researchers and contributes to academic training through teaching and supervision. Labs and Teams: He leads a research group conducting clinical trials and is Academic Director of the Cellular Health and Metabolism Facility at the University of Birmingham, supporting interdisciplinary research in metabolism and cellular health.

• Cardiovascular Biology
• Metabolic Disorders
• Stem Cell Research
• +۷ مورد دیگر

Terri Holmes is a Senior Research Associate at the Norwich Medical School, University of East Anglia, where she is a member of the Metabolic Health research group. Her work bridges cardiovascular biology, metabolic regulation, and stem cell-based disease modeling. Her research focuses on the molecular and metabolic mechanisms underlying cardiomyocyte development and cardiovascular disease. Key areas include the role of small nucleolar RNAs (snoRNAs) such as SNORD116, extracellular matrix proteins like Perlecan (HSPG2), and metabolic shifts during stem cell differentiation. She also investigates immune cell dynamics in response to coronary interventions. The trends in her recent publications indicate a strong emphasis on translational molecular cardiology , integrating human pluripotent stem cell models with clinical observations. Her work spans RNA biology , metabolic regulation , cardiac tissue development , and inflammatory responses , often in the context of metabolic and cardiovascular disorders. Dr. Holmes actively collaborates with leading researchers including James G. W. Smith, Chris Denning, and Mandy Peffers. Her publications appear in high-impact journals such as Cell Reports , Trends in Molecular Medicine , and PLoS One . She has not been publicly recognized with any scientific awards based on the available data. Dr. Holmes mentors no formally listed students and is involved in independent and collaborative research projects. There is no mention of grants or funding sources in the provided text. She contributes to research within the Metabolic Health group at UEA, focusing on multidisciplinary approaches to understanding heart metabolism and disease.

Simon Leaمشاهده پروفایل

پژوهشگر ارشد

• Immunology
• Respiratory Medicine
• Chronic Obstructive Pulmonary Disease (COPD)
• +۵ مورد دیگر

Simon Lea is a Research Fellow at the University of Manchester's Division of Immunology, Immunity to Infection and Respiratory Medicine. His work focuses on chronic obstructive pulmonary disease (COPD), macrophage biology, and inflammatory mechanisms. Lea holds a PhD from Newcastle University (2008) and a BSc from Durham University (2004). Research Interests: Lea investigates COPD pathophysiology, macrophage dysfunction in chronic inflammation, bacterial interactions in COPD exacerbations, and corticosteroid insensitivity. His studies integrate immunological, microbiological, and pharmacological approaches to understand airway inflammation and therapeutic targets. Collaborations: He works with Prof. Dave Singh (Clinical Pharmacology), Prof. Jorgen Vestbo (Respiratory Medicine), and researchers like Dr. Andrew Higham. His team includes postdoctoral associates (e.g., Dr. Jian Li) and research staff (e.g., Agusta Beech). Publications: Over 48 peer-reviewed articles, including work on corticosteroid mechanisms, Nrf2 activators, and bacterial responses in COPD macrophages. His recent work explores e-cigarette impacts on sputum inflammation and antimicrobial strategies against Haemophilus influenzae. Teaching: Supervises multiple PhD and MPhil students on topics like COPD macrophage subpopulations, iron metabolism, and MAP kinase pathways. Active in mentoring early-stage researchers in respiratory immunology.

Nicholas Scottمشاهده پروفایل

پژوهشگر

• Immunology
• Infectious Diseases
• Microbiology
• +۳ مورد دیگر

Nicholas Scott is a Researcher at the University of Manchester, affiliated with the Division of Immunology, Immunity to Infection, and Respiratory Medicine. He holds a PhD and Bachelor of Science from The University of Melbourne. His research focuses on immunology, particularly immune responses in infectious diseases like COVID-19 and autoimmune disorders such as type 1 diabetes. Key areas include monocyte/macrophage dynamics, microbiota interactions, and immune signatures in disease progression. Education: Doctor of Philosophy, The University of Melbourne Bachelor of Science, The University of Melbourne Research Interests: Clinical Immunology COVID-19 Pathogenesis Autoimmune Responses Monocyte/Macrophage Biology Microbiota-Immune Interactions Lung and Intestinal Immunology Recent Work Trends: His publications emphasize longitudinal immune profiling in acute/convalescent phases of diseases, with a focus on myeloid signatures in pandemic responses. Collaborations involve multi-institutional projects like Respiratory TRC and CIRCO, addressing immune mechanisms in respiratory and systemic disorders. Lab/Team Affiliations: Active within interdisciplinary teams studying respiratory medicine, infection immunity, and translational immunology at the University of Manchester.

Brian Huntlyمشاهده پروفایل

استاد

• Leukaemia Stem Cell Biology
• Leukaemogenesis
• Transcriptional and Epigenetic Alterations
• +۳ مورد دیگر

Professor Brian Huntly is a clinical research scientist at the University of Cambridge , leading the Department of Haematology and conducting research at the Cambridge Stem Cell Institute . As a Consultant Haematologist at Addenbrooke’s Hospital, he bridges clinical practice with fundamental research in leukaemia stem cell biology and malignant haematopoiesis . MD from University of Edinburgh PhD in Cambridge Postdoctoral training at Harvard Fellow of Royal College of Pathologists Member of Royal College of Physicians Chair of EHA Fellowships and Grants Committee His research explores how transcriptional and epigenetic alterations drive acute myeloid leukaemia (AML) and malignant lymphomas , with a focus on: Chromatin remodeling Enhancer dysfunction Cancer stem cell dependencies Metabolic vulnerabilities Therapeutic target discovery Mutation-specific disease mechanisms Recent publications highlight: 2025: BET inhibitor resistance mechanisms 2024: CREBBP inactivation in ALL 2024: BCR::ABL1 variant analysis 2023: Chromatin factor screening 2022: UTX/KDM6a tumor suppression Scientific awards and grants include: EHA-José Carreras Young Investigator Award AstraZeneca research funding Cancer Research UK European Hematology Association European Research Council Kay Kendall Leukaemia Fund Wellcome Trust Key collaborations with George Vassiliou and Tony Kouzarides have led to breakthroughs in AML epigenetics and BET protein inhibitors . His group maintains laboratory facilities at the Jeffrey Cheah Biomedical Centre on Cambridge Biomedical Campus. Students and researchers in his group investigate: Leukaemia initiation mechanisms Epigenetic priming Metabolic dependencies DNA repair vulnerabilities Chromatin organization Stem cell fate transitions

• Biochemistry
• Pharmacology
• Cancer Research
• +۳ مورد دیگر

Dr. Astrid Kahnt is a Researcher at the Institute of Pharmaceutical Chemistry within the Department 14 - Biochemistry, Chemistry and Pharmacy at Goethe University Frankfurt. Her work focuses on lipid mediators, enzymology, and their roles in inflammation and cancer. She is affiliated with the Biochemistry for Pharmacists unit and contributes to teaching through courses like Drug Analysis and Pharmaceutical/Medicinal Chemistry II . Research Interests: Dr. Kahnt’s research explores lipoxygenase enzymes (e.g., 5-LO), specialized pro-resolving mediators (SPMs), and their implications in cancer and inflammation. She investigates drug design targeting these pathways, including enzyme inhibitors and dual-modulators of receptors like PPARγ. Her work integrates biochemical assays, cellular models, and structural biology to uncover mechanisms linking lipid signaling to disease. Recent Trends in Publications: Her recent articles emphasize 5-lipoxygenase’s non-canonical roles in cancer progression, structure-based drug design for enzyme degradation (e.g., PROTACS), and the biosynthesis of pro-resolving mediators. She also explores polypharmacological approaches to modulate multiple targets (e.g., Farnesoid X Receptor/SEH) for therapeutic efficacy. Teaching and Affiliations: She coordinates courses on drug analysis and medicinal chemistry, reflecting her expertise in pharmaceutical applications. Her lab’s interdisciplinary approach bridges biochemistry, pharmacology, and drug design, contributing to both fundamental and translational research.

Dani Dixonمشاهده پروفایل

دانشیار

• Innate Immunology
• Acute and Chronic Lung Injury
• Heart Failure
• +۴ مورد دیگر

Associate Professor Dani Dixon holds academic positions at Flinders University (College of Medicine and Public Health) and the Northern Ontario School of Medicine, Canada. She is Head of The Lung Lab and Joint Head of the Radon Research Facility. Her expertise spans innate immunology, acute and chronic lung injury (e.g., ALI/ARDS, bronchiolitis), and heart failure. She has secured over $3M in research funding and published >60 peer-reviewed articles. Education includes a PhD in Paediatrics (2004) and a BSc in Immunology/Genetics (1995). Research focuses on leukocyte regulation of lung defense mechanisms, fluid dynamics in pulmonary edema, and translational therapies for acute lung injury. Key contributions include identifying immunological links between maternal breast milk and infant respiratory health. Awards include the 2003 International Lactation Consultant Association Research Poster Award, 2015 SA Medical Scientists Professional Development Award, and multiple grants/review roles. She mentors PhD students and advises on clinical translation, animal welfare, and intensive care medicine. Professional engagement includes peer-reviewing >20 journals annually, grant reviewing for NHMRC and international bodies, and science outreach via the CSIRO 'Scientists in Schools' program.

Mark McPhailمشاهده پروفایل

استاد بالینی

• Liver Failure Syndromes
• Metabolic Profiling
• Immunology
• +۳ مورد دیگر

Mark McPhail is a Clinical Professor in Experimental Medicine and Consultant in Liver Critical Care and Hepatology at King's College London's Institute of Liver Studies, with an additional role as Honorary Senior Lecturer at Imperial College London's Department of Hepatology. His research focuses on outcome prediction, metabolism, and immunity in liver failure syndromes, including novel diagnostic methods for hepatic encephalopathy and sepsis. He holds a PhD in Molecular Physics from the University of Strathclyde, with prior collaborations at NASA's Jet Propulsion Laboratory and the University of Bologna. Education includes a Bachelor of Medicine and Surgery (University of Glasgow, 2004), a PhD in Molecular Quantum Physics (University of Strathclyde, 1997), and a BSc in Physics (University of Strathclyde, 1994). His current work emphasizes metabolic profiling to improve prognostication and identify pathways for immune modulation via lipid interactions with CD14+ monocytes in acute and acute-on-chronic liver failure. Research trends in his articles highlight advancements in understanding monocyte behavior, sepsis prevention, and biomarker development for kidney injury post-transplantation. His projects include exploring adrenomedullin's role in immunosuppression and investigating checkpoint inhibitors to restore immune function in liver failure. Grants funded by MRC and KFAS support his work on fatty liver disease and immunometabolic pathways. Key grants include studies on normothermic machine perfusion for non-alcoholic fatty liver disease and the inhibition of lysophosphatidic acid pathways in cirrhosis. He collaborates internationally on topics like TIM-3 in immune dysregulation and gut microbiome interactions in cirrhosis.

Nico Melzerمشاهده پروفایل

دانشیار

• Neuroimmunology
• Epilepsy
• Autoimmune encephalitis
• +۶ مورد دیگر

PD Dr. med. Nico Melzer is Group Leader of the research unit "Inflammatory Mechanisms of epileptogenic Neurodegeneration" at the Department of Neurology, Heinrich-Heine-University Düsseldorf , Germany. His work integrates experimental, translational and clinical approaches to understand how immune and neurovascular mechanisms drive cortical hyperexcitability and neurodegeneration in epilepsy. Education & Academic Standing: Medical doctorate (Dr. med.) with subsequent habilitation conferring the title Privatdozent (PD) , the German equivalent of Associate Professor. Research Focus: The Melzer group investigates the tri-directional interplay between immunity, neurovascular function and neuronal excitability . Using human biosamples, advanced neuroimaging, and rodent models of limbic encephalitis, the team has demonstrated that CD8 + T-lymphocytes can directly trigger hippocampal sclerosis and chronic temporal lobe epilepsy. A second pillar centres on autoimmune encephalitis caused by antibodies to neuronal surface antigens (e.g. GAD65, IgLON5, GABA A -R), dissecting genetic risk, CSF proteomic signatures, and therapeutic outcomes. Current projects exploit TSPO PET imaging to quantify microglial activation, apply single-cell sequencing to cerebrospinal fluid, and test complement- and B-cell-directed therapies in national trials. The ultimate goal is to translate immunological insights into precision treatments that prevent pharmacoresistant epilepsy and associated cognitive decline. Scientific Awards & Recognition: Founding member and steering committee, German Network for Research on Autoimmune Encephalitis (GENERATE) – funded by the Federal Ministry of Education and Research (BMBF). Board member, German Society of Epileptology (DGfE) Epilepsy Surgery Working Group. Lead author on Deutsche Gesellschaft für Neurologie guidelines for myasthenia gravis and myasthenic syndromes. Grants & Collaborative Networks: The laboratory coordinates multi-centre observational studies and investigator-initiated trials across >30 German centres. Ongoing BMBF GENERATE funding supports prospective registries for autoimmune encephalitis and the first genome-wide association studies in anti-GAD65 and anti-IgLON5 syndromes. Clinical & Academic Service: Dr Melzer runs the university outpatient clinics for Autoimmune Encephalitis and Refractory Epilepsy and provides specialised inpatient care at the Department of Neurology, Heinrich-Heine-University Hospital Düsseldorf.